{"id":"https://openalex.org/W4392557076","doi":"https://doi.org/10.3324/haematol.2023.284719","title":"Prognostic impact of SF3B1 mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases","display_name":"Prognostic impact of SF3B1 mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases","publication_year":2024,"publication_date":"2024-03-07","ids":{"openalex":"https://openalex.org/W4392557076","doi":"https://doi.org/10.3324/haematol.2023.284719","pmid":"https://pubmed.ncbi.nlm.nih.gov/38450522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11290503"},"language":"en","primary_location":{"id":"doi:10.3324/haematol.2023.284719","doi":"https://doi.org/10.3324/haematol.2023.284719","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2023.284719","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3324/haematol.2023.284719","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073001728","display_name":"Faiqa Farrukh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Faiqa Farrukh","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019666474","display_name":"Maymona G. Abdelmagid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maymona Abdelmagid","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012298768","display_name":"Abhishek Avinash Mangaonkar","orcid":"https://orcid.org/0000-0003-2458-9887","observed_orcids":["https://orcid.org/0000-0003-2458-9887"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abhishek Mangaonkar","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072463255","display_name":"Mrinal M. Patnaik","orcid":"https://orcid.org/0000-0001-6998-662X","observed_orcids":["https://orcid.org/0000-0001-6998-662X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mrinal Patnaik","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008422091","display_name":"Aref Al\u2010Kali","orcid":"https://orcid.org/0000-0002-0824-3715","observed_orcids":["https://orcid.org/0000-0002-0824-3715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aref Al-Kali","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064374340","display_name":"Michelle Ann Elliott","orcid":"https://orcid.org/0000-0002-7366-9886","observed_orcids":["https://orcid.org/0000-0002-7366-9886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle A. Elliott","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080965667","display_name":"Kebede H. Begna","orcid":"https://orcid.org/0000-0003-2730-8593","observed_orcids":["https://orcid.org/0000-0003-2730-8593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kebede H. Begna","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058650054","display_name":"C. Christopher Hook","orcid":"https://orcid.org/0000-0001-7819-5395","observed_orcids":["https://orcid.org/0000-0001-7819-5395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher C. Hook","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084606047","display_name":"William J. Hogan","orcid":"https://orcid.org/0000-0002-5841-4105","observed_orcids":["https://orcid.org/0000-0002-5841-4105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William J. Hogan","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024612499","display_name":"Animesh Dev Pardanani","orcid":"https://orcid.org/0000-0002-9084-4148","observed_orcids":["https://orcid.org/0000-0002-9084-4148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Animesh Pardanani","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark R. Litzow","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079007941","display_name":"Rhett P. Ketterling","orcid":"https://orcid.org/0000-0001-6479-7897","observed_orcids":["https://orcid.org/0000-0001-6479-7897"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rhett P. Ketterling","raw_affiliation_strings":["Divisions of Hematopathology, Departments of Medicine and Laboratory Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematopathology, Departments of Medicine and Laboratory Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002643270","display_name":"Naseema Gangat","orcid":"https://orcid.org/0000-0002-9104-6172","observed_orcids":["https://orcid.org/0000-0002-9104-6172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naseema Gangat","raw_affiliation_strings":["Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070723591","display_name":"Daniel A. Arber","orcid":"https://orcid.org/0000-0002-2160-9689","observed_orcids":["https://orcid.org/0000-0002-2160-9689"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Arber","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037453366","display_name":"Attilio Orazi","orcid":"https://orcid.org/0000-0002-1660-7013","observed_orcids":["https://orcid.org/0000-0002-1660-7013"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Attilio Orazi","raw_affiliation_strings":["Department of Pathology, Texas Tech University Health Sciences Center, El Paso, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Texas Tech University Health Sciences Center, El Paso, Texas","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079731167","display_name":"Rong Lucy He","orcid":"https://orcid.org/0000-0001-6116-8163","observed_orcids":["https://orcid.org/0000-0001-6116-8163","https://orcid.org/0000-0002-6011-5964"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong He","raw_affiliation_strings":["Divisions of Hematopathology, Departments of Medicine and Laboratory Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematopathology, Departments of Medicine and Laboratory Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084686872","display_name":"Kaaren K. Reichard","orcid":"https://orcid.org/0000-0001-5439-0778","observed_orcids":["https://orcid.org/0000-0001-5439-0778"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaaren Reichard","raw_affiliation_strings":["Divisions of Hematopathology, Departments of Medicine and Laboratory Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematopathology, Departments of Medicine and Laboratory Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016216479","display_name":"Ayalew Tefferi","orcid":"https://orcid.org/0000-0003-4605-3821","observed_orcids":["https://orcid.org/0000-0003-4605-3821"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ayalew Tefferi","raw_affiliation_strings":["Divisions of Hematology. tefferi.ayalew@mayo.edu","Divisions of Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology. tefferi.ayalew@mayo.edu","institution_ids":[]},{"raw_affiliation_string":"Divisions of Hematology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016216479"],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"EUR","value_usd":2157},"apc_paid":{"value":2000,"currency":"EUR","value_usd":2157},"fwci":0.3095,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52841566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"109","issue":"8","first_page":"2525","last_page":"2532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sf3b1-mutation","display_name":"SF3B1 mutation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/multilineage-dysplasia","display_name":"multilineage dysplasia","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9919999837875366},{"id":"https://openalex.org/keywords/leukemia-free-survival","display_name":"leukemia-free survival","score":0.9750000238418579},{"id":"https://openalex.org/keywords/karyotypic-abnormalities","display_name":"karyotype abnormalities","score":0.9020000100135803},{"id":"https://openalex.org/keywords/runx1-mutation","display_name":"RUNX1 mutation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/international-consensus-classification","display_name":"International Consensus Classification","score":0.875},{"id":"https://openalex.org/keywords/transfusion-requirements","display_name":"transfusion requirements","score":0.5830000042915344},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.6690000295639038},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.7526577711105347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6975259780883789},{"id":"https://openalex.org/C2780240888","wikidata":"https://www.wikidata.org/wiki/Q6052586","display_name":"International Prognostic Scoring System","level":4,"score":0.6923984885215759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6468474268913269},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.5304136872291565},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45507609844207764},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4374772906303406},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.42537349462509155},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4126279354095459},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4016236364841461},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.26033639907836914},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20252832770347595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1874106526374817},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.1741403341293335},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1176123321056366}],"mesh":[{"descriptor_ui":"D000072260","descriptor_name":"RNA Splicing Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000756","descriptor_name":"Anemia, Sideroblastic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000756","descriptor_name":"Anemia, Sideroblastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000756","descriptor_name":"Anemia, Sideroblastic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000756","descriptor_name":"Anemia, Sideroblastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017413","descriptor_name":"Ribonucleoprotein, U2 Small Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3324/haematol.2023.284719","doi":"https://doi.org/10.3324/haematol.2023.284719","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2023.284719","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11290503","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11290503","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11290503/pdf/1092525.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Text"},{"id":"pmid:38450522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38450522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:79912b1af5524ceab5f595d1fdf3afc5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/79912b1af5524ceab5f595d1fdf3afc5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 999, Iss 1 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3324/haematol.2023.284719","doi":"https://doi.org/10.3324/haematol.2023.284719","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2023.284719","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392557076.pdf","grobid_xml":"https://content.openalex.org/works/W4392557076.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1978538135","https://openalex.org/W1983392832","https://openalex.org/W1994148156","https://openalex.org/W2005150790","https://openalex.org/W2107398329","https://openalex.org/W2150887357","https://openalex.org/W2339658711","https://openalex.org/W2794277570","https://openalex.org/W2803541121","https://openalex.org/W2983353988","https://openalex.org/W2998901800","https://openalex.org/W3017704884","https://openalex.org/W4211205320","https://openalex.org/W4220950309","https://openalex.org/W4283271244","https://openalex.org/W4283716970","https://openalex.org/W4293763612","https://openalex.org/W4295423248","https://openalex.org/W4303685370","https://openalex.org/W4380154556","https://openalex.org/W4386624408"],"related_works":["https://openalex.org/W2005150790","https://openalex.org/W2750378577","https://openalex.org/W2794277570","https://openalex.org/W3000036892","https://openalex.org/W2770108162","https://openalex.org/W2987340819","https://openalex.org/W2803541121","https://openalex.org/W2119065732","https://openalex.org/W605138955","https://openalex.org/W2140419897"],"abstract_inverted_index":{"The":[0,30,62],"revised":[1],"4th":[2],"edition":[3],"of":[4,57,81,90,121,156,216],"the":[5,49,55,88,152,183,226],"World":[6],"Health":[7],"Organization":[8],"(WHO4R)":[9],"classification":[10,238],"lists":[11],"myelodysplastic":[12],"syndromes":[13],"with":[14,22,40,70,97,115,143],"ring":[15],"sideroblasts":[16],"(MDS-RS)":[17],"as":[18,179,232],"a":[19,79],"separate":[20],"entity":[21],"single":[23],"lineage":[24],"(MDS-RS-SLD)":[25],"or":[26,187,212],"multilineage":[27],"(MDS-RS-MLD)":[28],"dysplasia.":[29],"more":[31,244],"recent":[32],"International":[33],"Consensus":[34],"Classification":[35],"(ICC)":[36],"distinguishes":[37],"between":[38,134,141],"MDS":[39,58],"SF3B1":[41,47,91,103,146,186,213,235],"mutation":[42,147],"(MDS-SF3B1)":[43],"and":[44,76,92,99,117,123,136,144,165,175,204],"MDS-RS":[45,142,240],"without":[46,102,145],"mutation;":[48],"latter":[50],"is":[51],"instead":[52],"included":[53],"under":[54],"category":[56],"not":[59,140,191,209,218,224],"otherwise":[60],"specified.":[61],"current":[63],"study":[64],"includes":[65],"170":[66,110],"Mayo":[67],"Clinic":[68],"patients":[69,83,111,217],"WHO4R-defined":[71],"MDS-RS,":[72],"including":[73,95],"MDS-RS-SLD":[74,137],"(N=83)":[75],"MDS-RSMLD":[77],"(N=87);":[78],"subset":[80],"145":[82],"were":[84],"also":[85,166],"evaluable":[86],"for":[87,108,221,239],"presence":[89],"other":[93,188],"mutations,":[94,207],"126":[96],"(87%)":[98],"19":[100],"(13%)":[101],"mutation.":[104,214],"Median":[105],"overall":[106,130,229],"survival":[107,119,131,194],"all":[109],"was":[112,132,190,195],"6.6":[113],"years":[114],"5-":[116],"10-year":[118],"rates":[120],"59%":[122],"25%,":[124],"respectively.":[125],"A":[126],"significant":[127],"difference":[128],"in":[129],"apparent":[133],"MDS-RS-MLD":[135],"(P<0.01)":[138],"but":[139,208],"(P=0.36).":[148],"Multivariable":[149],"analysis":[150],"confirmed":[151],"independent":[153],"prognostic":[154],"contribution":[155],"MLD":[157,211],"(hazard":[158],"ratio=1.8,":[159],"95%":[160],"confidence":[161],"interval:":[162],"1.1-2.8;":[163],"P=0.01)":[164],"identified":[167],"age":[168],"(P<0.01),":[169,174,178,201],"transfusion":[170],"need":[171],"at":[172],"diagnosis":[173],"abnormal":[176,199],"karyotype":[177,200],"additional":[180],"risk":[181],"factors;":[182],"impact":[184],"from":[185],"mutations":[189],"significant.":[192],"Leukemia-free":[193],"independently":[196],"affected":[197],"by":[198,210],"RUNX1":[202],"(P=0.02)":[203],"IDH1":[205],"(P=0.01)":[206],"Exclusion":[215],"meeting":[219],"ICC-criteria":[220],"MDS-SF3B1":[222],"did":[223],"change":[225],"observations":[227],"on":[228],"survival.":[230],"MLD-based,":[231],"opposed":[233],"to":[234],"mutation-based,":[236],"disease":[237],"might":[241],"be":[242],"prognostically":[243],"relevant.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-08T00:00:00"}