{"id":"https://openalex.org/W4392680801","doi":"https://doi.org/10.1158/0008-5472.c.6510075","title":"Data from Breast Cancer Risk and Insulin Resistance: Post Genome-Wide Gene\u2013Environment Interaction Study Using a Random Survival Forest","display_name":"Data from Breast Cancer Risk and Insulin Resistance: Post Genome-Wide Gene\u2013Environment Interaction Study Using a Random Survival Forest","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4392680801","doi":"https://doi.org/10.1158/0008-5472.c.6510075"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6510075","doi":"https://doi.org/10.1158/0008-5472.c.6510075","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6510075","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6510075","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012046553","display_name":"Su Yon Jung","orcid":"https://orcid.org/0000-0002-0513-1830","observed_orcids":["https://orcid.org/0000-0002-0513-1830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Su Yon Jung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067468133","display_name":"Jeanette C. Papp","orcid":"https://orcid.org/0000-0001-9561-7860","observed_orcids":["https://orcid.org/0000-0001-9561-7860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeanette C. Papp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061772385","display_name":"Eric M. Sobel","orcid":"https://orcid.org/0000-0002-1718-0031","observed_orcids":["https://orcid.org/0000-0002-1718-0031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric M. Sobel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1718-0031","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074071367","display_name":"Herbert Yu","orcid":"https://orcid.org/0000-0003-3950-4815","observed_orcids":["https://orcid.org/0000-0003-3950-4815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herbert Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100661022","display_name":"Zuo\u2010Feng Zhang","orcid":"https://orcid.org/0000-0002-4669-3995","observed_orcids":["https://orcid.org/0000-0002-4669-3995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zuo-Feng Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.22280000150203705,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postmenopausal-breast-cancer","display_name":"postmenopausal breast cancer","score":0.9279999732971191},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lifestyle-factors","display_name":"lifestyle factors","score":0.671999990940094},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6690000295639038},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7710000276565552},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7049999833106995},{"id":"https://openalex.org/keywords/fat-intake","display_name":"dietary fat intake","score":0.9589999914169312},{"id":"https://openalex.org/keywords/linc00460","display_name":"LINC00460","score":0.8629999756813049},{"id":"https://openalex.org/keywords/random-survival-forest","display_name":"random survival forest","score":0.675000011920929},{"id":"https://openalex.org/keywords/breast-cancer-risk-prediction","display_name":"breast cancer risk prediction","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5871543288230896},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5258898138999939},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5222386121749878},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.509039580821991},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45709505677223206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4361311197280884},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4193602204322815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.394826740026474},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38671934604644775},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.374332070350647},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34968844056129456},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34876686334609985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32425546646118164},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28860512375831604},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.25945332646369934},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.23944765329360962},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1983846127986908},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11156389117240906}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6510075","doi":"https://doi.org/10.1158/0008-5472.c.6510075","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6510075","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6510075","doi":"https://doi.org/10.1158/0008-5472.c.6510075","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6510075","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2925634262","https://openalex.org/W2953649353","https://openalex.org/W4392691015","https://openalex.org/W2895989264","https://openalex.org/W2611903691","https://openalex.org/W4392722294","https://openalex.org/W2740609900","https://openalex.org/W2766732618","https://openalex.org/W4318263958","https://openalex.org/W6943692012"],"abstract_inverted_index":{"Abstract":[0],"Obesity\u2013insulin":[1],"connections":[2],"have":[3,187],"been":[4],"considered":[5],"potential":[6,223],"risk":[7,58,118,201,270],"factors":[8,52,161,179,233,253],"for":[9,60,77,92,226,254],"postmenopausal":[10,61,69],"breast":[11,30,62,116,191,203,219,237,255,263],"cancer,":[12,192],"and":[13,21,53,79,101,109,134,139,149,157,170,195,221,231],"the":[14,38,46,72,130,175,181,200,269],"association":[15,85],"between":[16],"insulin":[17,244],"resistance":[18,245],"(IR)":[19],"genotypes":[20],"phenotypes":[22,96],"can":[23,261],"be":[24],"modified":[25],"by":[26,119,143],"obesity-lifestyle":[27],"factors,":[28],"affecting":[29],"cancer":[31,117,204,220,238,256,264],"risk.":[32,239],"In":[33],"this":[34],"study,":[35],"we":[36],"explored":[37],"role":[39],"of":[40,202,218],"IR":[41,95],"in":[42,71,113,137,205,247,265],"those":[43,105],"pathways":[44],"at":[45],"genome-wide":[47,84],"level.":[48],"We":[49,103,128],"identified":[50,89,129],"IR-genetic":[51],"selected":[54],"lifestyles":[55,112,196],"to":[56,115,163,167,214,234],"generate":[57],"profiles":[59],"cancer.":[63],"Using":[64],"large-scale":[65],"cohort":[66],"data":[67],"from":[68],"women":[70,227,266],"Women's":[73],"Health":[74],"Initiative":[75],"Database":[76],"Genotypes":[78],"Phenotypes":[80],"Study,":[81],"our":[82],"previous":[83],"gene\u2013behavior":[86],"interaction":[87],"study":[88],"58":[90],"loci":[91],"associations":[93,189],"with":[94,190,228,249],"(homeostatic":[97],"model":[98],"assessment\u2013IR,":[99],"hyperglycemia,":[100],"hyperinsulinemia).":[102],"evaluated":[104],"single-nucleotide":[106],"polymorphisms":[107],"(SNP)":[108],"additional":[110],"31":[111],"relation":[114],"conducting":[120],"a":[121,206],"two-stage":[122],"multimodal":[123],"random":[124],"survival":[125],"forest":[126],"analysis.":[127],"most":[131,176],"predictive":[132],"genetic":[133,230],"lifestyle":[135,232,250,259],"variables":[136],"overall":[138],"subgroup":[140],"analyses":[141],"[stratified":[142],"body":[144],"mass":[145],"index":[146],"(BMI),":[147],"exercise,":[148],"dietary":[150,171],"fat":[151],"intake].":[152],"Two":[153],"SNPs":[154,184,194,246],"(LINC00460":[155],"rs17254590":[156],"MKLN1":[158],"rs117911989),":[159],"exogenous":[160],"related":[162],"lifetime":[164],"cumulative":[165],"exposure":[166],"estrogen,":[168],"BMI,":[169],"alcohol":[172],"consumption":[173],"were":[174],"common":[177],"influential":[178],"across":[180],"analyses.":[182],"Individual":[183],"did":[185],"not":[186],"significant":[188],"but":[193],"combined":[197],"synergistically":[198],"increased":[199],"gene\u2013behavior,":[207],"dose-dependent":[208],"manner.":[209],"These":[210,241],"findings":[211,242],"may":[212],"contribute":[213],"more":[215],"accurate":[216],"predictions":[217],"suggest":[222],"intervention":[224],"strategies":[225],"specific":[229],"reduce":[235],"their":[236],"Significance:":[240],"identify":[243],"combination":[248],"as":[251],"synergistic":[252],"risk,":[257],"suggesting":[258],"changes":[260],"prevent":[262],"who":[267],"carry":[268],"genotypes.":[271]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2024-03-13T00:00:00"}