{"id":"https://openalex.org/W4392679655","doi":"https://doi.org/10.1158/0008-5472.c.6506298","title":"Data from Targeting Cancer Stem\u2013like Cells as an Approach to Defeating Cellular Heterogeneity in Ewing Sarcoma","display_name":"Data from Targeting Cancer Stem\u2013like Cells as an Approach to Defeating Cellular Heterogeneity in Ewing Sarcoma","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4392679655","doi":"https://doi.org/10.1158/0008-5472.c.6506298"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6506298","doi":"https://doi.org/10.1158/0008-5472.c.6506298","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6506298","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6506298","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002591718","display_name":"Sandrine Cornaz-Buros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandrine Cornaz-Buros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015843125","display_name":"Nicol\u00f2 Riggi","orcid":"https://orcid.org/0000-0001-9160-1984","observed_orcids":["https://orcid.org/0000-0001-9160-1984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolo Riggi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966933","display_name":"Claudio DeVito","orcid":"https://orcid.org/0000-0002-4966-1278","observed_orcids":["https://orcid.org/0000-0002-4966-1278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudio DeVito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056838185","display_name":"Alexandre Sarre","orcid":"https://orcid.org/0009-0008-7374-8278","observed_orcids":["https://orcid.org/0009-0008-7374-8278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandre Sarre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055285177","display_name":"Igor Letovanec","orcid":"https://orcid.org/0000-0002-0410-3491","observed_orcids":["https://orcid.org/0000-0002-0410-3491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor Letovanec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063120064","display_name":"Paolo Provero","orcid":"https://orcid.org/0000-0001-8664-8630","observed_orcids":["https://orcid.org/0000-0001-8664-8630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Provero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007648823","display_name":"Ivan Stamenkovic","orcid":"https://orcid.org/0000-0002-7913-7848","observed_orcids":["https://orcid.org/0000-0002-7913-7848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Stamenkovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ewing-sarcoma-family-of-tumors","display_name":"Ewing sarcoma family of tumors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cancer-stem-like-cells","display_name":"cancer stem-like cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-heterogeneity","display_name":"cellular heterogeneity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/enoxacin","display_name":"enoxacin","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fluoroquinolones","display_name":"fluoroquinolones","score":0.859000027179718},{"id":"https://openalex.org/keywords/tarbp2","display_name":"TARBP2","score":0.902999997138977},{"id":"https://openalex.org/keywords/microrna-maturation","display_name":"microRNA maturation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.953000009059906},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.8610000014305115},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5419999957084656},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5230000019073486},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.6240000128746033},{"id":"https://openalex.org/keywords/primary-tumor-cells","display_name":"primary tumor cells","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2777586341","wikidata":"https://www.wikidata.org/wiki/Q1138580","display_name":"Ewing's sarcoma","level":3,"score":0.6107756495475769},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5655267238616943},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5405565500259399},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5396528244018555},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4934953451156616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43826180696487427},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4016697108745575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2935373783111572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22816407680511475},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17935067415237427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14207395911216736}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6506298","doi":"https://doi.org/10.1158/0008-5472.c.6506298","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6506298","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6506298.v1","doi":"https://doi.org/10.1158/0008-5472.c.6506298.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6506298.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6506298","doi":"https://doi.org/10.1158/0008-5472.c.6506298","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6506298","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093419384","https://openalex.org/W7028322160","https://openalex.org/W4282970586","https://openalex.org/W2090042383","https://openalex.org/W2314440869","https://openalex.org/W1986720386","https://openalex.org/W4318203734","https://openalex.org/W4283645684","https://openalex.org/W2095799750","https://openalex.org/W7165005350"],"abstract_inverted_index":{"Abstract":[0],"Plasticity":[1],"in":[2,36,46,57,131,153,169],"cancer":[3,13],"stem\u2013like":[4],"cells":[5,92,109,130],"(CSC)":[6],"may":[7],"provide":[8],"a":[9,27,37,55,175,189,193],"key":[10],"basis":[11],"for":[12,180,200],"heterogeneity":[14],"and":[15,106,116,164],"therapeutic":[16,178],"response.":[17],"In":[18,71,156],"this":[19,47],"study,":[20],"we":[21],"assessed":[22],"the":[23,68,72,121,158],"effect":[24],"of":[25,44,89,186],"combining":[26],"drug":[28],"that":[29,182],"abrogates":[30],"CSC":[31,45,82,105,187],"properties":[32],"with":[33,97,192],"standard-of-care":[34,114,194],"therapy":[35],"Ewing":[38],"sarcoma":[39],"family":[40],"tumor":[41,91,108,122],"(ESFT).":[42],"Emergence":[43],"setting":[48],"has":[49],"been":[50],"shown":[51],"to":[52,67,87,95,113,135],"arise":[53],"from":[54,77,85],"defect":[56],"TARBP2-dependent":[58],"microRNA":[59],"maturation,":[60],"which":[61,119,141],"can":[62],"be":[63],"corrected":[64],"by":[65,145],"exposure":[66],"fluoroquinolone":[69],"enoxacin.":[70,117],"present":[73],"work,":[74],"primary":[75,127,167],"ESFT":[76,104,129,137,154,181],"four":[78],"patients":[79],"containing":[80],"CD133+":[81],"subpopulations":[83],"ranging":[84],"3%":[86],"17%":[88],"total":[90],"were":[93],"subjected":[94],"treatment":[96],"enoxacin,":[98,140],"doxorubicin,":[99],"or":[100],"both":[101],"drugs.":[102],"Primary":[103],"bulk":[107],"displayed":[110,124],"divergent":[111],"responses":[112],"chemotherapy":[115],"Doxorubicin,":[118],"targets":[120],"bulk,":[123],"toxicity":[125],"toward":[126],"adherent":[128],"culture":[132],"but":[133,151],"not":[134],"CSC-enriched":[136],"spheres.":[138,155],"Conversely,":[139],"enhances":[142],"miRNA":[143],"maturation":[144],"stimulating":[146],"TARBP2":[147],"function,":[148],"induced":[149],"apoptosis":[150],"only":[152],"combination,":[157],"two":[159],"drugs":[160],"markedly":[161],"depleted":[162],"CSCs":[163],"strongly":[165],"reduced":[166],"ESFTs":[168],"xenograft":[170],"assays.":[171],"Our":[172],"results":[173],"identify":[174],"potentially":[176],"attractive":[177],"strategy":[179],"combines":[183],"mechanism-based":[184],"targeting":[185],"using":[188],"low-toxicity":[190],"antibiotic":[191],"cytotoxic":[195],"drug,":[196],"offering":[197],"immediate":[198],"applications":[199],"clinical":[201],"evaluation.":[202],"Cancer":[203],"Res;":[204],"74(22);":[205],"6610\u201322.":[206],"\u00a92014":[207],"AACR.":[208]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-13T00:00:00"}