{"id":"https://openalex.org/W4392684840","doi":"https://doi.org/10.1158/0008-5472.c.6508464","title":"Data from UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling","display_name":"Data from UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4392684840","doi":"https://doi.org/10.1158/0008-5472.c.6508464"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6508464","doi":"https://doi.org/10.1158/0008-5472.c.6508464","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508464","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6508464","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102005107","display_name":"Haolong Li","orcid":"https://orcid.org/0000-0002-9777-0743","observed_orcids":["https://orcid.org/0000-0002-9777-0743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haolong Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100746429","display_name":"Ning Xie","orcid":"https://orcid.org/0000-0002-4628-2299","observed_orcids":["https://orcid.org/0000-0002-4628-2299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ruiqi Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruiqi Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114126720","display_name":"M\u00e9lanie Verreault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00e9lanie Verreault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034110828","display_name":"Ladan Fazli","orcid":"https://orcid.org/0009-0005-0731-0583","observed_orcids":["https://orcid.org/0009-0005-0731-0583","https://orcid.org/0000-0001-6488-4245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ladan Fazli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062125605","display_name":"Martin Edwin Gleave","orcid":"https://orcid.org/0000-0003-4235-0167","observed_orcids":["https://orcid.org/0000-0003-4235-0167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin E. Gleave","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Olivier Barbier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier Barbier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073827712","display_name":"Xuesen Dong","orcid":"https://orcid.org/0000-0002-3115-3371","observed_orcids":["https://orcid.org/0000-0002-3115-3371"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuesen Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ugt2b17","display_name":"UGT2B17","score":0.9929999709129333},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8730000257492065},{"id":"https://openalex.org/keywords/c-src-kinase","display_name":"c-Src kinase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/androgen-metabolism","display_name":"androgen metabolism","score":0.8050000071525574},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.8259999752044678},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7229999899864197},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5788894891738892},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5537251830101013},{"id":"https://openalex.org/C2779256933","wikidata":"https://www.wikidata.org/wiki/Q58929","display_name":"Castration","level":3,"score":0.5035199522972107},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4164820909500122},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39437633752822876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3532806932926178},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3441293239593506},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1388828456401825},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.05244031548500061}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6508464","doi":"https://doi.org/10.1158/0008-5472.c.6508464","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508464","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6508464","doi":"https://doi.org/10.1158/0008-5472.c.6508464","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508464","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2523469334","https://openalex.org/W2740660726","https://openalex.org/W2611616330","https://openalex.org/W4361897164","https://openalex.org/W4362421693","https://openalex.org/W4361875327","https://openalex.org/W4362421302","https://openalex.org/W2047893575","https://openalex.org/W2018948966","https://openalex.org/W4361897047"],"abstract_inverted_index":{"Abstract":[0],"Castration-resistant":[1],"prostate":[2,49,74],"cancer":[3,101,178],"(CRPC)":[4],"is":[5,23,76],"characterized":[6],"by":[7,31,42,143,168],"a":[8,24],"shift":[9],"in":[10,47,53,73,92,177],"androgen":[11,18,29,112],"receptor":[12],"(AR)":[13],"signaling":[14,56,172],"from":[15],"androgen-dependent":[16,48,96,121],"to":[17,95,108,173],"(ligand)-independent.":[19],"UDP-glucuronosyltransferase":[20],"2B17":[21],"(UGT2B17)":[22],"key":[25],"enzyme":[26],"that":[27,68,118,163],"maintains":[28],"homeostasis":[30],"catabolizing":[32],"AR":[33,55,122,171],"agonists":[34],"into":[35],"inactive":[36],"forms.":[37],"Although":[38],"enhanced":[39,126],"UGT2B17":[40,70,86,99,119,138,152,164],"expression":[41,72,87,153],"antiandrogens":[43],"has":[44],"been":[45],"reported":[46],"cancer,":[50],"its":[51],"roles":[52],"regulating":[54],"transformation":[57],"and":[58,83,88,105,125],"CRPC":[59,84,109,150,166],"progression":[60,107,167],"remain":[61],"unknown.":[62],"In":[63,149],"this":[64],"study,":[65],"we":[66],"show":[67],"higher":[69,79,91],"protein":[71],"tumors":[75],"associated":[77,133,155],"with":[78,134,157],"Gleason":[80],"score,":[81],"metastasis,":[82],"progression.":[85],"activity":[89,124,130],"were":[90,140],"androgen-independent":[93],"compared":[94],"cell":[97,102,135,175],"lines.":[98],"stimulated":[100],"proliferation,":[103],"invasion,":[104],"xenograft":[106],"after":[110],"prolonged":[111],"deprivation.":[113],"Gene":[114],"microarray":[115],"analysis":[116],"indicated":[117],"suppressed":[120],"transcriptional":[123,129],"of":[127,145],"ligand-independent":[128,170],"at":[131],"genes":[132],"mitosis.":[136],"These":[137,160],"actions":[139],"mainly":[141],"mediated":[142],"activation":[144],"the":[146],"c-Src":[147,158],"kinase.":[148],"tumors,":[151],"was":[154],"positively":[156],"activation.":[159],"results":[161],"indicate":[162],"expedites":[165],"enhancing":[169],"activate":[174],"mitosis":[176],"cells.":[179],"Cancer":[180],"Res;":[181],"76(22);":[182],"6701\u201311.":[183],"\u00a92016":[184],"AACR.":[185]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-03-13T00:00:00"}