{"id":"https://openalex.org/W4392454777","doi":"https://doi.org/10.1167/iovs.65.3.2","title":"Unraveling the Intraday Variations in the Tear Fluid Proteome","display_name":"Unraveling the Intraday Variations in the Tear Fluid Proteome","publication_year":2024,"publication_date":"2024-03-05","ids":{"openalex":"https://openalex.org/W4392454777","doi":"https://doi.org/10.1167/iovs.65.3.2","pmid":"https://pubmed.ncbi.nlm.nih.gov/38441890","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10916888"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.65.3.2","doi":"https://doi.org/10.1167/iovs.65.3.2","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.65.3.2","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938668/i1552-5783-65-3-2_1709630042.20647.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938668/i1552-5783-65-3-2_1709630042.20647.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046546646","display_name":"Garrett Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett Jones","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110262896","display_name":"Jeremy Altman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Altman","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036128230","display_name":"Saleh Ahmed","orcid":"https://orcid.org/0009-0000-8271-5234","observed_orcids":["https://orcid.org/0009-0000-8271-5234"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saleh Ahmed","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tae Jin Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae Jin Lee","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054056899","display_name":"Wenbo Zhi","orcid":"https://orcid.org/0000-0002-7720-7048","observed_orcids":["https://orcid.org/0000-0002-7720-7048"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenbo Zhi","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049498138","display_name":"Shruti Sharma","orcid":"https://orcid.org/0000-0001-8200-108X","observed_orcids":["https://orcid.org/0000-0001-8200-108X"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruti Sharma","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States","Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002893934","display_name":"Ashok Kumar Sharma","orcid":"https://orcid.org/0000-0001-9597-4374","observed_orcids":["https://orcid.org/0000-0001-9597-4374"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashok Sharma","raw_affiliation_strings":["Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States","Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, United States","Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002893934"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":1.4924,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.79821732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"65","issue":"3","first_page":"2","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.259799987077713,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tear-biomarkers","display_name":"tear biomarkers","score":0.7519999742507935},{"id":"https://openalex.org/keywords/lactoferrin","display_name":"lactoferrin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lipocalin-1","display_name":"lipocalin-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.9520000219345093},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.42500001192092896},{"id":"https://openalex.org/keywords/ocular-homeostasis","display_name":"ocular homeostasis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/technical-variation","display_name":"technical variability","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.8930873274803162},{"id":"https://openalex.org/C2778275304","wikidata":"https://www.wikidata.org/wiki/Q76469","display_name":"Tears","level":2,"score":0.6295055150985718},{"id":"https://openalex.org/C3020728648","wikidata":"https://www.wikidata.org/wiki/Q1058795","display_name":"Biological fluids","level":2,"score":0.5439825057983398},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49831676483154297},{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.45224910974502563},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4370507001876831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39084362983703613},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3689517378807068},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32195425033569336},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20011994242668152},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1987285017967224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12870341539382935},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078331","descriptor_name":"Correlation of Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018753","descriptor_name":"Diet, Protein-Restricted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1167/iovs.65.3.2","doi":"https://doi.org/10.1167/iovs.65.3.2","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.65.3.2","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938668/i1552-5783-65-3-2_1709630042.20647.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10916888","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10916888","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"},{"id":"pmid:38441890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38441890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-2416","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/1455","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1167/iovs.65.3.2","doi":"https://doi.org/10.1167/iovs.65.3.2","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.65.3.2","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938668/i1552-5783-65-3-2_1709630042.20647.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1992565218","display_name":"Targeting Interleukin-6 Trans-signaling in Diabetic Retinopathy","funder_award_id":"5r01ey026936-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G307844633","display_name":null,"funder_award_id":"R01-EY026936","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3152988427","display_name":"Center Core Grant for Vision Research","funder_award_id":"P30EY031631","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G888845652","display_name":"Proteomic Biomarkers for Glaucomatous Optic Neuropathy","funder_award_id":"R01EY029728","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000159896","display_name":null,"funder_award_id":"EY031631","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392454777.pdf","grobid_xml":"https://content.openalex.org/works/W4392454777.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W22461021","https://openalex.org/W49336634","https://openalex.org/W1529812339","https://openalex.org/W1538482378","https://openalex.org/W1984826031","https://openalex.org/W1994051469","https://openalex.org/W1995118441","https://openalex.org/W2000072299","https://openalex.org/W2004698731","https://openalex.org/W2006165324","https://openalex.org/W2006475889","https://openalex.org/W2011163417","https://openalex.org/W2020383411","https://openalex.org/W2034248704","https://openalex.org/W2046040565","https://openalex.org/W2053450362","https://openalex.org/W2057311987","https://openalex.org/W2082924908","https://openalex.org/W2086659926","https://openalex.org/W2088594156","https://openalex.org/W2095002499","https://openalex.org/W2113189797","https://openalex.org/W2141028762","https://openalex.org/W2157727996","https://openalex.org/W2160797468","https://openalex.org/W2163071831","https://openalex.org/W2294780202","https://openalex.org/W2621208977","https://openalex.org/W2737642784","https://openalex.org/W2738160893","https://openalex.org/W2897725838","https://openalex.org/W2942781639","https://openalex.org/W2993993456","https://openalex.org/W3136893693","https://openalex.org/W3138602024","https://openalex.org/W3216578158","https://openalex.org/W4200438696","https://openalex.org/W4212848637","https://openalex.org/W4225011953","https://openalex.org/W4236753931","https://openalex.org/W4247312166","https://openalex.org/W4287010044","https://openalex.org/W4289886991","https://openalex.org/W4387469952"],"related_works":["https://openalex.org/W4406596252","https://openalex.org/W7110974581","https://openalex.org/W4387472940","https://openalex.org/W4385799640","https://openalex.org/W4391252294","https://openalex.org/W2235913855","https://openalex.org/W1538482378","https://openalex.org/W3204588620","https://openalex.org/W2520029326","https://openalex.org/W4319771104"],"abstract_inverted_index":{"Purpose:":[0],"Tear":[1,97],"fluid":[2,9,73,84,244],"is":[3,34],"a":[4,55,182,192],"complex":[5],"and":[6,18,63,112,135,156,190,200,230,246],"dynamic":[7],"biological":[8,144,210],"that":[10,90],"plays":[11],"essential":[12],"roles":[13],"in":[14,38,71,81,176],"maintaining":[15],"ocular":[16,62],"homeostasis":[17],"protecting":[19],"against":[20],"the":[21,26,31,82,139,161,205,223,240,252],"external":[22],"environment.":[23],"Owing":[24,147],"to":[25,86,120,142,148,239],"small":[27],"sample":[28],"volume,":[29],"studying":[30],"tear":[32,44,72,83,243,253],"proteome":[33,45,85],"challenging.":[35],"However,":[36],"advances":[37],"high-resolution":[39],"mass":[40,118],"spectrometry":[41,119],"have":[42],"expanded":[43],"profiling,":[46],"revealing":[47],">500":[48],"unique":[49],"proteins.":[50],"Tears":[51],"are":[52],"emerging":[53],"as":[54,93],"noninvasive":[56],"source":[57],"of":[58,69,212,242,251],"biomarkers":[59],"for":[60,163],"both":[61],"systemic":[64],"diseases;":[65],"nevertheless,":[66],"intraday":[67,79],"variability":[68],"proteins":[70,89,153,159,208,218],"remains":[74],"questionable.":[75],"This":[76],"study":[77],"investigates":[78],"variations":[80],"identify":[87],"stable":[88,207],"could":[91],"act":[92],"candidate":[94],"biomarkers.":[95],"Methods:":[96],"samples":[98,134],"from":[99,138],"15":[100],"individuals":[101],"at":[102,171,177],"four":[103,173],"time":[104,174,225],"points":[105,175],"(10":[106],"am,":[107],"12":[108],"pm,":[109,111],"2":[110],"4":[113,224],"pm)":[114],"were":[115,154,203],"analyzed":[116],"using":[117],"evaluate":[121],"protein":[122],"variation":[123,128,141,194,213],"during":[124],"these":[125],"intervals.":[126],"Technical":[127],"was":[129,136],"assessed":[130],"by":[131],"analyzing":[132],"pooled":[133],"subtracted":[137],"total":[140],"isolate":[143],"variability.":[145],"Results:":[146],"high":[149],"technical":[150,193],"variation,":[151],"low-abundant":[152],"filtered,":[155],"only":[157],"115":[158],"met":[160],"criteria":[162,167],"further":[164,247],"analysis.":[165],"These":[166,236],"include":[168],"being":[169],"detected":[170],"all":[172],"least":[178],"eight":[179],"subjects,":[180],"having":[181,191],"mean":[183],"peptide-spectrum":[184],"match":[185],"count":[186],"greater":[187],"than":[188,196],"5,":[189],"less":[195],"0.10.":[197],"Lactotransferrin,":[198],"lipocalin-1,":[199],"several":[201],"immunoglobulins":[202],"among":[204],"51":[206],"(mean":[209],"coefficient":[211],"<":[214],"0.10).":[215],"Additionally,":[216],"43":[217],"displayed":[219],"significant":[220],"slopes":[221],"across":[222],"points,":[226],"with":[227],"17":[228],"increasing":[229],"26":[231],"decreasing":[232],"over":[233],"time.":[234],"Conclusions:":[235],"findings":[237],"contribute":[238],"understanding":[241],"dynamics":[245],"expand":[248],"our":[249],"knowledge":[250],"proteome.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-06T00:00:00"}
