{"id":"https://openalex.org/W4392409669","doi":"https://doi.org/10.1136/bmjgh-2023-edc.18","title":"OA-225 Optimising second line anchor drug options for children with HIV in Africa: 96 week results of the CHAPAS-4 randomised trial","display_name":"OA-225 Optimising second line anchor drug options for children with HIV in Africa: 96 week results of the CHAPAS-4 randomised trial","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4392409669","doi":"https://doi.org/10.1136/bmjgh-2023-edc.18"},"language":"en","primary_location":{"id":"doi:10.1136/bmjgh-2023-edc.18","doi":"https://doi.org/10.1136/bmjgh-2023-edc.18","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjgh-2023-edc.18","pdf_url":"https://gh.bmj.com/content/bmjgh/8/Suppl_10/A8.1.full.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Abstracts of Oral Presentations","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://gh.bmj.com/content/bmjgh/8/Suppl_10/A8.1.full.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088210610","display_name":"Abbas Lugemwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164031","display_name":"Joint Clinical Research Centre","ror":"https://ror.org/05gm41t98","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210164031"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Abbas Lugemwa","raw_affiliation_strings":["Joint Clinical Research Centre, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Clinical Research Centre, Uganda","institution_ids":["https://openalex.org/I4210164031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012570136","display_name":"Alexander J. Szubert","orcid":"https://orcid.org/0000-0002-2082-0861","observed_orcids":["https://orcid.org/0000-0002-2082-0861"]},"institutions":[{"id":"https://openalex.org/I4210091428","display_name":"MRC Clinical Trials Unit at UCL","ror":"https://ror.org/001mm6w73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210091428","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander J Szubert","raw_affiliation_strings":["MRC Clinical Trials Unit at UCL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Clinical Trials Unit at UCL, UK","institution_ids":["https://openalex.org/I4210091428","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081609351","display_name":"Wedu Ndebele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802063107","display_name":"Mpilo Central Hospital","ror":"https://ror.org/05d9wmt54","country_code":"ZW","type":"healthcare","lineage":["https://openalex.org/I2802063107"]}],"countries":["ZW"],"is_corresponding":false,"raw_author_name":"Wedu Ndebele","raw_affiliation_strings":["Mpilo Central Hospital, Zimbabwe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mpilo Central Hospital, Zimbabwe","institution_ids":["https://openalex.org/I2802063107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001331694","display_name":"Ann Sarah Walker","orcid":"https://orcid.org/0000-0002-0412-8509","observed_orcids":["https://orcid.org/0000-0002-0412-8509","https://orcid.org/0000-0003-0421-9264","https://orcid.org/0000-0002-5840-3414","https://orcid.org/0000-0001-6378-4867"]},"institutions":[{"id":"https://openalex.org/I4210091428","display_name":"MRC Clinical Trials Unit at UCL","ror":"https://ror.org/001mm6w73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210091428","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Walker","raw_affiliation_strings":["MRC Clinical Trials Unit at UCL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Clinical Trials Unit at UCL, UK","institution_ids":["https://openalex.org/I4210091428","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015306937","display_name":"Anna Turkova","orcid":"https://orcid.org/0000-0002-7008-4145","observed_orcids":["https://orcid.org/0000-0002-7008-4145"]},"institutions":[{"id":"https://openalex.org/I4210091428","display_name":"MRC Clinical Trials Unit at UCL","ror":"https://ror.org/001mm6w73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210091428","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Turkova","raw_affiliation_strings":["MRC Clinical Trials Unit at UCL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Clinical Trials Unit at UCL, UK","institution_ids":["https://openalex.org/I4210091428","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094058656","display_name":"Sue Tafeni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153455119","display_name":"University of Zimbabwe","ror":"https://ror.org/04ze6rb18","country_code":"ZW","type":"education","lineage":["https://openalex.org/I153455119"]}],"countries":["ZW"],"is_corresponding":false,"raw_author_name":"Sue Tafeni","raw_affiliation_strings":["University of Zimbabwe Clinical Research Centre, Zimbabwe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zimbabwe Clinical Research Centre, Zimbabwe","institution_ids":["https://openalex.org/I153455119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094058657","display_name":"Grace Siziba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802063107","display_name":"Mpilo Central Hospital","ror":"https://ror.org/05d9wmt54","country_code":"ZW","type":"healthcare","lineage":["https://openalex.org/I2802063107"]}],"countries":["ZW"],"is_corresponding":false,"raw_author_name":"Grace Siziba","raw_affiliation_strings":["Mpilo Central Hospital, Zimbabwe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mpilo Central Hospital, Zimbabwe","institution_ids":["https://openalex.org/I2802063107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023193867","display_name":"Clare Shakeshaft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091428","display_name":"MRC Clinical Trials Unit at UCL","ror":"https://ror.org/001mm6w73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210091428","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clare Shakeshaft","raw_affiliation_strings":["MRC Clinical Trials Unit at UCL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Clinical Trials Unit at UCL, UK","institution_ids":["https://openalex.org/I4210091428","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083218938","display_name":"Bwendo Nduna","orcid":"https://orcid.org/0000-0001-6613-4704","observed_orcids":["https://orcid.org/0000-0001-6613-4704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bwendo Nduna","raw_affiliation_strings":["Arthur Davison Children\u2019s Hospital, Zambia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthur Davison Children\u2019s Hospital, Zambia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070595609","display_name":"Rashidah Nazzinda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164031","display_name":"Joint Clinical Research Centre","ror":"https://ror.org/05gm41t98","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210164031"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Rashida Nazzinda","raw_affiliation_strings":["Joint Clinical Research Centre, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Clinical Research Centre, Uganda","institution_ids":["https://openalex.org/I4210164031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111140008","display_name":"Esether Nambi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164031","display_name":"Joint Clinical Research Centre","ror":"https://ror.org/05gm41t98","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210164031"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Esether Nambi","raw_affiliation_strings":["Joint Clinical Research Centre, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Clinical Research Centre, Uganda","institution_ids":["https://openalex.org/I4210164031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094058655","display_name":"Mwate Mwamabazi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mwate Mwamabazi","raw_affiliation_strings":["Arthur Davison Children\u2019s Hospital, Zambia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthur Davison Children\u2019s Hospital, Zambia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023988814","display_name":"Godfrey Musoro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153455119","display_name":"University of Zimbabwe","ror":"https://ror.org/04ze6rb18","country_code":"ZW","type":"education","lineage":["https://openalex.org/I153455119"]}],"countries":["ZW"],"is_corresponding":false,"raw_author_name":"Godfrey Musoro","raw_affiliation_strings":["University of Zimbabwe Clinical Research Centre, Zimbabwe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zimbabwe Clinical Research Centre, Zimbabwe","institution_ids":["https://openalex.org/I153455119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030021239","display_name":"Victor Musiime","orcid":"https://orcid.org/0000-0001-7472-9054","observed_orcids":["https://orcid.org/0000-0001-7472-9054"]},"institutions":[{"id":"https://openalex.org/I4210164031","display_name":"Joint Clinical Research Centre","ror":"https://ror.org/05gm41t98","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210164031"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Victor Musiime","raw_affiliation_strings":["Joint Clinical Research Centre, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Clinical Research Centre, Uganda","institution_ids":["https://openalex.org/I4210164031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012522909","display_name":"Veronica Mulenga","orcid":"https://orcid.org/0000-0003-1843-8169","observed_orcids":["https://orcid.org/0000-0003-1843-8169"]},"institutions":[{"id":"https://openalex.org/I2802614804","display_name":"University Teaching Hospital","ror":"https://ror.org/03zn9xk79","country_code":"ZM","type":"healthcare","lineage":["https://openalex.org/I2802614804"]}],"countries":["ZM"],"is_corresponding":false,"raw_author_name":"Veronica Mulenga","raw_affiliation_strings":["University Teaching Hospital, Zambia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Teaching Hospital, Zambia","institution_ids":["https://openalex.org/I2802614804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059245006","display_name":"Hilda Angela Mujuru","orcid":"https://orcid.org/0000-0003-1615-3856","observed_orcids":["https://orcid.org/0000-0003-1615-3856"]},"institutions":[{"id":"https://openalex.org/I153455119","display_name":"University of Zimbabwe","ror":"https://ror.org/04ze6rb18","country_code":"ZW","type":"education","lineage":["https://openalex.org/I153455119"]}],"countries":["ZW"],"is_corresponding":false,"raw_author_name":"Hilda Mujuru","raw_affiliation_strings":["University of Zimbabwe Clinical Research Centre, Zimbabwe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zimbabwe Clinical Research Centre, Zimbabwe","institution_ids":["https://openalex.org/I153455119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025069184","display_name":"Helen McIlleron","orcid":"https://orcid.org/0000-0002-0982-6226","observed_orcids":["https://orcid.org/0000-0002-0982-6226"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Helen McIlleron","raw_affiliation_strings":["University of Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038416217","display_name":"Shafic Makumbi","orcid":"https://orcid.org/0009-0009-2284-9017","observed_orcids":["https://orcid.org/0009-0009-2284-9017"]},"institutions":[{"id":"https://openalex.org/I4210164031","display_name":"Joint Clinical Research Centre","ror":"https://ror.org/05gm41t98","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210164031"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Shafic Makumbi","raw_affiliation_strings":["Joint Clinical Research Centre, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Clinical Research Centre, Uganda","institution_ids":["https://openalex.org/I4210164031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053573028","display_name":"Joyce Chipili Lungu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802614804","display_name":"University Teaching Hospital","ror":"https://ror.org/03zn9xk79","country_code":"ZM","type":"healthcare","lineage":["https://openalex.org/I2802614804"]}],"countries":["ZM"],"is_corresponding":false,"raw_author_name":"Joyce Lungu","raw_affiliation_strings":["University Teaching Hospital, Zambia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Teaching Hospital, Zambia","institution_ids":["https://openalex.org/I2802614804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070322756","display_name":"Cissy M Kityo","orcid":"https://orcid.org/0000-0002-9286-7052","observed_orcids":["https://orcid.org/0000-0002-9286-7052"]},"institutions":[{"id":"https://openalex.org/I4210164031","display_name":"Joint Clinical Research Centre","ror":"https://ror.org/05gm41t98","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210164031"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Cissy Kityo","raw_affiliation_strings":["Joint Clinical Research Centre, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Clinical Research Centre, Uganda","institution_ids":["https://openalex.org/I4210164031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046498750","display_name":"Nimisha Dudakia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091428","display_name":"MRC Clinical Trials Unit at UCL","ror":"https://ror.org/001mm6w73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210091428","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nimisha Dudakia","raw_affiliation_strings":["MRC Clinical Trials Unit at UCL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Clinical Trials Unit at UCL, UK","institution_ids":["https://openalex.org/I4210091428","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082559510","display_name":"Katja Doerholt","orcid":"https://orcid.org/0000-0001-5105-0970","observed_orcids":["https://orcid.org/0000-0001-5105-0970"]},"institutions":[{"id":"https://openalex.org/I4210091428","display_name":"MRC Clinical Trials Unit at UCL","ror":"https://ror.org/001mm6w73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210091428","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katja Doerholt","raw_affiliation_strings":["MRC Clinical Trials Unit at UCL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Clinical Trials Unit at UCL, UK","institution_ids":["https://openalex.org/I4210091428","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021381528","display_name":"Chishala Chabala","orcid":"https://orcid.org/0000-0002-5551-5752","observed_orcids":["https://orcid.org/0000-0002-5551-5752"]},"institutions":[{"id":"https://openalex.org/I2802614804","display_name":"University Teaching Hospital","ror":"https://ror.org/03zn9xk79","country_code":"ZM","type":"healthcare","lineage":["https://openalex.org/I2802614804"]}],"countries":["ZM"],"is_corresponding":false,"raw_author_name":"Chishala Chabala","raw_affiliation_strings":["University Teaching Hospital, Zambia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Teaching Hospital, Zambia","institution_ids":["https://openalex.org/I2802614804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074802254","display_name":"Mutsa Bwakura\u2010Dangarembizi","orcid":"https://orcid.org/0000-0001-7751-6177","observed_orcids":["https://orcid.org/0000-0001-7751-6177"]},"institutions":[{"id":"https://openalex.org/I153455119","display_name":"University of Zimbabwe","ror":"https://ror.org/04ze6rb18","country_code":"ZW","type":"education","lineage":["https://openalex.org/I153455119"]}],"countries":["ZW"],"is_corresponding":false,"raw_author_name":"Mutsa Bwakura-Dangarembizi","raw_affiliation_strings":["University of Zimbabwe Clinical Research Centre, Zimbabwe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zimbabwe Clinical Research Centre, Zimbabwe","institution_ids":["https://openalex.org/I153455119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026415916","display_name":"Alasdair Bamford","orcid":"https://orcid.org/0000-0003-4764-229X","observed_orcids":["https://orcid.org/0000-0003-4764-229X"]},"institutions":[{"id":"https://openalex.org/I4210091428","display_name":"MRC Clinical Trials Unit at UCL","ror":"https://ror.org/001mm6w73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210091428","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alasdair Bamford","raw_affiliation_strings":["MRC Clinical Trials Unit at UCL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Clinical Trials Unit at UCL, UK","institution_ids":["https://openalex.org/I4210091428","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030902925","display_name":"Diana M. Gibb","orcid":"https://orcid.org/0000-0002-9738-5490","observed_orcids":["https://orcid.org/0000-0002-9738-5490"]},"institutions":[{"id":"https://openalex.org/I4210091428","display_name":"MRC Clinical Trials Unit at UCL","ror":"https://ror.org/001mm6w73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210091428","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Diana M Gibb","raw_affiliation_strings":["MRC Clinical Trials Unit at UCL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Clinical Trials Unit at UCL, UK","institution_ids":["https://openalex.org/I4210091428","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A8.1","last_page":"A8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-hiv","display_name":"pediatric HIV","score":0.9480000138282776},{"id":"https://openalex.org/keywords/second-line-antiretroviral-therapy","display_name":"second-line antiretroviral therapy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dolutegravir","display_name":"dolutegravir","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ritonavir-boosted-darunavir","display_name":"ritonavir-boosted darunavir","score":0.9829999804496765},{"id":"https://openalex.org/keywords/atazanavir","display_name":"atazanavir","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lopinavir","display_name":"lopinavir","score":0.902999997138977},{"id":"https://openalex.org/keywords/viral-suppression","display_name":"viral suppression","score":0.7509999871253967},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.7990000247955322},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.37299999594688416},{"id":"https://openalex.org/keywords/tenofovir-alafenamide","display_name":"tenofovir alafenamide","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6037433743476868},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5601986050605774},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5128750801086426},{"id":"https://openalex.org/C2992672634","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Drug trial","level":3,"score":0.5023808479309082},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2470061182975769},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21983927488327026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19001862406730652},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.10624158382415771}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/bmjgh-2023-edc.18","doi":"https://doi.org/10.1136/bmjgh-2023-edc.18","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjgh-2023-edc.18","pdf_url":"https://gh.bmj.com/content/bmjgh/8/Suppl_10/A8.1.full.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Abstracts of Oral Presentations","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/bmjgh-2023-edc.18","doi":"https://doi.org/10.1136/bmjgh-2023-edc.18","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjgh-2023-edc.18","pdf_url":"https://gh.bmj.com/content/bmjgh/8/Suppl_10/A8.1.full.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Abstracts of Oral Presentations","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392409669.pdf","grobid_xml":"https://content.openalex.org/works/W4392409669.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6920698143","https://openalex.org/W6920443486","https://openalex.org/W4410354927","https://openalex.org/W4379599113","https://openalex.org/W4413817738","https://openalex.org/W7125360788","https://openalex.org/W4380569452","https://openalex.org/W7160283351","https://openalex.org/W4321003991","https://openalex.org/W2178112275"],"abstract_inverted_index":{"Background":[0],"Paediatric":[1],"second":[2,39,98,260,269],"line":[3,40,261,270,274],"antiretroviral":[4],"therapy":[5],"(ART)":[6],"formulations":[7],"are":[8,292],"limited.":[9],"CHAPAS-4":[10],"(ISRCTN22964075),":[11],"a":[12,163],"2X4":[13],"factorial":[14],"randomised":[15,43,125],"trial":[16],"investigated":[17],"efficacy":[18],"and":[19,30,75,80,126,155,169,185,187,191,233,258,282],"safety":[20],"of":[21,97,129,221,278],"4":[22],"anchor":[23],"drugs.":[24],"Methods":[25],"Children":[26],"from":[27],"Uganda,":[28],"Zambia":[29],"Zimbabwe":[31],"on":[32,93,131,137,140,143,146],"non-nucleoside":[33],"reverse":[34],"transcriptase":[35],"inhibitor-based":[36],"regimens,":[37],"requiring":[38],"ART,":[41],"were":[42,124,181,228],"to":[44,55,70,78,153,165,167,176,287],"dolutegravir":[45],"(DTG)":[46],"or":[47,51],"ritonavir-boosted":[48],"darunavir(DRV/r),":[49],"atazanavir(ATV/r)":[50],"lopinavir(LPV/r)":[52],"dosed":[53],"according":[54],"WHO":[56,254],"weight-bands.":[57],"Primary":[58],"endpoint":[59],"was":[60,90,151,174,218,236],"week-96":[61,135],"viral":[62,116],"load(VL)<400copies/mL.":[63],"We":[64],"hypothesised":[65],"ATV/r":[66,81,156,170,173,208],"would":[67],"be":[68,106,285],"non-inferior":[69,175],"LPV/r(12%":[71],"margin);":[72],"both":[73],"DRV/r":[74,161],"DTG":[76,150,211],"superior":[77,152],"LPV/r":[79,147,154,168,177],"arms":[82],"combined":[83],"(superiority":[84],"threshold":[85],"p\u22640.03;":[86],"multiple":[87],"comparisons).":[88],"Analysis":[89],"intention-to-treat,":[91],"based":[92],"logistic":[94],"regression.":[95],"Results":[96,109,180],"randomisation":[99],"(tenofovir":[100],"alafenamide(TAF)-based":[101],"vs.":[102,215],"SOC":[103],"backbone)":[104],"will":[105,267,284],"reported":[107],"separately.":[108],"919":[110],"children":[111,266,295],"aged":[112],"3\u201315years":[113],"(54%male,":[114],"median[IQR]":[115],"load":[117],"17,573copies/mL[5549,":[118],"55,700];":[119],"CD4":[120,193],"count":[121,194],"669[413,":[122],"971])":[123],"spent":[127],"98%":[128],"time":[130],"allocated":[132],"regimen.":[133],"At":[134],"208/226(92.0%)":[136],"DTG,":[138],"203/230(88.3%)":[139],"DRV/r,":[141],"193/229(84.3%)":[142],"ATV/r,":[144],"180/223(80.7%)":[145],"had":[148,212,245],"VL<400c/ml.":[149],"(adjusted":[157],"difference":[158],"9.7%[4.8,":[159],"14.5],p<0.0001);":[160],"showed":[162],"trend":[164],"superiority":[166],"(5.6%[0.3,":[171],"11.0],p=0.04);":[172],"(3.4%[-3.4,":[178],"10.2],p=0.33).":[179],"similar":[182,237],"for":[183,207,256,294],"VL<60copies/mL":[184],"<1000copies/mL":[186],"at":[188],"weeks":[189],"48":[190],"144.":[192],"improved":[195],"in":[196,225,296],"all":[197],"arms.":[198,239],"More":[199],"grade":[200],"3/4":[201],"adverse":[202,247],"events(AE),":[203],"predominantly":[204],"hyperbilirubinemia,":[205],"occurred":[206],"vs":[209],"LPV/r(p<0.0001);":[210],"fewer":[213],"AE":[214],"LPV/r(p=0.02).":[216],"There":[217],"no":[219],"evidence":[220],"excess":[222],"weight-gain.":[223],"Improvement":[224],"growth":[226],"parameters":[227],"lowest":[229],"with":[230],"LPV/r.":[231],"Renal":[232],"bone":[234],"health":[235],"between":[238],"One":[240],"child":[241],"died":[242],"(treatment-unrelated);":[243],"3%":[244],"serious":[246],"events.":[248],"Conclusion":[249],"These":[250],"results":[251],"supports":[252],"current":[253],"guidelines":[255],"preferred":[257],"alternative":[259],"ART.":[262],"In":[263],"the":[264],"future":[265],"require":[268],"ART":[271],"after":[272],"first":[273],"DTG.":[275],"Ongoing":[276],"development":[277],"child-friendly":[279],"boosted":[280],"DRV":[281],"ATV":[283],"key":[286],"ensure":[288],"robust":[289],"treatment":[290],"options":[291],"available":[293],"Africa.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-03-05T00:00:00"}