{"id":"https://openalex.org/W4392373095","doi":"https://doi.org/10.1002/bco2.335","title":"Immune checkpoint inhibitors in high\u2010grade upper tract urothelial carcinoma: Paradigm shift emphasizing organ preservation","display_name":"Immune checkpoint inhibitors in high\u2010grade upper tract urothelial carcinoma: Paradigm shift emphasizing organ preservation","publication_year":2024,"publication_date":"2024-03-03","ids":{"openalex":"https://openalex.org/W4392373095","doi":"https://doi.org/10.1002/bco2.335","pmid":"https://pubmed.ncbi.nlm.nih.gov/38751949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11090768"},"language":"en","primary_location":{"id":"doi:10.1002/bco2.335","doi":"https://doi.org/10.1002/bco2.335","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bco2.335","pdf_url":null,"source":{"id":"https://openalex.org/S4210190590","display_name":"BJUI Compass","issn_l":"2688-4526","issn":["2688-4526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI Compass","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/bco2.335","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101644430","display_name":"Mahmoud Khalil","orcid":"https://orcid.org/0000-0001-9007-2945","observed_orcids":["https://orcid.org/0000-0001-9007-2945"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210151307","display_name":"Phelps Hospital","ror":"https://ror.org/04cap6186","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210151307"]}],"countries":["EG","US"],"is_corresponding":false,"raw_author_name":"Mahmoud Khalil","raw_affiliation_strings":["Department of Urology, Ain Shams University, Cairo, Egypt","Department of Urology, Phelps Hospital, Northwell Health, Sleepy Hollow, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-9007-2945","affiliations":[{"raw_affiliation_string":"Department of Urology, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Department of Urology, Phelps Hospital, Northwell Health, Sleepy Hollow, New York, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210151307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037466950","display_name":"Andrew I. Fishman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210151307","display_name":"Phelps Hospital","ror":"https://ror.org/04cap6186","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210151307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Fishman","raw_affiliation_strings":["Department of Urology, Phelps Hospital, Northwell Health, Sleepy Hollow, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Phelps Hospital, Northwell Health, Sleepy Hollow, New York, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210151307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051785006","display_name":"Anna W. Komorowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210151307","display_name":"Phelps Hospital","ror":"https://ror.org/04cap6186","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210151307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Komorowski","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Phelps Hospital, Northwell Health, Sleepy Hollow, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Phelps Hospital, Northwell Health, Sleepy Hollow, New York, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210151307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054531832","display_name":"Israel Franco","orcid":"https://orcid.org/0000-0002-5675-873X","observed_orcids":["https://orcid.org/0000-0002-5675-873X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Israel Franco","raw_affiliation_strings":["Department of Urology, Yale School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":"https://orcid.org/0000-0002-5675-873X","affiliations":[{"raw_affiliation_string":"Department of Urology, Yale School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071151824","display_name":"Michael Grasso","orcid":"https://orcid.org/0000-0001-6455-6508","observed_orcids":["https://orcid.org/0000-0001-6455-6508"]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I4210151307","display_name":"Phelps Hospital","ror":"https://ror.org/04cap6186","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210151307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Grasso","raw_affiliation_strings":["Department of Urology, New York Medical College, Valhalla, New York, USA","Department of Urology, Phelps Hospital, Northwell Health, Sleepy Hollow, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, New York Medical College, Valhalla, New York, USA","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Urology, Phelps Hospital, Northwell Health, Sleepy Hollow, New York, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210151307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5071151824"],"corresponding_institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I181190671","https://openalex.org/I4210151307"],"apc_list":{"value":2520,"currency":"USD","value_usd":2520},"apc_paid":{"value":2520,"currency":"USD","value_usd":2520},"fwci":0.7794,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.67582104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"5","issue":"5","first_page":"604","last_page":"610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/upper-tract-urothelial-carcinoma","display_name":"upper tract urothelial carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/high-grade-urothelial-carcinoma","display_name":"high-grade urothelial carcinoma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/endoscopic-treatment","display_name":"endoscopic treatment","score":0.8659999966621399},{"id":"https://openalex.org/keywords/adjuvant-immunotherapy","display_name":"adjuvant immunotherapy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/organ-preservation","display_name":"organ preservation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9419999718666077},{"id":"https://openalex.org/keywords/metastasis-free-survival","display_name":"metastasis-free survival","score":1.0}],"concepts":[{"id":"https://openalex.org/C3019882237","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial carcinoma","level":4,"score":0.8585489988327026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6310175657272339},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5542381405830383},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4689960777759552},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.40823298692703247},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33336779475212097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33235442638397217},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21444007754325867},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16475450992584229},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.11711704730987549}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1002/bco2.335","doi":"https://doi.org/10.1002/bco2.335","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bco2.335","pdf_url":null,"source":{"id":"https://openalex.org/S4210190590","display_name":"BJUI Compass","issn_l":"2688-4526","issn":["2688-4526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI Compass","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11090768","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11090768","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11090768/pdf/BCO2-5-490.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI Compass","raw_type":"Text"},{"id":"pmid:38751949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38751949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI compass","raw_type":"Journal Article"},{"id":"pmh:oai:touroscholar.touro.edu:nymc_fac_pubs-6067","doi":null,"is_oa":false,"landing_page_url":"https://touroscholar.touro.edu/nymc_fac_pubs/5141","pdf_url":null,"source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NYMC Faculty Publications","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:be68000a24ad4f37bc956f8b82e52e1c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/be68000a24ad4f37bc956f8b82e52e1c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BJUI Compass, Vol 5, Iss 5, Pp 604-610 (2024)","raw_type":"article"},{"id":"pmh:oai:touroscholar.touro.edu:nymc_fac_pubs-7588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38751949/?myncbishare=nymclib","pdf_url":null,"source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NYMC Faculty Publications","raw_type":"article"},{"id":"doi:10.60692/a1qfm-pxv86","doi":"https://doi.org/10.60692/a1qfm-pxv86","is_oa":true,"landing_page_url":"https://doi.org/10.60692/a1qfm-pxv86","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/nn64x-03a21","doi":"https://doi.org/10.60692/nn64x-03a21","is_oa":true,"landing_page_url":"https://doi.org/10.60692/nn64x-03a21","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1002/bco2.335","doi":"https://doi.org/10.1002/bco2.335","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bco2.335","pdf_url":null,"source":{"id":"https://openalex.org/S4210190590","display_name":"BJUI Compass","issn_l":"2688-4526","issn":["2688-4526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJUI Compass","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392373095.pdf","grobid_xml":"https://content.openalex.org/works/W4392373095.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1513426632","https://openalex.org/W1523507198","https://openalex.org/W1524063860","https://openalex.org/W1969198243","https://openalex.org/W2024812275","https://openalex.org/W2059518661","https://openalex.org/W2076914872","https://openalex.org/W2143332153","https://openalex.org/W2165027975","https://openalex.org/W2588916311","https://openalex.org/W2736166064","https://openalex.org/W2760661635","https://openalex.org/W2786816161","https://openalex.org/W2897581535","https://openalex.org/W2964014383","https://openalex.org/W3007264925","https://openalex.org/W3021888588","https://openalex.org/W3090325325","https://openalex.org/W3094891754","https://openalex.org/W3114827544","https://openalex.org/W3164197656","https://openalex.org/W3172836937","https://openalex.org/W4249552371","https://openalex.org/W4309369016","https://openalex.org/W4313333351"],"related_works":["https://openalex.org/W7154907667","https://openalex.org/W4360609169","https://openalex.org/W3127307282","https://openalex.org/W7205709345","https://openalex.org/W3133503852","https://openalex.org/W7213241160","https://openalex.org/W4399394393","https://openalex.org/W3127338253","https://openalex.org/W7143315875","https://openalex.org/W2947612184"],"abstract_inverted_index":{"Objective:":[0],"The":[1,151,220],"aim":[2],"was":[3,107,155,180,190,200],"to":[4,109,170],"evaluate":[5],"the":[6,67,111,176,196,245],"role":[7],"of":[8,77,113,121,237,241,247],"immune":[9],"check":[10],"point":[11],"inhibitors":[12],"(ICIs)":[13],"in":[14,35,66,128,133,185,192,207,217,244,265],"patients":[15,36,50,70,123,183,203,250],"with":[16,52,126,233,251,256,272],"high-grade":[17,53,252],"upper":[18],"tract":[19],"urothelial":[20],"carcinoma":[21],"(UTUC)":[22],"who":[23,37,83,92],"are":[24,38,276],"managed":[25,56],"endoscopically":[26,57,248],"when":[27],"nephroureterectomy":[28],"(NU)":[29],"is":[30,254],"not":[31,40,85],"feasible,":[32],"such":[33],"as":[34],"either":[39],"candidates":[41],"for":[42],"NU":[43],"or":[44],"decline":[45],"extirpative":[46],"surgery.":[47],"Methods:":[48],"All":[49],"diagnosed":[51],"UTUC":[54,253],"and":[55,61,88,131,141,147,165,229],"between":[58,226],"January":[59],"1996":[60],"August":[62],"2022":[63],"were":[64,71,97,124],"included":[65],"study.":[68],"Subsequently,":[69],"categorised":[72],"based":[73],"on":[74,116],"their":[75],"use":[76],"ICIs":[78,243,261],"into":[79],"group":[80,89,129,134,159,171,186,193,208,218],"1":[81,130,209],"(patients":[82,91],"did":[84],"receive":[86],"ICIs)":[87],"2":[90,160],"received":[93],"ICIs).":[94],"Survival":[95],"outcomes":[96],"assessed":[98],"using":[99],"Kaplan-Meier":[100],"analysis,":[101],"while":[102],"a":[103,224,234],"multivariable":[104,221],"regression":[105],"model":[106],"employed":[108],"analyse":[110],"impact":[112],"clinical":[114],"characteristics":[115],"survival.":[117],"Results:":[118],"A":[119],"total":[120],"29":[122],"enrolled,":[125],"14":[127],"15":[132],"2.":[135,194,219],"Both":[136],"groups":[137],"exhibited":[138],"similar":[139],"demographic":[140],"disease":[142],"characteristics,":[143],"including":[144],"multifocality,":[145],"laterality":[146],"initial":[148],"tumour":[149],"size.":[150],"median":[152],"follow-up":[153],"period":[154],"29.2":[156],"months.":[157],"Notably,":[158],"demonstrated":[161],"significantly":[162,257],"enhanced":[163],"overall":[164,177],"metastasis-free":[166,197],"survival":[167,178,198,231,259],"rates":[168],"compared":[169],"1.":[172],"At":[173],"47.8":[174],"months,":[175,212],"rate":[179,199],"0%":[181,201],"(all":[182,202],"died)":[184],"1,":[187],"whereas":[188,213],"it":[189,214],"85.7%":[191],"Similarly,":[195],"had":[204],"metastatic":[205],"disease)":[206],"at":[210],"40.6":[211],"reached":[215],"78.0%":[216],"analysis":[222],"indicated":[223],"correlation":[225],"ICI":[227],"usage":[228],"improved":[230,258],"outcomes,":[232],"hazard":[235],"ratio":[236],"0.002.":[238],"Conclusion:":[239],"Utilisation":[240],"adjuvant":[242],"setting":[246],"treated":[249],"associated":[255],"rates.":[260],"should":[262],"be":[263],"considered":[264],"this":[266],"patient":[267],"population,":[268],"however,":[269],"more":[270],"studies":[271],"larger":[273],"sample":[274],"size":[275],"warranted.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-05T00:00:00"}