{"id":"https://openalex.org/W4392656549","doi":"https://doi.org/10.1186/s13024-024-00712-0","title":"Updates on mouse models of Alzheimer\u2019s disease","display_name":"Updates on mouse models of Alzheimer\u2019s disease","publication_year":2024,"publication_date":"2024-03-10","ids":{"openalex":"https://openalex.org/W4392656549","doi":"https://doi.org/10.1186/s13024-024-00712-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/38462606","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10926682"},"language":"en","primary_location":{"id":"doi:10.1186/s13024-024-00712-0","doi":"https://doi.org/10.1186/s13024-024-00712-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13024-024-00712-0","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-024-00712-0","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-024-00712-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109690279","display_name":"Michael Z Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Z. Zhong","raw_affiliation_strings":["Department of Biology, College of Arts and Science, Boston University, Boston, MA, 02215, USA","Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Arts and Science, Boston University, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104255935","display_name":"Thomas Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134570","display_name":"Scarsdale Public Schools","ror":"https://ror.org/042w3r845","country_code":"US","type":"education","lineage":["https://openalex.org/I4210134570"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Peng","raw_affiliation_strings":["Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","Science Research Program, Scarsdale High School, New York, NY, 10583, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Science Research Program, Scarsdale High School, New York, NY, 10583, USA","institution_ids":["https://openalex.org/I4210134570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013259171","display_name":"Mariana Lemos Duarte","orcid":"https://orcid.org/0000-0002-1611-7102","observed_orcids":["https://orcid.org/0000-0002-1611-7102"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mariana Lemos Duarte","raw_affiliation_strings":["Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. mariana.lemosduarte@mssm.edu","Research & Development, James J Peters VA Medical Center, Bronx, NY, 10468, USA. mariana.lemosduarte@mssm.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. mariana.lemosduarte@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Research & Development, James J Peters VA Medical Center, Bronx, NY, 10468, USA. mariana.lemosduarte@mssm.edu","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376896","display_name":"Minghui Wang","orcid":"https://orcid.org/0000-0001-9171-4962","observed_orcids":["https://orcid.org/0000-0001-9171-4962"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Minghui Wang","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. minghui.wang@mssm.edu","Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. minghui.wang@mssm.edu","Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. minghui.wang@mssm.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. minghui.wang@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. minghui.wang@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. minghui.wang@mssm.edu","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011899408","display_name":"Dongming Cai","orcid":"https://orcid.org/0000-0002-0601-6826","observed_orcids":["https://orcid.org/0000-0002-0601-6826"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I4210117246","display_name":"Minneapolis VA Health Care System","ror":"https://ror.org/02ry60714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dongming Cai","raw_affiliation_strings":["Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. cai00268@umn.edu","Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. cai00268@umn.edu","Department of Neurology, N. Bud Grossman Center for Memory Research and Care, The University of Minnesota, Minneapolis, MN, 55455, USA. cai00268@umn.edu","Geriatric Research Education & Clinical Center (GRECC), The Minneapolis VA Health Care System, Minneapolis, MN, 55417, USA. cai00268@umn.edu","Research & Development, James J Peters VA Medical Center, Bronx, NY, 10468, USA. cai00268@umn.edu","Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. cai00268@umn.edu"],"raw_orcid":"https://orcid.org/0000-0002-0601-6826","affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. cai00268@umn.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. cai00268@umn.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Neurology, N. Bud Grossman Center for Memory Research and Care, The University of Minnesota, Minneapolis, MN, 55455, USA. cai00268@umn.edu","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Geriatric Research Education & Clinical Center (GRECC), The Minneapolis VA Health Care System, Minneapolis, MN, 55417, USA. cai00268@umn.edu","institution_ids":["https://openalex.org/I4210117246","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Research & Development, James J Peters VA Medical Center, Bronx, NY, 10468, USA. cai00268@umn.edu","institution_ids":["https://openalex.org/I4210116369"]},{"raw_affiliation_string":"Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. cai00268@umn.edu","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5011899408","https://openalex.org/A5013259171","https://openalex.org/A5100376896"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210116369","https://openalex.org/I4210117246","https://openalex.org/I4210140408","https://openalex.org/I98704320"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":9.3533,"has_fulltext":true,"cited_by_count":203,"citation_normalized_percentile":{"value":0.99442473,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.8930000066757202},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.8709999918937683},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sporadic-alzheimer-s-disease","display_name":"sporadic Alzheimer's disease","score":0.9190000295639038},{"id":"https://openalex.org/keywords/crispr-gene-editing","display_name":"CRISPR gene editing","score":0.9940000176429749},{"id":"https://openalex.org/keywords/amyloid-pathology","display_name":"amyloid pathology","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.9990000128746033},{"id":"https://openalex.org/keywords/synaptic-degeneration","display_name":"synaptic degeneration","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.902999997138977},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8849999904632568},{"id":"https://openalex.org/keywords/molecular-signatures","display_name":"molecular signatures","score":0.7020000219345093},{"id":"https://openalex.org/keywords/omics-data","display_name":"omics data","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6724485158920288},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6404345035552979},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.564858078956604},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5405780673027039},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.4986746311187744},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.4956103563308716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4628654420375824},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4579227864742279},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4306635856628418},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.4267526865005493},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4231640100479126},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4226330816745758},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41942012310028076},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41532188653945923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3841305673122406},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37530234456062317},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2547093629837036},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2509898841381073},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13024-024-00712-0","doi":"https://doi.org/10.1186/s13024-024-00712-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13024-024-00712-0","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-024-00712-0","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10926682","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10926682","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10926682/pdf/13024_2024_Article_712.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Neurodegener","raw_type":"Text"},{"id":"pmid:38462606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38462606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular neurodegeneration","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5f415ab149b247a2934401aaf585cb41","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5f415ab149b247a2934401aaf585cb41","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-33 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13024-024-00712-0","doi":"https://doi.org/10.1186/s13024-024-00712-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13024-024-00712-0","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-024-00712-0","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1470646647","display_name":null,"funder_award_id":"I01 BX003380","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G1495158547","display_name":null,"funder_award_id":"I01BX005934","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4777055882","display_name":"Novel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer's Disease","funder_award_id":"R01AG068030","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5563013544","display_name":"Dissect the interplay between sex and APOE at the single cell level to uncover novel pathways, targets and therapeutics for Alzheimer's disease","funder_award_id":"RF1AG074010","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7756028788","display_name":"Characterization of ApoE4 Induced Phospholipid Dysregulation in AD Pathogenesis","funder_award_id":"RF1AG048923","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000878537","display_name":"Characterization of ApoE4 Induced Phospholipid Dysregulation in AD Pathogenesis","funder_award_id":"R01AG048923","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392656549.pdf","grobid_xml":"https://content.openalex.org/works/W4392656549.grobid-xml"},"referenced_works_count":198,"referenced_works":["https://openalex.org/W1919353","https://openalex.org/W1508946785","https://openalex.org/W1555936968","https://openalex.org/W1600908488","https://openalex.org/W1629933021","https://openalex.org/W1835461481","https://openalex.org/W1906956625","https://openalex.org/W1965275873","https://openalex.org/W1965709917","https://openalex.org/W1966312717","https://openalex.org/W1967464880","https://openalex.org/W1969129718","https://openalex.org/W1971210753","https://openalex.org/W1971402768","https://openalex.org/W1973276273","https://openalex.org/W1973629574","https://openalex.org/W1975922633","https://openalex.org/W1977434686","https://openalex.org/W1977813572","https://openalex.org/W1978232373","https://openalex.org/W1979536020","https://openalex.org/W1982180106","https://openalex.org/W1985420099","https://openalex.org/W1985799463","https://openalex.org/W2001210466","https://openalex.org/W2001436892","https://openalex.org/W2004340905","https://openalex.org/W2005627616","https://openalex.org/W2009870816","https://openalex.org/W2011041653","https://openalex.org/W2012590437","https://openalex.org/W2013770936","https://openalex.org/W2014111275","https://openalex.org/W2017867302","https://openalex.org/W2018109459","https://openalex.org/W2020266809","https://openalex.org/W2020819780","https://openalex.org/W2024606460","https://openalex.org/W2026576926","https://openalex.org/W2027845034","https://openalex.org/W2028757687","https://openalex.org/W2029869319","https://openalex.org/W2030500144","https://openalex.org/W2033105784","https://openalex.org/W2034315250","https://openalex.org/W2038392637","https://openalex.org/W2039962538","https://openalex.org/W2040949523","https://openalex.org/W2047577540","https://openalex.org/W2050558334","https://openalex.org/W2054388625","https://openalex.org/W2056230737","https://openalex.org/W2057249855","https://openalex.org/W2057327829","https://openalex.org/W2057955018","https://openalex.org/W2058120050","https://openalex.org/W2062131497","https://openalex.org/W2066644955","https://openalex.org/W2071174827","https://openalex.org/W2072780124","https://openalex.org/W2073995412","https://openalex.org/W2081095372","https://openalex.org/W2081098333","https://openalex.org/W2082429191","https://openalex.org/W2084177469","https://openalex.org/W2089936534","https://openalex.org/W2090054406","https://openalex.org/W2090586279","https://openalex.org/W2090620788","https://openalex.org/W2092036232","https://openalex.org/W2092512185","https://openalex.org/W2093618389","https://openalex.org/W2093666137","https://openalex.org/W2094831055","https://openalex.org/W2096068616","https://openalex.org/W2096410114","https://openalex.org/W2097632269","https://openalex.org/W2101889545","https://openalex.org/W2102118295","https://openalex.org/W2107281222","https://openalex.org/W2107804537","https://openalex.org/W2110065044","https://openalex.org/W2114104545","https://openalex.org/W2114729479","https://openalex.org/W2117800935","https://openalex.org/W2118751252","https://openalex.org/W2125606512","https://openalex.org/W2134475193","https://openalex.org/W2135309154","https://openalex.org/W2136901555","https://openalex.org/W2137860879","https://openalex.org/W2138207763","https://openalex.org/W2141210743","https://openalex.org/W2141653500","https://openalex.org/W2141975447","https://openalex.org/W2146512944","https://openalex.org/W2152546327","https://openalex.org/W2153747061","https://openalex.org/W2158198121","https://openalex.org/W2158402798","https://openalex.org/W2158765009","https://openalex.org/W2163349796","https://openalex.org/W2165348489","https://openalex.org/W2166267133","https://openalex.org/W2168288835","https://openalex.org/W2169456326","https://openalex.org/W2170446709","https://openalex.org/W2170644095","https://openalex.org/W2171495114","https://openalex.org/W2275610193","https://openalex.org/W2529470828","https://openalex.org/W2534587007","https://openalex.org/W2534837518","https://openalex.org/W2594688987","https://openalex.org/W2605159920","https://openalex.org/W2605401453","https://openalex.org/W2622277040","https://openalex.org/W2729351500","https://openalex.org/W2743727231","https://openalex.org/W2750682079","https://openalex.org/W2756959977","https://openalex.org/W2762857072","https://openalex.org/W2763928642","https://openalex.org/W2765616742","https://openalex.org/W2768567520","https://openalex.org/W2779463443","https://openalex.org/W2781382271","https://openalex.org/W2784206224","https://openalex.org/W2790983771","https://openalex.org/W2802943395","https://openalex.org/W2804633924","https://openalex.org/W2807252917","https://openalex.org/W2883703220","https://openalex.org/W2889808182","https://openalex.org/W2890074452","https://openalex.org/W2890487946","https://openalex.org/W2890556232","https://openalex.org/W2902887888","https://openalex.org/W2908182575","https://openalex.org/W2939430406","https://openalex.org/W2945729813","https://openalex.org/W2947805301","https://openalex.org/W2948955942","https://openalex.org/W2952517722","https://openalex.org/W2954476098","https://openalex.org/W2978136964","https://openalex.org/W2980668035","https://openalex.org/W2981166078","https://openalex.org/W2982115290","https://openalex.org/W2990946693","https://openalex.org/W2998827051","https://openalex.org/W3000390390","https://openalex.org/W3006131455","https://openalex.org/W3012405369","https://openalex.org/W3033760021","https://openalex.org/W3034536401","https://openalex.org/W3037497912","https://openalex.org/W3044901278","https://openalex.org/W3088756614","https://openalex.org/W3107908899","https://openalex.org/W3109450620","https://openalex.org/W3109942090","https://openalex.org/W3111203418","https://openalex.org/W3131317233","https://openalex.org/W3170603847","https://openalex.org/W3176022318","https://openalex.org/W3178776770","https://openalex.org/W3179374652","https://openalex.org/W3184377705","https://openalex.org/W3207056385","https://openalex.org/W3207717438","https://openalex.org/W4205397371","https://openalex.org/W4210363019","https://openalex.org/W4211016192","https://openalex.org/W4211221300","https://openalex.org/W4211238543","https://openalex.org/W4220847586","https://openalex.org/W4282918923","https://openalex.org/W4282932778","https://openalex.org/W4283360267","https://openalex.org/W4283460059","https://openalex.org/W4289525748","https://openalex.org/W4294312934","https://openalex.org/W4307695821","https://openalex.org/W4308293747","https://openalex.org/W4309507742","https://openalex.org/W4310461604","https://openalex.org/W4311704493","https://openalex.org/W4316193639","https://openalex.org/W4321180363","https://openalex.org/W4321369922","https://openalex.org/W4323542992","https://openalex.org/W4375847341","https://openalex.org/W4381435341","https://openalex.org/W4384522480","https://openalex.org/W4387142551","https://openalex.org/W4387773428","https://openalex.org/W4396844674"],"related_works":["https://openalex.org/W2969504130","https://openalex.org/W4280619291","https://openalex.org/W2779463443","https://openalex.org/W2055667558","https://openalex.org/W2148911867","https://openalex.org/W96512182","https://openalex.org/W4406242762","https://openalex.org/W4400053425","https://openalex.org/W4281394547","https://openalex.org/W2095268222"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,8,25],"(AD)":[2],"is":[3],"the":[4,10,39,86,107,126,175,200,218],"most":[5,207],"common":[6],"neurodegenerative":[7],"in":[9,38,99,121,217],"United":[11],"States":[12],"(US).":[13],"Animal":[14],"models,":[15],"specifically":[16],"mouse":[17,47,63,100,119,161,181],"models":[18,48,64,120,162,182,209],"have":[19,74,163,183],"been":[20,75,164,184],"developed":[21,76,118],"to":[22,88,186,202,214],"better":[23],"elucidate":[24],"mechanisms":[26],"and":[27,80,139,143,150,156],"test":[28],"therapeutic":[29],"strategies":[30],"for":[31,77,210],"AD.":[32],"A":[33],"large":[34],"portion":[35],"of":[36,51,62,95,109,130,134,158,169,190,194,206],"effort":[37],"field":[40],"was":[41],"focused":[42],"on":[43],"developing":[44],"transgenic":[45],"(Tg)":[46],"through":[49,65],"over-expression":[50,94],"genetic":[52],"mutations":[53],"associated":[54],"with":[55,85,167,199],"familial":[56,79],"AD":[57,82,97,135,160,180,196,219],"(FAD)":[58],"patients.":[59],"Newer":[60],"generations":[61],"knock-in":[66],"(KI)/knock-out":[67],"(KO)":[68],"or":[69,128],"CRISPR":[70],"gene":[71],"editing":[72],"technologies,":[73],"both":[78],"sporadic":[81],"risk":[83],"genes":[84,98],"hope":[87,201],"more":[89],"accurately":[90],"model":[91,192],"proteinopathies":[92],"without":[93],"human":[96,195],"brains.":[101],"In":[102,153],"this":[103],"review,":[104],"we":[105],"summarized":[106],"phenotypes":[108],"a":[110],"few":[111],"commonly":[112],"used":[113],"as":[114,116,137,146,148],"well":[115,147],"newly":[117],"translational":[122],"research":[123,212],"laboratories":[124],"including":[125],"presence":[127],"absence":[129],"key":[131],"pathological":[132],"features":[133],"such":[136],"amyloid":[138],"tau":[140],"pathology,":[141],"synaptic":[142],"neuronal":[144],"degeneration":[145],"cognitive":[149],"behavior":[151],"deficits.":[152],"addition,":[154],"advantages":[155],"limitations":[157],"these":[159],"elaborated":[165],"along":[166],"discussions":[168],"any":[170],"sex-specific":[171],"features.":[172],"More":[173],"importantly,":[174],"omics":[176],"data":[177],"from":[178],"available":[179],"analyzed":[185],"categorize":[187],"molecular":[188],"signatures":[189],"each":[191],"reminiscent":[193],"brain":[197],"changes,":[198],"guide":[203],"future":[204],"selection":[205],"suitable":[208],"specific":[211],"questions":[213],"be":[215],"addressed":[216],"field.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":84},{"year":2025,"cited_by_count":98},{"year":2024,"cited_by_count":21}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-03-12T00:00:00"}
