{"id":"https://openalex.org/W4392684669","doi":"https://doi.org/10.1158/0008-5472.c.6504803","title":"Data from RANKL Expression, Function, and Therapeutic Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia","display_name":"Data from RANKL Expression, Function, and Therapeutic Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392684669","doi":"https://doi.org/10.1158/0008-5472.c.6504803"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6504803","doi":"https://doi.org/10.1158/0008-5472.c.6504803","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6504803","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6504803","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071199486","display_name":"Benjamin Joachim Schmiedel","orcid":"https://orcid.org/0000-0002-9103-9378","observed_orcids":["https://orcid.org/0000-0002-9103-9378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Joachim Schmiedel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037956017","display_name":"Carolin Andrea Scheible","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolin Andrea Scheible","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046999122","display_name":"Tina Nuebling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tina Nuebling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036009814","display_name":"Hans\u2010Georg Kopp","orcid":"https://orcid.org/0000-0002-0825-8888","observed_orcids":["https://orcid.org/0000-0002-0825-8888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans-Georg Kopp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031869321","display_name":"Stefan Wirths","orcid":"https://orcid.org/0000-0003-2494-9862","observed_orcids":["https://orcid.org/0000-0003-2494-9862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Wirths","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069602567","display_name":"Miyuki Azuma","orcid":"https://orcid.org/0000-0002-3529-4585","observed_orcids":["https://orcid.org/0000-0002-3529-4585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miyuki Azuma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045281805","display_name":"Pascal Schneider","orcid":"https://orcid.org/0000-0003-0677-9409","observed_orcids":["https://orcid.org/0000-0003-0677-9409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pascal Schneider","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066615137","display_name":"Gundram Jung","orcid":"https://orcid.org/0000-0002-2831-2829","observed_orcids":["https://orcid.org/0000-0002-2831-2829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gundram Jung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002838487","display_name":"Ludger Gro\u00dfe\u2010Hovest","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ludger Grosse-Hovest","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026255080","display_name":"Helmut Rainer Salih","orcid":"https://orcid.org/0000-0002-6719-1847","observed_orcids":["https://orcid.org/0000-0002-6719-1847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helmut Rainer Salih","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":1.0},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.953000009059906},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9129999876022339},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/bone-destruction","display_name":"bone destruction","score":0.859000027179718},{"id":"https://openalex.org/keywords/soluble-rankl","display_name":"soluble RANKL","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.8151179552078247},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.756075918674469},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6086783409118652},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5215660929679871},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4844529628753662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4389272928237915},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.436704158782959},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4101611375808716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30124199390411377},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2873089015483856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2200506329536438},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1276777684688568},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12240123748779297},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.05698275566101074},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6504803","doi":"https://doi.org/10.1158/0008-5472.c.6504803","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6504803","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6504803.v1","doi":"https://doi.org/10.1158/0008-5472.c.6504803.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6504803.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6504803","doi":"https://doi.org/10.1158/0008-5472.c.6504803","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6504803","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2164204445","https://openalex.org/W2560912368","https://openalex.org/W2979709920","https://openalex.org/W2591750220","https://openalex.org/W2052795710","https://openalex.org/W2552592374","https://openalex.org/W4410884275","https://openalex.org/W1514772132","https://openalex.org/W2885117827","https://openalex.org/W2164174012"],"abstract_inverted_index":{"Abstract":[0],"Bone":[1],"destruction":[2],"is":[3,43],"a":[4],"prominent":[5],"feature":[6],"of":[7,20,34,57,85,94,109,120,124,128,166,209],"multiple":[8,47,64,78],"myeloma,":[9],"but":[10,172],"conflicting":[11],"data":[12],"exist":[13],"on":[14,96,168,188],"the":[15,21,30,92,164,206,213],"expression":[16],"and":[17,29,49,67,80,98,137],"pathophysiologic":[18],"involvement":[19],"bone":[22],"remodeling":[23],"ligand":[24],"RANKL":[25,42,59,76,95,121,167,210],"in":[26,88,170],"this":[27],"disease":[28,89],"potential":[31],"therapeutic":[32],"benefits":[33],"its":[35],"targeted":[36],"inhibition.":[37],"Here,":[38],"we":[39,115,145],"show":[40],"that":[41],"expressed":[44],"by":[45,71,101,107],"primary":[46,180],"myeloma":[48,65,79],"chronic":[50],"lymphocytic":[51],"leukemia":[52],"(CLL)":[53],"cells,":[54,184],"whereas":[55],"release":[56,84],"soluble":[58],"was":[60,68,186],"observed":[61],"exclusively":[62],"with":[63,112,122,150,160],"cells":[66,82,103,132,136],"strongly":[69],"influenced":[70],"posttranscriptional/posttranslational":[72],"regulation.":[73],"Signaling":[74],"via":[75],"into":[77],"CLL":[81],"induced":[83],"cytokines":[86],"involved":[87],"pathophysiology.":[90],"Both":[91],"effects":[93,165],"osteoclastogenesis":[97,169],"cytokine":[99],"production":[100],"malignant":[102,135,182],"could":[104],"be":[105],"blocked":[106],"disruption":[108],"RANK\u2013RANKL":[110],"interaction":[111],"denosumab.":[113],"As":[114],"aimed":[116],"to":[117,162,192,204],"combine":[118],"neutralization":[119],"induction":[123],"antibody-dependent":[125],"cellular":[126],"cytotoxicity":[127],"natural":[129],"killer":[130],"(NK)":[131],"against":[133,179],"RANKL-expressing":[134,181],"as":[138,201],"denosumab":[139,161],"does":[140],"not":[141],"stimulate":[142],"NK":[143,176,218],"reactivity,":[144],"generated":[146],"RANK-Fc":[147],"fusion":[148,199],"proteins":[149,200],"modified":[151],"Fc":[152],"moieties.":[153],"The":[154],"latter":[155],"displayed":[156],"similar":[157],"capacity":[158],"compared":[159],"neutralize":[163,205],"vitro,":[171],"also":[173],"potently":[174,216],"stimulated":[175],"cell":[177,219],"reactivity":[178],"B":[183],"which":[185],"dependent":[187],"their":[189],"engineered":[190],"affinity":[191],"CD16.":[193],"Our":[194],"findings":[195],"introduce":[196],"Fc-optimized":[197],"RANK-Ig":[198],"attractive":[202],"tools":[203],"detrimental":[207],"function":[208],"while":[211],"at":[212],"same":[214],"time":[215],"stimulating":[217],"antitumor":[220],"immunity.":[221],"Cancer":[222],"Res;":[223],"73(2);":[224],"683\u201394.":[225],"\u00a92012":[226],"AACR.":[227]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-13T00:00:00"}