{"id":"https://openalex.org/W4392681784","doi":"https://doi.org/10.1158/1535-7163.c.6537483","title":"Data from Optimization of RGD-Containing Cyclic Peptides against \u03b1v\u03b23 Integrin","display_name":"Data from Optimization of RGD-Containing Cyclic Peptides against \u03b1v\u03b23 Integrin","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4392681784","doi":"https://doi.org/10.1158/1535-7163.c.6537483"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6537483","doi":"https://doi.org/10.1158/1535-7163.c.6537483","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537483","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.c.6537483","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100741838","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0003-3262-9930","observed_orcids":["https://orcid.org/0000-0003-3262-9930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002480954","display_name":"Wenwu Xiao","orcid":"https://orcid.org/0000-0003-0387-7206","observed_orcids":["https://orcid.org/0000-0003-0387-7206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenwu Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100429052","display_name":"Yonghong Zhang","orcid":"https://orcid.org/0000-0002-7305-9295","observed_orcids":["https://orcid.org/0000-0002-7305-9295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yonghong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112574325","display_name":"Leah Meza","orcid":"https://orcid.org/0000-0003-1001-3350","observed_orcids":["https://orcid.org/0000-0003-1001-3350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leah Meza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043380474","display_name":"Harry P. Tseng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harry Tseng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037929411","display_name":"Yoshikazu Takada","orcid":"https://orcid.org/0000-0001-5481-9589","observed_orcids":["https://orcid.org/0000-0001-5481-9589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshikazu Takada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057047177","display_name":"James B. Ames","orcid":"https://orcid.org/0000-0003-0934-2595","observed_orcids":["https://orcid.org/0000-0003-0934-2595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James B. Ames","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016566536","display_name":"Kit S. Lam","orcid":"https://orcid.org/0000-0002-3076-6969","observed_orcids":["https://orcid.org/0000-0002-3076-6969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kit S. Lam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.9089999794960022},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cyclic-peptides","display_name":"cyclic peptides","score":0.8489999771118164},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8999999761581421},{"id":"https://openalex.org/keywords/peptide-optimization","display_name":"peptide optimization","score":0.3799999952316284},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.7480000257492065},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C60984968","wikidata":"https://www.wikidata.org/wiki/Q389172","display_name":"Cyclic peptide","level":3,"score":0.6041877269744873},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5651325583457947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47440478205680847},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34931355714797974},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34169596433639526},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3337078094482422},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3208339810371399},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30798184871673584},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.22832602262496948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17605900764465332},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08644336462020874}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6537483","doi":"https://doi.org/10.1158/1535-7163.c.6537483","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537483","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6537483","doi":"https://doi.org/10.1158/1535-7163.c.6537483","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537483","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2211868735","https://openalex.org/W4361813238","https://openalex.org/W2115256867","https://openalex.org/W7110585781","https://openalex.org/W3095525663","https://openalex.org/W6990592448","https://openalex.org/W2912419567","https://openalex.org/W1991071877","https://openalex.org/W2031174826","https://openalex.org/W7133434386"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"have":[2,59,96],"previously":[3],"reported":[4],"the":[5,66,69,89,140],"use":[6],"of":[7,68,88,142],"one-bead-one-compound":[8],"(OBOC)":[9],"combinatorial":[10],"technology":[11],"to":[12,34,95,107,114,117,145],"develop":[13],"a":[14,50],"disulfide":[15],"cyclic,":[16],"Arg-Gly-Asp\u2013containing":[17],"octapeptide":[18],"LXW7":[19],"(cGRGDdvc),":[20],"that":[21,133,151],"targets":[22,125],"\u03b1v\u03b23":[23,30,83,110,153],"integrin":[24,31],"with":[25],"high":[26],"affinity":[27,100],"and":[28,40,44,80,103,147],"specificity.":[29],"is":[32,135],"known":[33],"be":[35],"overexpressed":[36],"in":[37,41,121,129],"many":[38],"cancers":[39],"tumor":[42,148],"vasculature,":[43],"it":[45,134],"has":[46],"been":[47],"established":[48],"as":[49],"cancer":[51],"therapeutic":[52],"target.":[53],"To":[54],"further":[55],"optimize":[56],"LXW7,":[57,102],"we":[58],"performed":[60],"systematic":[61],"structure\u2013activity":[62],"relationship":[63],"studies.":[64],"On":[65],"basis":[67],"results,":[70],"two":[71],"highly":[72],"focused":[73],"OBOC":[74],"peptide":[75],"libraries":[76],"were":[77],"designed,":[78],"synthesized,":[79],"screened":[81],"against":[82],"integrin\u2013transfected":[84],"K562":[85],"cells.":[86],"One":[87],"best":[90],"ligands,":[91],"LXW64,":[92],"was":[93],"found":[94],"6.6-fold":[97],"higher":[98],"binding":[99,106,115],"than":[101],"showed":[104],"preferential":[105],"cells":[108,120],"expressing":[109],"integrin.":[111,154],"In":[112],"addition":[113],"strongly":[116],"U-87MG":[118,126],"glioblastoma":[119],"vitro,":[122],"LXW64":[123],"also":[124],"xenografts":[127],"implanted":[128],"nude":[130],"mice,":[131],"indicating":[132],"an":[136],"excellent":[137],"vehicle":[138],"for":[139],"delivery":[141],"cytotoxic":[143],"payload":[144],"tumors":[146],"blood":[149],"vessels":[150],"overexpress":[152],"Mol":[155],"Cancer":[156],"Ther;":[157],"15(2);":[158],"232\u201340.":[159],"\u00a92015":[160],"AACR.":[161]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2024-03-13T00:00:00"}