{"id":"https://openalex.org/W4392545009","doi":"https://doi.org/10.1371/journal.pone.0280858","title":"Insights into non-informative results from non-invasive prenatal screening through gestational age, maternal BMI, and age analyses","display_name":"Insights into non-informative results from non-invasive prenatal screening through gestational age, maternal BMI, and age analyses","publication_year":2024,"publication_date":"2024-03-07","ids":{"openalex":"https://openalex.org/W4392545009","doi":"https://doi.org/10.1371/journal.pone.0280858","pmid":"https://pubmed.ncbi.nlm.nih.gov/38452118","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10919614"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0280858","doi":"https://doi.org/10.1371/journal.pone.0280858","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0280858","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280858&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280858&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047760740","display_name":"Juraj Gazdarica","orcid":"https://orcid.org/0000-0002-9042-3589","observed_orcids":["https://orcid.org/0000-0002-9042-3589"]},"institutions":[{"id":"https://openalex.org/I4210155685","display_name":"Geneton (Slovakia)","ror":"https://ror.org/051nezy81","country_code":"SK","type":"company","lineage":["https://openalex.org/I4210155685"]},{"id":"https://openalex.org/I4210156920","display_name":"Slovak Centre of Scientific and Technical Information","ror":"https://ror.org/054ys1f07","country_code":"SK","type":"archive","lineage":["https://openalex.org/I4210156920"]},{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":true,"raw_author_name":"Juraj Gazdarica","raw_affiliation_strings":["Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","Geneton Ltd., Bratislava, Slovakia","Slovak Centre of Scientific and Technical Information, Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0000-0002-9042-3589","affiliations":[{"raw_affiliation_string":"Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Geneton Ltd., Bratislava, Slovakia","institution_ids":["https://openalex.org/I4210155685"]},{"raw_affiliation_string":"Slovak Centre of Scientific and Technical Information, Bratislava, Slovakia","institution_ids":["https://openalex.org/I4210156920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069634531","display_name":"Nat\u00e1lia Forg\u00e1\u010dov\u00e1","orcid":"https://orcid.org/0000-0001-6764-0895","observed_orcids":["https://orcid.org/0000-0001-6764-0895"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210123996","display_name":"Biomedical Research Center of the Slovak Academy of Sciences","ror":"https://ror.org/02s3ds748","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996"]},{"id":"https://openalex.org/I4405252893","display_name":"Institute of Clinical and Translational Research of the Slovak Academy of Sciences","ror":"https://ror.org/00392bh69","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4405252893"]},{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Natalia Forgacova","raw_affiliation_strings":["Comenius University Science Park, Bratislava, Slovakia","Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comenius University Science Park, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4405252893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078298725","display_name":"Tom\u00e1\u0161 Sl\u00e1de\u010dek","orcid":"https://orcid.org/0000-0002-2405-3735","observed_orcids":["https://orcid.org/0000-0002-2405-3735"]},"institutions":[{"id":"https://openalex.org/I4210155685","display_name":"Geneton (Slovakia)","ror":"https://ror.org/051nezy81","country_code":"SK","type":"company","lineage":["https://openalex.org/I4210155685"]},{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Tomas Sladecek","raw_affiliation_strings":["Comenius University Science Park, Bratislava, Slovakia","Geneton Ltd., Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0000-0002-2405-3735","affiliations":[{"raw_affiliation_string":"Comenius University Science Park, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Geneton Ltd., Bratislava, Slovakia","institution_ids":["https://openalex.org/I4210155685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017850074","display_name":"Marcel Kuchar\u00edk","orcid":"https://orcid.org/0000-0002-5373-8282","observed_orcids":["https://orcid.org/0000-0002-5373-8282"]},"institutions":[{"id":"https://openalex.org/I4210155685","display_name":"Geneton (Slovakia)","ror":"https://ror.org/051nezy81","country_code":"SK","type":"company","lineage":["https://openalex.org/I4210155685"]},{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Marcel Kucharik","raw_affiliation_strings":["Comenius University Science Park, Bratislava, Slovakia","Geneton Ltd., Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comenius University Science Park, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Geneton Ltd., Bratislava, Slovakia","institution_ids":["https://openalex.org/I4210155685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003521595","display_name":"Jaroslav Budi\u0161","orcid":"https://orcid.org/0000-0002-8667-6655","observed_orcids":["https://orcid.org/0000-0002-8667-6655"]},"institutions":[{"id":"https://openalex.org/I4210155685","display_name":"Geneton (Slovakia)","ror":"https://ror.org/051nezy81","country_code":"SK","type":"company","lineage":["https://openalex.org/I4210155685"]},{"id":"https://openalex.org/I4210156920","display_name":"Slovak Centre of Scientific and Technical Information","ror":"https://ror.org/054ys1f07","country_code":"SK","type":"archive","lineage":["https://openalex.org/I4210156920"]},{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Jaroslav Budis","raw_affiliation_strings":["Comenius University Science Park, Bratislava, Slovakia","Geneton Ltd., Bratislava, Slovakia","Slovak Centre of Scientific and Technical Information, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comenius University Science Park, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Geneton Ltd., Bratislava, Slovakia","institution_ids":["https://openalex.org/I4210155685"]},{"raw_affiliation_string":"Slovak Centre of Scientific and Technical Information, Bratislava, Slovakia","institution_ids":["https://openalex.org/I4210156920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033401747","display_name":"Michaela H\u00fdblov\u00e1","orcid":"https://orcid.org/0000-0001-6519-4967","observed_orcids":["https://orcid.org/0000-0001-6519-4967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michaela Hyblova","raw_affiliation_strings":["Trisomy test Ltd., Nitra, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trisomy test Ltd., Nitra, Slovakia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027044409","display_name":"Martina Sekelsk\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martina Sekelska","raw_affiliation_strings":["Trisomy test Ltd., Nitra, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trisomy test Ltd., Nitra, Slovakia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047470120","display_name":"Andrej Gnip","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrej Gnip","raw_affiliation_strings":["Medirex Inc., Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medirex Inc., Bratislava, Slovakia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065094477","display_name":"Gabriel Min\u00e1rik","orcid":"https://orcid.org/0000-0001-9399-2202","observed_orcids":["https://orcid.org/0000-0001-9399-2202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Minarik","raw_affiliation_strings":["Trisomy test Ltd., Nitra, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trisomy test Ltd., Nitra, Slovakia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085593232","display_name":"Tom\u00e1\u0161 Szemes","orcid":"https://orcid.org/0000-0002-0900-2534","observed_orcids":["https://orcid.org/0000-0002-0900-2534"]},"institutions":[{"id":"https://openalex.org/I4210155685","display_name":"Geneton (Slovakia)","ror":"https://ror.org/051nezy81","country_code":"SK","type":"company","lineage":["https://openalex.org/I4210155685"]},{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Tomas Szemes","raw_affiliation_strings":["Comenius University Science Park, Bratislava, Slovakia","Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","Geneton Ltd., Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comenius University Science Park, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Geneton Ltd., Bratislava, Slovakia","institution_ids":["https://openalex.org/I4210155685"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5047760740"],"corresponding_institution_ids":["https://openalex.org/I4210155685","https://openalex.org/I4210156920","https://openalex.org/I74788687"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":9.1752,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.98622765,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"19","issue":"3","first_page":"e0280858","last_page":"e0280858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-invasive-prenatal-testing","display_name":"non-invasive prenatal testing","score":0.996999979019165},{"id":"https://openalex.org/keywords/fetal-fraction","display_name":"fetal fraction","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.8970000147819519},{"id":"https://openalex.org/keywords/maternal-bmi","display_name":"maternal body mass index","score":0.996999979019165},{"id":"https://openalex.org/keywords/maternal-age","display_name":"maternal age","score":1.0},{"id":"https://openalex.org/keywords/cell-free-fetal-dna","display_name":"cell-free fetal DNA","score":0.8939999938011169},{"id":"https://openalex.org/keywords/repeated-testing","display_name":"retesting","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.7893319129943848},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.7458274364471436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6782534718513489},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6192882657051086},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6005574464797974},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5852985978126526},{"id":"https://openalex.org/C2779543058","wikidata":"https://www.wikidata.org/wiki/Q4200712","display_name":"Mass index","level":3,"score":0.5342677235603333},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.5258886218070984},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.49067485332489014},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.4630261957645416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1909390389919281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17925411462783813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11688736081123352}],"mesh":[{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008423","descriptor_name":"Maternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0280858","doi":"https://doi.org/10.1371/journal.pone.0280858","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0280858","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280858&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10919614","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10919614","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10919614/pdf/pone.0280858.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:38452118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38452118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pone00:0280858","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0280858","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4534c0d8a6454f4e93479f59541e5fb6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4534c0d8a6454f4e93479f59541e5fb6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 19, Iss 3, p e0280858 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0280858","doi":"https://doi.org/10.1371/journal.pone.0280858","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0280858","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280858&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2585677828","display_name":null,"funder_award_id":"872539","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G2628364946","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3112476385","display_name":null,"funder_award_id":"872539","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3345895242","display_name":null,"funder_award_id":"H2020-MSCA","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G3349476386","display_name":null,"funder_award_id":"H2020\u2010EU 1.3.3.","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G3477743816","display_name":null,"funder_award_id":"H2020-MSCA-RISE","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G4722531451","display_name":null,"funder_award_id":"313021BUZ3","funder_id":"https://openalex.org/F4320309919","funder_display_name":"Univerzita Komensk\u00e9ho v Bratislave"},{"id":"https://openalex.org/G8261127928","display_name":null,"funder_award_id":"313021BUZ3","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G8367957132","display_name":null,"funder_award_id":"MSCA-RISE-2019","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320309919","display_name":"Univerzita Komensk\u00e9ho v Bratislave","ror":"https://ror.org/0587ef340"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392545009.pdf","grobid_xml":"https://content.openalex.org/works/W4392545009.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W906205929","https://openalex.org/W1541410667","https://openalex.org/W1576120545","https://openalex.org/W1586519278","https://openalex.org/W1607914109","https://openalex.org/W1720911209","https://openalex.org/W2024834116","https://openalex.org/W2079300331","https://openalex.org/W2101234009","https://openalex.org/W2108641027","https://openalex.org/W2141302105","https://openalex.org/W2160764289","https://openalex.org/W2164298293","https://openalex.org/W2172268977","https://openalex.org/W2223596472","https://openalex.org/W2300163370","https://openalex.org/W2302258004","https://openalex.org/W2615781508","https://openalex.org/W2783273738","https://openalex.org/W2790430292","https://openalex.org/W2799535776","https://openalex.org/W2800628885","https://openalex.org/W2830235738","https://openalex.org/W2892638737","https://openalex.org/W2938400795","https://openalex.org/W2944944369","https://openalex.org/W2952654997","https://openalex.org/W2959237300","https://openalex.org/W2993338355","https://openalex.org/W2994723767","https://openalex.org/W2998066660","https://openalex.org/W3015202224","https://openalex.org/W3163063378","https://openalex.org/W4307112834","https://openalex.org/W4311576340"],"related_works":["https://openalex.org/W2993338355","https://openalex.org/W2830235738","https://openalex.org/W3126193156","https://openalex.org/W2892638737","https://openalex.org/W4364376447","https://openalex.org/W4394762688","https://openalex.org/W4307112834","https://openalex.org/W3163063378","https://openalex.org/W2557984335","https://openalex.org/W4387399983"],"abstract_inverted_index":{"The":[0],"discovery":[1],"of":[2,25,28,37,57,73,113,145,152,162],"cell-free":[3],"fetal":[4,38,70],"DNA":[5,44],"fragments":[6,39],"in":[7,16,40],"the":[8,26,31,41,49,55,69,74,107,110,114,117,120,123,127,139,143,153,156,160],"maternal":[9,60,66,135],"plasma":[10],"initiated":[11],"a":[12,34,85,97],"novel":[13],"testing":[14,99],"method":[15],"prenatal":[17,21],"care,":[18],"called":[19],"non-invasive":[20],"screening":[22],"(NIPS).":[23],"One":[24],"limitations":[27],"NIPS":[29,91],"is":[30,51],"necessity":[32],"for":[33],"sufficient":[35],"proportion":[36],"analyzed":[42,78],"circulating":[43],"mixture":[45],"(fetal":[46],"fraction),":[47],"otherwise,":[48],"sample":[50],"uninterpretable.":[52],"We":[53,76,105],"present":[54],"effect":[56],"gestational":[58,124],"age,":[59],"body":[61],"mass":[62],"index":[63],"(BMI),":[64],"and":[65,122,141],"age":[67,125],"on":[68,177],"fraction":[71],"(FF)":[72],"sample.":[75],"retrospectively":[77],"data":[79],"from":[80,92,165],"5543":[81],"pregnant":[82],"women":[83],"with":[84],"single":[86],"male":[87],"fetus":[88],"who":[89],"underwent":[90],"which":[93],"189":[94],"samples":[95,115],"received":[96],"repeat":[98],"due":[100],"to":[101,175,179],"an":[102,146],"insufficient":[103],"FF.":[104],"showed":[106],"relationship":[108],"between":[109],"failure":[111],"rate":[112],"after":[116],"repeated":[118,166],"analysis,":[119],"FF,":[121],"at":[126],"first":[128],"sampling.":[129],"Next,":[130],"we":[131,171],"found":[132],"that":[133],"different":[134],"BMI":[136],"categories":[137],"affect":[138],"FF":[140,157],"thus":[142],"chance":[144],"informative":[147],"redraw.":[148],"A":[149],"better":[150],"understanding":[151],"factors":[154],"affecting":[155],"will":[158],"reduce":[159],"number":[161],"non-informative":[163,181],"calls":[164],"analyzes.":[167],"In":[168],"this":[169],"study,":[170],"provide":[172],"helpful":[173],"information":[174],"clinicians":[176],"how":[178],"approach":[180],"analyses.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-03-08T00:00:00"}