{"id":"https://openalex.org/W4392687797","doi":"https://doi.org/10.1158/0008-5472.c.6505787.v1","title":"Data from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity","display_name":"Data from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392687797","doi":"https://doi.org/10.1158/0008-5472.c.6505787.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6505787.v1","doi":"https://doi.org/10.1158/0008-5472.c.6505787.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6505787.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6505787.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100400914","display_name":"Yuan Cao","orcid":"https://orcid.org/0000-0002-5873-2293","observed_orcids":["https://orcid.org/0000-0002-5873-2293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087180556","display_name":"Clare Y. Slaney","orcid":"https://orcid.org/0000-0002-6986-6115","observed_orcids":["https://orcid.org/0000-0002-6986-6115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clare Y. Slaney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110080160","display_name":"Bradley N. Bidwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradley N. Bidwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045235444","display_name":"Belinda S. Parker","orcid":"https://orcid.org/0000-0002-8333-1926","observed_orcids":["https://orcid.org/0000-0002-8333-1926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Belinda S. Parker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077935453","display_name":"Cameron N. Johnstone","orcid":"https://orcid.org/0000-0002-6464-8661","observed_orcids":["https://orcid.org/0000-0002-6464-8661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cameron N. Johnstone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025173076","display_name":"Jai Rautela","orcid":"https://orcid.org/0000-0002-4253-9966","observed_orcids":["https://orcid.org/0000-0002-4253-9966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jai Rautela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048206365","display_name":"Bedrich L. Eckhardt","orcid":"https://orcid.org/0000-0002-3402-3900","observed_orcids":["https://orcid.org/0000-0002-3402-3900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bedrich L. Eckhardt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102010745","display_name":"Robin L. Anderson","orcid":"https://orcid.org/0000-0002-6841-7422","observed_orcids":["https://orcid.org/0000-0002-6841-7422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin L. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.984000027179718},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":1.0},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7519999742507935},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.796999990940094},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.8136700987815857},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6406986117362976},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6237954497337341},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5788513422012329},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5495820641517639},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.47153836488723755},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4430849850177765},{"id":"https://openalex.org/C2993589390","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Breast cancer metastasis","level":5,"score":0.4306986629962921},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.42867642641067505},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4180946946144104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3894939422607422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38180869817733765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30323973298072815},{"id":"https://openalex.org/C2992691968","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Cancer metastasis","level":4,"score":0.1731056272983551},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12019234895706177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07673010230064392},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.05898687243461609}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6505787.v1","doi":"https://doi.org/10.1158/0008-5472.c.6505787.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6505787.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6505787.v1","doi":"https://doi.org/10.1158/0008-5472.c.6505787.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6505787.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2153646261","https://openalex.org/W4362242315","https://openalex.org/W4396515168","https://openalex.org/W2148458046","https://openalex.org/W2007868460","https://openalex.org/W2225677509","https://openalex.org/W4361846339","https://openalex.org/W2999789991","https://openalex.org/W4361252124","https://openalex.org/W2789490922"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"TGF\u03b2":[2],"growth":[3],"factor":[4,61],"family":[5],"member":[6],"BMP4":[7,44,86,121],"is":[8,26],"a":[9,125],"potent":[10],"suppressor":[11,33],"of":[12,21,31,38,66,92,120],"breast":[13,114,130],"cancer":[14],"metastasis.":[15],"In":[16],"the":[17,19,36,69,88],"mouse,":[18],"development":[20],"highly":[22],"metastatic":[23,84],"mammary":[24],"tumors":[25],"associated":[27],"with":[28,58,108,113],"an":[29],"accumulation":[30],"myeloid-derived":[32],"cells":[34],"(MDSC),":[35],"numbers":[37],"which":[39],"are":[40,47],"reduced":[41],"by":[42,56,64,94],"exogenous":[43],"expression.":[45],"MDSCs":[46,75,106],"undetectable":[48],"in":[49,99,111],"na\u00efve":[50],"mice":[51],"but":[52],"can":[53],"be":[54],"induced":[55],"treatment":[57,127],"granulocyte":[59],"colony-stimulating":[60],"(G-CSF/Csf3)":[62],"or":[63],"secretion":[65,91],"G-CSF":[67,93],"from":[68],"tumor.":[70],"Both":[71],"tumor-induced":[72],"and":[73,80,90,101],"G-CSF\u2013induced":[74],"effectively":[76],"suppress":[77],"T-cell":[78],"activation":[79,119],"proliferation,":[81],"leading":[82],"to":[83],"enhancement.":[85],"reduces":[87],"expression":[89],"inhibiting":[95],"NF-\u03baB":[96],"(Nfkb1)":[97],"activity":[98],"human":[100],"mouse":[102],"tumor":[103],"lines.":[104],"Because":[105],"correlate":[107],"poor":[109],"prognosis":[110],"patients":[112],"cancer,":[115],"therapies":[116],"based":[117],"on":[118],"signaling":[122],"may":[123],"offer":[124],"novel":[126],"strategy":[128],"for":[129],"cancer.":[131],"Cancer":[132],"Res;":[133],"74(18);":[134],"5091\u2013102.":[135],"\u00a92014":[136],"AACR.":[137]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2024-03-13T00:00:00"}
