{"id":"https://openalex.org/W4392687017","doi":"https://doi.org/10.1158/0008-5472.c.6506166.v1","title":"Data from Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary Carcinomas","display_name":"Data from Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary Carcinomas","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392687017","doi":"https://doi.org/10.1158/0008-5472.c.6506166.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6506166.v1","doi":"https://doi.org/10.1158/0008-5472.c.6506166.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6506166.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6506166.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024857998","display_name":"Irineu Illa-Bochaca","orcid":"https://orcid.org/0000-0002-8039-565X","observed_orcids":["https://orcid.org/0000-0002-8039-565X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irineu Illa-Bochaca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082963259","display_name":"Haoxu Ouyang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haoxu Ouyang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102006300","display_name":"Jonathan Tang","orcid":"https://orcid.org/0000-0002-8831-5976","observed_orcids":["https://orcid.org/0000-0002-8831-5976"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003028808","display_name":"Christopher Sebastiano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Sebastiano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032768695","display_name":"Jian\u2010Hua Mao","orcid":"https://orcid.org/0000-0001-9320-6021","observed_orcids":["https://orcid.org/0000-0001-9320-6021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Hua Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076358770","display_name":"Sylvain V. Costes","orcid":"https://orcid.org/0000-0002-8542-2389","observed_orcids":["https://orcid.org/0000-0002-8542-2389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvain V. Costes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052554629","display_name":"Sandra Demaria","orcid":"https://orcid.org/0000-0003-4426-0499","observed_orcids":["https://orcid.org/0000-0003-4426-0499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Demaria","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062551209","display_name":"Mary Helen Barcellos\u2010Hoff","orcid":"https://orcid.org/0000-0002-5994-9558","observed_orcids":["https://orcid.org/0000-0002-5994-9558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Helen Barcellos-Hoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-let-radiation","display_name":"high-LET radiation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7929999828338623},{"id":"https://openalex.org/keywords/radiation-induced-cancer","display_name":"radiation-induced cancer","score":0.5730000138282776},{"id":"https://openalex.org/keywords/cytokeratin-18","display_name":"cytokeratin 18","score":0.7789999842643738},{"id":"https://openalex.org/keywords/keratin-14","display_name":"keratin 14","score":0.9980000257492065},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.765999972820282},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.7540000081062317},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.9959999918937683},{"id":"https://openalex.org/keywords/e-cadherin-loss","display_name":"E-cadherin loss","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5849999785423279},{"id":"https://openalex.org/keywords/radiation-chimeras","display_name":"radiation chimeras","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.8883533477783203},{"id":"https://openalex.org/C203763787","wikidata":"https://www.wikidata.org/wiki/Q371029","display_name":"Null (SQL)","level":2,"score":0.6413142085075378},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5101628303527832},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37161532044410706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3493068516254425},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2525579333305359},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.22715863585472107},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16239479184150696},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6506166.v1","doi":"https://doi.org/10.1158/0008-5472.c.6506166.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6506166.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6506166.v1","doi":"https://doi.org/10.1158/0008-5472.c.6506166.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6506166.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116184323","https://openalex.org/W6964556299","https://openalex.org/W7095456206","https://openalex.org/W2049860203","https://openalex.org/W2024116708","https://openalex.org/W65241012","https://openalex.org/W4300692491","https://openalex.org/W2127449951","https://openalex.org/W4361944365","https://openalex.org/W6927123532"],"abstract_inverted_index":{"Abstract":[0],"Densely":[1],"ionizing":[2,25,45,244],"radiation,":[3],"which":[4,39,251],"is":[5,28],"present":[6],"in":[7,14,38,65,85,115,131,159,196,218,227,261],"the":[8,249],"space":[9],"radiation":[10,15,26,36,245],"environment":[11],"and":[12,52,77,104,109,123,170,173,186,202,232],"used":[13,34],"oncology,":[16],"has":[17],"potentially":[18],"greater":[19],"carcinogenic":[20,240],"effect":[21],"compared":[22,82,162,206,221,256],"with":[23,57,68,83,142,163,168,178,207,222,257],"sparsely":[24],"that":[27,213,239],"prevalent":[29],"on":[30],"earth.":[31],"Here,":[32],"we":[33],"a":[35,71],"chimera":[37],"mice":[40,66,198,220,224],"were":[41,91,118,134,147,153,166,203],"exposed":[42],"to":[43,75,183],"densely":[44,243],"350":[46],"MeV/amu":[47],"Si-particles,":[48],"\u03b3-radiation,":[49],"or":[50,87],"sham-irradiated":[51,86,116,208,223,262],"transplanted":[53],"3":[54],"days":[55],"later":[56],"syngeneic":[58],"Trp53-null":[59,62],"mammary":[60,228],"fragments.":[61],"tumors":[63,113,129,146,152,161,181,195,216,255,259],"arising":[64,114,130,217,260],"irradiated":[67,132],"Si-particles":[69],"had":[70],"shorter":[72],"median":[73],"time":[74],"appearance":[76],"grew":[78,199],"faster":[79,185],"once":[80],"detected":[81],"those":[84,128],"\u03b3-irradiated":[88],"mice.":[89,209],"Tumors":[90],"further":[92],"classified":[93],"by":[94,248],"markers":[95],"keratin":[96,100],"8/18":[97],"(K18,":[98],"KRT18),":[99],"14":[101],"(K14,":[102],"KRT14)":[103],"estrogen":[105],"receptor":[106],"(ER,":[107],"ESR1),":[108],"expression":[110,211],"profiling.":[111],"Most":[112],"hosts":[117,133],"comprised":[119],"of":[120,175,242],"both":[121],"K18-":[122],"K14-positive":[124],"cells":[125],"(K14/18)":[126],"while":[127],"mostly":[135],"K18.":[136],"Keratin":[137],"staining":[138],"was":[139,225],"significantly":[140,200],"associated":[141,167],"ER":[143],"status:":[144],"K14/18":[145,164,191],"predominantly":[148,154],"ER-positive,":[149],"whereas":[150],"K18":[151,160,180,194,215],"ER-negative.":[155],"Genes":[156],"differentially":[157],"expressed":[158],"tumor":[165],"ERBB2":[169],"KRAS,":[171],"metastasis,":[172],"loss":[174],"E-cadherin.":[176],"Consistent":[177],"this,":[179],"tended":[182],"grow":[184],"be":[187],"more":[188,204,253],"metastatic":[189,205],"than":[190],"tumors,":[192],"however,":[193],"particle-irradiated":[197,219],"larger":[201],"An":[210],"profile":[212],"distinguished":[214],"enriched":[226],"stem":[229],"cell,":[230],"stroma,":[231],"Notch":[233],"signaling":[234],"genes.":[235],"These":[236],"data":[237],"suggest":[238],"effects":[241],"are":[246],"mediated":[247],"microenvironment,":[250],"elicits":[252],"aggressive":[254],"similar":[258],"hosts.":[263],"Cancer":[264],"Res;":[265],"74(23);":[266],"7137\u201348.":[267],"\u00a92014":[268],"AACR.":[269]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-03-13T00:00:00"}