{"id":"https://openalex.org/W4392554446","doi":"https://doi.org/10.3389/fcell.2024.1380475","title":"Editorial: Reviews and advances in the molecular mechanisms of breast cancer","display_name":"Editorial: Reviews and advances in the molecular mechanisms of breast cancer","publication_year":2024,"publication_date":"2024-03-07","ids":{"openalex":"https://openalex.org/W4392554446","doi":"https://doi.org/10.3389/fcell.2024.1380475","pmid":"https://pubmed.ncbi.nlm.nih.gov/38516129","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10955372"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2024.1380475","doi":"https://doi.org/10.3389/fcell.2024.1380475","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2024.1380475","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2024.1380475/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2024.1380475/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004957581","display_name":"Andrew David Redfern","orcid":"https://orcid.org/0000-0001-6728-8713","observed_orcids":["https://orcid.org/0000-0001-6728-8713"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2799971621","display_name":"Harry Perkins Institute of Medical Research","ror":"https://ror.org/02xz7d723","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799971621"]},{"id":"https://openalex.org/I2800728469","display_name":"Fiona Stanley Hospital","ror":"https://ror.org/027p0bm56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800728469","https://openalex.org/I2800882159","https://openalex.org/I4388446375","https://openalex.org/I4388482742"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"A. Redfern","raw_affiliation_strings":["Department of Medical Oncology, Fiona Stanley Hospital, Perth, WA, Australia","Harry Perkins Institute of Medical Research, Perth, WA, Australia","School of Medicine, University of Western Australia, Perth, WA, Australia","Department of Medical Oncology, Australia","Harry Perkins Institute of Medical Research, Australia","School of Medicine, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fiona Stanley Hospital, Perth, WA, Australia","institution_ids":["https://openalex.org/I2800728469"]},{"raw_affiliation_string":"Harry Perkins Institute of Medical Research, Perth, WA, Australia","institution_ids":["https://openalex.org/I2799971621"]},{"raw_affiliation_string":"School of Medicine, University of Western Australia, Perth, WA, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"Department of Medical Oncology, Australia","institution_ids":[]},{"raw_affiliation_string":"Harry Perkins Institute of Medical Research, Australia","institution_ids":["https://openalex.org/I2799971621"]},{"raw_affiliation_string":"School of Medicine, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007156981","display_name":"Veenoo Agarwal","orcid":"https://orcid.org/0000-0003-3951-2946","observed_orcids":["https://orcid.org/0000-0003-3951-2946"]},"institutions":[{"id":"https://openalex.org/I2800728469","display_name":"Fiona Stanley Hospital","ror":"https://ror.org/027p0bm56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800728469","https://openalex.org/I2800882159","https://openalex.org/I4388446375","https://openalex.org/I4388482742"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"V. Agarwal","raw_affiliation_strings":["Department of Medical Oncology, Fiona Stanley Hospital, Perth, WA, Australia","Department of Medical Oncology, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fiona Stanley Hospital, Perth, WA, Australia","institution_ids":["https://openalex.org/I2800728469"]},{"raw_affiliation_string":"Department of Medical Oncology, Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049332865","display_name":"Suresh K. Alahari","orcid":"https://orcid.org/0000-0002-9651-6727","observed_orcids":["https://orcid.org/0000-0002-9651-6727"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Alahari","raw_affiliation_strings":["Stanley S. Scott Cancer Center, School of Medicine, Louisiana State University, New Orleans, LA, United States","Stanley S. Scott Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley S. Scott Cancer Center, School of Medicine, Louisiana State University, New Orleans, LA, United States","institution_ids":["https://openalex.org/I121820613"]},{"raw_affiliation_string":"Stanley S. Scott Cancer Center, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004957581"],"corresponding_institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2799971621","https://openalex.org/I2800728469"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":null,"first_page":"1380475","last_page":"1380475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6840999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6840999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.2883000075817108,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9179999828338623},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.8460000157356262},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7639999985694885},{"id":"https://openalex.org/keywords/luminal-breast-cancer","display_name":"luminal breast cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cdk4-6-inhibitor-resistance","display_name":"CDK4/6 inhibitor resistance","score":0.9120000004768372},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7009999752044678},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.8050000071525574},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.628000020980835},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5861180424690247},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4009898602962494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39531517028808594},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3463748097419739},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3241457939147949},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32375288009643555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14297449588775635}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fcell.2024.1380475","doi":"https://doi.org/10.3389/fcell.2024.1380475","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2024.1380475","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2024.1380475/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10955372","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10955372","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10955372/pdf/fcell-12-1380475.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:38516129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38516129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Editorial"},{"id":"pmh:oai:pure.atira.dk:openaire/7c805f0c-118a-4688-8f95-b45c2a58372d","doi":null,"is_oa":true,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/7c805f0c-118a-4688-8f95-b45c2a58372d","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redfern, A, Agarwal, V & Alahari, S 2024, 'Editorial : Reviews and advances in the molecular mechanisms of breast cancer', Frontiers in Cell and Developmental Biology, vol. 12, 1380475. https://doi.org/10.3389/fcell.2024.1380475","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:ecc747bc67854535a483e533d4d08865","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ecc747bc67854535a483e533d4d08865","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 12 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2024.1380475","doi":"https://doi.org/10.3389/fcell.2024.1380475","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2024.1380475","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2024.1380475/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392554446.pdf","grobid_xml":"https://content.openalex.org/works/W4392554446.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2117692326","https://openalex.org/W2154215291","https://openalex.org/W2309969893","https://openalex.org/W2575732134","https://openalex.org/W2750328162","https://openalex.org/W2771978163","https://openalex.org/W2907564726","https://openalex.org/W2982361599","https://openalex.org/W3030998444","https://openalex.org/W3129934890","https://openalex.org/W4309028503","https://openalex.org/W4322774130","https://openalex.org/W4378801565","https://openalex.org/W4388655440","https://openalex.org/W4390496872"],"related_works":["https://openalex.org/W4292454420","https://openalex.org/W7167787629","https://openalex.org/W4410130365","https://openalex.org/W6903952341","https://openalex.org/W4319294014","https://openalex.org/W4401811574","https://openalex.org/W2939720823","https://openalex.org/W4205336484","https://openalex.org/W7135026764","https://openalex.org/W7170148153"],"abstract_inverted_index":{"This":[0,268,747,813],"editorial":[1],"distils":[2],"the":[3,30,41,65,81,102,143,243,258,271,283,385,438,473,502,518,521,576,603,620,664,761,820,833,913,920,932,940,988,997,1027,1097],"key":[4,978,1084],"messages":[5],"and":[6,48,77,86,123,158,218,237,266,320,372,380,412,467,477,500,543,553,561,569,602,613,654,690,715,744,776,839,939,963,984,994,1012,1062,1079],"lessons":[7],"learned":[8],"from":[9,43,450,788,805,934],"this":[10,954],"article":[11],"collection":[12],"to":[13,39,45,50,89,100,117,121,126,174,257,280,356,370,384,619,692,722,740,837,858,886,937,1035,1059,1074],"identify":[14,90,118],"future":[15],"directions":[16],"for":[17,139,286,592,750],"advancing":[18],"breast":[19],"cancer":[20,627,1086],"(BC)":[21],"care.":[22],"First,":[23],"we":[24,969],"have":[25,354,382,484],"reviews":[26,796],"addressing":[27],"two":[28,795],"of":[29,67,84,105,202,204,225,230,260,273,309,358,389,403,475,504,513,524,579,623,666,724,752,760,770,835,855,880,905,916,922,928,942,965,973,1000,1018],"most":[31],"important":[32,674,1075],"questions":[33],"currently":[34],"in":[35,72,110,253,395,406,432,486,615,626,634,637,656,675,699,845,851,861,874,882,960,980,1007,1016,1049,1067,1096],"BC":[36,75,133,153,291,884],"therapeutics,":[37],"how":[38,49,99,116,125],"extend":[40],"gains":[42],"immunotherapy":[44,1078],"luminal":[46,54,111,119,171,177,290,433,883],"cancers,":[47],"best":[51],"treat":[52],"metastatic":[53,289],"cancers":[55,434],"following":[56],"progression":[57,827],"on":[58,418,528,652,680],"CDK4/6":[59,264,281,458,807,1008],"inhibitor":[60,808,1009],"therapy.":[61,812],"We":[62],"then":[63,731],"explore":[64,114],"potential":[66],"modulating":[68],"ER":[69],"beta":[70],"signaling":[71,451,719,763,1081],"triple":[73],"negative":[74],"(TNBC)":[76],"finally":[78],"look":[79],"at":[80,362,755],"biological":[82],"underpinnings":[83],"migration":[85,653,714],"invasion":[87,676,993,1038],"control":[88],"therapeutic":[91,491,584,785,801,901],"intervention":[92],"points.":[93],"First":[94],"Attalla":[95],"et":[96,275,509,661,1041],"al.":[97,1042],"examine":[98,278],"optimize":[101],"marginal":[103],"benefits":[104],"immune":[106,155,249,454,635,647,859,891,923,989,1019],"checkpoint":[107],"inhibitors":[108,265,405],"(ICI)":[109],"BC.":[112],"They":[113,702],"both":[115],"responders":[120],"ICIs":[122],"discuss":[124],"overcome":[127],"low":[128,159],"responsiveness.":[129],"With":[130],"current":[131,284],"pathological":[132],"classification,":[134],"only":[135],"TNBCs":[136],"are":[137,324,563,614,673],"approved":[138],"ICI":[140,811,872],"treatment.":[141],"However,":[142],"authors":[144,303,519],"note":[145,970],"that":[146,180,245,305,641,704,782,799,971,1090],"using":[147],"alternative":[148],"immune-based":[149],"transcriptomic":[150],"classifications":[151],"dividing":[152],"into":[154,270,945],"high,":[156],"medium":[157],"categories":[160],"(1)":[161],"may":[162,167,247,803,897,1045,1091],"better":[163],"encompass":[164],"all":[165],"who":[166,277],"benefit":[168,187],"including":[169,494,996],"rarer":[170],"responders.":[172],"Moving":[173,448],"improving":[175,190],"poor":[176],"responsiveness,":[178],"observations":[179],"tumour-located":[181],"cytotoxic":[182],"T":[183],"cells":[184,775],"correlate":[185],"with":[186,255,295,392,415,420,446,457,463,470,517,677,687,694,711,733,810,832,912,931,956,1026,1051,1064,1083],"suggests":[188,889],"therapies":[189,1095],"tumour":[191,624],"lymphocyte":[192],"infiltration":[193],"could":[194,582,645,870],"be":[195],"beneficial.":[196],"Potential":[197],"summarized":[198],"interventions":[199],"include;":[200],"agonism":[201],"stimulator":[203],"interferon":[205],"genes":[206],"(STING),":[207],"reducing":[208],"immunesuppressive":[209],"hypoxic":[210],"conditions":[211],"through":[212,228,307,351,571,758,819],"Hypoxia":[213],"Inducible":[214],"Factor":[215],"(HIF)":[216],"inhibition":[217,459,751,767],"suppressing":[219,535,545,554],"cytokine":[220,231],"gene":[221],"silencing.":[222],"Direct":[223],"manipulation":[224],"local":[226],"immunity":[227,625],"introduction":[229],"mRNAs":[232],"or":[233,445,768],"genetically":[234],"engineered":[235],"T-cells":[236],"NK-cells":[238],"is":[239,251,313,342,368,515,685,697,780,843,976,1005,1013,1031],"also":[240,426,632,986,1014],"covered.":[241],"Finally,":[242,992,1043],"finding":[244],"antiestrogens":[246],"cause":[248],"activation":[250,431,636,720,854,860],"discussed":[252,925],"concert":[254],"leading":[256],"concept":[259,814],"synergy":[261],"between":[262,1077],"anti-estrogens,":[263],"ICIs.":[267,471],"segways":[269],"review":[272,466,507],"Zhou":[274],"al":[276,662],"resistance":[279,306,337,367,982,1010],"inhibitors,":[282],"standard-of-care":[285],"first":[287,465],"line":[288],"management,":[292],"a":[293,678,846,865,949,957,977,1023,1047,1052],"question":[294],"expanding":[296],"relevance":[297,485],"as":[298,443,539],"adjuvant":[299],"usage":[300],"commences.":[301],"The":[302,511,876],"conclude":[304,798],"attenuation":[308],"cell":[310,329,348,688,713],"cycle":[311,330,349],"arrest":[312],"uncommon":[314],"although":[315,339,841],"acquired":[316,366],"retinoblastoma":[317],"protein":[318,737],"mutations":[319],"CDK":[321],"6":[322],"over-expression":[323],"occasionally":[325],"implicated.":[326],"Considering":[327],"alternate":[328],"entry":[331,350],"points,":[332],"c-myc":[333],"changes":[334,456],"can":[335,609,985],"drive":[336,745],"pre-clinically":[338],"clinical":[340,616,638],"targeting":[341,585,648],"difficult.":[343],"Encouraging":[344,423],"pre-clinical":[345],"results":[346],"blocking":[347],"CDK2":[352,359],"(2)":[353],"lead":[355,383,857],"development":[357],"inhibitors.":[360],"Looking":[361],"parallel":[363],"pathway":[364,979],"activation,":[365],"linked":[369],"AKT":[371],"FGFR":[373,404],"signaling.":[374],"Successful":[375],"trials":[376,402,416,436],"inhibiting":[377],"AKT,":[378],"mTOR":[379],"PI3kinase":[381],"recent":[386],"FDA":[387],"approval":[388],"capivasertib":[390],"(3)":[391],"other":[393,481,595,1080],"agents":[394],"confirmatory":[396],"randomised":[397,821],"trials.":[398,617],"In":[399,557,1069],"contrast":[400,558],"early":[401],"unselected":[407],"patients":[408,419,862],"show":[409],"modest":[410],"activity":[411,644],"high":[413],"toxicity":[414],"refocusing":[417],"FGFR1":[421],"alteration.":[422],"preclinical":[424],"data":[425],"support":[427],"androgen":[428],"receptor":[429,735],"(AR)":[430],"prompting":[435],"evaluating":[437],"selective":[439,598],"AR":[440,495],"modulator":[441],"enobosarm":[442],"monotherapy":[444],"abemaciclib.":[447],"away":[449],"modulation,":[452],"observed":[453,831],"modulatory":[455],"(4)":[460],"intertwine":[461],"nicely":[462],"our":[464,505,657],"intimate":[468],"synergies":[469,1076],"Despite":[472],"lack":[474],"ER-\uf061":[476],"progesterone":[478],"receptor,":[479],"several":[480,756,783,903],"nuclear":[482],"receptors":[483],"TNBC,":[487],"introducing":[488],"prospective":[489],"new":[490],"targets":[492],"(5)":[493],"(6),":[496],"thyroid":[497],"receptor-\u03b2":[498],"(7)":[499],"ER\u03b2,":[501],"subject":[503],"final":[506,658],"(Yan":[508],"al).":[510],"role":[512],"ER\u03b2":[514],"complex":[516],"elucidating":[520],"diverse":[522,791],"impacts":[523],"different":[525],"splice":[526],"variants":[527,581],"TNBC":[529,611,852,887],"biology.":[530],"ER\u03b21":[531,587,605,856,952,1044],"has":[532,588,815],"beneficial":[533],"roles,":[534],"oncogenic":[536],"pathways":[537,1082],"such":[538],"mTOR,":[540],"TGF-beta,":[541],"HIF-1a":[542],"AR,":[544],"epithelial":[546],"mesenchymal":[547],"transition":[548],"(EMT),":[549],"maintaining":[550],"oxidative":[551,935,961],"phosphorylation":[552,936,962],"cholesterol":[555,946,966,974],"biosynthesis.":[556,967],"ER\u03b22,":[559],"Er\u03b24":[560],"ER\u03b25":[562],"oncogenic,":[564],"enhancing":[565],"proliferation,":[566],"invasion,":[567,655],"angiogenesis,":[568],"EMT":[570,1001,1063],"upregulating":[572],"HIF-1\u03b1":[573],"activity.":[574],"Although":[575],"opposing":[577],"roles":[578],"these":[580,789,894,899,1071],"make":[583],"difficult":[586],"significantly":[589],"greater":[590],"affinity":[591],"estradiol":[593,601],"than":[594],"isoforms":[596],"allowing":[597],"stimulation.":[599],"Both":[600],"oral":[604],"agonist":[606],"S-equol":[607,629],"(8)":[608,863],"inhibit":[610],"proliferation":[612],"Returning":[618],"central":[621],"theme":[622],"homeostasis,":[628],"neoadjuvant":[630],"treatment":[631],"resulted":[633],"subjects":[639],"suggesting":[640,864],"manipulating":[642],"Er\u03b21":[643],"enhance":[646,871],"(8).":[649],"Focusing":[650],"directly":[651],"study":[659,823,848],"Qiu":[660,1040],"dissect":[663],"function":[665,754,873],"migratory":[667],"surface":[668],"structures":[669],"called":[670],"lamellipodia":[671,681,700,709,753,773],"which":[672,696,730,896],"focus":[679],"CD44":[682,684,705],"overexpression.":[683],"associated":[686,1025],"adhesion":[689],"known":[691],"interact":[693],"F-actin":[695],"involved":[698],"function.":[701],"demonstrate":[703],"overexpression":[706,723],"drives":[707],"increased":[708,826],"formation":[710],"enhanced":[712],"EMT.":[716],"Mechanistically,":[717],"PI3K/Akt":[718,766],"leads":[721],"tissue":[725],"type":[726],"plasminogen":[727],"activator":[728],"(tPA)":[729],"interacts":[732],"LDL":[734],"related":[736,998],"1":[738],"(LRP1)":[739],"activate":[741],"downstream":[742],"NF\u03baB":[743],"invasion.":[746,1068],"provides":[748],"opportunity":[749],"points":[757],"blockade":[759,809],"tPA/LRP1/NFkB":[762],"cascade.":[764],"Pre-clinically":[765],"knockdown":[769],"tPA":[771],"reduced":[772],"positive":[774],"attenuated":[777],"migration.":[778],"It":[779,1004],"notable":[781],"conceptual":[784],"intersections":[786],"arise":[787],"outwardly":[790],"studies.":[792],"Our":[793],"initial":[794],"independently":[797],"synergistic":[800],"value":[802],"come":[804],"combining":[806],"already":[816],"been":[817,1057],"piloted":[818],"PACE":[822],"where":[824,868],"numerically":[825],"free":[828],"survival":[829],"was":[830,948],"addition":[834],"avelumab":[836],"fulvestrant":[838],"palbociclib":[840],"confirmation":[842],"awaited":[844],"larger":[847],"(9).":[849],"Interestingly,":[850],"estrogenic":[853],"reverse":[866],"strategy":[867],"estrogen":[869],"TNBC.":[875],"differing":[877,890],"prognostic":[878],"significance":[879],"TILs":[881],"compared":[885],"(10)":[888],"populations":[892],"infiltrate":[893],"tumours":[895,1050],"underlie":[898],"divergent":[900],"opportunities.Additionally,":[902],"areas":[904],"cellular":[906],"oncobiology":[907],"repeatedly":[908],"appear,":[909],"substantially":[910],"aligning":[911],"classical":[914],"Hallmarks":[915],"Cancer":[917],"(11).":[918],"Beyond":[919],"evasion":[921],"destruction":[924],"above,":[926],"reprogramming":[927],"energy":[929],"metabolism":[930],"shift":[933],"glycolysis":[938,943],"redirection":[941],"products":[944],"biosynthesis":[947,975],"recurring":[950],"theme.":[951],"reversed":[953],"effect":[955],"consequent":[958,1065],"increase":[959,1036],"downregulation":[964],"Further,":[968],"upregulation":[972],"CDK4/6i":[981],"(12)":[983],"influence":[987],"microenvironment":[990],"(13).":[991],"metastasis,":[995],"process":[999],"frequently":[1002],"recurs.":[1003],"upregulated":[1006],"(14)":[1011],"implicated":[1015,1088],"modulation":[1017],"response":[1020],"(15).":[1021],"CD44,":[1022],"molecule":[1024],"EM":[1028],"hybrid":[1029],"state,":[1030],"convincingly":[1032],"shown":[1033,1058],"by":[1034,1039],"lamellipodiadriven":[1037],"hold":[1046],"solution":[1048],"suitable":[1053],"isoform":[1054],"balance":[1055],"having":[1056],"downregulate":[1060],"HIF-alpha":[1061],"reduction":[1066],"summary,":[1070],"studies":[1072],"point":[1073],"common":[1085],"behaviours":[1087],"mechanistically":[1089],"further":[1092],"guide":[1093],"individualized":[1094],"future.":[1098]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-03-08T00:00:00"}
