{"id":"https://openalex.org/W4392360016","doi":"https://doi.org/10.3390/molecules29051117","title":"Anti-Inflammatory Effect of Chamaecyparis obtusa (Siebold & Zucc.) Endl. Leaf Essential Oil","display_name":"Anti-Inflammatory Effect of Chamaecyparis obtusa (Siebold & Zucc.) Endl. Leaf Essential Oil","publication_year":2024,"publication_date":"2024-03-01","ids":{"openalex":"https://openalex.org/W4392360016","doi":"https://doi.org/10.3390/molecules29051117","pmid":"https://pubmed.ncbi.nlm.nih.gov/38474629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10933829"},"language":"en","primary_location":{"id":"doi:10.3390/molecules29051117","doi":"https://doi.org/10.3390/molecules29051117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29051117","pdf_url":"https://www.mdpi.com/1420-3049/29/5/1117/pdf?version=1709303047","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/29/5/1117/pdf?version=1709303047","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085444186","display_name":"Sung-Hee Kim","orcid":"https://orcid.org/0009-0007-2638-9164","observed_orcids":["https://orcid.org/0009-0007-2638-9164"]},"institutions":[{"id":"https://openalex.org/I118722661","display_name":"Kyungsung University","ror":"https://ror.org/05h9pgm95","country_code":"KR","type":"education","lineage":["https://openalex.org/I118722661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Hee Kim","raw_affiliation_strings":["Department of Cosmeceutical Science, Kyungsung University, Busan 48434, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0007-2638-9164","affiliations":[{"raw_affiliation_string":"Department of Cosmeceutical Science, Kyungsung University, Busan 48434, Republic of Korea","institution_ids":["https://openalex.org/I118722661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004956626","display_name":"Young\u2010Ah Jang","orcid":"https://orcid.org/0000-0001-7688-5245","observed_orcids":["https://orcid.org/0000-0001-7688-5245"]},"institutions":[{"id":"https://openalex.org/I138826464","display_name":"Daegu Haany University","ror":"https://ror.org/045wr3278","country_code":"KR","type":"education","lineage":["https://openalex.org/I138826464"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young-Ah Jang","raw_affiliation_strings":["Division of Cosmetic Science, Daegu Haany University, Gyeongsan 38610, Gyeongbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cosmetic Science, Daegu Haany University, Gyeongsan 38610, Gyeongbuk, Republic of Korea","institution_ids":["https://openalex.org/I138826464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104251668","display_name":"Yong\u2010Jin Kwon","orcid":"https://orcid.org/0009-0006-9760-9358","observed_orcids":["https://orcid.org/0009-0006-9760-9358"]},"institutions":[{"id":"https://openalex.org/I118722661","display_name":"Kyungsung University","ror":"https://ror.org/05h9pgm95","country_code":"KR","type":"education","lineage":["https://openalex.org/I118722661"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong-Jin Kwon","raw_affiliation_strings":["Department of Cosmeceutical Science, Kyungsung University, Busan 48434, Republic of Korea","Department of Cosmetic Science, Kyungsung University, Busan 48434, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cosmeceutical Science, Kyungsung University, Busan 48434, Republic of Korea","institution_ids":["https://openalex.org/I118722661"]},{"raw_affiliation_string":"Department of Cosmetic Science, Kyungsung University, Busan 48434, Republic of Korea","institution_ids":["https://openalex.org/I118722661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004956626","https://openalex.org/A5104251668"],"corresponding_institution_ids":["https://openalex.org/I118722661","https://openalex.org/I138826464"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3069},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3069},"fwci":2.0247,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.83701923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"29","issue":"5","first_page":"1117","last_page":"1117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.16660000383853912,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.08229999989271164,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chamaecyparis-obtusa","display_name":"Chamaecyparis obtusa","score":1.0},{"id":"https://openalex.org/keywords/leaf-essential-oil","display_name":"leaf essential oil","score":0.9430000185966492},{"id":"https://openalex.org/keywords/sabinene","display_name":"sabinene","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8650000095367432},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/jnk-phosphorylation","display_name":"JNK phosphorylation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7059999704360962},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8820000290870667},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8769999742507935},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.890999972820282},{"id":"https://openalex.org/keywords/cupressaceae","display_name":"Cupressaceae","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2778919576","wikidata":"https://www.wikidata.org/wiki/Q421278","display_name":"Sabinene","level":4,"score":0.9522755146026611},{"id":"https://openalex.org/C2776621788","wikidata":"https://www.wikidata.org/wiki/Q147791","display_name":"Chamaecyparis","level":2,"score":0.736506462097168},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5657830834388733},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.48157572746276855},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.43794673681259155},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.41342929005622864},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.3911744952201843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.276641845703125},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.14450758695602417},{"id":"https://openalex.org/C2776134268","wikidata":"https://www.wikidata.org/wiki/Q278809","display_name":"Limonene","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081008","descriptor_name":"Bicyclic Monoterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009822","descriptor_name":"Oils, Volatile","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029780","descriptor_name":"Chamaecyparis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules29051117","doi":"https://doi.org/10.3390/molecules29051117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29051117","pdf_url":"https://www.mdpi.com/1420-3049/29/5/1117/pdf?version=1709303047","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10933829","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10933829","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10933829/pdf/molecules-29-01117.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:38474629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38474629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:827687281c434fab8a0886b948362a08","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/827687281c434fab8a0886b948362a08","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 29, Iss 5, p 1117 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules29051117","doi":"https://doi.org/10.3390/molecules29051117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29051117","pdf_url":"https://www.mdpi.com/1420-3049/29/5/1117/pdf?version=1709303047","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7300101497","display_name":null,"funder_award_id":"2022R1F1A1074297","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392360016.pdf","grobid_xml":"https://content.openalex.org/works/W4392360016.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1596484490","https://openalex.org/W1969929211","https://openalex.org/W1974781648","https://openalex.org/W1980110441","https://openalex.org/W1986544628","https://openalex.org/W1986855364","https://openalex.org/W1991047945","https://openalex.org/W1995986855","https://openalex.org/W1998470844","https://openalex.org/W2000011073","https://openalex.org/W2007115885","https://openalex.org/W2017191505","https://openalex.org/W2019449356","https://openalex.org/W2022052477","https://openalex.org/W2036932644","https://openalex.org/W2042166751","https://openalex.org/W2051020514","https://openalex.org/W2054464764","https://openalex.org/W2058142370","https://openalex.org/W2068145282","https://openalex.org/W2087863662","https://openalex.org/W2092054181","https://openalex.org/W2096931514","https://openalex.org/W2134558816","https://openalex.org/W2172747923","https://openalex.org/W2230052557","https://openalex.org/W2556561046","https://openalex.org/W2771472591","https://openalex.org/W2779517020","https://openalex.org/W2898753645","https://openalex.org/W2990337693","https://openalex.org/W2993908729","https://openalex.org/W3013726226","https://openalex.org/W3188923472","https://openalex.org/W4284970951","https://openalex.org/W4318478422","https://openalex.org/W4379052550","https://openalex.org/W6755289993","https://openalex.org/W7100088330"],"related_works":["https://openalex.org/W1974781648","https://openalex.org/W4412712895","https://openalex.org/W2906921924","https://openalex.org/W2903298709","https://openalex.org/W3188923472","https://openalex.org/W2405960397","https://openalex.org/W2284590160","https://openalex.org/W2770606293","https://openalex.org/W2898753645","https://openalex.org/W2293052384"],"abstract_inverted_index":{"Chamaecyparis":[0],"obtusa":[1,32,53,68],"(Siebold":[2],"&":[3],"Zucc.)":[4],"Endl.":[5],"(C.":[6],"obtusa)":[7],"belongs":[8],"to":[9,16,198],"the":[10,24,48,60,64,78,138,147,167,202],"Cupressaceae":[11],"family":[12],"and":[13,28,36,39,77,97,109,116,119,135,146,154,163,180,190,201,205],"is":[14],"native":[15],"East":[17],"Asian":[18],"regions.":[19],"Essential":[20],"oils":[21],"extracted":[22],"from":[23],"leaves,":[25],"bark,":[26],"branches,":[27],"roots":[29],"of":[30,47,51,66,81,87,140,149,169,188],"C.":[31,52,67],"have":[33],"both":[34,133],"aesthetic":[35],"medicinal":[37],"properties":[38],"are":[40,55],"thus":[41],"widely":[42],"used.":[43],"However,":[44],"detailed":[45],"analyses":[46],"active":[49],"ingredients":[50],"extract":[54],"lacking.":[56],"In":[57],"this":[58],"study,":[59],"sabinene":[61,136,164,191,206],"content":[62],"in":[63,156],"hydro-distillation":[65],"leaf":[69],"essential":[70],"oil":[71],"(COD)":[72],"was":[73,83,92,102,196],"analyzed":[74,113,123],"using":[75,104,114,124],"GC-MS,":[76],"anti-inflammatory":[79,186],"effect":[80],"COD":[82,134,162,189,195],"compared":[84],"with":[85],"that":[86,132],"pure":[88],"sabinene.":[89],"Cell":[90],"viability":[91],"evaluated":[93],"by":[94],"MTT":[95],"assay,":[96],"nitric":[98,142],"oxide":[99,143],"(NO)":[100],"production":[101,168],"measured":[103],"Griess":[105],"reagent.":[106],"Relative":[107],"mRNA":[108],"protein":[110],"levels":[111],"were":[112,122],"RT-qPCR":[115],"western":[117],"blot,":[118],"secreted":[120],"cytokines":[121,171],"a":[125],"cytokine":[126],"array":[127],"kit.":[128],"The":[129,185],"results":[130],"showed":[131],"inhibited":[137,207],"expression":[139],"inducible":[141],"synthase":[144],"(iNOS)":[145],"phosphorylation":[148],"c-Jun":[150],"N-terminal":[151],"kinase":[152],"(JNK)":[153],"p38":[155],"lipopolysaccharide":[157],"(LPS)-induced":[158],"RAW":[159],"264.7":[160],"cells.":[161],"also":[165],"reduced":[166],"pro-inflammatory":[170],"interleukin":[172],"(IL)-1\u03b2,":[173],"IL-6,":[174],"IL-27,":[175],"IL-1":[176],"receptor":[177],"antagonist":[178],"(IL-1ra),":[179],"granulocyte-macrophage":[181],"colony-stimulating":[182],"factor":[183],"(GM-CSF).":[184],"mechanisms":[187],"partially":[192],"overlap,":[193],"as":[194],"shown":[197],"inhibit":[199],"MAPKs":[200],"JAK/STAT":[203],"axis,":[204],"MAPKs,":[208],"thereby":[209],"preventing":[210],"LPS-induced":[211],"macrophage":[212],"activation.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-03-05T00:00:00"}