{"id":"https://openalex.org/W4392681986","doi":"https://doi.org/10.1158/0008-5472.c.6514109","title":"Data from Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy","display_name":"Data from Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4392681986","doi":"https://doi.org/10.1158/0008-5472.c.6514109"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6514109","doi":"https://doi.org/10.1158/0008-5472.c.6514109","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6514109","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6514109","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100697213","display_name":"Zhuangzhuang Zhang","orcid":"https://orcid.org/0000-0003-2578-7375","observed_orcids":["https://orcid.org/0000-0003-2578-7375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhuangzhuang Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2578-7375","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060412535","display_name":"Lijun Cheng","orcid":"https://orcid.org/0000-0002-6336-5416","observed_orcids":["https://orcid.org/0000-0002-6336-5416","https://orcid.org/0000-0001-7606-9563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lijun Cheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6336-5416","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428309","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-9909-9105","observed_orcids":["https://orcid.org/0000-0002-9909-9105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9909-9105","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101427952","display_name":"Qi Qiao","orcid":"https://orcid.org/0000-0003-1240-0506","observed_orcids":["https://orcid.org/0000-0003-1240-0506"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Qiao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1240-0506","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064877683","display_name":"Anju Karki","orcid":"https://orcid.org/0000-0003-4042-0045","observed_orcids":["https://orcid.org/0000-0003-4042-0045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anju Karki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4042-0045","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046352646","display_name":"Derek B. Allison","orcid":"https://orcid.org/0000-0002-5119-2474","observed_orcids":["https://orcid.org/0000-0002-5119-2474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derek B. Allison","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5119-2474","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061726476","display_name":"Nuha Shaker","orcid":"https://orcid.org/0000-0002-7540-6916","observed_orcids":["https://orcid.org/0000-0002-7540-6916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nuha Shaker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7540-6916","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006034931","display_name":"Kunyu Li","orcid":"https://orcid.org/0000-0001-6095-3020","observed_orcids":["https://orcid.org/0000-0001-6095-3020","https://orcid.org/0009-0000-0822-2482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunyu Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6095-3020","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081241043","display_name":"Sagar M. Utturkar","orcid":"https://orcid.org/0000-0002-3453-1948","observed_orcids":["https://orcid.org/0000-0002-3453-1948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sagar M. Utturkar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3453-1948","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026862562","display_name":"Nadia A. Lanman","orcid":"https://orcid.org/0000-0002-1819-7070","observed_orcids":["https://orcid.org/0000-0002-1819-7070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadia M. Atallah Lanman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1819-7070","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072447942","display_name":"Xiongjian Rao","orcid":"https://orcid.org/0000-0001-5645-9994","observed_orcids":["https://orcid.org/0000-0001-5645-9994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiongjian Rao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5645-9994","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068753759","display_name":"Piotr G. Rychahou","orcid":"https://orcid.org/0000-0001-7352-9122","observed_orcids":["https://orcid.org/0000-0001-7352-9122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Piotr Rychahou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7352-9122","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078924265","display_name":"Daheng He","orcid":"https://orcid.org/0000-0003-0399-2466","observed_orcids":["https://orcid.org/0000-0003-0399-2466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daheng He","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0399-2466","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014807279","display_name":"Stephen F. Konieczny","orcid":"https://orcid.org/0000-0002-3281-3714","observed_orcids":["https://orcid.org/0000-0002-3281-3714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen F. Konieczny","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3281-3714","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342205","display_name":"Chi Wang","orcid":"https://orcid.org/0000-0001-8984-4995","observed_orcids":["https://orcid.org/0000-0001-8984-4995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chi Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8984-4995","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Qing Shao","orcid":"https://orcid.org/0000-0001-9433-1131","observed_orcids":["https://orcid.org/0000-0001-9433-1131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing Shao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9433-1131","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066347342","display_name":"Bernard Mark Evers","orcid":"https://orcid.org/0000-0002-9425-2342","observed_orcids":["https://orcid.org/0000-0002-9425-2342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Mark Evers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9425-2342","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100740693","display_name":"Xiaoqi Liu","orcid":"https://orcid.org/0000-0002-6613-1746","observed_orcids":["https://orcid.org/0000-0002-6613-1746","https://orcid.org/0000-0002-7038-333X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoqi Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6613-1746","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plk1","display_name":"PLK1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.906000018119812},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9599999785423279},{"id":"https://openalex.org/keywords/rb-phosphorylation","display_name":"retinoblastoma protein phosphorylation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/acinar-to-ductal-metaplasia","display_name":"acinar-to-ductal metaplasia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/pancreatic-intraepithelial-neoplasia","display_name":"pancreatic intraepithelial neoplasia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"acute pancreatitis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C146276462","wikidata":"https://www.wikidata.org/wiki/Q21131841","display_name":"PLK1","level":4,"score":0.6982806324958801},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5966846942901611},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5735195279121399},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5362284779548645},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47382959723472595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4672437012195587},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4626399576663971},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4296899437904358},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4123988747596741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25800180435180664},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2383268177509308},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.20274072885513306},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.08038350939750671}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6514109","doi":"https://doi.org/10.1158/0008-5472.c.6514109","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6514109","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6514109","doi":"https://doi.org/10.1158/0008-5472.c.6514109","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6514109","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4290803922","https://openalex.org/W2333406468","https://openalex.org/W4414806705","https://openalex.org/W4409626373","https://openalex.org/W2767311484","https://openalex.org/W3104930108","https://openalex.org/W2165437109","https://openalex.org/W2802579643","https://openalex.org/W6887795715","https://openalex.org/W1972644607"],"abstract_inverted_index":{"Abstract":[0],"Polo-like":[1],"kinase":[2],"1":[3],"(Plk1)":[4],"plays":[5],"an":[6,85,181],"important":[7],"role":[8,61],"in":[9,25,39,64,80,95,121,126,141,203,214],"cell-cycle":[10],"regulation.":[11],"Recent":[12],"work":[13],"has":[14,36],"suggested":[15],"that":[16,73],"Plk1":[17,32,53,63,74,94,98,123,139,170,186,196,208],"could":[18],"be":[19],"a":[20],"biomarker":[21],"of":[22,50,62,93,108,138,143,147,154,161,169,180,201,207,211],"gemcitabine":[23],"response":[24],"pancreatic":[26,112,215],"ductal":[27,216],"adenocarcinoma":[28],"(PDAC).":[29],"Although":[30],"targeting":[31,195],"to":[33,52,163,173,224],"treat":[34],"PDAC":[35,65,127,172,188],"been":[37],"attempted":[38],"clinical":[40],"trials,":[41],"the":[42,48,60,96,118,148,159,166,199],"results":[43],"were":[44],"not":[45],"promising,":[46],"and":[47,105,111,190,194,221],"mechanisms":[49],"resistance":[51],"inhibition":[54,135],"is":[55,124],"poorly":[56],"understood.":[57],"In":[58,84],"addition,":[59],"progression":[66,189],"requires":[67],"further":[68],"elucidation.":[69],"Here,":[70],"we":[71],"showed":[72],"was":[75],"associated":[76],"with":[77,82,90],"poor":[78],"outcomes":[79],"patients":[81],"PDAC.":[83,204],"inducible":[86],"transgenic":[87],"mouse":[88],"line":[89],"specific":[91],"expression":[92,213],"pancreas,":[97],"overexpression":[99],"significantly":[100],"inhibited":[101,158],"caerulein-induced":[102],"acute":[103],"pancreatitis":[104],"delayed":[106],"development":[107],"acinar-to-ductal":[109],"metaplasia":[110],"intraepithelial":[113],"neoplasia.":[114],"Bioinformatics":[115],"analyses":[116],"identified":[117],"regulatory":[119],"networks":[120],"which":[122],"involved":[125],"disease":[128],"progression,":[129],"including":[130],"multiple":[131],"inflammation-related":[132],"pathways.":[133],"Unexpectedly,":[134],"or":[136],"depletion":[137],"resulted":[140],"upregulation":[142,210],"PD-L1":[144,212],"via":[145],"activation":[146,179],"NF-\u03baB":[149,162,192],"pathway.":[150,167],"Mechanistically,":[151],"Plk1-mediated":[152],"phosphorylation":[153],"RB":[155],"at":[156],"S758":[157],"translocation":[160],"nucleus,":[164],"inactivating":[165],"Inhibition":[168,206],"sensitized":[171],"immune":[174,183],"checkpoint":[175],"blockade":[176],"therapy":[177],"through":[178],"antitumor":[182,219],"response.":[184],"Together,":[185],"suppresses":[187],"inhibits":[191],"activity,":[193],"can":[197],"potentiate":[198],"efficacy":[200],"immunotherapy":[202],"Significance:":[205],"induces":[209],"adenocarcinoma,":[217],"stimulating":[218],"immunity":[220],"sensitizing":[222],"tumors":[223],"immunotherapy.":[225]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-03-13T00:00:00"}
