{"id":"https://openalex.org/W4392510340","doi":"https://doi.org/10.1007/s10557-024-07567-z","title":"Evinacumab Reduces Triglyceride-Rich Lipoproteins in Patients with Hyperlipidemia: A Post-Hoc Analysis of Three Randomized Clinical Trials","display_name":"Evinacumab Reduces Triglyceride-Rich Lipoproteins in Patients with Hyperlipidemia: A Post-Hoc Analysis of Three Randomized Clinical Trials","publication_year":2024,"publication_date":"2024-03-06","ids":{"openalex":"https://openalex.org/W4392510340","doi":"https://doi.org/10.1007/s10557-024-07567-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/38446275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12297002"},"language":"en","primary_location":{"id":"doi:10.1007/s10557-024-07567-z","doi":"https://doi.org/10.1007/s10557-024-07567-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10557-024-07567-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10557-024-07567-z.pdf","source":{"id":"https://openalex.org/S131791641","display_name":"Cardiovascular Drugs and Therapy","issn_l":"0920-3206","issn":["0920-3206","1573-7241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drugs and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10557-024-07567-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060465607","display_name":"Robert S. Rosenson","orcid":"https://orcid.org/0000-0002-5599-0633","observed_orcids":["https://orcid.org/0000-0002-5599-0633"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert S. Rosenson","raw_affiliation_strings":["Metabolism and Lipids Unit, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA. robert.rosenson@mssm.edu","Metabolism and Lipids Unit, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA"],"raw_orcid":"https://orcid.org/0000-0002-5599-0633","affiliations":[{"raw_affiliation_string":"Metabolism and Lipids Unit, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA. robert.rosenson@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Metabolism and Lipids Unit, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067149045","display_name":"Daniel James Rader","orcid":"https://orcid.org/0000-0002-9245-9876","observed_orcids":["https://orcid.org/0000-0002-9245-9876"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Rader","raw_affiliation_strings":["Department of Genetics and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010266741","display_name":"Shazia Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shazia Ali","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York, NY, 10591, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York, NY, 10591, USA","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077276053","display_name":"Poulabi Banerjee","orcid":"https://orcid.org/0000-0001-5304-9543","observed_orcids":["https://orcid.org/0000-0001-5304-9543"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Poulabi Banerjee","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York, NY, 10591, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York, NY, 10591, USA","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059427880","display_name":"Jennifer McGinniss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer McGinniss","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York, NY, 10591, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York, NY, 10591, USA","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042842097","display_name":"Robert C. Pordy","orcid":"https://orcid.org/0000-0002-8001-6795","observed_orcids":["https://orcid.org/0000-0002-8001-6795"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Pordy","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York, NY, 10591, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York, NY, 10591, USA","institution_ids":["https://openalex.org/I186523950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060465607"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":5.4413,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.96555221,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"39","issue":"4","first_page":"925","last_page":"931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evinacumab","display_name":"evinacumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triglyceride-rich-lipoproteins","display_name":"triglyceride-rich lipoproteins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.8730000257492065},{"id":"https://openalex.org/keywords/homozygous-familial-hypercholesterolemia","display_name":"homozygous familial hypercholesterolemia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.4740000069141388},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/pcsk9-inhibition","display_name":"PCSK9 inhibition","score":0.6029999852180481},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.6589999794960022},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8980834484100342},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.8457209467887878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7083772420883179},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.6314478516578674},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.6148096323013306},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5982505083084106},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5434207916259766},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5218509435653687},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.516293466091156},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4663003981113434},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.4524496793746948},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.4389979839324951},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.426433801651001},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.424039751291275},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.41773372888565063},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.401866614818573},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1414133608341217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07392808794975281},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05915111303329468},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10557-024-07567-z","doi":"https://doi.org/10.1007/s10557-024-07567-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10557-024-07567-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10557-024-07567-z.pdf","source":{"id":"https://openalex.org/S131791641","display_name":"Cardiovascular Drugs and Therapy","issn_l":"0920-3206","issn":["0920-3206","1573-7241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drugs and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12297002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12297002","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12297002/pdf/10557_2024_Article_7567.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Drugs Ther","raw_type":"Text"},{"id":"pmid:38446275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38446275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular drugs and therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s10557-024-07567-z","doi":"https://doi.org/10.1007/s10557-024-07567-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10557-024-07567-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10557-024-07567-z.pdf","source":{"id":"https://openalex.org/S131791641","display_name":"Cardiovascular Drugs and Therapy","issn_l":"0920-3206","issn":["0920-3206","1573-7241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drugs and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392510340.pdf","grobid_xml":"https://content.openalex.org/works/W4392510340.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2048070048","https://openalex.org/W2079979713","https://openalex.org/W2234444148","https://openalex.org/W2279177089","https://openalex.org/W2609543937","https://openalex.org/W2899669642","https://openalex.org/W3011963422","https://openalex.org/W3041635484","https://openalex.org/W3061843793","https://openalex.org/W3098138308","https://openalex.org/W3103257019","https://openalex.org/W3107163014","https://openalex.org/W3121122589","https://openalex.org/W3134769826","https://openalex.org/W3135251972","https://openalex.org/W3155398643","https://openalex.org/W3210587009","https://openalex.org/W3213057406","https://openalex.org/W4293253252","https://openalex.org/W4308367139","https://openalex.org/W4313327127","https://openalex.org/W4323320185","https://openalex.org/W4382011883"],"related_works":["https://openalex.org/W3216308079","https://openalex.org/W4396691569","https://openalex.org/W4293776324","https://openalex.org/W2955013370","https://openalex.org/W4323320185","https://openalex.org/W3061843793","https://openalex.org/W7141431523","https://openalex.org/W4366235033","https://openalex.org/W3171415262","https://openalex.org/W7164205382"],"abstract_inverted_index":{"PURPOSE:":[0],"Natural":[1],"selection":[2],"(Mendelian":[3],"randomization)":[4],"studies":[5,197],"support":[6],"a":[7,59,89,107,245],"causal":[8],"relationship":[9],"between":[10,234],"elevated":[11],"triglyceride-rich":[12],"lipoproteins":[13],"(TRLs)":[14],"and":[15,48,152,168],"atherosclerotic":[16],"cardiovascular":[17],"disease":[18],"(ASCVD).":[19],"This":[20],"post-hoc":[21],"analysis":[22],"assessed":[23],"the":[24,184,208],"efficacy":[25],"of":[26],"evinacumab":[27,115,223],"in":[28,31,58,88,106,140,191,212,231],"reducing":[29],"TRLs":[30,141,192],"patient":[32],"cohorts":[33],"from":[34,156,204],"three":[35,221],"separate":[36],"clinical":[37],"trials":[38],"with":[39,43,67,70,81,96,180,198,200,214],"evinacumab.":[40],"METHODS:":[41],"Patients":[42,65,95,113],"homozygous":[44],"familial":[45],"hypercholesterolemia":[46],"(HoFH)":[47],"low-density":[49],"lipoprotein":[50,148],"cholesterol":[51,145,149],"(LDL-C)":[52],"\u2265":[53,72,76,101],"70":[54,73],"mg/dL":[55,74,78],"were":[56,86,104,176,193],"enrolled":[57,87,105],"phase":[60,90,108],"III":[61],"trial":[62,92,110,165,186],"(R1500-CL-1629;":[63],"NCT03399786).":[64],"diagnosed":[66],"refractory":[68,217],"hypercholesterolemia,":[69],"LDL-C":[71],"or":[75,82,118,124,127,132,161,216],"100":[77],"for":[79,164,178,248],"those":[80],"without":[83],"ASCVD,":[84],"respectively,":[85],"II":[91,109],"(R1500-CL-1643;":[93],"NCT03175367).":[94],"severe":[97,181],"hypertriglyceridemia":[98,182],"(fasting":[99],"TGs":[100],"500":[102],"mg/dL)":[103],"(R1500-HTG-1522;":[111],"NCT03452228).":[112],"received":[114],"intravenously":[116],"(5":[117],"15":[119],"mg/kg)":[120],"every":[121,130,133],"4":[122],"weeks,":[123],"subcutaneously":[125],"(300":[126],"450":[128],"mg)":[129],"week":[131],"2":[134],"weeks.":[135],"Efficacy":[136],"outcomes":[137],"included":[138],"change":[139],"(calculated":[142],"as":[143],"total":[144],"minus":[146,150],"high-density":[147],"LDL-C)":[151],"other":[153,188],"lipid":[154],"parameters":[155],"baseline":[157,205],"to":[158],"12,":[159],"16,":[160],"24":[162],"weeks":[163],"1522,":[166],"1643,":[167],"1629,":[169],"respectively.":[170],"RESULTS:":[171],"At":[172],"baseline,":[173],"TRL":[174,241],"levels":[175,242],"higher":[177],"patients":[179,213],"entering":[183],"1522":[185],"vs.":[187],"cohorts.":[189],"Reductions":[190],"observed":[194,206],"across":[195],"all":[196,220],"evinacumab,":[199],">":[201],"50%":[202],"reduction":[203],"at":[207],"highest":[209],"doses":[210],"evaluated":[211],"HoFH":[215],"hypercholesterolemia.":[218],"Within":[219],"trials,":[222],"was":[224],"generally":[225],"well":[226],"tolerated.":[227],"CONCLUSIONS:":[228],"Despite":[229],"limitations":[230],"direct":[232],"comparisons":[233],"study":[235],"groups,":[236],"these":[237],"data":[238],"indicate":[239],"that":[240],"could":[243],"be":[244],"future":[246],"target":[247],"lipid-lowering":[249],"therapies.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-07T00:00:00"}