{"id":"https://openalex.org/W4392409210","doi":"https://doi.org/10.1136/bmjgh-2023-edc.159","title":"PA-318 Comparative analysis of multiplex immunoassays for host biomarker profiling in tuberculosis diagnosis and TB treatment response","display_name":"PA-318 Comparative analysis of multiplex immunoassays for host biomarker profiling in tuberculosis diagnosis and TB treatment response","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4392409210","doi":"https://doi.org/10.1136/bmjgh-2023-edc.159"},"language":"en","primary_location":{"id":"doi:10.1136/bmjgh-2023-edc.159","doi":"https://doi.org/10.1136/bmjgh-2023-edc.159","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjgh-2023-edc.159","pdf_url":"https://gh.bmj.com/content/bmjgh/8/Suppl_10/A64.3.full.pdf","source":{"id":"https://openalex.org/S2764928273","display_name":"BMJ Global Health","issn_l":"2059-7908","issn":["2059-7908"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Abstracts of Poster and e-Poster Presentations","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://gh.bmj.com/content/bmjgh/8/Suppl_10/A64.3.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032008766","display_name":"Candice Snyders","orcid":"https://orcid.org/0000-0002-8571-6029","observed_orcids":["https://orcid.org/0000-0002-8571-6029"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Candice Irene Snyders","raw_affiliation_strings":["Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009965342","display_name":"Marika Flinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Marika Flinn","raw_affiliation_strings":["Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075472009","display_name":"L\u00e9anie Kleynhans","orcid":"https://orcid.org/0000-0003-1635-253X","observed_orcids":["https://orcid.org/0000-0003-1635-253X"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Leanie Kleynhans","raw_affiliation_strings":["Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022897595","display_name":"Gerhard Walzl","orcid":"https://orcid.org/0000-0003-2487-125X","observed_orcids":["https://orcid.org/0000-0003-2487-125X"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gerhard Walzl","raw_affiliation_strings":["Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028696154","display_name":"Novel N. Chegou","orcid":"https://orcid.org/0000-0002-8690-1699","observed_orcids":["https://orcid.org/0000-0002-8690-1699"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Novel Chegou","raw_affiliation_strings":["Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I26092322"],"apc_list":{"value":3000,"currency":"GBP","value_usd":3679},"apc_paid":{"value":3000,"currency":"GBP","value_usd":3679},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A64.3","last_page":"A65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiplex-immunoassay","display_name":"multiplex immunoassay","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.6510000228881836},{"id":"https://openalex.org/keywords/host-biomarkers","display_name":"host biomarkers","score":0.847000002861023},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9359999895095825},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7390000224113464},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9959999918937683},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/luminex","display_name":"Luminex","score":0.8510000109672546},{"id":"https://openalex.org/keywords/meso-scale-discovery","display_name":"Meso Scale Discovery","score":0.8859999775886536},{"id":"https://openalex.org/keywords/assay-sensitivity","display_name":"assay sensitivity","score":0.47600001096725464},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.9048551917076111},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5474267601966858},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5384511947631836},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.531261146068573},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5077977776527405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4698297679424286},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.4445614814758301},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43058550357818604},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.41373229026794434},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38800957798957825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28751280903816223},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.268888920545578},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23184242844581604},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.20017307996749878},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.11477351188659668},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/bmjgh-2023-edc.159","doi":"https://doi.org/10.1136/bmjgh-2023-edc.159","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjgh-2023-edc.159","pdf_url":"https://gh.bmj.com/content/bmjgh/8/Suppl_10/A64.3.full.pdf","source":{"id":"https://openalex.org/S2764928273","display_name":"BMJ Global Health","issn_l":"2059-7908","issn":["2059-7908"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Abstracts of Poster and e-Poster Presentations","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/bmjgh-2023-edc.159","doi":"https://doi.org/10.1136/bmjgh-2023-edc.159","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjgh-2023-edc.159","pdf_url":"https://gh.bmj.com/content/bmjgh/8/Suppl_10/A64.3.full.pdf","source":{"id":"https://openalex.org/S2764928273","display_name":"BMJ Global Health","issn_l":"2059-7908","issn":["2059-7908"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Abstracts of Poster and e-Poster Presentations","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392409210.pdf","grobid_xml":"https://content.openalex.org/works/W4392409210.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077002902","https://openalex.org/W2082784086","https://openalex.org/W2094387583","https://openalex.org/W2738404537","https://openalex.org/W2118042605","https://openalex.org/W4405650491","https://openalex.org/W3003376590","https://openalex.org/W3140586060","https://openalex.org/W4287522150","https://openalex.org/W2130180453"],"abstract_inverted_index":{"Background":[0],"Proteins":[1],"such":[2],"as":[3,17,168,228,238],"cytokines,":[4,140],"chemokines":[5],"and":[6,43,57,106,130,150,196,236],"growth":[7],"factors":[8],"play":[9],"critical":[10],"roles":[11],"in":[12,20,86,111,116,135,154,277],"biological":[13,49],"processes.":[14],"These":[15],"act":[16],"disease":[18,51],"biomarkers":[19,32,115],"the":[21,66,78,83,87,97,100,107,112,122,131,136,155,171,176,186,212,221,229,233,239,258,261],"study":[22,93],"of":[23,30,37,54,68,80,82,91,99,114,124,138,158,178],"various":[24],"infectious":[25],"diseases.":[26],"Dysfunction":[27],"or":[28],"dysregulation":[29],"these":[31,69],"may":[33],"cause":[34],"a":[35,248],"variety":[36],"pathophysiological":[38],"conditions.":[39],"Consequently,":[40],"biomarker":[41],"profiling":[42],"related":[44],"technologies":[45],"are":[46,63,287],"essential":[47],"for":[48,65,215,242,274],"studies,":[50,282],"diagnosis,":[52],"monitoring":[53],"treatment":[55],"response":[56],"drug":[58],"discovery.":[59],"Many":[60],"multiplexing":[61],"platforms":[62,84,201,234,259,271],"available":[64,85],"detection":[67,113,137],"biomarkers.":[70],"There":[71],"is":[72],"limited":[73],"independently":[74],"published":[75],"information":[76],"about":[77],"reliability":[79],"most":[81,230,240],"market.":[88],"The":[89],"objectives":[90],"this":[92],"were":[94,166,202,255,265,272],"to":[95,204],"assess":[96],"abilities":[98,123],"Luminex,":[101,128],"Meso":[102],"Scale":[103],"Discovery":[104],"(MSD)":[105],"Curiox":[108,132,237],"Drop-Array":[109,133],"system":[110,134],"spiked":[117,159],"sera.":[118],"Methods":[119],"We":[120,174],"assessed":[121,175],"three":[125,222,270],"multiplex":[126],"technologies;":[127],"MSD":[129,227],"five":[139],"interleukin":[141],"(IL)-2,":[142],"IL-6,":[143],"IL-10,":[144],"Tumour":[145],"necrosis":[146],"factor":[147],"alpha":[148],"(TNF-\u03b1)":[149],"Interferon":[151],"gamma":[152],"(IFNg),":[153],"same":[156],"set":[157],"serum":[160],"samples.":[161],"Experiments":[162],"on":[163],"each":[164,179,183,216],"platform":[165,184],"performed":[167],"recommended":[169],"by":[170,182],"kit":[172],"manufacturer.":[173],"concentration":[177,214],"analyte":[180],"detected":[181,264],"Vs.":[185,208],"expected":[187],"actual":[188,213],"concentrations.":[189],"Results":[190],"For":[191],"samples":[192],"with":[193,285],"known":[194],"low":[195,207],"high":[197,209],"cytokine":[198,217,279],"concentrations,":[199],"all":[200,269],"able":[203],"discriminate":[205],"between":[206,257],"expression,":[210],"however,":[211],"varied":[218],"greatly":[219],"amongst":[220,232],"platforms.":[223],"Our":[224],"data":[225],"revealed":[226],"sensitive":[231],"compared,":[235],"suitable":[241,273],"high-throughput":[243],"multiplexing,":[244],"when":[245],"employed":[246],"alongside":[247],"Luminex":[249],"platform.":[250],"Conclusion":[251],"Although":[252],"quantitative":[253],"differences":[254],"found":[256],"assessed,":[260],"relative":[262],"concentrations":[263],"comparable,":[266],"showing":[267],"that":[268],"analyzing":[275],"trends":[276],"multiple":[278],"profiles.":[280],"Further":[281],"including":[283],"comparison":[284],"ELISA":[286],"ongoing.":[288]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2024-03-05T00:00:00"}