{"id":"https://openalex.org/W4392595083","doi":"https://doi.org/10.3390/ijms25063124","title":"Extracellular Vesicles from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients Deliver MiR-21 and Induce Methotrexate Resistance in Lung Cancer Cells","display_name":"Extracellular Vesicles from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients Deliver MiR-21 and Induce Methotrexate Resistance in Lung Cancer Cells","publication_year":2024,"publication_date":"2024-03-08","ids":{"openalex":"https://openalex.org/W4392595083","doi":"https://doi.org/10.3390/ijms25063124","pmid":"https://pubmed.ncbi.nlm.nih.gov/38542098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10970033"},"language":"en","primary_location":{"id":"doi:10.3390/ijms25063124","doi":"https://doi.org/10.3390/ijms25063124","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25063124","pdf_url":"https://www.mdpi.com/1422-0067/25/6/3124/pdf?version=1709887656","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4392595083"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/25/6/3124/pdf?version=1709887656","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043282427","display_name":"Ji Hye Im","orcid":"https://orcid.org/0000-0002-3941-4134","observed_orcids":["https://orcid.org/0000-0002-3941-4134"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Hye Im","raw_affiliation_strings":["Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3941-4134","affiliations":[{"raw_affiliation_string":"Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001692064","display_name":"Kyue-Yim Lee","orcid":"https://orcid.org/0000-0003-4050-1523","observed_orcids":["https://orcid.org/0000-0003-4050-1523"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyue-Yim Lee","raw_affiliation_strings":["Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-4050-1523","affiliations":[{"raw_affiliation_string":"Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048189044","display_name":"Yoona Seo","orcid":"https://orcid.org/0000-0001-7510-2501","observed_orcids":["https://orcid.org/0000-0001-7510-2501"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoona Seo","raw_affiliation_strings":["Cancer Molecular Biology Branch, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea","Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7510-2501","affiliations":[{"raw_affiliation_string":"Cancer Molecular Biology Branch, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]},{"raw_affiliation_string":"Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086638125","display_name":"Jiho Rhim","orcid":"https://orcid.org/0009-0001-0849-0775","observed_orcids":["https://orcid.org/0009-0001-0849-0775"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiho Rhim","raw_affiliation_strings":["Cancer Molecular Biology Branch, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea","Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Molecular Biology Branch, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]},{"raw_affiliation_string":"Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030902185","display_name":"Yun\u2010Sik Dho","orcid":"https://orcid.org/0000-0001-5505-0812","observed_orcids":["https://orcid.org/0000-0001-5505-0812"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]},{"id":"https://openalex.org/I4405261544","display_name":"National Cancer Center Hospital","ror":"https://ror.org/05fgmqm64","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052","https://openalex.org/I4405261544"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun-Sik Dho","raw_affiliation_strings":["Neuro-Oncology Clinic, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro-Oncology Clinic, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052","https://openalex.org/I4405261544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063653461","display_name":"Byong Chul Yoo","orcid":"https://orcid.org/0000-0001-7937-0167","observed_orcids":["https://orcid.org/0000-0001-7937-0167","https://orcid.org/0000-0001-9726-9492"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byong Chul Yoo","raw_affiliation_strings":["Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7937-0167","affiliations":[{"raw_affiliation_string":"Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101798629","display_name":"Jong Bae Park","orcid":"https://orcid.org/0000-0003-0207-0697","observed_orcids":["https://orcid.org/0000-0003-0207-0697","https://orcid.org/0000-0002-1091-8099"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Bae Park","raw_affiliation_strings":["Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101421955","display_name":"Sang Hoon Shin","orcid":"https://orcid.org/0000-0002-8404-1162","observed_orcids":["https://orcid.org/0000-0002-8404-1162"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]},{"id":"https://openalex.org/I4405261544","display_name":"National Cancer Center Hospital","ror":"https://ror.org/05fgmqm64","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052","https://openalex.org/I4405261544"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Hoon Shin","raw_affiliation_strings":["Neuro-Oncology Clinic, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro-Oncology Clinic, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052","https://openalex.org/I4405261544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088738470","display_name":"Heon Yoo","orcid":"https://orcid.org/0000-0002-9223-4300","observed_orcids":["https://orcid.org/0000-0002-9223-4300"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]},{"id":"https://openalex.org/I4405261544","display_name":"National Cancer Center Hospital","ror":"https://ror.org/05fgmqm64","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052","https://openalex.org/I4405261544"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Heon Yoo","raw_affiliation_strings":["Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","Neuro-Oncology Clinic, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-9223-4300","affiliations":[{"raw_affiliation_string":"Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]},{"raw_affiliation_string":"Neuro-Oncology Clinic, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052","https://openalex.org/I4405261544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101999570","display_name":"Jong Heon Kim","orcid":"https://orcid.org/0000-0002-1091-8099","observed_orcids":["https://orcid.org/0000-0002-1091-8099"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jong Heon Kim","raw_affiliation_strings":["Cancer Molecular Biology Branch, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea","Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-1091-8099","affiliations":[{"raw_affiliation_string":"Cancer Molecular Biology Branch, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]},{"raw_affiliation_string":"Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073174440","display_name":"Ho\u2010Shin Gwak","orcid":"https://orcid.org/0000-0001-7175-4553","observed_orcids":["https://orcid.org/0000-0001-7175-4553"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]},{"id":"https://openalex.org/I4405261544","display_name":"National Cancer Center Hospital","ror":"https://ror.org/05fgmqm64","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052","https://openalex.org/I4405261544"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ho-Shin Gwak","raw_affiliation_strings":["Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","Neuro-Oncology Clinic, National Cancer Center, Goyang 10408, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7175-4553","affiliations":[{"raw_affiliation_string":"Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052"]},{"raw_affiliation_string":"Neuro-Oncology Clinic, National Cancer Center, Goyang 10408, Republic of Korea","institution_ids":["https://openalex.org/I4210120052","https://openalex.org/I4405261544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073174440","https://openalex.org/A5101999570"],"corresponding_institution_ids":["https://openalex.org/I4210120052","https://openalex.org/I4405261544"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":1.5177,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81804033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"6","first_page":"3124","last_page":"3124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptomeningeal-metastasis","display_name":"leptomeningeal metastasis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9819999933242798},{"id":"https://openalex.org/keywords/methotrexate-resistance","display_name":"methotrexate resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/intraventricular-chemotherapy","display_name":"intraventricular chemotherapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/microrna-delivery","display_name":"microRNA delivery","score":0.6320000290870667},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6924176216125488},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6799808740615845},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.6301921010017395},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5934597253799438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5818257331848145},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5583305358886719},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5027651786804199},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.4938381314277649},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4875597357749939},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4578060805797577},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4136629104614258},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4130391776561737},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3276500105857849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2717108130455017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2443457841873169},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms25063124","doi":"https://doi.org/10.3390/ijms25063124","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25063124","pdf_url":"https://www.mdpi.com/1422-0067/25/6/3124/pdf?version=1709887656","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10970033","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10970033","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10970033/pdf/ijms-25-03124.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:38542098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38542098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms25063124","doi":"https://doi.org/10.3390/ijms25063124","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25063124","pdf_url":"https://www.mdpi.com/1422-0067/25/6/3124/pdf?version=1709887656","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2513233087","display_name":null,"funder_award_id":"NCC-2310320","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G2562641522","display_name":null,"funder_award_id":"H17C1018","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G3144877683","display_name":null,"funder_award_id":"NCC-2211640","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G3806135107","display_name":null,"funder_award_id":"NCC-2010273","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G5018501611","display_name":null,"funder_award_id":"NCC-2210650","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G8907118719","display_name":null,"funder_award_id":"2022R1A2B5B01001914","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G979030254","display_name":null,"funder_award_id":"2022R1A2B5B 01001914","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392595083.pdf","grobid_xml":"https://content.openalex.org/works/W4392595083.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1748502071","https://openalex.org/W1973790664","https://openalex.org/W1989125392","https://openalex.org/W2027542963","https://openalex.org/W2033816787","https://openalex.org/W2058328925","https://openalex.org/W2075752921","https://openalex.org/W2078590818","https://openalex.org/W2105952544","https://openalex.org/W2109454262","https://openalex.org/W2110373216","https://openalex.org/W2116624561","https://openalex.org/W2125736017","https://openalex.org/W2127696281","https://openalex.org/W2164536476","https://openalex.org/W2169491358","https://openalex.org/W2315994376","https://openalex.org/W2518630307","https://openalex.org/W2558389982","https://openalex.org/W2736520162","https://openalex.org/W2760567897","https://openalex.org/W2807871781","https://openalex.org/W2883963675","https://openalex.org/W2886514991","https://openalex.org/W2904802348","https://openalex.org/W2918928681","https://openalex.org/W2922323050","https://openalex.org/W2999495440","https://openalex.org/W3008596935","https://openalex.org/W3088152077","https://openalex.org/W3097682857","https://openalex.org/W3111997214","https://openalex.org/W3118465937","https://openalex.org/W4206125279","https://openalex.org/W4249144655","https://openalex.org/W4295106636","https://openalex.org/W4311315004","https://openalex.org/W4366064951","https://openalex.org/W4387002265","https://openalex.org/W4391908739"],"related_works":["https://openalex.org/W3118465937","https://openalex.org/W4394952712","https://openalex.org/W3088152077","https://openalex.org/W4384469686","https://openalex.org/W2890827169","https://openalex.org/W2900699041","https://openalex.org/W2741926990","https://openalex.org/W4353052182","https://openalex.org/W7216116480","https://openalex.org/W2995057010"],"abstract_inverted_index":{"Leptomeningeal":[0],"metastasis":[1],"(LM)":[2],"is":[3,63],"a":[4,104,186],"common":[5],"and":[6,26,123,155,173,188],"fatal":[7],"complication":[8],"of":[9,20,56,133,145,158],"advanced":[10],"non-small":[11],"cell":[12,153],"lung":[13],"cancer":[14],"(NSCLC)":[15],"caused":[16],"by":[17],"the":[18,24,54,70,143,152],"spread":[19],"malignant":[21],"cells":[22],"to":[23,92],"leptomeninges":[25],"cerebrospinal":[27],"fluid":[28],"(CSF).":[29],"While":[30],"intra-CSF":[31],"methotrexate":[32],"(MTX)":[33],"chemotherapy":[34],"can":[35,166],"improve":[36],"prognosis,":[37],"eventual":[38],"MTX":[39,110,137,156,176,193],"resistance":[40,75,157,194],"deters":[41],"continued":[42],"chemotherapy.":[43],"Recent":[44],"studies":[45],"have":[46],"shown":[47],"that":[48,87,113,130,164,179],"increased":[49],"miRNA-21":[50],"(miR-21)":[51],"expression":[52,90,116],"in":[53,82,103,109,181,195],"CSF":[55,144,182],"patients":[57,84,147,196],"with":[58,65,85,95,118,197],"LM":[59,146],"after":[60],"intraventricular":[61],"MTX-chemotherapy":[62],"associated":[64],"poor":[66,96],"overall":[67],"survival;":[68],"however,":[69],"molecular":[71],"mechanisms":[72],"underlying":[73],"this":[74],"are":[76],"poorly":[77],"understood.":[78],"Here,":[79],"we":[80],"confirm,":[81],"36":[83],"NSCLC-LM,":[86],"elevated":[88],"miR-21":[89,115,134,149,165,180],"prior":[91],"treatment":[93],"correlates":[94,117],"prognosis.":[97],"MiR-21":[98],"overexpression":[99],"or":[100,107],"sponging":[101],"results":[102,162],"corresponding":[105],"increase":[106],"decrease":[108],"resistance,":[111],"demonstrating":[112],"cellular":[114],"drug":[119],"resistance.":[120,138],"MiR-21-monitoring":[121],"sensor":[122],"fluorescent":[124],"extracellular":[125],"vesicle":[126],"(EV)":[127],"staining":[128],"revealed":[129],"EV-mediated":[131],"delivery":[132],"could":[135,150],"modulate":[136,175],"Moreover,":[139],"EVs":[140,172,183],"isolated":[141],"from":[142,169],"containing":[148],"enhance":[151],"proliferation":[154],"recipient":[159],"cells.":[160],"These":[161],"indicate":[163],"be":[167,185],"transferred":[168],"cell-to-cell":[170],"via":[171],"potentially":[174],"sensitivity,":[177],"suggesting":[178],"may":[184],"prognostic":[187],"therapeutic":[189],"target":[190],"for":[191],"overcoming":[192],"NSCLC-LM.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-03-09T00:00:00"}
