{"id":"https://openalex.org/W4392376328","doi":"https://doi.org/10.1158/1538-7445.brain23-pr-006","title":"Abstract PR-006: Brain metastases roadmap reveals conserved regulatory dynamics rooted in dormant tumor cells","display_name":"Abstract PR-006: Brain metastases roadmap reveals conserved regulatory dynamics rooted in dormant tumor cells","publication_year":2024,"publication_date":"2024-03-04","ids":{"openalex":"https://openalex.org/W4392376328","doi":"https://doi.org/10.1158/1538-7445.brain23-pr-006"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.brain23-pr-006","doi":"https://doi.org/10.1158/1538-7445.brain23-pr-006","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.brain23-pr-006","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049861172","display_name":"Remi V. Klotz","orcid":"https://orcid.org/0000-0003-2100-0635","observed_orcids":["https://orcid.org/0000-0003-2100-0635","https://orcid.org/0000-0002-4726-8413"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Remi Klotz","raw_affiliation_strings":["1University of Maryland School of Medicine, Baltimore, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland School of Medicine, Baltimore, MD,","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084700012","display_name":"Yiru Jess Wang","orcid":"https://orcid.org/0009-0009-1040-3229","observed_orcids":["https://orcid.org/0009-0009-1040-3229"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiru Jess Wang","raw_affiliation_strings":["1University of Maryland School of Medicine, Baltimore, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland School of Medicine, Baltimore, MD,","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031104571","display_name":"Alexis Zukowski","orcid":"https://orcid.org/0000-0002-1212-2254","observed_orcids":["https://orcid.org/0000-0002-1212-2254"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Zukowski","raw_affiliation_strings":["2University of Colorado School of Medicine, Aurora, CO,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Colorado School of Medicine, Aurora, CO,","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092123070","display_name":"Frank Attenelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Attenelo","raw_affiliation_strings":["3Keck School of Medicine of the University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Keck School of Medicine of the University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031508822","display_name":"Srinivas Ramachandran","orcid":"https://orcid.org/0000-0003-2929-1377","observed_orcids":["https://orcid.org/0000-0003-2929-1377"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivas Ramachandran","raw_affiliation_strings":["2University of Colorado School of Medicine, Aurora, CO,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Colorado School of Medicine, Aurora, CO,","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039053483","display_name":"Min Yu","orcid":"https://orcid.org/0000-0002-3969-8720","observed_orcids":["https://orcid.org/0000-0002-3969-8720"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Yu","raw_affiliation_strings":["1University of Maryland School of Medicine, Baltimore, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Maryland School of Medicine, Baltimore, MD,","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"5_Supplement_1","first_page":"PR","last_page":"006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.7445999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.7445999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.17970000207424164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-dormancy","display_name":"tumor dormancy","score":0.847000002861023},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-subpopulations","display_name":"tumor cell subpopulations","score":0.8309999704360962},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8050000071525574},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.800000011920929},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.6119999885559082},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.699999988079071},{"id":"https://openalex.org/keywords/cellular-plasticity","display_name":"cellular plasticity","score":0.6470000147819519},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5485594272613525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45636293292045593},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38091322779655457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3526756167411804},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32771748304367065},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.09939467906951904},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.brain23-pr-006","doi":"https://doi.org/10.1158/1538-7445.brain23-pr-006","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.brain23-pr-006","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379984859","https://openalex.org/W4384405030","https://openalex.org/W4393085380","https://openalex.org/W7148736455","https://openalex.org/W7130390965","https://openalex.org/W7155606386","https://openalex.org/W4206361954","https://openalex.org/W7150141461","https://openalex.org/W4414255498","https://openalex.org/W4409329578"],"abstract_inverted_index":{"Abstract":[0],"Capturing":[1],"comprehensive":[2],"brain":[3,38,76,176,261,273,324],"metastasis":[4,77,177,262],"landscape":[5,296,321],"is":[6,159,314],"critical":[7],"to":[8,24,90,165,184,194,260,302,338],"the":[9,26,71,171,189,219,281,287,294,298,315,319,377],"establishment":[10],"of":[11,19,75,234,280,318,331,376],"effective":[12],"anti-tumor":[13],"strategies.":[14],"This":[15,264],"study":[16,313],"took":[17],"advantage":[18],"single":[20],"cell":[21,55,163,201,207],"multiomics":[22,316],"sequencing":[23],"profile":[25],"molecular":[27],"and":[28,34,66,86,93,110,125,134,157,210,215,229,283,308],"cellular":[29],"dynamics":[30,367],"in":[31,61,248,311,369],"tumor":[32,54,73,119,135,162,181,196,224,237,277,288,304,340,371],"cells":[33,104,120,136,156,182,197,225,242,372],"associated":[35,160],"microenvironment":[36,191],"during":[37],"metastasis.":[39],"Among":[40],"different":[41],"primary":[42,284],"cancer":[43,241],"types,":[44],"our":[45,114],"data":[46,115],"suggest":[47,116,170],"that":[48,117,144,254,267],"there":[49],"are":[50],"conserved":[51,72,276,365],"yet":[52],"distinct":[53,106],"subpopulations,":[56],"governed":[57],"by":[58,128,154],"specific":[59],"changes":[60],"gene":[62],"expression,":[63],"chromatin":[64],"accessibility":[65],"tumor-stroma":[67],"interactions.":[68],"We":[69],"characterized":[70],"subpopulations":[74,278],"with":[78,100,161,188,222,231,342],"features":[79],"of:":[80],"(1)":[81],"dormancy,":[82],"(2)":[83],"enhanced":[84],"translation":[85],"migration,":[87],"(3)":[88],"epithelial":[89,164],"mesenchymal":[91,166],"transition":[92,299],"(4)":[94],"high":[95],"proliferation":[96],"rate.":[97],"In":[98],"line":[99],"previous":[101],"observations,":[102],"dormant":[103,118,180,223,301,370],"exhibit":[105],"stimulation":[107],"for":[108],"interferon":[109],"oxidative":[111],"phosphorylation.":[112],"Furthermore,":[113],"increase":[121],"amino":[122],"acids":[123],"metabolism":[124],"antigen":[126],"presentation":[127],"upregulating":[129],"HLA":[130],"class":[131],"molecules.":[132],"Stromal":[133],"interaction":[137],"network":[138],"analysis":[139,204],"predicted":[140],"most":[141],"active":[142],"ligands":[143],"might":[145],"shape":[146],"intratumoral":[147,271],"heterogeneity.":[148],"For":[149],"example,":[150],"TGF\u03b2":[151],"signaling":[152],"induced":[153],"immune":[155],"astrocytes":[158],"transition.":[167],"Additionally,":[168],"results":[169],"vascular":[172],"endothelial":[173],"niche":[174],"supports":[175],"proliferation.":[178],"Interestingly,":[179],"appear":[183],"limit":[185],"cell-cell":[186],"interactions":[187],"surrounding":[190],"when":[192],"compared":[193],"other":[195],"subpopulations.":[198],"Despite":[199],"pronounced":[200,270],"plasticity,":[202],"trajectory":[203,220,289],"uncovered":[205],"a":[206,232,246,269],"progression":[208],"pattern":[209],"its":[211,227],"major":[212],"sequential":[213],"states":[214],"driving":[216],"genes.":[217],"Notably,":[218],"embarked":[221],"at":[226],"root":[228],"ended":[230],"prevalence":[233],"rapidly":[235],"proliferating":[236,303],"cells.":[238,305],"As":[239],"cycling":[240],"arise,":[243],"we":[244,327],"observed":[245],"disruption":[247],"circadian":[249,256],"rhythm":[250],"regulators":[251],"activities,":[252],"indicating":[253],"altered":[255],"regulation":[257],"may":[258],"contribute":[259],"progression.":[263],"work":[265],"demonstrated":[266],"despite":[268],"heterogeneity,":[272],"metastases":[274,362],"present":[275],"regardless":[279],"patient":[282],"type.":[285],"Importantly,":[286],"provides":[290],"new":[291],"insights":[292],"into":[293],"regulatory":[295,320,334,366],"controlling":[297],"from":[300],"A":[306],"novel":[307,339],"key":[309,333],"finding":[310],"this":[312],"characterization":[317],"shaping":[322],"human":[323],"metastases.":[325],"Thus,":[326],"believe":[328],"further":[329],"understanding":[330],"these":[332],"elements":[335],"could":[336],"lead":[337],"targets":[341],"broad":[343],"translational":[344],"potential.":[345],"Citation":[346],"Format:":[347],"Remi":[348],"Klotz,":[349],"Yiru":[350],"Jess":[351],"Wang,":[352],"Alexis":[353],"Zukowski,":[354],"Frank":[355],"Attenelo,":[356],"Srinivas":[357],"Ramachandran,":[358],"Min":[359],"Yu.":[360],"Brain":[361,382],"roadmap":[363],"reveals":[364],"rooted":[368],"[abstract].":[373],"In:":[374],"Proceedings":[375],"AACR":[378],"Special":[379],"Conference":[380],"on":[381],"Cancer;":[383],"2023":[384],"Oct":[385],"19-22;":[386],"Minneapolis,":[387],"Minnesota.":[388],"Philadelphia":[389],"(PA):":[390],"AACR;":[391],"Cancer":[392],"Res":[393],"2024;84(5":[394],"Suppl_1):Abstract":[395],"nr":[396],"PR-006.":[397]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-05T00:00:00"}
