{"id":"https://openalex.org/W4392686248","doi":"https://doi.org/10.1158/0008-5472.c.6503645.v1","title":"Data from Systemic Combination Virotherapy for Melanoma with Tumor Antigen-Expressing Vesicular Stomatitis Virus and Adoptive T-cell Transfer","display_name":"Data from Systemic Combination Virotherapy for Melanoma with Tumor Antigen-Expressing Vesicular Stomatitis Virus and Adoptive T-cell Transfer","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392686248","doi":"https://doi.org/10.1158/0008-5472.c.6503645.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6503645.v1","doi":"https://doi.org/10.1158/0008-5472.c.6503645.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6503645.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6503645.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091779165","display_name":"Diana M. Rommelfanger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana M. Rommelfanger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078258328","display_name":"Phonphimon Wongthida","orcid":"https://orcid.org/0009-0004-1250-8159","observed_orcids":["https://orcid.org/0009-0004-1250-8159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phonphimon Wongthida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109094916","display_name":"Rosa Mar\u00eda D\u00edaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosa M. Diaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079693878","display_name":"Karen M. Kaluza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen M. Kaluza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048427923","display_name":"Jill Thompson","orcid":"https://orcid.org/0000-0001-5005-7257","observed_orcids":["https://orcid.org/0000-0001-5005-7257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill M. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002555051","display_name":"Timothy J. Kottke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy J. Kottke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070554485","display_name":"Richard G. Vile","orcid":"https://orcid.org/0000-0003-2192-9372","observed_orcids":["https://orcid.org/0000-0003-2192-9372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard G. Vile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.43549999594688416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9039999842643738},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vesicular-stomatitis-virus","display_name":"vesicular stomatitis virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/gp100","display_name":"gp100","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tumor-antigen-expression","display_name":"tumor antigen expression","score":0.6660000085830688},{"id":"https://openalex.org/keywords/systemic-immunotherapy","display_name":"systemic immunotherapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/vitiligo","display_name":"vitiligo","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.8069999814033508},{"id":"https://openalex.org/keywords/t-cell-persistence","display_name":"T cell persistence","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.8461867570877075},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.7022808790206909},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6470937728881836},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5547545552253723},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5150103569030762},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5042392015457153},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.49878931045532227},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4784814715385437},{"id":"https://openalex.org/C3019255331","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive immunotherapy","level":4,"score":0.4314742386341095},{"id":"https://openalex.org/C2779051857","wikidata":"https://www.wikidata.org/wiki/Q911386","display_name":"Stomatitis","level":2,"score":0.41639822721481323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40672481060028076},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38849908113479614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3374054431915283},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3172610104084015},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2606218457221985},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2045961618423462},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07145828008651733}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6503645.v1","doi":"https://doi.org/10.1158/0008-5472.c.6503645.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6503645.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6503645.v1","doi":"https://doi.org/10.1158/0008-5472.c.6503645.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6503645.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2137990420","https://openalex.org/W4245881004","https://openalex.org/W2008620560","https://openalex.org/W4313385681","https://openalex.org/W3135751170","https://openalex.org/W1987069333","https://openalex.org/W2088594694","https://openalex.org/W2564100530","https://openalex.org/W2901718439","https://openalex.org/W2548225532"],"abstract_inverted_index":{"Abstract":[0],"Oncolytic":[1],"virotherapy":[2,143],"offers":[3],"the":[4,64,123,167],"potential":[5],"to":[6,62,130,151],"treat":[7],"tumors":[8],"both":[9],"as":[10,21,39,93,95],"a":[11,56,100],"single":[12],"agent":[13],"and":[14,23,77,91,153],"in":[15,72,87,99,133,166],"combination":[16,49,127],"with":[17,43,52,86,122,145,158],"traditional":[18],"modalities":[19],"such":[20],"chemotherapy":[22],"radiotherapy.":[24],"Here":[25],"we":[26],"describe":[27],"an":[28,40,118],"effective,":[29],"fully":[30],"systemic":[31,53,142],"treatment":[32],"regimen,":[33],"which":[34,162],"combines":[35],"virotherapy,":[36],"acting":[37],"essentially":[38],"adjuvant":[41],"immunotherapy,":[42],"adoptive":[44,159],"cell":[45],"transfer":[46],"(ACT).":[47],"The":[48],"of":[50,55,74,79,102,135],"ACT":[51,126],"administration":[54],"vesicular":[57],"stomatitis":[58],"virus":[59],"(VSV)":[60],"engineered":[61],"express":[63],"endogenous":[65],"melanocyte":[66],"antigen":[67,121],"glycoprotein":[68],"100":[69],"(gp100)":[70],"resulted":[71],"regression":[73],"established":[75],"melanomas":[76],"generation":[78],"antitumor":[80],"immunity.":[81],"Tumor":[82],"response":[83,132],"was":[84,113],"associated":[85],"vivo":[88],"T-cell":[89,160],"persistence":[90],"activation":[92],"well":[94],"treatment-related":[96],"vitiligo.":[97],"However,":[98],"proportion":[101],"treated":[103],"mice,":[104],"initial":[105],"tumor":[106,120],"regressions":[107],"were":[108],"followed":[109],"by":[110,116],"recurrences.":[111],"Therapy":[112],"further":[114],"enhanced":[115],"targeting":[117],"additional":[119],"VSV-antigen":[124],"+":[125],"strategy,":[128],"leading":[129],"sustained":[131],"100%":[134],"mice.":[136],"Together,":[137],"our":[138],"findings":[139],"suggest":[140],"that":[141],"combined":[144],"antigen-expressing":[146],"VSV":[147],"could":[148],"be":[149],"used":[150,165],"support":[152],"enhance":[154],"clinical":[155],"immunotherapy":[156],"protocols":[157],"transfer,":[161],"are":[163],"already":[164],"clinic.":[168],"Cancer":[169],"Res;":[170],"72(18);":[171],"4753\u201364.":[172],"\u00a92012":[173],"AACR.":[174]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-13T00:00:00"}
