{"id":"https://openalex.org/W4392684769","doi":"https://doi.org/10.1158/0008-5472.c.6505209","title":"Data from A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation","display_name":"Data from A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392684769","doi":"https://doi.org/10.1158/0008-5472.c.6505209"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6505209","doi":"https://doi.org/10.1158/0008-5472.c.6505209","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6505209","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6505209","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061809819","display_name":"Xiaolei Zhang","orcid":"https://orcid.org/0000-0003-2395-2453","observed_orcids":["https://orcid.org/0000-0003-2395-2453"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaolei Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355558","display_name":"Ying Sun","orcid":"https://orcid.org/0000-0002-2042-6514","observed_orcids":["https://orcid.org/0000-0002-2042-6514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000278449","display_name":"Roberta Pireddu","orcid":"https://orcid.org/0000-0003-2322-2346","observed_orcids":["https://orcid.org/0000-0003-2322-2346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberta Pireddu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423337","display_name":"Hua Yang","orcid":"https://orcid.org/0000-0002-5518-5255","observed_orcids":["https://orcid.org/0000-0002-5518-5255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005785768","display_name":"Murali K. Urlam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murali K. Urlam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057921101","display_name":"Harshani R. Lawrence","orcid":"https://orcid.org/0000-0002-9263-7775","observed_orcids":["https://orcid.org/0000-0002-9263-7775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harshani R. Lawrence","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061379138","display_name":"Wayne C. Guida","orcid":"https://orcid.org/0000-0003-3353-4853","observed_orcids":["https://orcid.org/0000-0003-3353-4853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wayne C. Guida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027503793","display_name":"Nicholas J. Lawrence","orcid":"https://orcid.org/0000-0003-1129-2558","observed_orcids":["https://orcid.org/0000-0003-1129-2558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas J. Lawrence","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103060677","display_name":"Sa\u0131\u0308d M. Sebti","orcid":"https://orcid.org/0000-0001-5163-1038","observed_orcids":["https://orcid.org/0000-0001-5163-1038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sa\u00efd M. Sebti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8479999899864197},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tyrosine-705-phosphorylation","display_name":"tyrosine 705 phosphorylation","score":0.824999988079071},{"id":"https://openalex.org/keywords/sh2-domain","display_name":"SH2 domain","score":0.890999972820282},{"id":"https://openalex.org/keywords/egfr-binding","display_name":"EGFR binding","score":0.7250000238418579},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/stat3-target-genes","display_name":"STAT3 target genes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.7889999747276306},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.6720883846282959},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.6062995195388794},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4817652702331543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4775722324848175},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.4705033004283905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2210487425327301},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.18795019388198853},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17617633938789368},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11292076110839844}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6505209","doi":"https://doi.org/10.1158/0008-5472.c.6505209","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6505209","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6505209.v1","doi":"https://doi.org/10.1158/0008-5472.c.6505209.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6505209.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6505209","doi":"https://doi.org/10.1158/0008-5472.c.6505209","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6505209","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2146016509","https://openalex.org/W1997814360","https://openalex.org/W2029638319","https://openalex.org/W2980903182","https://openalex.org/W2130644579","https://openalex.org/W7043522003","https://openalex.org/W6996862497","https://openalex.org/W7052980668","https://openalex.org/W2117525838","https://openalex.org/W2230354098"],"abstract_inverted_index":{"Abstract":[0],"STAT3\u2013STAT3":[1,40,215],"dimerization,":[2,41],"which":[3,117,182],"involves":[4],"reciprocal":[5],"binding":[6,72,99],"of":[7,26,38,104,127,136,148,178,192,205,219],"the":[8,58,62,125,145,203],"STAT3-SH2":[9],"domain":[10,64],"to":[11,73],"phosphorylated":[12],"tyrosine-705":[13],"(Y-705),":[14],"is":[15],"required":[16],"for":[17],"STAT3":[18,79,82,93,121,128,149,193,222],"nuclear":[19,134],"translocation,":[20],"DNA":[21],"binding,":[22,139],"and":[23,43,50,65,80,83,87,95,131,140,143,161,172,176,223],"transcriptional":[24,141],"regulation":[25],"downstream":[27],"target":[28,150],"genes.":[29],"Here,":[30],"we":[31,209],"describe":[32],"a":[33,112,188,196,214],"small":[34],"molecule":[35],"S3I-1757":[36,55,91,109,206,212],"capable":[37,218],"disrupting":[39],"activation,":[42],"malignant":[44,225],"transforming":[45],"activity.":[46],"Fluorescence":[47],"polarization":[48],"assay":[49],"molecular":[51],"modeling":[52],"suggest":[53],"that":[54,90,194,231],"interacts":[56],"with":[57,108],"phospho-Y-705\u2013binding":[59],"site":[60],"in":[61,100,227],"SH2":[63],"displaces":[66],"fluorescein-labeled":[67],"GpYLPQTV":[68],"phosphotyrosine":[69],"peptide":[70],"from":[71,202],"STAT3.":[74,185,234],"We":[75],"generated":[76],"hemagglutinin":[77],"(HA)-tagged":[78],"FLAG-tagged":[81],"showed":[84],"using":[85],"coimmunoprecipitation":[86],"colocalization":[88],"studies":[89],"inhibits":[92,123,170],"dimerization":[94,216],"STAT3\u2013EGF":[96],"receptor":[97],"(EGFR)":[98],"intact":[101],"cells.":[102],"Treatment":[103],"human":[105,179,228],"cancer":[106,180,229],"cells":[107,201,230],"(but":[110],"not":[111,119,168],"closely":[113],"related":[114],"analog,":[115],"S3I-1756,":[116,169],"does":[118],"inhibit":[120],"dimerization),":[122],"selectively":[124],"phosphorylation":[126],"over":[129],"AKT1":[130],"ERK1/2":[132],"(MAPK3/1),":[133],"accumulation":[135],"P-Y705-STAT3,":[137],"STAT3\u2013DNA":[138],"activation":[142],"suppresses":[144],"expression":[146],"levels":[147],"genes,":[151],"such":[152],"as":[153,213],"Bcl-xL":[154],"(BCL2L1),":[155],"survivin":[156],"(BIRC5),":[157],"cyclin":[158],"D1":[159],"(CCND1),":[160],"matrix":[162],"metalloproteinase":[163],"(MMP)-9.":[164],"Furthermore,":[165],"S3I-1757,":[166],"but":[167],"anchorage-dependent":[171],"-independent":[173],"growth,":[174],"migration,":[175],"invasion":[177],"cells,":[181],"depend":[183,232],"on":[184,233],"Finally,":[186],"STAT3-C,":[187],"genetically":[189],"engineered":[190],"mutant":[191],"forms":[195],"constitutively":[197],"dimerized":[198],"STAT3,":[199],"rescues":[200],"effects":[204],"inhibition.":[207],"Thus,":[208],"have":[210],"developed":[211],"inhibitor":[217],"blocking":[220],"hyperactivated":[221],"suppressing":[224],"transformation":[226],"Cancer":[235],"Res;":[236],"73(6);":[237],"1922\u201333.":[238],"\u00a92012":[239],"AACR.":[240]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-13T00:00:00"}