{"id":"https://openalex.org/W4392680347","doi":"https://doi.org/10.1158/0008-5472.c.6507401","title":"Data from CCL9 Induced by TGF\u03b2 Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ","display_name":"Data from CCL9 Induced by TGF\u03b2 Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392680347","doi":"https://doi.org/10.1158/0008-5472.c.6507401"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507401","doi":"https://doi.org/10.1158/0008-5472.c.6507401","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507401","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6507401","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001914070","display_name":"Hangyi H. Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hangyi H. Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054384395","display_name":"Jian Chun Jiang","orcid":"https://orcid.org/0000-0002-5695-3420","observed_orcids":["https://orcid.org/0000-0002-5695-3420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030910131","display_name":"Yanli Pang","orcid":"https://orcid.org/0000-0003-1967-2416","observed_orcids":["https://orcid.org/0000-0003-1967-2416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanli Pang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066599891","display_name":"B.R. Achyut","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.R. Achyut","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040570196","display_name":"Michael M. Lizardo","orcid":"https://orcid.org/0000-0003-3981-0978","observed_orcids":["https://orcid.org/0000-0003-3981-0978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Lizardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xinhua Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinhua Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050759731","display_name":"Kent W. Hunter","orcid":"https://orcid.org/0000-0001-5963-8808","observed_orcids":["https://orcid.org/0000-0001-5963-8808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kent Hunter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112077722","display_name":"Chand Khanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chand Khanna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069691571","display_name":"Christine M. Hollander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Hollander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021988023","display_name":"Yang Li","orcid":"https://orcid.org/0000-0002-2697-9566","observed_orcids":["https://orcid.org/0000-0002-2697-9566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccl9","display_name":"CCL9","score":1.0},{"id":"https://openalex.org/keywords/ccl23","display_name":"CCL23","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.8240000009536743},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/pre-metastatic-niche","display_name":"pre-metastatic niche","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tumor-cell-survival","display_name":"tumor cell survival","score":0.8629999756813049},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/bone-marrow-derived-myeloid-cells","display_name":"bone marrow-derived myeloid cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/anti-metastasis-therapy","display_name":"anti-metastasis therapy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5212100744247437},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5023651123046875},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.471215158700943},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.43342986702919006},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4101142883300781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3287857174873352},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12845391035079956}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6507401","doi":"https://doi.org/10.1158/0008-5472.c.6507401","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507401","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507401","doi":"https://doi.org/10.1158/0008-5472.c.6507401","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507401","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1771462465","https://openalex.org/W2563433371","https://openalex.org/W2065576871","https://openalex.org/W4362483367","https://openalex.org/W4392724872","https://openalex.org/W2127421703","https://openalex.org/W2136000914","https://openalex.org/W2159414492","https://openalex.org/W2030882091","https://openalex.org/W3215607492"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"cell":[2,48,79,148],"survival":[3,80,123],"in":[4,13,38,59,65,68,74,86,98,114],"the":[5,39,93,109,143,156],"hostile":[6],"distant":[7],"organ":[8],"is":[9,32],"a":[10,22,27,135],"rate-limiting":[11,144],"step":[12,145],"cancer":[14,125,147],"metastasis.":[15,82],"Bone":[16],"marrow\u2013derived":[17],"myeloid":[18,36,62,75,87],"cells":[19,37,63,76,88,118],"can":[20],"form":[21],"premetastatic":[23,40,66],"niche":[24],"and":[25,64,81,122],"provide":[26],"tumor-promoting":[28],"microenvironment.":[29],"However,":[30],"it":[31],"unclear":[33],"whether":[34],"these":[35],"site":[41],"have":[42],"any":[43],"direct":[44],"effect":[45],"on":[46],"tumor":[47,78,94],"survival.":[49,149],"Here,":[50],"we":[51],"report":[52],"that":[53,130],"chemokine":[54],"CCL9":[55,73,84,131,153],"was":[56],"highly":[57],"induced":[58],"Gr-1+CD11b+":[60],"immature":[61],"lung":[67],"tumor-bearing":[69],"mice.":[70],"Knockdown":[71],"of":[72,107,124,146,159],"decreased":[77],"Importantly,":[83],"overexpression":[85],"lacking":[89],"TGF\u03b2":[90],"signaling":[91],"rescued":[92],"metastasis":[95],"defect":[96],"observed":[97],"mice":[99],"with":[100,120],"myeloid-specific":[101],"Tgfbr2":[102],"deletion.":[103],"The":[104],"expression":[105],"level":[106],"CCL23,":[108],"human":[110],"orthologue":[111],"for":[112,138],"CCL9,":[113],"peripheral":[115],"blood":[116],"mononuclear":[117],"correlated":[119],"progression":[121],"patients.":[126],"Our":[127],"study":[128],"demonstrates":[129],"could":[132],"serve":[133],"as":[134],"good":[136],"candidate":[137],"anti-metastasis":[139],"treatment":[140],"by":[141],"targeting":[142,152],"In":[150],"addition,":[151],"may":[154],"avoid":[155],"adverse":[157],"effects":[158],"TGF\u03b2-targeted":[160],"therapy.":[161],"Cancer":[162],"Res;":[163],"75(24);":[164],"5283\u201398.":[165],"\u00a92015":[166],"AACR.":[167]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2024-03-13T00:00:00"}