{"id":"https://openalex.org/W4392354716","doi":"https://doi.org/10.1158/1557-3265.endo24-b015","title":"Abstract B015: A novel Cluster 3 Endometrial Cancer PDX model to test hormone therapy regimens","display_name":"Abstract B015: A novel Cluster 3 Endometrial Cancer PDX model to test hormone therapy regimens","publication_year":2024,"publication_date":"2024-03-01","ids":{"openalex":"https://openalex.org/W4392354716","doi":"https://doi.org/10.1158/1557-3265.endo24-b015"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3265.endo24-b015","doi":"https://doi.org/10.1158/1557-3265.endo24-b015","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1557-3265.endo24-b015","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011828487","display_name":"Kimberly Kay Leslie","orcid":"https://orcid.org/0000-0002-2704-8990","observed_orcids":["https://orcid.org/0000-0002-2704-8990"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly K. Leslie","raw_affiliation_strings":["1The University of New Mexico, Albuquerque, NM,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of New Mexico, Albuquerque, NM,","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114082788","display_name":"Lane E. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lane E. Smith","raw_affiliation_strings":["1The University of New Mexico, Albuquerque, NM,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of New Mexico, Albuquerque, NM,","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104167230","display_name":"Jamie Padilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Padilla","raw_affiliation_strings":["1The University of New Mexico, Albuquerque, NM,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of New Mexico, Albuquerque, NM,","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"last","author":{"id":null,"display_name":"Adrian Quintana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian Quintana","raw_affiliation_strings":["2Vanderbilt University, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"5_Supplement","first_page":"B015","last_page":"B015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.6069999933242798},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.7559999823570251},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8019999861717224},{"id":"https://openalex.org/keywords/onapristone","display_name":"onapristone","score":0.8999999761581421},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9020000100135803},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hormone-resistance","display_name":"hormone resistance","score":0.8259999752044678},{"id":"https://openalex.org/keywords/endometrioid-carcinoma","display_name":"endometrioid carcinoma","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cell-cycle-regulators","display_name":"cell cycle regulators","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.3720000088214874},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.4650000035762787},{"id":"https://openalex.org/keywords/nsg-mice","display_name":"NSG mice","score":0.5239999890327454},{"id":"https://openalex.org/keywords/ishikawa-cells","display_name":"Ishikawa cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.42800000309944153},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.7580869197845459},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6216622591018677},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5885866284370422},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.5839583873748779},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5373557806015015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5162253379821777},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3885672688484192},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.14883604645729065}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3265.endo24-b015","doi":"https://doi.org/10.1158/1557-3265.endo24-b015","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1557-3265.endo24-b015","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409626293","https://openalex.org/W3126345100","https://openalex.org/W4309473110","https://openalex.org/W4393087689","https://openalex.org/W7171449717","https://openalex.org/W2067970783","https://openalex.org/W3127873686","https://openalex.org/W4312139801","https://openalex.org/W1907524930","https://openalex.org/W2014927106"],"abstract_inverted_index":{"Abstract":[0],"Endometrial":[1,437,455],"cancer":[2,9,49,130,289,305,375],"is":[3,50,104],"the":[4,21,27,51,57,68,116,125,172,227,320,345,355,381,385,450],"most":[5,44],"commonly":[6],"diagnosed":[7],"gynecologic":[8],"and":[10,16,63,169,207,213,251,293,324,351,392],"continues":[11],"to":[12,70,72,91,99,110,211,235,248,264,300,319,403,417,441],"rise":[13],"in":[14,171,178,181,238,286,290,342,373,395,407],"incidence":[15],"mortality":[17],"rates":[18],"worldwide.":[19],"With":[20],"evaluation":[22],"of":[23,47,59,119,127,155,229,348,371,384,449],"large":[24],"datasets":[25],"including":[26,380],"TCGA,":[28],"endometrial":[29,48,120,129,148,288,374],"cancers":[30],"have":[31],"been":[32],"subdivided":[33],"into":[34],"four":[35],"different":[36],"cluster":[37],"groups":[38],"based":[39],"on":[40,304,454],"molecular":[41],"characteristics.":[42],"The":[43,136,160],"common":[45],"subtype":[46],"Cluster":[52,76,408,435],"3":[53,77,409,436],"category,":[54],"demarcated":[55],"by":[56],"expression":[58,83,254],"estrogen":[60],"receptors":[61,65],"(ER)":[62],"progesterone":[64,274,323,350],"(PR)":[66],"with":[67,262,273,281,309,378],"potential":[69],"respond":[71,247,413],"hormonal":[73,249,405],"therapy.":[74],"However,":[75],"tumors":[78,410],"frequently":[79],"lose":[80],"hormone":[81,189,231,302,332,443],"receptor":[82],"over":[84,240,419],"time,":[85],"particularly":[86],"PR,":[87],"making":[88,184],"them":[89],"resistant":[90,232],"treatment.":[92],"Although":[93],"numerous":[94],"cell":[95,386],"line":[96],"models":[97,109],"exist":[98],"study":[100],"this":[101,185],"disease,":[102],"there":[103],"a":[105,145,152,230,401],"need":[106],"for":[107,115,166,188],"improved":[108],"select":[111],"best":[112],"treatment":[113,328,418],"options":[114],"specific":[117],"types":[118],"cancers.":[121],"Here,":[122],"we":[123],"describe":[124],"development":[126,228],"an":[128,277],"patient":[131,174],"derived":[132,143],"xenograft":[133],"(PDX),":[134],"EC-PDX3.":[135],"initial":[137,179],"tumor":[138,161,315],"from":[139,358],"which":[140,353],"EC-PDX3":[141,195,359,399],"was":[142,144,334],"low-grade":[146],"endometrioid":[147],"carcinoma":[149],"that":[150,215,236,331,411],"contained":[151],"low":[153],"number":[154,158],"somatic":[156],"copy":[157],"alterations.":[159],"initially":[162,260,412],"tested":[163],"robustly":[164],"positive":[165],"both":[167],"ER":[168,206,217],"PR":[170,208,221,253,266],"donor":[173],"as":[175,177,317,390],"well":[176],"passages":[180],"athymic":[182],"mice,":[183],"model":[186,402,440],"valuable":[187],"therapy":[190,250,406,444],"research.":[191],"In":[192,397],"these":[193,245],"studies,":[194],"cells":[196,246,341,376],"were":[197,223,259,270,297],"grown":[198],"within":[199],"immunodeficient":[200],"NSG":[201],"mice.":[202],"We":[203],"performed":[204],"H&E,":[205],"staining":[209],"prior":[210],"experimentation":[212],"found":[214],"while":[216],"remained":[218],"highly":[219],"positive,":[220],"levels":[222],"significantly":[224],"downregulated,":[225],"indicating":[226,330],"state":[233],"similar":[234],"occurring":[237],"patients":[239],"time.":[241,420],"To":[242],"determine":[243,301],"if":[244,252],"could":[255],"be":[256],"induced,":[257],"mice":[258,269,361],"treated":[261,272,308,362],"estradiol":[263,310,321,325,379],"enhance":[265],"expression.":[267],"Next,":[268],"further":[271],"or":[275],"onapristone,":[276],"experimental":[278],"progestin":[279],"agonist/antagonist":[280],"previously":[282],"reported":[283],"encouraging":[284],"activity":[285],"advanced":[287],"phase":[291],"I":[292],"II":[294],"trials.":[295],"Tumors":[296],"measured":[298],"weekly":[299],"effects":[303,347,370],"growth.":[306],"Mice":[307],"alone":[311],"showed":[312],"substantially":[313],"larger":[314],"growth":[316,368],"compared":[318],"+":[322,326],"onapristone":[327,352,372],"groups,":[329],"sensitivity":[333],"likely":[335],"re-instated.":[336],"RNA":[337],"sequencing":[338],"using":[339],"Ishikawa":[340],"culture":[343],"revealed":[344],"transcriptional":[346],"estradiol,":[349],"complement":[354],"data":[356],"obtained":[357],"bearing":[360],"similarly.":[363],"These":[364],"studies":[365],"identify":[366],"interesting":[367],"inhibitory":[369],"primed":[377],"significant":[382],"induction":[383],"cycle":[387],"regulators":[388],"such":[389],"p21":[391],"genes":[393],"involved":[394],"apoptosis.":[396],"addition,":[398],"provides":[400],"assess":[404],"but":[414],"develop":[415],"resistance":[416],"Citation":[421],"Format:":[422],"Kimberly":[423],"K.":[424],"Leslie,":[425],"Lane":[426],"E.":[427],"Smith,":[428],"Jamie":[429],"Padilla,":[430],"Adrian":[431],"Quintana.":[432],"A":[433],"novel":[434],"Cancer":[438,470],"PDX":[439],"test":[442],"regimens":[445],"[abstract].":[446],"In:":[447],"Proceedings":[448],"AACR":[451],"Special":[452],"Conference":[453],"Cancer:":[456],"Transforming":[457],"Care":[458],"through":[459],"Science;":[460],"2023":[461],"Nov":[462],"16-18;":[463],"Boston,":[464],"Massachusetts.":[465],"Philadelphia":[466],"(PA):":[467],"AACR;":[468],"Clin":[469],"Res":[471],"2024;30(5_Suppl):Abstract":[472],"nr":[473],"B015.":[474]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-03-05T00:00:00"}
