{"id":"https://openalex.org/W4392679803","doi":"https://doi.org/10.1158/0008-5472.c.6506946","title":"Data from Metastatic Heterogeneity of Breast Cancer Cells Is Associated with Expression of a Heterogeneous TGF\u03b2-Activating miR424\u2013503 Gene Cluster","display_name":"Data from Metastatic Heterogeneity of Breast Cancer Cells Is Associated with Expression of a Heterogeneous TGF\u03b2-Activating miR424\u2013503 Gene Cluster","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392679803","doi":"https://doi.org/10.1158/0008-5472.c.6506946"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6506946","doi":"https://doi.org/10.1158/0008-5472.c.6506946","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6506946","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6506946","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100369197","display_name":"Yun Li","orcid":"https://orcid.org/0000-0001-8414-2724","observed_orcids":["https://orcid.org/0000-0001-8414-2724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zhe Ying","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhe Ying","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100559041","display_name":"Han Tian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Han Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714858","display_name":"Xun Zhu","orcid":"https://orcid.org/0000-0002-9239-0055","observed_orcids":["https://orcid.org/0000-0002-9239-0055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xun Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362016","display_name":"Jun Li","orcid":"https://orcid.org/0000-0003-0516-5894","observed_orcids":["https://orcid.org/0000-0003-0516-5894"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054499936","display_name":"Mengfeng Li","orcid":"https://orcid.org/0000-0002-5103-6367","observed_orcids":["https://orcid.org/0000-0002-5103-6367","https://orcid.org/0000-0001-6497-4232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mengfeng Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8069999814033508},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.6850000023841858},{"id":"https://openalex.org/keywords/smad7","display_name":"Smad7","score":0.8960000276565552},{"id":"https://openalex.org/keywords/smurf2","display_name":"Smurf2","score":1.0},{"id":"https://openalex.org/keywords/metastatic-heterogeneity","display_name":"metastatic heterogeneity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.608945906162262},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5735631585121155},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5347961783409119},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.5033478140830994},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5011649131774902},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48134908080101013},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.44374048709869385},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4259335398674011},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42510825395584106},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4053853154182434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3866024315357208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38577818870544434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28125154972076416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22223347425460815},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1570119559764862},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6506946","doi":"https://doi.org/10.1158/0008-5472.c.6506946","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6506946","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6506946","doi":"https://doi.org/10.1158/0008-5472.c.6506946","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6506946","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2113433800","https://openalex.org/W2974370812","https://openalex.org/W7134890875","https://openalex.org/W7024482025","https://openalex.org/W2002306705","https://openalex.org/W2398424914","https://openalex.org/W4362542182","https://openalex.org/W2321667820","https://openalex.org/W4362423399","https://openalex.org/W4235894941"],"abstract_inverted_index":{"Abstract":[0],"TGF\u03b2":[1,17,42,54,105,110,152,180],"signaling":[2,43,111],"is":[3,19],"known":[4],"to":[5,108,148],"drive":[6],"metastasis":[7,74,127,183],"in":[8,58,84,122,128],"human":[9,185],"cancer.":[10,87,187],"Under":[11],"physiologic":[12],"conditions,":[13],"the":[14,53,78,144,149,176],"level":[15],"of":[16,104,115,143,151,175,184],"activity":[18,153],"tightly":[20],"controlled":[21],"by":[22,172],"a":[23,168],"regulatory":[24],"network":[25],"involving":[26],"multiple":[27],"negative":[28],"regulators.":[29],"At":[30],"metastasis,":[31],"however,":[32],"these":[33],"inhibitory":[34,102],"mechanisms":[35],"are":[36,56],"usually":[37],"overridden":[38],"so":[39],"that":[40,77,91,140],"oncogenic":[41],"can":[44],"be":[45],"overactivated":[46],"and":[47,75,93,98,112,130,156,182],"sustained.":[48],"To":[49],"better":[50],"understand":[51],"how":[52],"inhibitors":[55],"suppressed":[57,96,126],"metastatic":[59,85,113,157],"breast":[60,69,86,116,123,160,186],"cancer":[61,117,124,161],"cells,":[62],"we":[63],"compared":[64],"miRNA":[65],"expression":[66,142,174],"profiles":[67],"between":[68],"cancers":[70],"with":[71],"or":[72],"without":[73],"found":[76,139],"miR424\u2013503":[79,121,145,177],"cluster":[80,146],"was":[81],"markedly":[82],"overexpressed":[83],"Mechanistic":[88],"studies":[89],"revealed":[90],"miR424":[92],"miR503":[94],"simultaneously":[95],"Smad7":[97],"Smurf2,":[99],"two":[100],"key":[101],"factors":[103],"signaling,":[106],"leading":[107],"enhanced":[109],"capability":[114],"cells.":[118],"Moreover,":[119],"antagonizing":[120],"cells":[125],"vivo":[129],"increased":[131],"overall":[132],"host":[133],"survival.":[134],"Interestingly,":[135],"our":[136,165],"study":[137],"also":[138],"heterogeneous":[141],"contributed":[147],"heterogeneity":[150],"levels":[154],"in,":[155],"potential":[158],"of,":[159],"cell":[162],"subsets.":[163],"Overall,":[164],"findings":[166],"demonstrate":[167],"novel":[169],"mechanism,":[170],"mediated":[171],"elevated":[173],"cluster,":[178],"underlying":[179],"activation":[181],"Cancer":[188],"Res;":[189],"74(21);":[190],"6107\u201318.":[191],"\u00a92014":[192],"AACR.":[193]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-03-13T00:00:00"}
