{"id":"https://openalex.org/W4392646903","doi":"https://doi.org/10.1038/s41589-024-01573-w","title":"A solid beta-sheet structure is formed at the surface of FUS droplets during aging","display_name":"A solid beta-sheet structure is formed at the surface of FUS droplets during aging","publication_year":2024,"publication_date":"2024-03-11","ids":{"openalex":"https://openalex.org/W4392646903","doi":"https://doi.org/10.1038/s41589-024-01573-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/38467846","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11288893"},"language":"en","primary_location":{"id":"doi:10.1038/s41589-024-01573-w","doi":"https://doi.org/10.1038/s41589-024-01573-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41589-024-01573-w","pdf_url":"https://www.nature.com/articles/s41589-024-01573-w.pdf","source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41589-024-01573-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021917610","display_name":"Leonidas Emmanouilidis","orcid":"https://orcid.org/0000-0001-8931-8901","observed_orcids":["https://orcid.org/0000-0001-8931-8901"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405254385","display_name":"Institute of Biochemistry","ror":"https://ror.org/01rd8n845","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254385"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Leonidas Emmanouilidis","raw_affiliation_strings":["Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland. leonidas@bc.biol.ethz.ch","Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland. leonidas@bc.biol.ethz.ch"],"raw_orcid":"https://orcid.org/0000-0001-8931-8901","affiliations":[{"raw_affiliation_string":"Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland. leonidas@bc.biol.ethz.ch","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland. leonidas@bc.biol.ethz.ch","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033756075","display_name":"Ettore Bartalucci","orcid":"https://orcid.org/0000-0002-6029-6582","observed_orcids":["https://orcid.org/0000-0002-6029-6582"]},"institutions":[{"id":"https://openalex.org/I4210110444","display_name":"Max Planck Institute for Chemical Energy Conversion","ror":"https://ror.org/01y9arx16","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210110444"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ettore Bartalucci","raw_affiliation_strings":["Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany","Max Planck Institute for Chemical Energy Conversion, M\u00fclheim/Ruhr, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6029-6582","affiliations":[{"raw_affiliation_string":"Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Max Planck Institute for Chemical Energy Conversion, M\u00fclheim/Ruhr, Germany","institution_ids":["https://openalex.org/I4210110444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015822185","display_name":"Yelena Kan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095245","display_name":"Max Planck Institute for Polymer Research","ror":"https://ror.org/00sb7hc59","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210095245"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Yelena Kan","raw_affiliation_strings":["Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA","Max Planck Institute for Polymer Research, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Max Planck Institute for Polymer Research, Mainz, Germany","institution_ids":["https://openalex.org/I4210095245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061073015","display_name":"Mahdiye Ijavi","orcid":"https://orcid.org/0000-0003-2417-9730","observed_orcids":["https://orcid.org/0000-0003-2417-9730"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mahdiye Ijavi","raw_affiliation_strings":["Department of Materials, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-2417-9730","affiliations":[{"raw_affiliation_string":"Department of Materials, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087153095","display_name":"Maria Escura P\u00e9rez","orcid":"https://orcid.org/0000-0003-3141-8023","observed_orcids":["https://orcid.org/0000-0003-3141-8023"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405254385","display_name":"Institute of Biochemistry","ror":"https://ror.org/01rd8n845","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254385"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Maria Escura P\u00e9rez","raw_affiliation_strings":["Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3141-8023","affiliations":[{"raw_affiliation_string":"Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052545187","display_name":"Pavel Afanasyev","orcid":"https://orcid.org/0000-0002-6353-6895","observed_orcids":["https://orcid.org/0000-0002-6353-6895"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pavel Afanasyev","raw_affiliation_strings":["Cryo-EM Knowledge Hub, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6353-6895","affiliations":[{"raw_affiliation_string":"Cryo-EM Knowledge Hub, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050474897","display_name":"Daniel Boehringer","orcid":"https://orcid.org/0000-0002-6666-8447","observed_orcids":["https://orcid.org/0000-0002-6666-8447"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Boehringer","raw_affiliation_strings":["Cryo-EM Knowledge Hub, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6666-8447","affiliations":[{"raw_affiliation_string":"Cryo-EM Knowledge Hub, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080377343","display_name":"Johannes Zehnder","orcid":"https://orcid.org/0000-0003-3165-6080","observed_orcids":["https://orcid.org/0000-0003-3165-6080"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405253565","display_name":"Laboratory of Physical Chemistry","ror":"https://ror.org/00v171g37","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253565"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Johannes Zehnder","raw_affiliation_strings":["Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078362785","display_name":"Sapun H. Parekh","orcid":"https://orcid.org/0000-0001-8522-1854","observed_orcids":["https://orcid.org/0000-0001-8522-1854"]},"institutions":[{"id":"https://openalex.org/I4210095245","display_name":"Max Planck Institute for Polymer Research","ror":"https://ror.org/00sb7hc59","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210095245"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Sapun H. Parekh","raw_affiliation_strings":["Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA","Max Planck Institute for Polymer Research, Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8522-1854","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Max Planck Institute for Polymer Research, Mainz, Germany","institution_ids":["https://openalex.org/I4210095245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017647814","display_name":"Mischa Bonn","orcid":"https://orcid.org/0000-0001-6851-8453","observed_orcids":["https://orcid.org/0000-0001-6851-8453"]},"institutions":[{"id":"https://openalex.org/I4210095245","display_name":"Max Planck Institute for Polymer Research","ror":"https://ror.org/00sb7hc59","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210095245"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mischa Bonn","raw_affiliation_strings":["Max Planck Institute for Polymer Research, Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6851-8453","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Polymer Research, Mainz, Germany","institution_ids":["https://openalex.org/I4210095245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006983623","display_name":"Thomas C. T. Michaels","orcid":"https://orcid.org/0000-0001-6931-5041","observed_orcids":["https://orcid.org/0000-0001-6931-5041"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405254385","display_name":"Institute of Biochemistry","ror":"https://ror.org/01rd8n845","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254385"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas C. T. Michaels","raw_affiliation_strings":["Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland","Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6931-5041","affiliations":[{"raw_affiliation_string":"Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058987127","display_name":"Thomas Wiegand","orcid":"https://orcid.org/0000-0003-3655-6150","observed_orcids":["https://orcid.org/0000-0003-3655-6150","https://orcid.org/0000-0002-1076-6777"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210110444","display_name":"Max Planck Institute for Chemical Energy Conversion","ror":"https://ror.org/01y9arx16","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210110444"]},{"id":"https://openalex.org/I4405253565","display_name":"Laboratory of Physical Chemistry","ror":"https://ror.org/00v171g37","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253565"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["CH","DE"],"is_corresponding":true,"raw_author_name":"Thomas Wiegand","raw_affiliation_strings":["Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany. thomas.wiegand@cec.mpg.de","Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland. thomas.wiegand@cec.mpg.de","Max Planck Institute for Chemical Energy Conversion, M\u00fclheim/Ruhr, Germany. thomas.wiegand@cec.mpg.de"],"raw_orcid":"https://orcid.org/0000-0003-3655-6150","affiliations":[{"raw_affiliation_string":"Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany. thomas.wiegand@cec.mpg.de","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland. thomas.wiegand@cec.mpg.de","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253565"]},{"raw_affiliation_string":"Max Planck Institute for Chemical Energy Conversion, M\u00fclheim/Ruhr, Germany. thomas.wiegand@cec.mpg.de","institution_ids":["https://openalex.org/I4210110444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088099050","display_name":"Fr\u00e9d\u00e9ric H.\u2010T. Allain","orcid":"https://orcid.org/0000-0002-2131-6237","observed_orcids":["https://orcid.org/0000-0002-2131-6237"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405254385","display_name":"Institute of Biochemistry","ror":"https://ror.org/01rd8n845","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254385"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Fr\u00e9d\u00e9ric H.-T. Allain","raw_affiliation_strings":["Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland. allain@bc.biol.ethz.ch","Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland. allain@bc.biol.ethz.ch"],"raw_orcid":"https://orcid.org/0000-0002-2131-6237","affiliations":[{"raw_affiliation_string":"Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland. allain@bc.biol.ethz.ch","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland. allain@bc.biol.ethz.ch","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254385"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5021917610","https://openalex.org/A5058987127","https://openalex.org/A5088099050"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4210110444","https://openalex.org/I4405253565","https://openalex.org/I4405254385","https://openalex.org/I887968799"],"apc_list":{"value":12290,"currency":"USD","value_usd":12290},"apc_paid":{"value":12290,"currency":"USD","value_usd":12290},"fwci":28.013,"has_fulltext":true,"cited_by_count":115,"citation_normalized_percentile":{"value":0.99854516,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"20","issue":"8","first_page":"1044","last_page":"1052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.7627000212669373,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.7627000212669373,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fus-protein","display_name":"FUS protein","score":0.953000009059906},{"id":"https://openalex.org/keywords/liquid-liquid-phase-separation","display_name":"liquid-liquid phase separation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/solidification","display_name":"solidification","score":0.9129999876022339},{"id":"https://openalex.org/keywords/beta-sheet-formation","display_name":"\u03b2-sheet formation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/droplet-surface","display_name":"droplet surface","score":0.6399999856948853},{"id":"https://openalex.org/keywords/rgg-motif","display_name":"RGG motif","score":0.6949999928474426},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.640999972820282},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7179999947547913},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.4009999930858612},{"id":"https://openalex.org/keywords/surface-to-volume-ratio","display_name":"surface-to-volume ratio","score":0.6899999976158142},{"id":"https://openalex.org/keywords/protein-condensates","display_name":"protein condensates","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.7645550966262817},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5604861974716187},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.47385528683662415},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46042299270629883},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4510733485221863},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4451856017112732},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.43113577365875244},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3825790584087372},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.14483627676963806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12441346049308777},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08673539757728577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08446639776229858},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034702","descriptor_name":"RNA-Binding Protein FUS","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034702","descriptor_name":"RNA-Binding Protein FUS","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044367","descriptor_name":"Phase Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1038/s41589-024-01573-w","doi":"https://doi.org/10.1038/s41589-024-01573-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41589-024-01573-w","pdf_url":"https://www.nature.com/articles/s41589-024-01573-w.pdf","source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2023.06.02.542764","doi":"https://doi.org/10.1101/2023.06.02.542764","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.06.02.542764","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/03/2023.06.02.542764.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11288893","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11288893","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11288893/pdf/41589_2024_Article_1573.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Chem Biol","raw_type":"Text"},{"id":"pmid:38467846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38467846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:dare.uva.nl:openaire/48e01c20-c3d9-4675-9860-7c235ae863d9","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/a-solid-betasheet-structure-is-formed-at-the-surface-of-fus-droplets-during-aging(48e01c20-c3d9-4675-9860-7c235ae863d9).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emmanouilidis, L, Bartalucci, E, Kan, Y, Ijavi, M, P\u00e9rez, M E, Afanasyev, P, Boehringer, D, Zehnder, J, Parekh, S H, Bonn, M, Michaels, T C T, Wiegand, T & Allain, FH-T 2024, 'A solid beta-sheet structure is formed at the surface of FUS droplets during aging', Nature chemical biology, vol. 20, no. 8, pp. 1044\u20131052. https://doi.org/10.1038/s41589-024-01573-w","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_3586794","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/21.11116/0000-000F-32D5-8","pdf_url":"https://hdl.handle.net/21.11116/0000-000F-AC18-5","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Chemical Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publications.rwth-aachen.de:983332","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/record/983332","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature chemical biology 20, 1044-1052 (2024). doi:10.1038/s41589-024-01573-w","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/666860","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/666860","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Chemical Biology, 20 (8)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000666860","doi":"https://doi.org/10.3929/ethz-b-000666860","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000666860","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41589-024-01573-w","doi":"https://doi.org/10.1038/s41589-024-01573-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41589-024-01573-w","pdf_url":"https://www.nature.com/articles/s41589-024-01573-w.pdf","source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1278951854","display_name":null,"funder_award_id":"SFB1551","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2095338500","display_name":null,"funder_award_id":"SPP 2191 #PA2526/3-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2222446239","display_name":null,"funder_award_id":"ETH-43 17\u22122","funder_id":"https://openalex.org/F4320321652","funder_display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich"},{"id":"https://openalex.org/G3893672598","display_name":"SFB 1551: Polymerkonzepte zum Verstehen zellul\u00e4rer Funktionen","funder_award_id":"464588647","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4093275835","display_name":"Zellul\u00e4re Organisation durch Phasenseparationsprozesse untersucht mittels Festk\u00f6rperNMR: Erkenntnise von RNAbindenden Proteinen und konstruierten Spinnenseideproteinen","funder_award_id":"455238107","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4376339242","display_name":null,"funder_award_id":"SPP2191","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6934997966","display_name":"ProteinNukleins\u00e4ureErkennung untersucht durch Festk\u00f6rperKernresonanzspektroskopie bei schnellen Rotationen um den magischen Winkel","funder_award_id":"455240421","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7940875173","display_name":"Role of Disordered Regions in RNA-Binding Proteins for Function and Pathology","funder_award_id":"170976","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7979452392","display_name":null,"funder_award_id":"PA2526/3-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320331353","display_name":"National Center of Competence in Research Chemical Biology","ror":"https://ror.org/033f9yy33"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392646903.pdf","grobid_xml":"https://content.openalex.org/works/W4392646903.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1912455695","https://openalex.org/W1938908576","https://openalex.org/W1952608303","https://openalex.org/W1963826942","https://openalex.org/W1976077400","https://openalex.org/W1995477021","https://openalex.org/W2002869713","https://openalex.org/W2015757782","https://openalex.org/W2017284646","https://openalex.org/W2019574228","https://openalex.org/W2031292508","https://openalex.org/W2042442392","https://openalex.org/W2050494478","https://openalex.org/W2053158671","https://openalex.org/W2056742908","https://openalex.org/W2061612744","https://openalex.org/W2069045437","https://openalex.org/W2072239657","https://openalex.org/W2081785133","https://openalex.org/W2082373932","https://openalex.org/W2093140735","https://openalex.org/W2111796925","https://openalex.org/W2152675476","https://openalex.org/W2168958678","https://openalex.org/W2169707043","https://openalex.org/W2170823043","https://openalex.org/W2214191075","https://openalex.org/W2272324466","https://openalex.org/W2402791934","https://openalex.org/W2755105920","https://openalex.org/W2756821926","https://openalex.org/W2758396775","https://openalex.org/W2788744596","https://openalex.org/W2789175476","https://openalex.org/W2794654572","https://openalex.org/W2795571682","https://openalex.org/W2797600975","https://openalex.org/W2802839169","https://openalex.org/W2810866092","https://openalex.org/W2884082692","https://openalex.org/W2953933961","https://openalex.org/W2966541398","https://openalex.org/W2973637866","https://openalex.org/W2998272317","https://openalex.org/W3000423196","https://openalex.org/W3011599658","https://openalex.org/W3023602638","https://openalex.org/W3082518512","https://openalex.org/W3089421831","https://openalex.org/W3112951837","https://openalex.org/W3125803497","https://openalex.org/W3130414253","https://openalex.org/W3133546102","https://openalex.org/W3191096373","https://openalex.org/W3197335476","https://openalex.org/W3200264936","https://openalex.org/W3211474652","https://openalex.org/W3216813740","https://openalex.org/W4200231324","https://openalex.org/W4220887281","https://openalex.org/W4281767302","https://openalex.org/W4283212222","https://openalex.org/W4306248639","https://openalex.org/W4310702852","https://openalex.org/W4311343072","https://openalex.org/W4366331111","https://openalex.org/W4380569127"],"related_works":["https://openalex.org/W4400531764","https://openalex.org/W3130414253","https://openalex.org/W3129926370","https://openalex.org/W3133546102","https://openalex.org/W4385618104","https://openalex.org/W4211091736","https://openalex.org/W4319880764","https://openalex.org/W4390139729","https://openalex.org/W4387245808","https://openalex.org/W4401094819"],"abstract_inverted_index":{"Abstract":[0],"Phase":[1],"transitions":[2],"are":[3,70],"important":[4],"to":[5,17,28,35,84],"understand":[6],"cell":[7],"dynamics,":[8],"and":[9,23,101],"the":[10,40,50,53,85,99,102,129,141,147],"maturation":[11,38,68,97],"of":[12,33,39,52,104,109],"liquid":[13],"droplets":[14,54,135],"is":[15,107,126],"relevant":[16],"neurodegenerative":[18],"disorders.":[19],"We":[20],"combined":[21],"NMR":[22],"Raman":[24,91],"spectroscopies":[25],"with":[26,78,119],"microscopy":[27],"follow,":[29],"over":[30],"a":[31,56,79,122],"period":[32],"days":[34],"months,":[36],"droplet":[37],"protein":[41],"fused":[42],"in":[43,59,72],"sarcoma":[44],"(FUS).":[45],"Our":[46],"study":[47],"reveals":[48],"that":[49],"surface":[51,103,130],"plays":[55],"critical":[57],"role":[58],"this":[60],"process,":[61],"while":[62],"RNA":[63],"binding":[64],"prevents":[65],"it.":[66],"The":[67],"kinetics":[69],"faster":[71],"an":[73],"agarose-stabilized":[74],"biphasic":[75],"sample":[76],"compared":[77],"monophasic":[80],"condensed":[81],"sample,":[82],"owing":[83],"larger":[86],"surface-to-volume":[87],"ratio.":[88],"In":[89,117],"addition,":[90],"spectroscopy":[92],"reports":[93],"structural":[94],"differences":[95],"upon":[96],"between":[98],"inside":[100],"droplets,":[105],"which":[106],"comprised":[108],"\u03b2-sheet":[110],"content,":[111],"as":[112,144,146],"revealed":[113],"by":[114],"solid-state":[115],"NMR.":[116],"agreement":[118],"these":[120],"observations,":[121],"solid":[123],"crust-like":[124],"shell":[125],"observed":[127],"at":[128],"using":[131],"microaspiration.":[132],"Ultimately,":[133],"matured":[134],"were":[136],"converted":[137],"into":[138],"fibrils":[139],"involving":[140],"prion-like":[142],"domain":[143],"well":[145],"first":[148],"RGG":[149],"motif.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":55},{"year":2025,"cited_by_count":44},{"year":2024,"cited_by_count":16}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-03-12T00:00:00"}