{"id":"https://openalex.org/W4392455419","doi":"https://doi.org/10.4103/jfmpc.jfmpc_1127_23","title":"APRI as a predictor of severe dengue fever","display_name":"APRI as a predictor of severe dengue fever","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4392455419","doi":"https://doi.org/10.4103/jfmpc.jfmpc_1127_23","pmid":"https://pubmed.ncbi.nlm.nih.gov/38605798","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11006074"},"language":"en","primary_location":{"id":"doi:10.4103/jfmpc.jfmpc_1127_23","doi":"https://doi.org/10.4103/jfmpc.jfmpc_1127_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jfmpc.jfmpc_1127_23","pdf_url":null,"source":{"id":"https://openalex.org/S2764801637","display_name":"Journal of Family Medicine and Primary Care","issn_l":"2249-4863","issn":["2249-4863","2278-7135"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Family Medicine and Primary Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4103/jfmpc.jfmpc_1127_23","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017892669","display_name":"Ajith Kumar Jayachandran","orcid":"https://orcid.org/0000-0003-4282-4086","observed_orcids":["https://orcid.org/0000-0003-4282-4086"]},"institutions":[{"id":"https://openalex.org/I4405262442","display_name":"Travancore medicity medical College hospital","ror":"https://ror.org/03a3kr148","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405262442"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ajith K. Jayachandran","raw_affiliation_strings":["Department of Emergency Medicine, Travancore Medical College, Kollam, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Travancore Medical College, Kollam, Kerala, India","institution_ids":["https://openalex.org/I4405262442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081246838","display_name":"Vincy Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262442","display_name":"Travancore medicity medical College hospital","ror":"https://ror.org/03a3kr148","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405262442"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vincy Nelson","raw_affiliation_strings":["Department of Community Medicine, Travancore Medical College, Kollam, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Medicine, Travancore Medical College, Kollam, Kerala, India","institution_ids":["https://openalex.org/I4405262442"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113783272","display_name":"Kutty Anisha","orcid":"https://orcid.org/0009-0001-3472-5187","observed_orcids":["https://orcid.org/0009-0001-3472-5187"]},"institutions":[{"id":"https://openalex.org/I4405262442","display_name":"Travancore medicity medical College hospital","ror":"https://ror.org/03a3kr148","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405262442"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. Anisha","raw_affiliation_strings":["Department of Emergency Medicine, Travancore Medical College, Kollam, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Travancore Medical College, Kollam, Kerala, India","institution_ids":["https://openalex.org/I4405262442"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017892669"],"corresponding_institution_ids":["https://openalex.org/I4405262442"],"apc_list":{"value":450,"currency":"USD","value_usd":450},"apc_paid":{"value":450,"currency":"USD","value_usd":450},"fwci":1.6442,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.81872551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"2","first_page":"613","last_page":"618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ast-to-platelet-ratio-index","display_name":"AST to platelet ratio index","score":0.9409999847412109},{"id":"https://openalex.org/keywords/severe-dengue","display_name":"severe dengue","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dengue-severity-prediction","display_name":"dengue severity prediction","score":0.9290000200271606},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8740000128746033},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/platelet-transfusion","display_name":"platelet transfusion","score":0.8259999752044678},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.9940000176429749},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.4429999887943268},{"id":"https://openalex.org/keywords/emergency-department","display_name":"emergency department","score":0.4869999885559082},{"id":"https://openalex.org/keywords/resource-allocation","display_name":"resource allocation","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9529932737350464},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.8964605331420898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6778210401535034},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.587963879108429},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.4533859193325043},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4415142834186554},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4258444607257843},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.4153056740760803},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.41220641136169434},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.31126514077186584},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.272885262966156},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/jfmpc.jfmpc_1127_23","doi":"https://doi.org/10.4103/jfmpc.jfmpc_1127_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jfmpc.jfmpc_1127_23","pdf_url":null,"source":{"id":"https://openalex.org/S2764801637","display_name":"Journal of Family Medicine and Primary Care","issn_l":"2249-4863","issn":["2249-4863","2278-7135"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Family Medicine and Primary Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11006074","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11006074","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11006074/pdf/JFMPC-13-613.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Family Med Prim Care","raw_type":"Text"},{"id":"pmid:38605798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38605798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of family medicine and primary care","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:183e7f05f3db4d58b61976782e0e6b88","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/183e7f05f3db4d58b61976782e0e6b88","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Family Medicine and Primary Care, Vol 13, Iss 2, Pp 613-618 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/jfmpc.jfmpc_1127_23","doi":"https://doi.org/10.4103/jfmpc.jfmpc_1127_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jfmpc.jfmpc_1127_23","pdf_url":null,"source":{"id":"https://openalex.org/S2764801637","display_name":"Journal of Family Medicine and Primary Care","issn_l":"2249-4863","issn":["2249-4863","2278-7135"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Family Medicine and Primary Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392455419.pdf","grobid_xml":"https://content.openalex.org/works/W4392455419.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1545732697","https://openalex.org/W1572788004","https://openalex.org/W1832604137","https://openalex.org/W1979882098","https://openalex.org/W2009094928","https://openalex.org/W2009296003","https://openalex.org/W2013644996","https://openalex.org/W2022292268","https://openalex.org/W2028793338","https://openalex.org/W2045258983","https://openalex.org/W2047995211","https://openalex.org/W2048302860","https://openalex.org/W2067193640","https://openalex.org/W2148054109","https://openalex.org/W2213458517","https://openalex.org/W2332161022","https://openalex.org/W2783640759","https://openalex.org/W2791331511","https://openalex.org/W2889297310","https://openalex.org/W2901793909","https://openalex.org/W2939427099","https://openalex.org/W2952094509","https://openalex.org/W2993700551","https://openalex.org/W3014170828","https://openalex.org/W3133408366","https://openalex.org/W3164977837","https://openalex.org/W3198570063","https://openalex.org/W3201684620","https://openalex.org/W3207679345"],"related_works":["https://openalex.org/W3210866709","https://openalex.org/W4399181281","https://openalex.org/W4313249348","https://openalex.org/W2783640759","https://openalex.org/W4396923787","https://openalex.org/W7115948782","https://openalex.org/W2903298102","https://openalex.org/W7220604597","https://openalex.org/W3170544157","https://openalex.org/W6939342923"],"abstract_inverted_index":{"A":[0,103],"BSTRACT":[1],"Introduction:":[2],"The":[3],"AST/platelet":[4],"ratio":[5],"index":[6,239],"(APRI)":[7],"is":[8,33,236],"a":[9,25,80,123,145,150,164,169,183,188,208,237,259,264],"well-researched":[10],"indicator":[11],"of":[12,27,59,67,77,82,90,94,147,152,166,171,185,190,205,212,227,252,261,266,270,278,283],"liver":[13],"fibrosis.":[14],"Some":[15],"studies":[16],"have":[17],"shown":[18],"that":[19,139,240],"APRI":[20,49,78,91,179,204,226,235,250,268],"can":[21,50,241,254],"be":[22,242],"used":[23],"as":[24,79],"predictor":[26,81],"severe":[28,83,199,256],"dengue,":[29],"but":[30],"the":[31,57,64,75,88,113,135,276],"data":[32],"limited.":[34],"As":[35],"dengue":[36,60,257],"epidemics":[37],"are":[38,272],"common":[39],"in":[40,55],"our":[41],"country":[42],"with":[43,92,122,202,258,275],"limited":[44,68],"healthcare":[45,69],"resources,":[46],"we":[47],"believe":[48],"help":[51],"emergency":[52],"physicians/primary":[53],"physicians":[54],"predicting":[56],"severity":[58],"and":[61,97,101,149,168,178,187,247,263,281],"plan":[62],"for":[63],"appropriate":[65],"use":[66],"resources.":[70],"Objective:":[71],"1)":[72],"To":[73,86],"determine":[74,87],"utility":[76],"dengue.":[84,200],"2)":[85],"association":[89],"length":[93,277],"hospital":[95,210,279],"stay":[96,211,280],"platelet":[98,222,248,284],"requirement.":[99],"Materials":[100],"Methods:":[102],"retrospective":[104],"cross-sectional":[105],"study":[106],"was":[107],"done":[108],"on":[109],"patients":[110],"presented":[111],"to":[112,197],"Emergency":[114],"Medicine":[115],"department":[116],"at":[117],"Travancore":[118],"Medicity":[119],"Medical":[120],"College":[121],"positive":[124],"Dengue":[125],"NS1":[126],"antigen":[127],"or":[128],"IgM":[129],"antibody.":[130],"Results:":[131],"We":[132],"found":[133],"from":[134,245],"univariate":[136],"analysis":[137],"results":[138],"ALT":[140],">":[141,160,180,228],"74.5":[142],"IU/L":[143,162],"has":[144,163,182],"sensitivity":[146,165,184,260],"59.6":[148],"specificity":[151,170,189,265],"76.3":[153],"(AUC:":[154,173,192],"0.696;":[155],"95%":[156,175,194],"CI:":[157,176,195],"0.606\u20130.786),":[158],"AST":[159,246],"160.5":[161],"42.3":[167],"93.7":[172],"0.747;":[174],"0.665\u20130.829),":[177],"3.2":[181,229],"69.2":[186,262],"84.2":[191],"0.806;":[193],"0.72\u20130.884)":[196],"predict":[198,255],"Patients":[201],"an":[203,225],">3.2":[206,253,271],"required":[207],"mean":[209],"5.47":[213],"days":[214],"(":[215,230],"P":[216,231],"=":[217,232],"0.005);":[218],"27":[219],"(81.8%)":[220],"requiring":[221],"transfusion":[223],"had":[224],"0.00).":[233],"Conclusion:":[234],"straightforward":[238],"easily":[243],"derived":[244],"values.":[249],"values":[251,269],"84.2.":[267],"also":[273],"associated":[274],"requirement":[282],"transfusion.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-06T00:00:00"}