{"id":"https://openalex.org/W4392503581","doi":"https://doi.org/10.1101/2024.03.05.24303808","title":"Voxel-wise hemispheric Amyloid Asymmetry and its association with cerebral metabolism and grey matter density in cognitively normal older adults","display_name":"Voxel-wise hemispheric Amyloid Asymmetry and its association with cerebral metabolism and grey matter density in cognitively normal older adults","publication_year":2024,"publication_date":"2024-03-06","ids":{"openalex":"https://openalex.org/W4392503581","doi":"https://doi.org/10.1101/2024.03.05.24303808","pmid":"https://pubmed.ncbi.nlm.nih.gov/38496561","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10942537"},"language":"en","primary_location":{"id":"doi:10.1101/2024.03.05.24303808","doi":"https://doi.org/10.1101/2024.03.05.24303808","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.03.05.24303808","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/03/06/2024.03.05.24303808.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2024/03/06/2024.03.05.24303808.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094079336","display_name":"Hunsica J. Jayaprakash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210086114","display_name":"Center for the Neural Basis of Cognition","ror":"https://ror.org/00jfeg660","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210086114","https://openalex.org/I74973139"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hunsica J. Jayaprakash","raw_affiliation_strings":["Center for Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh","Department of Bioengineering, University of Pittsburgh","Department of Computer Science, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210086114","https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Computer Science, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027487816","display_name":"Akiko N. Mizuno","orcid":"https://orcid.org/0000-0001-5671-8044","observed_orcids":["https://orcid.org/0000-0001-5671-8044"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akiko Mizuno","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053071315","display_name":"Beth Ellen Snitz","orcid":"https://orcid.org/0000-0002-9978-1374","observed_orcids":["https://orcid.org/0000-0002-9978-1374"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth E. Snitz","raw_affiliation_strings":["Department of Neurology, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024995302","display_name":"Ann D. Cohen","orcid":"https://orcid.org/0000-0001-7395-9624","observed_orcids":["https://orcid.org/0000-0001-7395-9624"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann D. Cohen","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105724938","display_name":"Willian E. Klunk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Willian E. Klunk","raw_affiliation_strings":["Department of Neurology, University of Pittsburgh","Department of Psychiatry, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056508217","display_name":"Howard Jay Aizenstein","orcid":"https://orcid.org/0000-0003-4897-6582","observed_orcids":["https://orcid.org/0000-0003-4897-6582"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard J. Aizenstein","raw_affiliation_strings":["Department of Bioengineering, University of Pittsburgh","Department of Psychiatry, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002115637","display_name":"Helmet Talib Karim","orcid":"https://orcid.org/0000-0002-9286-0694","observed_orcids":["https://orcid.org/0000-0002-9286-0694"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Helmet T. Karim","raw_affiliation_strings":["Department of Bioengineering, University of Pittsburgh","Department of Psychiatry, University of Pittsburgh"],"raw_orcid":"https://orcid.org/0000-0002-9286-0694","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002115637"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12621","display_name":"Hemispheric Asymmetry in Neuroscience","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemispheric-asymmetry","display_name":"hemispheric lateralization","score":0.921999990940094},{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cerebral-glucose-metabolism","display_name":"brain glucose metabolism","score":0.9750000238418579},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.6460000276565552},{"id":"https://openalex.org/keywords/pittsburgh-compound-b-pet","display_name":"Pittsburgh compound B PET","score":0.847000002861023},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cognitively-normal-older-adults","display_name":"cognitively normal older adults","score":0.906000018119812},{"id":"https://openalex.org/keywords/superior-frontal-gyrus","display_name":"superior frontal gyrus","score":0.8069999814033508},{"id":"https://openalex.org/keywords/visuospatial-processing","display_name":"visuospatial processing","score":0.9750000238418579},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.6039999723434448},{"id":"https://openalex.org/keywords/parahippocampal-gyrus","display_name":"parahippocampal gyrus","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.6610357761383057},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5378038287162781},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5216027498245239},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.5064691305160522},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5059117674827576},{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.49350225925445557},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.4791354835033417},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.47035837173461914},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.46614471077919006},{"id":"https://openalex.org/C2779369059","wikidata":"https://www.wikidata.org/wiki/Q1758383","display_name":"Gyrus","level":2,"score":0.4605812728404999},{"id":"https://openalex.org/C2775956885","wikidata":"https://www.wikidata.org/wiki/Q3064113","display_name":"Superior frontal gyrus","level":3,"score":0.44057267904281616},{"id":"https://openalex.org/C2993858690","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal cortex","level":2,"score":0.43729519844055176},{"id":"https://openalex.org/C2780621315","wikidata":"https://www.wikidata.org/wiki/Q5407200","display_name":"Middle temporal gyrus","level":3,"score":0.41948214173316956},{"id":"https://openalex.org/C200134340","wikidata":"https://www.wikidata.org/wiki/Q845664","display_name":"Voxel-based morphometry","level":4,"score":0.4167087972164154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36862897872924805},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.35709095001220703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30407196283340454},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.2919953763484955},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.19885560870170593},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.14608237147331238},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.11470633745193481},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.098094642162323}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2024.03.05.24303808","doi":"https://doi.org/10.1101/2024.03.05.24303808","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.03.05.24303808","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/03/06/2024.03.05.24303808.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:38496561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38496561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Preprint"},{"id":"pmh:oai:pubmedcentral.nih.gov:10942537","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10942537","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10942537/pdf/nihpp-2024.03.05.24303808v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2024.03.05.24303808","doi":"https://doi.org/10.1101/2024.03.05.24303808","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.03.05.24303808","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/03/06/2024.03.05.24303808.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2112592252","display_name":"The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer's Disease","funder_award_id":"P01AG025204","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3080460668","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005133","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8347152028","display_name":"AMYLOID PATHOLOGY AND COGNITION IN NORMAL ELDERLY","funder_award_id":"R37AG025516","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000919303","display_name":"Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology","funder_award_id":"R01AG025516","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392503581.pdf","grobid_xml":"https://content.openalex.org/works/W4392503581.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1528119265","https://openalex.org/W1549082171","https://openalex.org/W1962852742","https://openalex.org/W1967823816","https://openalex.org/W1993571512","https://openalex.org/W1995091318","https://openalex.org/W2000555003","https://openalex.org/W2019671076","https://openalex.org/W2026307872","https://openalex.org/W2061195971","https://openalex.org/W2064963539","https://openalex.org/W2067442759","https://openalex.org/W2105306137","https://openalex.org/W2125887218","https://openalex.org/W2138790588","https://openalex.org/W2155298532","https://openalex.org/W2158766477","https://openalex.org/W2404929473","https://openalex.org/W2766125374","https://openalex.org/W2766782573","https://openalex.org/W2973007151","https://openalex.org/W3023992844","https://openalex.org/W3152791046","https://openalex.org/W4220825176","https://openalex.org/W4230920194","https://openalex.org/W4238809637","https://openalex.org/W4293428323","https://openalex.org/W6999336064"],"related_works":["https://openalex.org/W2102961304","https://openalex.org/W6922704885","https://openalex.org/W3169737736","https://openalex.org/W4386161214","https://openalex.org/W4256125232","https://openalex.org/W2080798392","https://openalex.org/W2601722532","https://openalex.org/W7221755320","https://openalex.org/W1973187633","https://openalex.org/W4293428323"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Alzheimer\u2019s":[2],"disease":[3,336],"(AD)":[4],"is":[5],"a":[6,184,342],"neurodegenerative":[7],"disorder":[8],"characterized":[9],"by":[10],"changes":[11,21],"in":[12,22,57,134,149,175,201,244,255,263,296,308,321],"beta":[13],"amyloid":[14],"(A\u00df)":[15],"and":[16,26,41,50,67,76,97,107,114,139,151,178,211,222,239,338],"tau":[17],"as":[18,20,34,341],"well":[19],"cerebral":[23,55,328],"glucose":[24,115,329],"metabolism":[25,56,330],"gray":[27,73,152,179,218,285],"matter":[28,74,153,180,219,286],"volume.":[29,181],"This":[30],"has":[31,317],"been":[32,319],"categorized":[33],"three":[35],"distinct":[36],"stages":[37],"of":[38,224],"amyloid,":[39],"tau,":[40],"neurodegeneration.":[42],"Past":[43],"studies":[44],"have":[45],"shown":[46],"asymmetric":[47,54],"A\u03b2":[48,113,135],"accumulation":[49],"its":[51],"association":[52],"with":[53,72,102,259,281,303],"preclinical":[58],"AD.":[59],"We":[60,80,118,142,161,182,192,289],"analyzed":[61],"data":[62],"to":[63,70,129],"replicate":[64],"these":[65,145,214,225],"findings":[66],"extend":[68],"them":[69],"associations":[71],"volume":[75,154,287],"cognitive":[77,189,310,347],"function.":[78],"Methods":[79],"recruited":[81],"93":[82],"(mean":[83],"age":[84],"=":[85],"76.4\u00b16.1":[86],"years)":[87],"cognitively":[88],"normal":[89],"adults":[90],"who":[91],"underwent":[92],"magnetic":[93],"resonance":[94],"imaging":[95],"(MRI)":[96],"positron":[98],"emission":[99],"tomography":[100],"(PET)":[101],"Pittsburgh":[103],"compound":[104],"B":[105],"(PiB)":[106],"Fluorodeoxyglucose":[108],"(FDG)":[109],"tracers":[110],"(to":[111],"estimate":[112],"metabolism,":[116],"respectively).":[117],"conducted":[119,163],"voxel-wise":[120],"paired":[121,156],"t-test":[122],"on":[123,158,188],"PiB":[124,202,256],"(left":[125],"vs.":[126],"right":[127,140],"hemispheres)":[128],"identify":[130],"regions":[131,146,195,215,226,275],"that":[132,171,196,251,291,327],"differ":[133],"between":[136,165],"the":[137,232,245,297,335],"left":[138],"cortex.":[141],"identified":[143],"whether":[144],"showed":[147,216,227,276],"asymmetry":[148,166,174,200,230,254,262,279,295],"FDG":[150,229,283,294],"using":[155],"t-tests":[157],"each":[159,169],"region.":[160],"then":[162],"correlations":[164],"indices":[167],"for":[168,345],"region":[170],"had":[172,197],"significant":[173,198,217,228,277],"PiB,":[176],"FDG,":[177,264],"ran":[183],"group":[185,312],"regression":[186,313],"analysis":[187],"functions.":[190],"Results":[191],"found":[193,250,290],"26":[194],"rightward":[199,220,253,261,293],"including":[203],"prefrontal":[204],"cortex,":[205,207,235],"temporal":[206,241],"insula,":[208],"parahippocampus,":[209],"caudate,":[210,233],"putamen.":[212],"All":[213],"asymmetry,":[221],"most":[223],"except":[231],"orbital":[234],"medial":[236],"frontal":[237,247,299],"gyrus,":[238,248],"superior":[240,246,298],"gyrus.":[242],"Only":[243],"we":[249],"greater":[252,260,292,304],"was":[257,301],"associated":[258,302],"r":[265],"(82)":[266],"=0.38,":[267],"p":[268],"<0.005":[269],"(FDR":[270],"corrected)":[271],"\u2013":[272],"no":[273],"other":[274],"A\u00df":[278],"correlation":[280],"either":[282],"or":[284],"asymmetry.":[288],"gyrus":[300],"visuospatial":[305],"processing":[306],"scores":[307],"our":[309,324],"domain":[311],"analysis.":[314],"Discussion":[315],"AD":[316],"previously":[318],"modeled":[320],"three-stages:":[322],"however,":[323],"results":[325],"indicate":[326],"may":[331,339],"be":[332],"dynamic":[333],"throughout":[334],"progression":[337],"serve":[340],"compensatory":[343],"pathway":[344],"maintaining":[346],"functioning.":[348]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-07T00:00:00"}
