{"id":"https://openalex.org/W4392685332","doi":"https://doi.org/10.1158/0008-5472.c.6511107","title":"Data from Mcl-1 Interacts with Akt to Promote Lung Cancer Progression","display_name":"Data from Mcl-1 Interacts with Akt to Promote Lung Cancer Progression","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4392685332","doi":"https://doi.org/10.1158/0008-5472.c.6511107"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6511107","doi":"https://doi.org/10.1158/0008-5472.c.6511107","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6511107","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6511107","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100445726","display_name":"Guo Chen","orcid":"https://orcid.org/0000-0001-8886-1873","observed_orcids":["https://orcid.org/0000-0001-8886-1873","https://orcid.org/0009-0005-2308-4678"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6301-4931","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057870036","display_name":"Dongkyoo Park","orcid":"https://orcid.org/0000-0002-3233-2478","observed_orcids":["https://orcid.org/0000-0002-3233-2478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dongkyoo Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035252203","display_name":"Andrew T. Magis","orcid":"https://orcid.org/0000-0003-0576-677X","observed_orcids":["https://orcid.org/0000-0003-0576-677X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew T. Magis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0576-677X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012015166","display_name":"Madhusmita Behera","orcid":"https://orcid.org/0000-0003-1121-6002","observed_orcids":["https://orcid.org/0000-0003-1121-6002","https://orcid.org/0000-0003-1095-0395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhusmita Behera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088178599","display_name":"Suresh S. Ramalingam","orcid":"https://orcid.org/0000-0002-0757-3106","observed_orcids":["https://orcid.org/0000-0002-0757-3106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh S. Ramalingam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015060656","display_name":"Taofeek Kunle Owonikoko","orcid":"https://orcid.org/0000-0002-7724-7728","observed_orcids":["https://orcid.org/0000-0002-7724-7728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taofeek K. Owonikoko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023971012","display_name":"Gabriel Sica","orcid":"https://orcid.org/0000-0002-1080-2432","observed_orcids":["https://orcid.org/0000-0002-1080-2432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel L. Sica","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073266870","display_name":"Keqiang Ye","orcid":"https://orcid.org/0000-0002-7657-8154","observed_orcids":["https://orcid.org/0000-0002-7657-8154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keqiang Ye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460210","display_name":"Chao Zhang","orcid":"https://orcid.org/0000-0002-7863-0737","observed_orcids":["https://orcid.org/0000-0002-7863-0737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042210553","display_name":"Zhengjia Chen","orcid":"https://orcid.org/0000-0002-6301-4931","observed_orcids":["https://orcid.org/0000-0002-6301-4931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhengjia Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6301-4931","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026088869","display_name":"Walter John Curran","orcid":"https://orcid.org/0000-0002-7552-4453","observed_orcids":["https://orcid.org/0000-0002-7552-4453"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter J. Curran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101413535","display_name":"Xingming Deng","orcid":"https://orcid.org/0000-0003-0319-1511","observed_orcids":["https://orcid.org/0000-0003-0319-1511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingming Deng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.11500000208616257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":1.0},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8740000128746033},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.828000009059906},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.625},{"id":"https://openalex.org/keywords/pest-domain","display_name":"PEST domain","score":0.6710000038146973},{"id":"https://openalex.org/keywords/ph-domain","display_name":"pleckstrin homology domain","score":0.9919999837875366},{"id":"https://openalex.org/keywords/akt-activation","display_name":"Akt activation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cancer-cell-growth","display_name":"cancer cell growth","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.669013500213623},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5756110548973083},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5230811238288879},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5034634470939636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35698938369750977},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2637242078781128},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2602275013923645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2589191794395447},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2407294511795044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23324060440063477}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6511107","doi":"https://doi.org/10.1158/0008-5472.c.6511107","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6511107","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6511107","doi":"https://doi.org/10.1158/0008-5472.c.6511107","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6511107","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2982619316","https://openalex.org/W2012835470","https://openalex.org/W2008521829","https://openalex.org/W4403538118","https://openalex.org/W2024623791","https://openalex.org/W2751251487","https://openalex.org/W2146426819","https://openalex.org/W4362479116","https://openalex.org/W1503417586","https://openalex.org/W2011102246"],"abstract_inverted_index":{"Abstract":[0],"Mcl-1":[1,47,59,68,88,139],"is":[2,23,35,104],"a":[3,12,44,163,168,209,235],"unique":[4],"antiapoptotic":[5],"Bcl2":[6],"family":[7],"protein":[8],"that":[9,27,106,173,223],"functions":[10,31],"as":[11,162,232],"gatekeeper":[13],"in":[14,19,38,50,82,85,122,145,195,198],"manipulating":[15],"apoptosis":[16],"and":[17,32,48,84,113,179,189,197,238],"survival":[18],"cancer":[20,53,63,79,194,242],"cells.":[21],"Akt":[22,49,72,96,121,143,161,187],"an":[24,123],"oncogenic":[25],"kinase":[26,114],"regulates":[28],"multiple":[29],"cellular":[30],"its":[33,92],"activity":[34,144,188],"significantly":[36,70],"elevated":[37],"human":[39,61],"cancers.":[40],"Here":[41],"we":[42,166],"discovered":[43],"cross-talk":[45],"between":[46,109],"promoting":[51],"lung":[52,62,78,153,193,217],"cell":[54,80,152],"growth.":[55],"Depletion":[56],"of":[57,77,128,160,186,192,216],"endogenous":[58],"from":[60,148],"cells":[64],"using":[65],"CRISPR/Cas9":[66],"or":[67],"shRNA":[69],"decreased":[71],"activity,":[73],"leading":[74,183],"to":[75,135,184],"suppression":[76,185],"growth":[81,190],"vitro":[83,196],"xenografts.":[86],"Mechanistically,":[87],"directly":[89,174],"interacted":[90],"via":[91],"PEST":[93],"domain":[94,112,115,130,159,178],"with":[95,142,150],"at":[97],"the":[98,107,110,156,176,202,214],"pleckstrin":[99],"homology":[100],"(PH)":[101],"domain.":[102],"It":[103],"known":[105],"interactions":[108,134],"PH":[111,158,177],"(KD)":[116],"are":[117],"important":[118],"for":[119,213,241],"maintaining":[120],"inactive":[124],"state.":[125],"The":[126],"binding":[127],"Mcl-1/PH":[129],"disrupted":[131],"intramolecular":[132],"PH/KD":[133],"activate":[136],"Akt.":[137],"Intriguingly,":[138],"expression":[140],"correlated":[141],"tumor":[146],"tissues":[147],"patients":[149],"non\u2013small":[151],"cancer.":[154,218],"Using":[155],"Mcl-1\u2013binding":[157],"docking":[164],"site,":[165],"identified":[167],"novel":[169],"small":[170,229],"molecule,":[171],"PH-687,":[172],"targets":[175],"disrupts":[180],"Mcl-1/Akt":[181,203,225],"binding,":[182],"inhibition":[191],"vivo.":[199],"By":[200],"targeting":[201,224],"interaction,":[204],"this":[205],"mechanism-driven":[206],"agent":[207],"provides":[208],"highly":[210],"attractive":[211],"strategy":[212,240],"treatment":[215],"Significance:":[219],"These":[220],"findings":[221],"indicate":[222],"interaction":[226],"by":[227],"employing":[228],"molecules":[230],"such":[231],"PH-687":[233],"represents":[234],"potentially":[236],"new":[237],"effective":[239],"treatment.":[243]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-03-13T00:00:00"}