{"id":"https://openalex.org/W4392686131","doi":"https://doi.org/10.1158/0008-5472.c.6503690","title":"Data from The Oncogenic Lung Cancer Fusion Kinase CD74-ROS Activates a Novel Invasiveness Pathway through E-Syt1 Phosphorylation","display_name":"Data from The Oncogenic Lung Cancer Fusion Kinase CD74-ROS Activates a Novel Invasiveness Pathway through E-Syt1 Phosphorylation","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392686131","doi":"https://doi.org/10.1158/0008-5472.c.6503690"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6503690","doi":"https://doi.org/10.1158/0008-5472.c.6503690","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6503690","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6503690","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102736194","display_name":"Hyun Jung Jun","orcid":"https://orcid.org/0000-0003-0825-8068","observed_orcids":["https://orcid.org/0000-0003-0825-8068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyun Jung Jun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088250417","display_name":"Hannah Johnson","orcid":"https://orcid.org/0009-0003-1126-8440","observed_orcids":["https://orcid.org/0009-0003-1126-8440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054412365","display_name":"Roderick Terry Bronson","orcid":"https://orcid.org/0000-0003-3725-2511","observed_orcids":["https://orcid.org/0000-0003-3725-2511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roderick T. Bronson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031031443","display_name":"S\u00e9bastien M. de Feraudy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebastien de Feraudy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002079869","display_name":"Forest M. White","orcid":"https://orcid.org/0000-0002-1545-1651","observed_orcids":["https://orcid.org/0000-0002-1545-1651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Forest White","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084589096","display_name":"Alain Charest","orcid":"https://orcid.org/0000-0002-1548-6950","observed_orcids":["https://orcid.org/0000-0002-1548-6950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alain Charest","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8360000252723694},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/oncogenic-tyrosine-kinase","display_name":"oncogenic tyrosine kinase","score":0.7509999871253967},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.48899999260902405},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.8169999718666077},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6838231086730957},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.63266521692276},{"id":"https://openalex.org/C119997001","wikidata":"https://www.wikidata.org/wiki/Q21113110","display_name":"CD74","level":5,"score":0.5547604560852051},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48629316687583923},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4739782214164734},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44379791617393494},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4186980724334717},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4167071580886841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.335773766040802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2684899568557739},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2149367332458496},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13271144032478333},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10548126697540283},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06861042976379395},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.0},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6503690","doi":"https://doi.org/10.1158/0008-5472.c.6503690","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6503690","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6503690.v1","doi":"https://doi.org/10.1158/0008-5472.c.6503690.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6503690.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6503690","doi":"https://doi.org/10.1158/0008-5472.c.6503690","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6503690","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1526528816","https://openalex.org/W7101109382","https://openalex.org/W7148627543","https://openalex.org/W2607581659","https://openalex.org/W2115929982","https://openalex.org/W2161329624","https://openalex.org/W4281797873","https://openalex.org/W4416062968","https://openalex.org/W4361944326","https://openalex.org/W2148332636"],"abstract_inverted_index":{"Abstract":[0],"Patients":[1],"with":[2,7],"lung":[3,32],"cancer":[4,33,183],"often":[5],"present":[6],"metastatic":[8,84],"disease":[9],"and":[10,69,83,142,186],"therefore":[11],"have":[12],"a":[13,36,107,113,180],"very":[14],"poor":[15],"prognosis.":[16],"The":[17],"recent":[18],"discovery":[19],"of":[20,42,59,89,120,126,133,150,154,169,182,198],"several":[21],"novel":[22,114],"ROS":[23,61,189],"receptor":[24],"tyrosine":[25,71],"kinase":[26,91],"molecular":[27],"alterations":[28],"in":[29,64,81,85,123,140,143,156,195],"non\u2013small":[30],"cell":[31,117,159,184],"(NSCLC)":[34],"presents":[35],"therapeutic":[37,193],"opportunity":[38],"for":[39,57],"the":[40,51,124,127,147,167,196],"development":[41],"new":[43],"targeted":[44],"treatment":[45,197],"strategies.":[46],"Here,":[47],"we":[48,105],"report":[49],"that":[50,75,165,177],"NSCLC-derived":[52],"fusion":[53,62,190],"CD74-ROS,":[54],"which":[55,110],"accounts":[56],"30%":[58],"all":[60],"kinases":[63,191],"NSCLC,":[65],"is":[66,179],"an":[67],"active":[68],"oncogenic":[70,148],"kinase.":[72],"We":[73],"found":[74],"CD74-ROS\u2013expressing":[76],"cells":[77],"were":[78],"highly":[79],"invasive":[80,163],"vitro":[82,141],"vivo.":[86],"Pharmacologic":[87],"inhibition":[88],"CD74-ROS":[90,111,121,155],"activity":[92,149],"reversed":[93],"its":[94],"transforming":[95],"capacity":[96],"by":[97,109],"attenuating":[98],"downstream":[99],"signaling":[100],"networks.":[101],"Using":[102],"quantitative":[103],"phosphoproteomics,":[104],"uncovered":[106],"mechanism":[108],"activates":[112],"pathway":[115],"driving":[116],"invasion.":[118],"Expression":[119],"resulted":[122],"phosphorylation":[125],"extended":[128],"synaptotagmin-like":[129],"protein":[130],"E-Syt1.":[131],"Elimination":[132],"E-Syt1":[134,170,178],"expression":[135,153],"drastically":[136],"reduced":[137],"invasiveness":[138],"both":[139],"vivo":[144],"without":[145],"modifying":[146],"CD74-ROS.":[151],"Furthermore,":[152],"noninvasive":[157],"NSCLC":[158],"lines":[160],"readily":[161],"conferred":[162],"properties":[164],"paralleled":[166],"acquisition":[168],"phosphorylation.":[171],"Taken":[172],"together,":[173],"our":[174],"findings":[175],"indicate":[176],"mediator":[181],"invasion":[185],"molecularly":[187],"define":[188],"as":[192],"targets":[194],"NSCLC.":[199],"Cancer":[200],"Res;":[201],"72(15);":[202],"3764\u201374.":[203],"\u00a92012":[204],"AACR.":[205]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-13T00:00:00"}