{"id":"https://openalex.org/W4392380719","doi":"https://doi.org/10.1158/1538-7445.ovarian23-b051","title":"Abstract B051: Genome-wide association studies of 26,187 women without ovarian cancer identifies 12 genetic loci of blood CA125","display_name":"Abstract B051: Genome-wide association studies of 26,187 women without ovarian cancer identifies 12 genetic loci of blood CA125","publication_year":2024,"publication_date":"2024-03-04","ids":{"openalex":"https://openalex.org/W4392380719","doi":"https://doi.org/10.1158/1538-7445.ovarian23-b051"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.ovarian23-b051","doi":"https://doi.org/10.1158/1538-7445.ovarian23-b051","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.ovarian23-b051","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078015467","display_name":"Naoko Sasamoto","orcid":"https://orcid.org/0000-0002-4526-2181","observed_orcids":["https://orcid.org/0000-0002-4526-2181"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoko Sasamoto","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA,","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384977","display_name":"Jihye Kim","orcid":"https://orcid.org/0000-0001-7096-820X","observed_orcids":["https://orcid.org/0000-0001-7096-820X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihye Kim","raw_affiliation_strings":["2Harvard T.H. Chan School of Public Health, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Harvard T.H. Chan School of Public Health, Boston, MA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056108228","display_name":"Constance Turman","orcid":"https://orcid.org/0000-0002-7790-8311","observed_orcids":["https://orcid.org/0000-0002-7790-8311"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Constance Turman","raw_affiliation_strings":["2Harvard T.H. Chan School of Public Health, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Harvard T.H. Chan School of Public Health, Boston, MA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054091966","display_name":"Shelley S. Tworoger","orcid":"https://orcid.org/0000-0002-6986-7046","observed_orcids":["https://orcid.org/0000-0002-6986-7046"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley S. Tworoger","raw_affiliation_strings":["3Moffitt Cancer Center, Tampa, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Moffitt Cancer Center, Tampa, FL,","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033124357","display_name":"Rudolf Kaaks","orcid":"https://orcid.org/0000-0003-3751-3929","observed_orcids":["https://orcid.org/0000-0003-3751-3929"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rudolf Kaaks","raw_affiliation_strings":["4German Cancer Research Center, Heidelberg, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4German Cancer Research Center, Heidelberg, Germany,","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059302865","display_name":"Ren\u00e9e T. Fortner","orcid":"https://orcid.org/0000-0002-1426-8505","observed_orcids":["https://orcid.org/0000-0002-1426-8505"]},"institutions":[{"id":"https://openalex.org/I4210129856","display_name":"Cancer Registry of Norway","ror":"https://ror.org/03sm1ej59","country_code":"NO","type":"archive","lineage":["https://openalex.org/I1333353642","https://openalex.org/I4210129856","https://openalex.org/I4210149801","https://openalex.org/I4210163359"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ren\u00e9e T. Fortner","raw_affiliation_strings":["5Cancer Registry of Norway, Oslo, Norway,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cancer Registry of Norway, Oslo, Norway,","institution_ids":["https://openalex.org/I4210129856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061753517","display_name":"Daniel William Cramer","orcid":"https://orcid.org/0000-0002-8024-3066","observed_orcids":["https://orcid.org/0000-0002-8024-3066"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel W. Cramer","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA,","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051731200","display_name":"Kathryn L. Terry","orcid":"https://orcid.org/0009-0002-5848-4661","observed_orcids":["https://orcid.org/0009-0002-5848-4661"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn L. Terry","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA,","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063003263","display_name":"Nicolas Wentzensen","orcid":"https://orcid.org/0000-0003-1251-0836","observed_orcids":["https://orcid.org/0000-0003-1251-0836"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas Wentzensen","raw_affiliation_strings":["6National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056487867","display_name":"Peter L. Kraft","orcid":"https://orcid.org/0000-0002-4472-8103","observed_orcids":["https://orcid.org/0000-0002-4472-8103"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kraft","raw_affiliation_strings":["6National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"5_Supplement_2","first_page":"B051","last_page":"B051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.09910000115633011,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.9929999709129333},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.6380000114440918},{"id":"https://openalex.org/keywords/blood-biomarkers","display_name":"blood biomarkers","score":0.5249999761581421},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mesothelin","display_name":"mesothelin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/menopausal-status","display_name":"menopausal status","score":0.628000020980835},{"id":"https://openalex.org/keywords/genetic-loci","display_name":"genetic loci","score":0.5580000281333923},{"id":"https://openalex.org/keywords/ovarian-cancer-risk","display_name":"ovarian cancer risk","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7362204194068909},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5625700950622559},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5439276099205017},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4488369822502136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43830758333206177},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.41582241654396057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3943660855293274},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3674343228340149},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3299633264541626},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3251460790634155},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2050521969795227},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1876983940601349},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1522054374217987}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.ovarian23-b051","doi":"https://doi.org/10.1158/1538-7445.ovarian23-b051","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.ovarian23-b051","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2887397939","https://openalex.org/W3040995538","https://openalex.org/W6957961542","https://openalex.org/W2885798905","https://openalex.org/W2925925144","https://openalex.org/W2890012244","https://openalex.org/W1967011667","https://openalex.org/W2318215828","https://openalex.org/W4280539954","https://openalex.org/W2155775254"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"CA125":[2,43,63,84,104,116,159,197,211,265,284,326,355,382,393,417,424,485],"is":[3,11,64,286],"elevated":[4],"in":[5,32,45,85,236,288,316,332,340,347,358,375,395,430],"women":[6,47,86,109,396,475],"with":[7,66,103,264,283,299,305,324,353,380,391],"ovarian":[8,15,33,54,67,88,111,341,376,398,426,477],"cancer":[9,16,34,55,427,478],"and":[10,69,118,125,136,143,163,169,185,201,285,301],"the":[12,166,172,239,255,289,317,348,359,405,421,490],"single":[13],"best":[14],"screening":[17,25,56,428],"biomarker":[18,429],"candidate":[19],"to":[20,79,97,249,337,345],"date,":[21],"although":[22],"two":[23],"randomized":[24],"trials":[26],"showed":[27],"no":[28,230],"clinically":[29],"significant":[30,231,241],"difference":[31],"mortality.":[35],"Consideration":[36],"of":[37,83,210,238,274,308,407,423,440,473,483,489],"genetic":[38,81,100,119,412,481],"variants":[39,82,101],"that":[40,320,343,414],"influence":[41,415],"blood":[42,115,158,205,392,416,484],"levels":[44,307,394,418],"healthy":[46],"could":[48,419],"improve":[49,420],"its":[50,71],"performance":[51,422],"as":[52,425],"an":[53],"biomarker.":[57],"Furthermore,":[58],"while":[59],"studies":[60,472],"have":[61],"suggested":[62],"associated":[65,102,263,298,304,323,352,379,390],"carcinogenesis":[68],"progression,":[70],"biological":[72,402],"role":[73,406],"remains":[74],"unclear.":[75],"Thus,":[76],"we":[77,216,224,244],"aimed":[78],"identify":[80,98],"without":[87,110,397,476],"cancer.":[89],"Methods:":[90],"We":[91,175,258,310,328,385],"conducted":[92,194,217],"a":[93,246,267,334,365],"genome-wide":[94,240,268],"association":[95,471],"analysis":[96],"common":[99],"using":[105,155],"data":[106,117,120,152],"on":[107,313,362,404,494],"26,187":[108,474],"cancer,":[112,399],"leveraging":[113],"existing":[114],"from":[121],"Prostate,":[122],"Lung,":[123],"Colorectal,":[124],"Ovarian":[126,495],"Cancer":[127,135,505],"Screening":[128],"Trial":[129],"(PLCO),":[130],"European":[131],"Prospective":[132],"Investigation":[133],"into":[134],"Nutrition":[137],"(EPIC),":[138],"Nurses\u2019":[139],"Health":[140],"Studies":[141],"(NHS/NHSII),":[142],"New":[144],"England":[145],"Case":[146],"Control":[147],"Study":[148],"(NEC).":[149],"All":[150],"genotype":[151],"were":[153,193,229,297,303,321,351],"inputted":[154],"TOPMed.":[156],"For":[157],"measurement,":[160],"PLCO,":[161],"NHS/NHSII,":[162],"NEC":[164],"used":[165,171,176],"CA125II":[167],"assay":[168],"EPIC":[170],"MSD":[173],"assay.":[174],"multivariable":[177],"linear":[178],"regression":[179],"models":[180],"adjusting":[181],"for":[182,410],"age,":[183],"study,":[184],"population":[186],"ancestry":[187],"(top":[188],"4":[189],"principal":[190],"components).":[191],"Analyses":[192],"separately":[195],"by":[196,213,220,233],"assay,":[198],"genotyping":[199],"platforms,":[200],"menopausal":[202,214,221,234],"status":[203,235],"at":[204,266],"draw.":[206],"Because":[207],"epidemiological":[208],"predictors":[209],"differ":[212],"status,":[215],"analyses":[218],"stratified":[219],"status.":[222],"When":[223],"meta-analyzed":[225],"these":[226,411],"results,":[227],"there":[228],"heterogeneity":[232],"majority":[237],"SNPs.":[242],"Therefore,":[243],"performed":[245],"fixed-effects":[247],"meta-analysis":[248],"combine":[250],"summary":[251],"statistics":[252],"across":[253],"all":[254],"results.":[256],"Results:":[257],"identified":[259,386],"12":[260,387,480],"independent":[261,388],"loci":[262,389,482],"significance":[269],"level":[270],"(p<5":[271],"\u00d7":[272],"10\u22128),":[273],"which":[275],"one":[276],"SNP":[277],"(rs73005869)":[278],"had":[279],"been":[280,373],"previously":[281],"linked":[282],"located":[287],"MUC16":[290],"gene.":[291],"In":[292],"our":[293],"meta-analysis,":[294],"7":[295],"SNPs":[296,312,331,357],"lower":[300,354,381],"5":[302],"higher":[306],"CA125.":[309,408],"discovered":[311,330],"chromosome":[314,363],"16":[315],"TET2":[318],"gene":[319,335,361,368],"significantly":[322],"increased":[325],"levels.":[327,356,383],"also":[329],"MSLN,":[333],"reported":[336],"be":[338],"overexpressed":[339],"tumors":[342],"contributes":[344],"metastasis":[346],"peritoneal":[349],"microenvironment,":[350],"HIC1":[360],"17,":[364],"tumor":[366],"suppressor":[367],"whose":[369],"aberrant":[370],"methylation":[371],"has":[372],"observed":[374],"tumors,":[377],"was":[378],"Conclusion:":[384],"providing":[400],"novel":[401],"insights":[403],"Accounting":[409],"factors":[413],"average":[431],"risk":[432],"women,":[433],"substantially":[434],"improving":[435],"survival":[436],"through":[437],"earlier":[438],"detection":[439],"this":[441],"deadly":[442],"disease.":[443],"Citation":[444],"Format:":[445],"Naoko":[446],"Sasamoto,":[447],"Jihye":[448],"Kim,":[449],"Constance":[450],"Turman,":[451],"Shelley":[452],"S.":[453],"Tworoger,":[454],"Rudolf":[455],"Kaaks,":[456],"Ren\u00e9e":[457],"T.":[458],"Fortner,":[459],"Daniel":[460],"W.":[461],"Cramer,":[462],"Kathryn":[463],"L.":[464],"Terry,":[465],"Nicolas":[466],"Wentzensen,":[467],"Peter":[468],"Kraft.":[469],"Genome-wide":[470],"identifies":[479],"[abstract].":[486],"In:":[487],"Proceedings":[488],"AACR":[491],"Special":[492],"Conference":[493],"Cancer;":[496],"2023":[497],"Oct":[498],"5-7;":[499],"Boston,":[500],"Massachusetts.":[501],"Philadelphia":[502],"(PA):":[503],"AACR;":[504],"Res":[506],"2024;84(5":[507],"Suppl_2):Abstract":[508],"nr":[509],"B051.":[510]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-03-05T00:00:00"}
