{"id":"https://openalex.org/W4392648336","doi":"https://doi.org/10.1038/s41467-024-46546-8","title":"YTHDF2 governs muscle size through a targeted modulation of proteostasis","display_name":"YTHDF2 governs muscle size through a targeted modulation of proteostasis","publication_year":2024,"publication_date":"2024-03-11","ids":{"openalex":"https://openalex.org/W4392648336","doi":"https://doi.org/10.1038/s41467-024-46546-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/38467649","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10928198"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-46546-8","doi":"https://doi.org/10.1038/s41467-024-46546-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-46546-8","pdf_url":"https://www.nature.com/articles/s41467-024-46546-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-024-46546-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christopher J. Gilbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Gilbert","raw_affiliation_strings":["Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA","Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035118689","display_name":"Charles P. Rabolli","orcid":"https://orcid.org/0000-0002-4383-8706","observed_orcids":["https://orcid.org/0000-0002-4383-8706"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles P. Rabolli","raw_affiliation_strings":["Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA","Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026045147","display_name":"Volha A. Golubeva","orcid":"https://orcid.org/0000-0001-5430-3507","observed_orcids":["https://orcid.org/0000-0001-5430-3507"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volha A. Golubeva","raw_affiliation_strings":["Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038036473","display_name":"Kristina M. Sattler","orcid":"https://orcid.org/0000-0002-3603-8516","observed_orcids":["https://orcid.org/0000-0002-3603-8516"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina M. Sattler","raw_affiliation_strings":["Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-3603-8516","affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100771914","display_name":"Meifang Wang","orcid":"https://orcid.org/0000-0003-3718-6788","observed_orcids":["https://orcid.org/0000-0003-3718-6788"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meifang Wang","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA","NextGen Precision Health, University of Missouri, Columbia, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"NextGen Precision Health, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081273000","display_name":"Arsh Haj Mohamad Ebrahim Ketabforoush","orcid":"https://orcid.org/0000-0002-2773-3170","observed_orcids":["https://orcid.org/0000-0002-2773-3170"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arsh Ketabforoush","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA","NextGen Precision Health, University of Missouri, Columbia, MO, USA"],"raw_orcid":"https://orcid.org/0000-0002-2773-3170","affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"NextGen Precision Health, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016640472","display_name":"William David Arnold","orcid":"https://orcid.org/0000-0001-9889-7036","observed_orcids":["https://orcid.org/0000-0001-9889-7036"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. David Arnold","raw_affiliation_strings":["Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA","Department of Neurology, University of Missouri, Columbia, MO, USA","Department of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH, USA","Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA","Division of Neuromuscular Disorders, Department of Neurology, The Ohio State University, Columbus, OH, USA","NextGen Precision Health, University of Missouri, Columbia, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Neurology, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Neuromuscular Disorders, Department of Neurology, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"NextGen Precision Health, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035888169","display_name":"Christoph Lepper","orcid":"https://orcid.org/0000-0002-6466-0820","observed_orcids":["https://orcid.org/0000-0002-6466-0820","https://orcid.org/0009-0008-4022-8057"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph Lepper","raw_affiliation_strings":["Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079413356","display_name":"Federica Accornero","orcid":"https://orcid.org/0000-0003-1209-7228","observed_orcids":["https://orcid.org/0000-0003-1209-7228"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Federica Accornero","raw_affiliation_strings":["Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA. federica_accornero@brown.edu","Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA. federica_accornero@brown.edu","Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA","Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-1209-7228","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA. federica_accornero@brown.edu","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA. federica_accornero@brown.edu","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079413356"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I52357470"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":6790,"currency":"USD","value_usd":6790},"fwci":2.1292,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.88535845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"2176","last_page":"2176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.3319999873638153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ythdf2","display_name":"YTHDF2","score":1.0},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.746999979019165},{"id":"https://openalex.org/keywords/skeletal-muscle-growth","display_name":"skeletal muscle growth","score":0.7440000176429749},{"id":"https://openalex.org/keywords/muscle-hypertrophy","display_name":"muscle hypertrophy","score":0.6240000128746033},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/asb2","display_name":"ASB2","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.9290000200271606},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.9395212531089783},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5880556106567383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3624016046524048},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33501169085502625}],"mesh":[{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-024-46546-8","doi":"https://doi.org/10.1038/s41467-024-46546-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-46546-8","pdf_url":"https://www.nature.com/articles/s41467-024-46546-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10928198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10928198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:38467649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38467649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46546-8","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-46546-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:76a086d225274d19b9e5e63a238d8b1e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/76a086d225274d19b9e5e63a238d8b1e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-46546-8","doi":"https://doi.org/10.1038/s41467-024-46546-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-46546-8","pdf_url":"https://www.nature.com/articles/s41467-024-46546-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1581437734","display_name":null,"funder_award_id":"154001","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1670106947","display_name":null,"funder_award_id":"136951","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1858189645","display_name":null,"funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320309374","funder_display_name":"Ohio State University"},{"id":"https://openalex.org/G1885445165","display_name":null,"funder_award_id":"154001","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G207698803","display_name":"Mechanistic characterization of a new master regulator of cardiac virus infections","funder_award_id":"R01HL154001","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2599043616","display_name":"The role of YTHDF2 in postnatal cardiac growth and homeostasis","funder_award_id":"F31HL158234","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2716040950","display_name":"The Role of m6A Binding Protein YTHDF1 in Cardiac Homeostasis","funder_award_id":"F30HL160104","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6834052811","display_name":null,"funder_award_id":"R01 HL 154001","funder_id":"https://openalex.org/F4320309374","funder_display_name":"Ohio State University"},{"id":"https://openalex.org/G697781352","display_name":"Structured Illumination Microscope for high resolution imaging of cells and tissues","funder_award_id":"1s10od025008-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7608207679","display_name":null,"funder_award_id":"R01 HL 136951","funder_id":"https://openalex.org/F4320309374","funder_display_name":"Ohio State University"},{"id":"https://openalex.org/G8461815449","display_name":null,"funder_award_id":"136951","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G9000879325","display_name":"Regulation of Muscle Stem Cell Number via Paracrine Signaling","funder_award_id":"R01AR078231","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000887552","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000896217","display_name":"YTHDF3 as a critical regulator of cardiac function","funder_award_id":"F30HL165812","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000899483","display_name":"Post-transcriptional regulation of cardiac hypertrophy","funder_award_id":"R01HL136951","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392648336.pdf","grobid_xml":"https://content.openalex.org/works/W4392648336.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1941339056","https://openalex.org/W1973268693","https://openalex.org/W1974124243","https://openalex.org/W1976226298","https://openalex.org/W1976760923","https://openalex.org/W1983405576","https://openalex.org/W1991807334","https://openalex.org/W2000066959","https://openalex.org/W2007006841","https://openalex.org/W2009396278","https://openalex.org/W2018242137","https://openalex.org/W2033924360","https://openalex.org/W2035555824","https://openalex.org/W2037048755","https://openalex.org/W2043391289","https://openalex.org/W2059088759","https://openalex.org/W2064217368","https://openalex.org/W2067488166","https://openalex.org/W2071930821","https://openalex.org/W2082115260","https://openalex.org/W2096840621","https://openalex.org/W2110839189","https://openalex.org/W2112587264","https://openalex.org/W2115150337","https://openalex.org/W2119383037","https://openalex.org/W2132864654","https://openalex.org/W2137618038","https://openalex.org/W2147955588","https://openalex.org/W2148527632","https://openalex.org/W2150556572","https://openalex.org/W2150607823","https://openalex.org/W2154042628","https://openalex.org/W2160105048","https://openalex.org/W2163276416","https://openalex.org/W2198207772","https://openalex.org/W2210597779","https://openalex.org/W2262352538","https://openalex.org/W2266075481","https://openalex.org/W2336035698","https://openalex.org/W2397347597","https://openalex.org/W2465672002","https://openalex.org/W2507685096","https://openalex.org/W2520925527","https://openalex.org/W2562211106","https://openalex.org/W2563912688","https://openalex.org/W2571927015","https://openalex.org/W2575691519","https://openalex.org/W2587586269","https://openalex.org/W2600643360","https://openalex.org/W2615786896","https://openalex.org/W2753095878","https://openalex.org/W2769106524","https://openalex.org/W2891513200","https://openalex.org/W2891865027","https://openalex.org/W2901294932","https://openalex.org/W2912282082","https://openalex.org/W2926740022","https://openalex.org/W2952911404","https://openalex.org/W2972151198","https://openalex.org/W2987737829","https://openalex.org/W2988348870","https://openalex.org/W3009279595","https://openalex.org/W3026427316","https://openalex.org/W3029046617","https://openalex.org/W3047255002","https://openalex.org/W3089770012","https://openalex.org/W3092757562","https://openalex.org/W3126052213","https://openalex.org/W3130633305","https://openalex.org/W3160997593","https://openalex.org/W3202009288","https://openalex.org/W3216788755","https://openalex.org/W4206334121","https://openalex.org/W4244139079","https://openalex.org/W4301398073","https://openalex.org/W4307502246","https://openalex.org/W4318219777","https://openalex.org/W4381548624"],"related_works":["https://openalex.org/W4387910252","https://openalex.org/W2336035698","https://openalex.org/W7126198940","https://openalex.org/W4407457195","https://openalex.org/W4395659504","https://openalex.org/W4409355034","https://openalex.org/W4404106417","https://openalex.org/W6920950682","https://openalex.org/W6976784661","https://openalex.org/W2397347597"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"regulation":[2,58],"of":[3,9,15,29,59,67,91,112,137],"proteostasis":[4],"is":[5,39,80],"fundamental":[6],"for":[7,134],"maintenance":[8],"muscle":[10,31,45,85,95],"mass":[11],"and":[12,21,64,97],"function.":[13],"Activation":[14],"the":[16,26,52,56,65,74,99,109,113,135],"TGF-\u03b2":[17,69],"pathway":[18],"drives":[19],"wasting":[20],"premature":[22],"aging":[23],"by":[24],"favoring":[25],"proteasomal":[27],"degradation":[28],"structural":[30],"proteins.":[32],"Yet,":[33],"how":[34],"this":[35],"critical":[36],"post-translational":[37,132],"mechanism":[38,133],"kept":[40],"in":[41,140],"check":[42],"to":[43,82,101,131],"preserve":[44],"health":[46],"remains":[47],"unclear.":[48],"Here,":[49],"we":[50],"reveal":[51],"molecular":[53],"link":[54],"between":[55],"post-transcriptional":[57,130],"m":[60,75],"6":[61,76],"A-modified":[62],"mRNA":[63,110],"modulation":[66],"SMAD-dependent":[68],"signaling.":[70],"We":[71,104],"show":[72],"that":[73,106],"A-binding":[77],"protein":[78],"YTHDF2":[79,92,107],"essential":[81],"determining":[83],"postnatal":[84],"size.":[86],"Indeed,":[87],"muscle-specific":[88],"genetic":[89],"deletion":[90],"impairs":[93],"skeletal":[94],"growth":[96],"abrogates":[98],"response":[100],"hypertrophic":[102],"stimuli.":[103],"report":[105],"controls":[108],"stability":[111],"ubiquitin":[114],"ligase":[115],"ASB2":[116],"with":[117],"consequences":[118],"on":[119],"anti-growth":[120],"gene":[121,138],"program":[122],"activation":[123],"through":[124],"SMAD3.":[125],"Our":[126],"study":[127],"identifies":[128],"a":[129],"coordination":[136],"expression":[139],"muscle.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-12T00:00:00"}