{"id":"https://openalex.org/W4392684128","doi":"https://doi.org/10.1158/0008-5472.c.6499842","title":"Data from TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2","display_name":"Data from TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392684128","doi":"https://doi.org/10.1158/0008-5472.c.6499842"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6499842","doi":"https://doi.org/10.1158/0008-5472.c.6499842","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499842","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6499842","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013938293","display_name":"Jeremy Copp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Copp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073342778","display_name":"Gerard Manning","orcid":"https://orcid.org/0000-0002-5087-9151","observed_orcids":["https://orcid.org/0000-0002-5087-9151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerard Manning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010612497","display_name":"Tony R. Hunter","orcid":"https://orcid.org/0000-0002-7691-6993","observed_orcids":["https://orcid.org/0000-0002-7691-6993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tony Hunter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9570000171661377},{"id":"https://openalex.org/keywords/mtorc2","display_name":"mTORC2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/serine-phosphorylation","display_name":"serine phosphorylation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/rapamycin-sensitivity","display_name":"rapamycin sensitivity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/signaling-complex-assembly","display_name":"signaling complex assembly","score":0.7149999737739563},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7570000290870667},{"id":"https://openalex.org/keywords/akt-activation","display_name":"Akt activation","score":0.4790000021457672},{"id":"https://openalex.org/keywords/actin-cytoskeleton-regulation","display_name":"actin cytoskeleton regulation","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7592130303382874},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6345271468162537},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47537294030189514},{"id":"https://openalex.org/C43060935","wikidata":"https://www.wikidata.org/wiki/Q18043110","display_name":"RPTOR","level":4,"score":0.45571187138557434},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45139288902282715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.258526474237442},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.252176433801651},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17719686031341553}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6499842","doi":"https://doi.org/10.1158/0008-5472.c.6499842","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499842","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6499842","doi":"https://doi.org/10.1158/0008-5472.c.6499842","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499842","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159714906","https://openalex.org/W2058544861","https://openalex.org/W1976643149","https://openalex.org/W2150595264","https://openalex.org/W2095433168","https://openalex.org/W2152589884","https://openalex.org/W3082098757","https://openalex.org/W2021510881","https://openalex.org/W1515719208","https://openalex.org/W2590999575"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"mammalian":[2],"target":[3],"of":[4,13,28,41],"rapamycin":[5,125,145],"(mTOR)":[6],"serine/threonine":[7],"kinase":[8,35],"is":[9,24,36,67,122],"the":[10,37,53],"catalytic":[11],"component":[12],"two":[14],"evolutionarily":[15],"conserved":[16],"signaling":[17,20,44],"complexes.":[18],"mTOR":[19,43,66,85,93,101,150],"complex":[21,45],"1":[22],"(mTORC1)":[23],"a":[25,49,110,153],"key":[26],"regulator":[27],"growth":[29],"factor":[30],"and":[31,56,74,76,142,158],"nutrient":[32],"signaling.":[33],"S6":[34],"best-characterized":[38],"downstream":[39],"effector":[40],"mTORC1.":[42],"2":[46],"(mTORC2)":[47],"has":[48],"role":[50],"in":[51,123,127,132],"regulating":[52],"actin":[54],"cytoskeleton":[55],"activating":[57],"Akt":[58],"through":[59],"S473":[60],"phosphorylation.":[61],"Herein,":[62],"we":[63,88,117],"show":[64],"that":[65,77,90,119,139],"phosphorylated":[68,94,102],"differentially":[69],"when":[70],"associated":[71],"with":[72],"mTORC1":[73,91],"mTORC2":[75,99,113,120,140,157],"intact":[78,156],"complexes":[79],"are":[80],"required":[81],"for":[82,112,155],"these":[83],"mTORC-specific":[84],"phosphorylations.":[86],"Specifically,":[87],"find":[89,118],"contains":[92,100],"predominantly":[95,103],"on":[96,104,149],"S2448,":[97],"whereas":[98],"S2481.":[105],"Using":[106],"S2481":[107],"phosphorylation":[108],"as":[109,152],"marker":[111],"sensitivity":[114,160],"to":[115,161],"rapamycin,":[116],"formation":[121],"fact":[124],"sensitive":[126],"several":[128],"cancer":[129],"cell":[130],"lines":[131],"which":[133],"it":[134],"had":[135],"been":[136],"previously":[137],"reported":[138],"assembly":[141],"function":[143],"were":[144],"insensitive.":[146],"Thus,":[147],"phospho-S2481":[148],"serves":[151],"biomarker":[154],"its":[159],"rapamycin.":[162],"[Cancer":[163],"Res":[164],"2009;69(5):1821\u20137]":[165]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-13T00:00:00"}