{"id":"https://openalex.org/W4392545129","doi":"https://doi.org/10.1073/pnas.2315989121","title":"CD38\u2013RyR2 axis\u2013mediated signaling impedes CD8 + T cell response to anti-PD1 therapy in cancer","display_name":"CD38\u2013RyR2 axis\u2013mediated signaling impedes CD8 + T cell response to anti-PD1 therapy in cancer","publication_year":2024,"publication_date":"2024-03-07","ids":{"openalex":"https://openalex.org/W4392545129","doi":"https://doi.org/10.1073/pnas.2315989121","pmid":"https://pubmed.ncbi.nlm.nih.gov/38451948"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2315989121","doi":"https://doi.org/10.1073/pnas.2315989121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2315989121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2315989121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035107057","display_name":"Anwesha Kar","orcid":"https://orcid.org/0000-0002-4455-6276","observed_orcids":["https://orcid.org/0000-0002-4455-6276"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anwesha Kar","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India","Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0002-4455-6276","affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India","institution_ids":["https://openalex.org/I160344538","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091291763","display_name":"Puspendu Ghosh","orcid":"https://orcid.org/0000-0003-0920-2306","observed_orcids":["https://orcid.org/0000-0003-0920-2306"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Puspendu Ghosh","raw_affiliation_strings":["Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0003-0920-2306","affiliations":[{"raw_affiliation_string":"Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India","institution_ids":["https://openalex.org/I160344538","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030112517","display_name":"Anupam Gautam","orcid":"https://orcid.org/0000-0002-6460-6525","observed_orcids":["https://orcid.org/0000-0002-6460-6525"]},"institutions":[{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anupam Gautam","raw_affiliation_strings":["Algorithms in Bioinformatics, Institute for Bioinformatics and Medical Informatics, University of T\u00fcbingen, Sand 14 72076, T\u00fcbingen, Baden-W\u00fcrttemberg, Germany","International Max Planck Research School \u201cFrom Molecules to Organisms\u201d, Max Planck Institute for Biology T\u00fcbingen 72076, T\u00fcbingen, Baden-W\u00fcrttemberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6460-6525","affiliations":[{"raw_affiliation_string":"Algorithms in Bioinformatics, Institute for Bioinformatics and Medical Informatics, University of T\u00fcbingen, Sand 14 72076, T\u00fcbingen, Baden-W\u00fcrttemberg, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"International Max Planck Research School \u201cFrom Molecules to Organisms\u201d, Max Planck Institute for Biology T\u00fcbingen 72076, T\u00fcbingen, Baden-W\u00fcrttemberg, Germany","institution_ids":["https://openalex.org/I4210165766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039286511","display_name":"Snehanshu Chowdhury","orcid":"https://orcid.org/0000-0002-7114-4656","observed_orcids":["https://orcid.org/0000-0002-7114-4656"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Snehanshu Chowdhury","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India","Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India","institution_ids":["https://openalex.org/I160344538","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006276944","display_name":"Debashree Basak","orcid":"https://orcid.org/0000-0001-8651-7745","observed_orcids":["https://orcid.org/0000-0001-8651-7745"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debashree Basak","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India","Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India","institution_ids":["https://openalex.org/I160344538","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046803655","display_name":"Ishita Sarkar","orcid":"https://orcid.org/0000-0003-2253-2385","observed_orcids":["https://orcid.org/0000-0003-2253-2385"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ishita Sarkar","raw_affiliation_strings":["Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India","institution_ids":["https://openalex.org/I160344538","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017474142","display_name":"Arpita Bhoumik","orcid":"https://orcid.org/0000-0002-0842-4487","observed_orcids":["https://orcid.org/0000-0002-0842-4487"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arpita Bhoumik","raw_affiliation_strings":["Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India","institution_ids":["https://openalex.org/I160344538","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102964675","display_name":"Shubhrajit Barman","orcid":"https://orcid.org/0009-0006-0981-4424","observed_orcids":["https://orcid.org/0009-0006-0981-4424"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shubhrajit Barman","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India","Division of Structural Biology & Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India"],"raw_orcid":"https://orcid.org/0009-0006-0981-4424","affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Division of Structural Biology & Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India","institution_ids":["https://openalex.org/I160344538","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050013071","display_name":"Paramita Chakraborty","orcid":"https://orcid.org/0000-0002-0320-8697","observed_orcids":["https://orcid.org/0000-0002-0320-8697"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paramita Chakraborty","raw_affiliation_strings":["Department of Surgery, Medical University of South Carolina, Charleston, South Carolina SC- 29425"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical University of South Carolina, Charleston, South Carolina SC- 29425","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054935353","display_name":"Asima Mukhopadhyay","orcid":"https://orcid.org/0000-0003-0761-9562","observed_orcids":["https://orcid.org/0000-0003-0761-9562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asima Mukhopadhyay","raw_affiliation_strings":["Kolkata Gynaecology Oncology Trials and Translational Research Group, Kolkata 700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0003-0761-9562","affiliations":[{"raw_affiliation_string":"Kolkata Gynaecology Oncology Trials and Translational Research Group, Kolkata 700156, West Bengal, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041139369","display_name":"Shikhar Mehrotra","orcid":"https://orcid.org/0000-0002-5411-9504","observed_orcids":["https://orcid.org/0000-0002-5411-9504"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shikhar Mehrotra","raw_affiliation_strings":["Department of Surgery, Medical University of South Carolina, Charleston, South Carolina SC- 29425"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical University of South Carolina, Charleston, South Carolina SC- 29425","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102014879","display_name":"Senthil Kumar Ganesan","orcid":"https://orcid.org/0000-0001-6040-4814","observed_orcids":["https://orcid.org/0000-0001-6040-4814"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Senthil Kumar Ganesan","raw_affiliation_strings":["Division of Structural Biology & Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural Biology & Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India","institution_ids":["https://openalex.org/I160344538","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049123297","display_name":"Sandip Paul","orcid":"https://orcid.org/0000-0001-7406-3598","observed_orcids":["https://orcid.org/0000-0001-7406-3598"]},"institutions":[{"id":"https://openalex.org/I4405256552","display_name":"JIS University","ror":"https://ror.org/049ndh460","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405256552"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandip Paul","raw_affiliation_strings":["System Biology Informatics Lab, Center for Health Science and Technology, JIS Institute of Advanced Studies and Research, JIS University, Kolkata 700091, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0001-7406-3598","affiliations":[{"raw_affiliation_string":"System Biology Informatics Lab, Center for Health Science and Technology, JIS Institute of Advanced Studies and Research, JIS University, Kolkata 700091, West Bengal, India","institution_ids":["https://openalex.org/I4405256552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019092763","display_name":"Shilpak Chatterjee","orcid":"https://orcid.org/0000-0002-8428-6434","observed_orcids":["https://orcid.org/0000-0002-8428-6434"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shilpak Chatterjee","raw_affiliation_strings":["Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India","institution_ids":["https://openalex.org/I160344538","https://openalex.org/I66760702"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5019092763","https://openalex.org/A5030112517","https://openalex.org/A5039286511"],"corresponding_institution_ids":["https://openalex.org/I160344538","https://openalex.org/I4210165766","https://openalex.org/I66760702","https://openalex.org/I8087733","https://openalex.org/I99364266"],"apc_list":null,"apc_paid":null,"fwci":3.4263,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.94354948,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"121","issue":"11","first_page":"e2315989121","last_page":"e2315989121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ryanodine-receptor-2","display_name":"RyR2","score":0.878000020980835},{"id":"https://openalex.org/keywords/cd8-t-cell-exhaustion","display_name":"CD8+ T cell exhaustion","score":0.8090000152587891},{"id":"https://openalex.org/keywords/anti-pd-1-resistance","display_name":"anti-PD-1 resistance","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tcf1","display_name":"TCF1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8009999990463257},{"id":"https://openalex.org/keywords/akt-activation","display_name":"Akt activation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/intratumoral-t-cells","display_name":"intratumoral T cells","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.7593937516212463},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6880548596382141},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6451046466827393},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5595497488975525},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43612807989120483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40770527720451355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3470059931278229},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3460445702075958},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27357590198516846},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21578150987625122},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12311777472496033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09394025802612305},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.2315989121","doi":"https://doi.org/10.1073/pnas.2315989121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2315989121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:38451948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38451948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10945783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10945783","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10945783/pdf/pnas.202315989.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.2315989121","doi":"https://doi.org/10.1073/pnas.2315989121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2315989121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4036850060","display_name":null,"funder_award_id":"R01 CA236379","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5045962411","display_name":null,"funder_award_id":"R01 CA250458","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5777587153","display_name":null,"funder_award_id":"R41 CA239952","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5941978298","display_name":null,"funder_award_id":"R42 CA239952","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8273141855","display_name":null,"funder_award_id":"CRG/2019/001334","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G8299068389","display_name":"Role of endoplasmic reticulum (ER) stress induced UPR signaling in regulating the metabolic fitness and functionality of CD8+ T cells in cancer","funder_award_id":"IA/I/19/1/504277","funder_id":"https://openalex.org/F4320325580","funder_display_name":"The Wellcome Trust DBT India Alliance"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"},{"id":"https://openalex.org/F4320330124","display_name":"German Network for Bioinformatics Infrastructure","ror":"https://ror.org/01vmpm840"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1488869774","https://openalex.org/W2009376981","https://openalex.org/W2011649333","https://openalex.org/W2020094759","https://openalex.org/W2023824740","https://openalex.org/W2041748354","https://openalex.org/W2077116159","https://openalex.org/W2096270448","https://openalex.org/W2109495864","https://openalex.org/W2117552772","https://openalex.org/W2123895023","https://openalex.org/W2140924908","https://openalex.org/W2152897456","https://openalex.org/W2162006028","https://openalex.org/W2506616866","https://openalex.org/W2513922839","https://openalex.org/W2514996992","https://openalex.org/W2560367415","https://openalex.org/W2561322596","https://openalex.org/W2587048937","https://openalex.org/W2616155686","https://openalex.org/W2620687394","https://openalex.org/W2767542715","https://openalex.org/W2767761069","https://openalex.org/W2797429263","https://openalex.org/W2899145148","https://openalex.org/W2909486828","https://openalex.org/W2912648593","https://openalex.org/W2913558101","https://openalex.org/W2947902196","https://openalex.org/W2964993184","https://openalex.org/W2994938720","https://openalex.org/W3020888809","https://openalex.org/W3040911066","https://openalex.org/W3043098037","https://openalex.org/W3119279345","https://openalex.org/W3134655285","https://openalex.org/W3167004947","https://openalex.org/W4200625773","https://openalex.org/W4205711062","https://openalex.org/W4292121925","https://openalex.org/W4296746220","https://openalex.org/W4312095486","https://openalex.org/W4364352584","https://openalex.org/W4380359731","https://openalex.org/W4385216428","https://openalex.org/W4385330446","https://openalex.org/W4385975202","https://openalex.org/W4392545129"],"related_works":["https://openalex.org/W42562563","https://openalex.org/W2027999423","https://openalex.org/W127140033","https://openalex.org/W2132735695","https://openalex.org/W1992999743","https://openalex.org/W2041201944","https://openalex.org/W2398341294","https://openalex.org/W2362506364","https://openalex.org/W2064440970","https://openalex.org/W2040212555"],"abstract_inverted_index":{"PD1":[0],"blockade":[1],"therapy,":[2,78],"harnessing":[3],"the":[4,27,55,59,64,119,164,236],"cytotoxic":[5],"potential":[6,232],"of":[7,30,67,96,133,151,202,206,238],"CD8":[8,32,46,70,104,111,134,155,176,209],"+":[9,33,47,71,105,112,135,156,177,210],"T":[10,34,48,72,106,113,136,157,178,211],"cells,":[11,107],"has":[12],"yielded":[13],"clinical":[14],"success":[15],"in":[16,83,98,129,153,169,191,208,241],"treating":[17],"malignancies.":[18],"However,":[19],"its":[20,81],"efficacy":[21,237],"is":[22],"often":[23],"limited":[24],"due":[25],"to":[26,76,146,166,198,224,234],"progressive":[28],"differentiation":[29,132],"intratumoral":[31,103],"cells":[35,114,137,158,179,212],"into":[36],"a":[37,217,231],"hypofunctional":[38],"state":[39],"known":[40],"as":[41],"terminal":[42,131],"exhaustion.":[43],"Despite":[44],"identifying":[45],"cell":[49,73],"subsets":[50,74],"associated":[51],"with":[52,69,91],"immunotherapy":[53],"resistance,":[54],"molecular":[56,120],"pathway":[57],"triggering":[58],"resistance":[60],"remains":[61],"elusive.":[62],"Given":[63],"clear":[65],"association":[66],"CD38":[68,125,152,172,229],"resistant":[75],"anti-PD1":[77,147,167,225,239],"we":[79,122],"investigated":[80],"role":[82],"inducing":[84],"resistance.":[85],"Phenotypic":[86],"and":[87,102,162,221],"functional":[88],"characterization,":[89],"along":[90],"single-cell":[92],"RNA":[93],"sequencing":[94],"analysis":[95],"both":[97],"vitro":[99],"chronically":[100],"stimulated":[101],"revealed":[108],"that":[109,124],"CD38-expressing":[110],"are":[115],"terminally":[116],"exhausted.":[117],"Exploring":[118],"mechanism,":[121],"found":[123],"expression":[126,173],"was":[127],"crucial":[128],"promoting":[130],"by":[138],"suppressing":[139],"TCF1":[140,160,199,214],"expression,":[141],"thereby":[142],"rendering":[143],"them":[144],"unresponsive":[145],"therapy.":[148,226],"Genetic":[149],"ablation":[150],"tumor-reactive":[154],"restored":[159],"levels":[161,184],"improved":[163],"responsiveness":[165,223],"therapy":[168],"mice.":[170],"Mechanistically,":[171],"on":[174],"exhausted":[175],"elevated":[180],"intracellular":[181],"Ca":[182],"2+":[183],"through":[185],"RyR2":[186,203],"calcium":[187],"channel":[188],"activation.":[189],"This,":[190],"turn,":[192],"promoted":[193],"chronic":[194],"AKT":[195,207],"activation,":[196],"leading":[197],"loss.":[200],"Knockdown":[201],"or":[204],"inhibition":[205],"maintained":[213],"levels,":[215],"induced":[216],"sustained":[218],"anti-tumor":[219],"response,":[220],"enhanced":[222],"Thus,":[227],"targeting":[228],"represents":[230],"strategy":[233],"improve":[235],"treatment":[240],"cancer.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":5}],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2024-03-08T00:00:00"}