{"id":"https://openalex.org/W4392595274","doi":"https://doi.org/10.3389/fsysb.2024.1351555","title":"Advancing precision medicine therapeutics for Parkinson\u2019s utilizing a shared quantitative systems pharmacology model and framework","display_name":"Advancing precision medicine therapeutics for Parkinson\u2019s utilizing a shared quantitative systems pharmacology model and framework","publication_year":2024,"publication_date":"2024-03-08","ids":{"openalex":"https://openalex.org/W4392595274","doi":"https://doi.org/10.3389/fsysb.2024.1351555","pmid":"https://pubmed.ncbi.nlm.nih.gov/40809117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12342022"},"language":"en","primary_location":{"id":"doi:10.3389/fsysb.2024.1351555","doi":"https://doi.org/10.3389/fsysb.2024.1351555","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fsysb.2024.1351555","pdf_url":"https://www.frontiersin.org/articles/10.3389/fsysb.2024.1351555/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4386621871","display_name":"Frontiers in Systems Biology","issn_l":"2674-0702","issn":["2674-0702"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Systems Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fsysb.2024.1351555/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5134506126","display_name":"Christopher Anthony Denaro","orcid":"https://orcid.org/0000-0003-1124-7554","observed_orcids":["https://orcid.org/0000-0003-1124-7554"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Denaro","raw_affiliation_strings":["Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, United States","Center for Computational and Integrative Biology, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, United States","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Center for Computational and Integrative Biology, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073027575","display_name":"Diane T. Stephenson","orcid":"https://orcid.org/0000-0002-4262-436X","observed_orcids":["https://orcid.org/0000-0002-4262-436X"]},"institutions":[{"id":"https://openalex.org/I2801686373","display_name":"Critical Path Institute","ror":"https://ror.org/02mgtg880","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2801686373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Stephenson","raw_affiliation_strings":["Critical Path Institute, Tucson, AZ, United States","Critical Path Institute, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Path Institute, Tucson, AZ, United States","institution_ids":["https://openalex.org/I2801686373"]},{"raw_affiliation_string":"Critical Path Institute, United States","institution_ids":["https://openalex.org/I2801686373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068115190","display_name":"Martijn L.T.M. M\u00fcller","orcid":"https://orcid.org/0000-0002-1133-7202","observed_orcids":["https://orcid.org/0000-0002-1133-7202"]},"institutions":[{"id":"https://openalex.org/I2801686373","display_name":"Critical Path Institute","ror":"https://ror.org/02mgtg880","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2801686373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martijn L. T. M. M\u00fcller","raw_affiliation_strings":["Critical Path Institute, Tucson, AZ, United States","Critical Path Institute, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Path Institute, Tucson, AZ, United States","institution_ids":["https://openalex.org/I2801686373"]},{"raw_affiliation_string":"Critical Path Institute, United States","institution_ids":["https://openalex.org/I2801686373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057629608","display_name":"Benedetto Piccoli","orcid":"https://orcid.org/0000-0002-6000-5394","observed_orcids":["https://orcid.org/0000-0002-6000-5394"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benedetto Piccoli","raw_affiliation_strings":["Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, United States","Department of Mathematical Sciences, Rutgers University-Camden, Camden, NJ, United States","Center for Computational and Integrative Biology, United States","Department of Mathematical Sciences, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, United States","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Mathematical Sciences, Rutgers University-Camden, Camden, NJ, United States","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Center for Computational and Integrative Biology, United States","institution_ids":[]},{"raw_affiliation_string":"Department of Mathematical Sciences, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016513741","display_name":"Karim Azer","orcid":"https://orcid.org/0000-0002-0236-4858","observed_orcids":["https://orcid.org/0000-0002-0236-4858"]},"institutions":[{"id":"https://openalex.org/I4210143681","display_name":"Axcella Health (United States)","ror":"https://ror.org/0553bq478","country_code":"US","type":"company","lineage":["https://openalex.org/I4210143681"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karim Azer","raw_affiliation_strings":["Axcella, Cambridge, MA, United States","Axcella, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axcella, Cambridge, MA, United States","institution_ids":["https://openalex.org/I4210143681"]},{"raw_affiliation_string":"Axcella, United States","institution_ids":["https://openalex.org/I4210143681"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016513741"],"corresponding_institution_ids":["https://openalex.org/I4210143681"],"apc_list":{"value":2125,"currency":"USD","value_usd":2125},"apc_paid":{"value":2125,"currency":"USD","value_usd":2125},"fwci":3.1667,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.92224355,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"4","issue":null,"first_page":"1351555","last_page":"1351555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/quantitative-systems-pharmacology","display_name":"quantitative systems pharmacology","score":0.8999999761581421},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.8519999980926514},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/model-informed-drug-development","display_name":"model-informed drug development","score":0.8130000233650208},{"id":"https://openalex.org/keywords/snca","display_name":"SNCA","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":1.0},{"id":"https://openalex.org/keywords/glucocerebrosidase","display_name":"glucocerebrosidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lysosomal-pathway","display_name":"lysosomal pathway","score":0.8600000143051147},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.9520000219345093},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6629999876022339},{"id":"https://openalex.org/keywords/regulatory-framework","display_name":"regulatory framework","score":0.4909999966621399},{"id":"https://openalex.org/keywords/genetic-parkinson-s-disease","display_name":"genetic Parkinson's disease","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.6702297925949097},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.6074971556663513},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5583848357200623},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.5546370148658752},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.5401171445846558},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.49444031715393066},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4944193363189697},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48580431938171387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4459831118583679},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4454199969768524},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.43183547258377075},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.41031524538993835},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4054294228553772},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3615657389163971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28641244769096375},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.23553141951560974},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22183647751808167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1384550929069519},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11039295792579651},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fsysb.2024.1351555","doi":"https://doi.org/10.3389/fsysb.2024.1351555","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fsysb.2024.1351555","pdf_url":"https://www.frontiersin.org/articles/10.3389/fsysb.2024.1351555/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4386621871","display_name":"Frontiers in Systems Biology","issn_l":"2674-0702","issn":["2674-0702"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Systems Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12342022","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12342022/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12342022/pdf/fsysb-04-1351555.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Syst Biol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11156046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12342022","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40809117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40809117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f28f045c4f2845ea9ef9c8eca3076802","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f28f045c4f2845ea9ef9c8eca3076802","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Systems Biology, Vol 4 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fsysb.2024.1351555","doi":"https://doi.org/10.3389/fsysb.2024.1351555","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fsysb.2024.1351555","pdf_url":"https://www.frontiersin.org/articles/10.3389/fsysb.2024.1351555/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4386621871","display_name":"Frontiers in Systems Biology","issn_l":"2674-0702","issn":["2674-0702"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320320021","display_name":"Parkinson's UK","ror":"https://ror.org/02417p338"},{"id":"https://openalex.org/F4320329118","display_name":"IXICO","ror":"https://ror.org/00paezp73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392595274.pdf","grobid_xml":"https://content.openalex.org/works/W4392595274.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1979930569","https://openalex.org/W2032481706","https://openalex.org/W2044843068","https://openalex.org/W2058298068","https://openalex.org/W2091026347","https://openalex.org/W2092573663","https://openalex.org/W2256070729","https://openalex.org/W2292737110","https://openalex.org/W2420015008","https://openalex.org/W2517258203","https://openalex.org/W2617822359","https://openalex.org/W2692583471","https://openalex.org/W2720343158","https://openalex.org/W2738697628","https://openalex.org/W2754977030","https://openalex.org/W2789572491","https://openalex.org/W2794085009","https://openalex.org/W2801264549","https://openalex.org/W2809088929","https://openalex.org/W2887057252","https://openalex.org/W2891411797","https://openalex.org/W2898850833","https://openalex.org/W2899084046","https://openalex.org/W2901519529","https://openalex.org/W2904774980","https://openalex.org/W2964957938","https://openalex.org/W2972937106","https://openalex.org/W2975614862","https://openalex.org/W2984058577","https://openalex.org/W3000171350","https://openalex.org/W3000501046","https://openalex.org/W3000974767","https://openalex.org/W3028956199","https://openalex.org/W3036599071","https://openalex.org/W3085661281","https://openalex.org/W3102378442","https://openalex.org/W3112606616","https://openalex.org/W3128544300","https://openalex.org/W3132304136","https://openalex.org/W3136796470","https://openalex.org/W3143891686","https://openalex.org/W3158242131","https://openalex.org/W3158274091","https://openalex.org/W3177149152","https://openalex.org/W3193129090","https://openalex.org/W3200805036","https://openalex.org/W3201041057","https://openalex.org/W3206798151","https://openalex.org/W4200061343","https://openalex.org/W4200084373","https://openalex.org/W4205339954","https://openalex.org/W4206464678","https://openalex.org/W4211177904","https://openalex.org/W4220661255","https://openalex.org/W4229015642","https://openalex.org/W4283155313","https://openalex.org/W4286716392","https://openalex.org/W4289667121","https://openalex.org/W4289667141","https://openalex.org/W4291690167","https://openalex.org/W4307028181","https://openalex.org/W4307511784","https://openalex.org/W4310461604","https://openalex.org/W4311210412","https://openalex.org/W4311604302","https://openalex.org/W4315651219","https://openalex.org/W4317242213","https://openalex.org/W4317870343","https://openalex.org/W4317938463","https://openalex.org/W4319438271","https://openalex.org/W4319461701","https://openalex.org/W4320040276","https://openalex.org/W4322718837","https://openalex.org/W4324017377","https://openalex.org/W4364374799","https://openalex.org/W4365459497","https://openalex.org/W4376273173","https://openalex.org/W4380627568","https://openalex.org/W4382345304","https://openalex.org/W4385064775","https://openalex.org/W4385514873","https://openalex.org/W4386087061","https://openalex.org/W4386279645","https://openalex.org/W4387563701","https://openalex.org/W4388783262","https://openalex.org/W4392845496"],"related_works":["https://openalex.org/W4402597341","https://openalex.org/W2895826271","https://openalex.org/W3034760723","https://openalex.org/W3085661281","https://openalex.org/W3111218292","https://openalex.org/W6979777512","https://openalex.org/W3003022248","https://openalex.org/W4297464260","https://openalex.org/W3154377112","https://openalex.org/W7117318758"],"abstract_inverted_index":{"A":[0,204],"rich":[1,207],"pipeline":[2],"of":[3,12,19,35,59,85,144,150,173,180,199,206,216,251,266],"therapeutic":[4,38,202],"candidates":[5],"is":[6,30,134,166,186,211],"advancing":[7,161,237,269],"for":[8,40,56,170,195,236,272],"Parkinson's":[9],"disease,":[10],"many":[11],"which":[13],"are":[14,78,155,231],"targeting":[15],"the":[16,32,196,213,223,234,249,260,264],"underlying":[17,67],"pathophysiology":[18],"disease.":[20],"Emerging":[21],"evidence":[22],"grounded":[23],"in":[24,82,152,160,240,257,268],"novel":[25],"genetics":[26],"and":[27,87,93,114,188,222,262],"biomarker":[28],"discoveries":[29],"illuminating":[31],"true":[33],"promise":[34],"precision":[36],"medicine-based":[37],"strategies":[39,194],"PD.":[41],"There":[42,165],"has":[43],"been":[44],"a":[45,63,167],"growing":[46],"effort":[47],"to":[48,66,120,135,157,177,190,242,259],"investigate":[49],"disease-modifying":[50,201,276],"therapies":[51,176],"by":[52],"designing":[53],"clinical":[54,118],"trials":[55,119],"genetic":[57,75],"forms":[58],"PD":[60,200,241,275],"-":[61],"providing":[62],"clearer":[64],"link":[65],"pathophysiology.":[68],"Leading":[69],"candidate":[70,175],"genes":[71,103],"based":[72,122],"on":[73,123],"human":[74],"findings":[76],"that":[77,101,147,210],"under":[79],"active":[80],"investigation":[81],"an":[83],"array":[84],"basic":[86],"translational":[88,192],"models":[89,99],"include":[90,148],"SNCA,":[91],"LRRK2,":[92],"GBA.":[94],"Broad":[95],"investigations":[96],"across":[97],"mechanistic":[98],"show":[100],"these":[102],"signal":[104],"through":[105],"common":[106],"molecular":[107],"pathways,":[108,112],"namely,":[109],"autosomal":[110],"lysosomal":[111],"inflammation":[113],"mitochondrial":[115],"function.":[116],"Therapeutic":[117],"date":[121],"genetically":[124],"defined":[125],"targets":[126],"have":[127,158],"not":[128],"yet":[129],"achieved":[130],"approvals;":[131],"however,":[132],"much":[133],"be":[136],"learned":[137],"from":[138],"such":[139,162],"pioneering":[140],"trials.":[141],"Fundamental":[142],"principles":[143],"drug":[145,219],"development":[146,220],"proof":[149,179],"pharmacology":[151,254],"target":[153],"tissue":[154],"critical":[156],"confidence":[159],"precision-based":[163],"therapies.":[164],"clear":[168],"need":[169],"downstream":[171],"biomarkers":[172],"leading":[174],"demonstrate":[178],"mechanism.":[181],"The":[182],"current":[183],"regulatory":[184,214],"landscape":[185],"poised":[187],"primed":[189],"support":[191],"modeling":[193,256],"effective":[197],"advancement":[198],"candidates.":[203],"convergence":[205],"complex":[208],"data":[209],"available,":[212],"framework":[215],"model":[217],"informed":[218],"(MIDD),":[221],"new":[224,238],"biological":[225],"integrated":[226],"staging":[227],"frameworks":[228],"when":[229],"combined":[230],"collectively":[232],"setting":[233],"stage":[235],"approaches":[239,271],"accelerate":[243],"progress.":[244],"This":[245],"perspective":[246],"review":[247],"highlights":[248],"potential":[250],"quantitative":[252],"systems":[253],"(QSP)":[255],"contributing":[258],"field":[261],"hastening":[263],"pace":[265],"progress":[267],"collaborative":[270],"urgently":[273],"needed":[274],"treatments.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-03-09T00:00:00"}