{"id":"https://openalex.org/W4392520344","doi":"https://doi.org/10.1155/2024/1386980","title":"Pharmacokinetics, Safety, and Tolerability of Tenapanor in Healthy Chinese and Caucasian Volunteers: A Randomized, Open-Label, Single-Center, Placebo-Controlled Phase 1 Study","display_name":"Pharmacokinetics, Safety, and Tolerability of Tenapanor in Healthy Chinese and Caucasian Volunteers: A Randomized, Open-Label, Single-Center, Placebo-Controlled Phase 1 Study","publication_year":2024,"publication_date":"2024-03-06","ids":{"openalex":"https://openalex.org/W4392520344","doi":"https://doi.org/10.1155/2024/1386980","pmid":"https://pubmed.ncbi.nlm.nih.gov/38481823","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10937073"},"language":"en","primary_location":{"id":"doi:10.1155/2024/1386980","doi":"https://doi.org/10.1155/2024/1386980","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2024/1386980","pdf_url":"https://downloads.hindawi.com/journals/ijclp/2024/1386980.pdf","source":{"id":"https://openalex.org/S22344484","display_name":"International Journal of Clinical Practice","issn_l":"1368-5031","issn":["1368-5031","1742-1241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/ijclp/2024/1386980.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066153198","display_name":"Gang Yuan","orcid":"https://orcid.org/0000-0001-7715-8787","observed_orcids":["https://orcid.org/0000-0001-7715-8787"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Yuan","raw_affiliation_strings":["The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0001-7715-8787","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000972933","display_name":"Yili Chen","orcid":"https://orcid.org/0000-0001-8455-9378","observed_orcids":["https://orcid.org/0000-0001-8455-9378"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yili Chen","raw_affiliation_strings":["The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0001-8455-9378","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361139","display_name":"Li Li","orcid":"https://orcid.org/0000-0002-3203-901X","observed_orcids":["https://orcid.org/0000-0002-3203-901X"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":["The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0002-3203-901X","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xin Wang","orcid":"https://orcid.org/0009-0009-9515-3897","observed_orcids":["https://orcid.org/0009-0009-9515-3897"]},"institutions":[{"id":"https://openalex.org/I4210104190","display_name":"Fosun Pharma (China)","ror":"https://ror.org/01kk11s67","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210104190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0009-9515-3897","affiliations":[{"raw_affiliation_string":"Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210104190"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gang Wei","orcid":"https://orcid.org/0009-0008-5110-0796","observed_orcids":["https://orcid.org/0009-0008-5110-0796"]},"institutions":[{"id":"https://openalex.org/I4210104190","display_name":"Fosun Pharma (China)","ror":"https://ror.org/01kk11s67","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210104190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Wei","raw_affiliation_strings":["Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0008-5110-0796","affiliations":[{"raw_affiliation_string":"Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210104190"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiawei Zeng","orcid":"https://orcid.org/0000-0002-2998-1645","observed_orcids":["https://orcid.org/0000-0002-2998-1645"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Zeng","raw_affiliation_strings":["The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0002-2998-1645","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026189241","display_name":"Ai\u2010Min Hui","orcid":"https://orcid.org/0000-0002-3688-1570","observed_orcids":["https://orcid.org/0000-0002-3688-1570"]},"institutions":[{"id":"https://openalex.org/I4210104190","display_name":"Fosun Pharma (China)","ror":"https://ror.org/01kk11s67","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210104190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ai-Min Hui","raw_affiliation_strings":["Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-3688-1570","affiliations":[{"raw_affiliation_string":"Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210104190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076101616","display_name":"Yueyun Jiang","orcid":"https://orcid.org/0009-0004-4394-683X","observed_orcids":["https://orcid.org/0009-0004-4394-683X"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueyun Jiang","raw_affiliation_strings":["The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0009-0004-4394-683X","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012257808","display_name":"Han Zhao","orcid":"https://orcid.org/0009-0007-7243-005X","observed_orcids":["https://orcid.org/0009-0007-7243-005X"]},"institutions":[{"id":"https://openalex.org/I4210104190","display_name":"Fosun Pharma (China)","ror":"https://ror.org/01kk11s67","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210104190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Zhao","raw_affiliation_strings":["Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0007-7243-005X","affiliations":[{"raw_affiliation_string":"Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210104190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011739456","display_name":"Lei Diao","orcid":"https://orcid.org/0000-0002-0979-8827","observed_orcids":["https://orcid.org/0000-0002-0979-8827"]},"institutions":[{"id":"https://openalex.org/I4210104190","display_name":"Fosun Pharma (China)","ror":"https://ror.org/01kk11s67","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210104190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Diao","raw_affiliation_strings":["Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-0979-8827","affiliations":[{"raw_affiliation_string":"Global R&D Center, Shanghai Fosun Pharmaceutical Development, Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210104190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084796163","display_name":"Yongchun Zhou","orcid":"https://orcid.org/0009-0000-0671-2162","observed_orcids":["https://orcid.org/0009-0000-0671-2162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongchun Zhou","raw_affiliation_strings":["Wanbang Biopharmaceuticals, Xuzhou, Jiangsu, China"],"raw_orcid":"https://orcid.org/0009-0000-0671-2162","affiliations":[{"raw_affiliation_string":"Wanbang Biopharmaceuticals, Xuzhou, Jiangsu, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356354","display_name":"Ying Xiao","orcid":"https://orcid.org/0000-0002-4223-4943","observed_orcids":["https://orcid.org/0000-0002-4223-4943"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yinglian Xiao","raw_affiliation_strings":["The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0002-4223-4943","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210128921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076035375","display_name":"Minhu Chen","orcid":"https://orcid.org/0000-0003-2421-9966","observed_orcids":["https://orcid.org/0000-0003-2421-9966"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Minhu Chen","raw_affiliation_strings":["The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0003-2421-9966","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210128921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076035375","https://openalex.org/A5100356354"],"corresponding_institution_ids":["https://openalex.org/I4210128921"],"apc_list":{"value":2240,"currency":"USD","value_usd":2240},"apc_paid":{"value":2240,"currency":"USD","value_usd":2240},"fwci":0.5128,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.62057712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.11919999867677689,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenapanor","display_name":"tenapanor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.7710000276565552},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome-with-constipation","display_name":"irritable bowel syndrome with constipation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fluid-overload","display_name":"fluid overload","score":0.7889999747276306},{"id":"https://openalex.org/keywords/single-ascending-dose","display_name":"single ascending dose","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9290884733200073},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7860742211341858},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.7690975069999695},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7418557405471802},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6739649772644043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49094417691230774},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4602777659893036},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4534679353237152},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.4388734996318817},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.36590486764907837},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2024/1386980","doi":"https://doi.org/10.1155/2024/1386980","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2024/1386980","pdf_url":"https://downloads.hindawi.com/journals/ijclp/2024/1386980.pdf","source":{"id":"https://openalex.org/S22344484","display_name":"International Journal of Clinical Practice","issn_l":"1368-5031","issn":["1368-5031","1742-1241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Practice","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10937073","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10937073","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10937073/pdf/IJCLP2024-1386980.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Pract","raw_type":"Text"},{"id":"pmid:38481823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38481823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical practice","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:doaj.org/article:d85dbf56ed6043709878e54acef2fe34","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d85dbf56ed6043709878e54acef2fe34","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Clinical Practice, Vol 2024 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2024/1386980","doi":"https://doi.org/10.1155/2024/1386980","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2024/1386980","pdf_url":"https://downloads.hindawi.com/journals/ijclp/2024/1386980.pdf","source":{"id":"https://openalex.org/S22344484","display_name":"International Journal of Clinical Practice","issn_l":"1368-5031","issn":["1368-5031","1742-1241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392520344.pdf","grobid_xml":"https://content.openalex.org/works/W4392520344.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1967275179","https://openalex.org/W2004494117","https://openalex.org/W2030174339","https://openalex.org/W2046549547","https://openalex.org/W2057791830","https://openalex.org/W2065163505","https://openalex.org/W2103572684","https://openalex.org/W2125575764","https://openalex.org/W2142051176","https://openalex.org/W2351622604","https://openalex.org/W2462905742","https://openalex.org/W2584796864","https://openalex.org/W2603692101","https://openalex.org/W2784781807","https://openalex.org/W2791427360","https://openalex.org/W2810404796","https://openalex.org/W2884699902","https://openalex.org/W2922107684","https://openalex.org/W2951533026","https://openalex.org/W2983471658","https://openalex.org/W3005957464","https://openalex.org/W3010153256","https://openalex.org/W3016136018","https://openalex.org/W3136674758","https://openalex.org/W3216968006","https://openalex.org/W4211140718","https://openalex.org/W4237871677","https://openalex.org/W4387574287"],"related_works":["https://openalex.org/W2784781807","https://openalex.org/W2462905742","https://openalex.org/W4389884928","https://openalex.org/W2603692101","https://openalex.org/W6958610382","https://openalex.org/W6958519976","https://openalex.org/W4403831382","https://openalex.org/W4316086896","https://openalex.org/W7169720475","https://openalex.org/W2606254265"],"abstract_inverted_index":{"Background.":[0],"Tenapanor":[1,270,316],"is":[2,332],"a":[3,119,124,134,146],"locally":[4],"acting":[5],"selective":[6],"sodium-hydrogen":[7],"exchanger":[8],"3":[9,185],"inhibitor":[10],"with":[11,133,230,319,334],"the":[12,34,49,138,200,220,265,275,281],"potential":[13],"to":[14,101,131,214,246,259,312],"treat":[15],"sodium/phosphorus":[16],"and":[17,41,51,60,76,104,190,225,234,255,267,274,283,296,301,322,327],"fluid":[18],"overload":[19],"in":[20,33,57,137,145,207,253],"various":[21],"cardiac-renal":[22],"diseases,":[23],"which":[24],"has":[25],"been":[26],"approved":[27],"for":[28,86,91],"constipation-predominant":[29],"irritable":[30],"bowel":[31],"syndrome":[32],"US.":[35],"The":[36,240],"pharmacokinetics":[37],"(PK)":[38],"of":[39,53,202,217,227],"tenapanor":[40,107,156,194,287],"its":[42],"metabolite":[43],"tenapanor-M1":[44,204,228,260],"(AZ13792925),":[45],"as":[46,48,112,118,290],"well":[47],"safety":[50,276,323],"tolerability":[52],"tenapanor,":[54],"were":[55,99,197],"investigated":[56],"healthy":[58,78,153],"Chinese":[59,75,87,218,254,266,282,326],"Caucasian":[61,77,92,256,268,284,328],"subjects.":[62,257,269,329],"Methods.":[63],"This":[64,330],"randomized,":[65],"open-label,":[66],"single-center,":[67],"placebo-controlled":[68],"phase":[69],"1":[70,89,149],"study":[71],"(https://www.chinadrugtrials.org.cn;":[72],"CTR20201783)":[73],"enrolled":[74],"volunteers":[79,154],"into":[80],"4":[81,147],"parallel":[82],"cohorts":[83,85],"(3":[84],"subjects,":[88,219],"cohort":[90],"subjects).":[93],"In":[94,209],"each":[95],"cohort,":[96],"15":[97],"subjects":[98],"expected":[100],"be":[102],"included":[103],"received":[105,155],"oral":[106],"(10":[108,213],"or":[109,115,143,169,180,308],"30":[110,163],"mg":[111,117,158,164,171,250],"single":[113,120,135,189],"dose,":[114],"50":[116,170,215,249,288],"dose":[121,127,136,211,232,238,252],"followed":[122],"by":[123,292],"twice-daily":[125,191],"repeated":[126,192,251],"from":[128],"Day":[129,141],"5":[130],"11,":[132],"morning":[139],"on":[140],"11)":[142],"placebo":[144,181],":":[148],"ratio.":[150],"Results.":[151],"59":[152],"10":[157],"(n":[159,165,172,182],"=":[160,166,173,177,183],"12":[161,167,174],"Chinese),":[162,168],"(Chinese),":[175],"n":[176],"11":[178],"(Caucasian))":[179],"12,":[184],"per":[186],"cohort).":[187],"After":[188],"doses,":[193],"plasma":[195],"concentrations":[196],"all":[198],"below":[199],"limit":[201],"quantitation;":[203],"appeared":[205],"slowly":[206],"plasma.":[208],"single-ascending":[210],"evaluation":[212],"mg)":[216],"mean":[221],"Cmax":[222,241],",":[223],"AUC0-t,":[224],"AUC0-\u221e":[226],"increased":[229,236],"increasing":[231],"level,":[233],"AUC0-t":[235],"approximately":[237],"proportionally.":[239],"accumulation":[242],"ratio":[243],"was":[244,261,271,278,317],"1.55":[245],"6.92":[247],"after":[248],"Exposure":[258],"generally":[262,272],"similar":[263,279,320],"between":[264,280,325],"well-tolerated":[273],"profile":[277],"participants":[285],"receiving":[286],"mg,":[289],"measured":[291],"vital":[293],"signs,":[294],"physical":[295],"laboratory":[297],"examination,":[298],"12-lead":[299],"ECG,":[300],"adverse":[302,306,309],"events.":[303],"No":[304],"serious":[305],"event":[307,310],"leading":[311],"withdrawal":[313],"occurred.":[314],"Conclusion.":[315],"well-tolerated,":[318],"PK":[321],"profiles":[324],"trial":[331],"registered":[333],"CTR20201783.":[335]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-07T00:00:00"}
