{"id":"https://openalex.org/W4392589692","doi":"https://doi.org/10.52711/0974-360x.2024.00075","title":"Optimizing Warfarin use in Egyptian patients with Autoimmune Diseases \u2013 Genetic and Clinical Related Factors","display_name":"Optimizing Warfarin use in Egyptian patients with Autoimmune Diseases \u2013 Genetic and Clinical Related Factors","publication_year":2024,"publication_date":"2024-02-20","ids":{"openalex":"https://openalex.org/W4392589692","doi":"https://doi.org/10.52711/0974-360x.2024.00075"},"language":"en","primary_location":{"id":"doi:10.52711/0974-360x.2024.00075","doi":"https://doi.org/10.52711/0974-360x.2024.00075","is_oa":false,"landing_page_url":"http://dx.doi.org/10.52711/0974-360x.2024.00075","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031139144","display_name":"Nermeen Nabeel Abuelsoud","orcid":"https://orcid.org/0000-0001-5732-2324","observed_orcids":["https://orcid.org/0000-0001-5732-2324"]},"institutions":[{"id":"https://openalex.org/I67337280","display_name":"Egyptian Russian University","ror":"https://ror.org/029me2q51","country_code":"EG","type":"education","lineage":["https://openalex.org/I67337280"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nermeen N. Abuelsoud","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmacy Practice,  Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacy Practice,  Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt","institution_ids":["https://openalex.org/I67337280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090401838","display_name":"Lamees Ahmed Samy","orcid":"https://orcid.org/0000-0001-9541-0181","observed_orcids":["https://orcid.org/0000-0001-9541-0181"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Lamees A. Samy","raw_affiliation_strings":["Department of Clinical and Chemical Pathology, Kasr Alaini University Hospital,  Faculty of Medicine, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Chemical Pathology, Kasr Alaini University Hospital,  Faculty of Medicine, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"479","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.05209999904036522,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6639999747276306},{"id":"https://openalex.org/keywords/vkorc1","display_name":"VKORC1","score":0.6830000281333923},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7889999747276306},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9629999995231628},{"id":"https://openalex.org/keywords/warfarin-toxicity","display_name":"warfarin toxicity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.6980000138282776},{"id":"https://openalex.org/keywords/rivaroxaban","display_name":"rivaroxaban","score":0.7820000052452087},{"id":"https://openalex.org/keywords/enoxaparin","display_name":"enoxaparin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/international-normalized-ratio","display_name":"international normalized ratio","score":0.5379999876022339},{"id":"https://openalex.org/keywords/egyptian-patients","display_name":"Egyptian patients","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.753204345703125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5575851202011108},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3233909606933594},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.07901111245155334}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52711/0974-360x.2024.00075","doi":"https://doi.org/10.52711/0974-360x.2024.00075","is_oa":false,"landing_page_url":"http://dx.doi.org/10.52711/0974-360x.2024.00075","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1973743170","https://openalex.org/W1982950986","https://openalex.org/W2005176718","https://openalex.org/W2008943938","https://openalex.org/W2012657970","https://openalex.org/W2035383410","https://openalex.org/W2067930880","https://openalex.org/W2077592468","https://openalex.org/W2080342926","https://openalex.org/W2090950588","https://openalex.org/W2092554381","https://openalex.org/W2101829409","https://openalex.org/W2154464108","https://openalex.org/W2163331533","https://openalex.org/W2266453376","https://openalex.org/W2306582133","https://openalex.org/W2435303807","https://openalex.org/W2547518114","https://openalex.org/W2577910274","https://openalex.org/W2588108371","https://openalex.org/W2770102165","https://openalex.org/W2789357206","https://openalex.org/W2790036218","https://openalex.org/W2790932077","https://openalex.org/W2793790918","https://openalex.org/W2804973406","https://openalex.org/W2806999536","https://openalex.org/W2911422313","https://openalex.org/W2944891981","https://openalex.org/W2969848408","https://openalex.org/W2998394206","https://openalex.org/W3036910334","https://openalex.org/W3158539620","https://openalex.org/W3201146212"],"related_works":["https://openalex.org/W4385840537","https://openalex.org/W2040284168","https://openalex.org/W4389552639","https://openalex.org/W2017236798","https://openalex.org/W4312255315","https://openalex.org/W2527040220","https://openalex.org/W2387414372","https://openalex.org/W1586010474","https://openalex.org/W2042888930","https://openalex.org/W7025419836"],"abstract_inverted_index":{"Introduction:":[0],"Over":[1],"the":[2,12,39,49,68,84,98,113,143,148,154,172,181,207,210,219],"last":[3],"Century,":[4],"Thousands":[5],"of":[6,20,41,55,73,115,137,140,156,200,206,209,221],"studies":[7,22,230],"were":[8,95,109,168],"conducted":[9],"to":[10,37,111,163,195],"highlight":[11],"factors":[13,47,174,211],"affecting":[14],"warfarin":[15,56,133,160,222],"efficacy":[16,128,223],"and":[17,45,53,77,122,129,150,158,161,165,177,192,202,224,246],"toxicity.":[18,130],"Many":[19],"these":[21],"had":[23,175],"major":[24],"limitations":[25],"because":[26,236],"they":[27],"focused":[28],"only":[29],"on":[30,48,126,180,247],"one":[31],"or":[32],"a":[33,90,193,197],"few":[34],"factors.":[35],"Objectives:":[36],"determine":[38],"effect":[40,114,208],"14":[42],"different":[43,237,248],"clinical":[44,50,176,182],"genetic":[46,71],"outcomes":[51],"(efficacy":[52],"toxicity)":[54],"in":[57,83,97,213,233],"Egyptian":[58,85],"patients":[59,94],"with":[60,189,243],"autoimmune":[61],"diseases.":[62],"The":[63,131,184],"secondary":[64],"objective":[65],"was":[66,187],"detecting":[67],"association":[69],"between":[70,147],"polymorphisms":[72],"VKORC1":[74],"(rs":[75],"9923231)":[76],"systemic":[78],"lupus":[79],"erythematosus":[80],"(SLE)":[81],"susceptibility":[82],"population.":[86],"Methods:":[87],"after":[88],"signing":[89],"consent":[91],"form,":[92],"150":[93],"included":[96],"study":[99,215],"from":[100],"Kasr":[101],"Aleiny":[102],"Hospital,":[103],"Cairo":[104],"University.":[105],"All":[106],"medical":[107],"records":[108],"reviewed":[110],"extract":[112],"age,":[116],"sex,":[117],"diagnoses,":[118],"genotypes,":[119],"warfarin-drug":[120,238],"interactions,":[121],"all":[123,171],"patients'":[124],"comorbidities":[125,245],"warfarin's":[127],"average":[132],"doses,":[134],"INR,":[135],"(No.":[136],"times)/total":[138],"times":[139],"INR":[141,152],"within":[142],"therapeutic":[144],"range,":[145],"differences":[146],"maximum":[149],"minimum":[151],"values,":[153],"addition":[155],"enoxaparin":[157],"discontinuing":[159],"shifting":[162],"Rivaroxaban,":[164],"bleeding":[166,201],"episodes":[167],"determined.":[169],"Results:":[170],"studied":[173],"statistical":[178],"significance":[179],"outcomes.":[183],"T":[185],"allele":[186],"associated":[188],"treatment":[190],"failure":[191],"shift":[194],"rivaroxaban,":[196],"higher":[198],"risk":[199],"SLE.":[203],"Conclusions:":[204],"Awareness":[205],"addressed":[212],"this":[214],"is":[216],"mandatory":[217],"for":[218,226],"assessment":[220],"toxicity":[225],"each":[227],"patient.":[228],"Further":[229],"are":[231],"essential":[232],"other":[234,244],"specialties":[235],"interactions":[239],"may":[240],"be":[241],"detected,":[242],"genes.":[249]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-03-09T00:00:00"}
