{"id":"https://openalex.org/W4392349230","doi":"https://doi.org/10.1002/pbc.30929","title":"Hypofractionated re\u2010irradiation for diffuse intrinsic pontine glioma","display_name":"Hypofractionated re\u2010irradiation for diffuse intrinsic pontine glioma","publication_year":2024,"publication_date":"2024-03-02","ids":{"openalex":"https://openalex.org/W4392349230","doi":"https://doi.org/10.1002/pbc.30929","pmid":"https://pubmed.ncbi.nlm.nih.gov/38430472"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.30929","doi":"https://doi.org/10.1002/pbc.30929","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.30929","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood & Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11791744/pdf/nihms-2047587.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040097148","display_name":"Nikhil P. Mankuzhy","orcid":"https://orcid.org/0000-0001-9004-7598","observed_orcids":["https://orcid.org/0000-0001-9004-7598"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nikhil P. Mankuzhy","raw_affiliation_strings":["Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-9004-7598","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058490970","display_name":"Kathryn Ries Tringale","orcid":"https://orcid.org/0000-0002-1506-4870","observed_orcids":["https://orcid.org/0000-0002-1506-4870"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn R. Tringale","raw_affiliation_strings":["Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-1506-4870","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068118481","display_name":"Ira J. Dunkel","orcid":"https://orcid.org/0000-0001-8091-6067","observed_orcids":["https://orcid.org/0000-0001-8091-6067"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira J. Dunkel","raw_affiliation_strings":["Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-8091-6067","affiliations":[{"raw_affiliation_string":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046103284","display_name":"Sameer Farouk Sait","orcid":"https://orcid.org/0000-0001-6715-2402","observed_orcids":["https://orcid.org/0000-0001-6715-2402"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameer Farouk Sait","raw_affiliation_strings":["Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-6715-2402","affiliations":[{"raw_affiliation_string":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050235191","display_name":"Mark M. Souweidane","orcid":"https://orcid.org/0000-0001-5627-4551","observed_orcids":["https://orcid.org/0000-0001-5627-4551"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark M. Souweidane","raw_affiliation_strings":["Department of Neurosurgery Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039483794","display_name":"Yasmin Khakoo","orcid":"https://orcid.org/0000-0003-1633-6759","observed_orcids":["https://orcid.org/0000-0003-1633-6759"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasmin Khakoo","raw_affiliation_strings":["Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007528270","display_name":"Matthias A. Karajannis","orcid":"https://orcid.org/0000-0002-7151-6528","observed_orcids":["https://orcid.org/0000-0002-7151-6528"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias A. Karajannis","raw_affiliation_strings":["Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-7151-6528","affiliations":[{"raw_affiliation_string":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074725191","display_name":"Suzanne L. Wolden","orcid":"https://orcid.org/0000-0002-5234-4134","observed_orcids":["https://orcid.org/0000-0002-5234-4134"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Wolden","raw_affiliation_strings":["Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-5234-4134","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040097148"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":3.0214,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.91464351,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"71","issue":"5","first_page":"e30929","last_page":"e30929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-intrinsic-pontine-glioma","display_name":"diffuse intrinsic pontine glioma","score":0.996999979019165},{"id":"https://openalex.org/keywords/reirradiation","display_name":"re-irradiation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/fractionation","display_name":"fractionation","score":0.5659999847412109},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7070000171661377},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.8119999766349792},{"id":"https://openalex.org/keywords/corticosteroid-taper","display_name":"corticosteroid taper","score":0.8389999866485596},{"id":"https://openalex.org/keywords/radiation-necrosis","display_name":"radiation necrosis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pediatric-brainstem-tumors","display_name":"pediatric brainstem tumors","score":0.7730000019073486},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9935122728347778},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.5193094611167908},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5086973309516907},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.41136303544044495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3218543529510498},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2710666060447693},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.12206235527992249},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069473","descriptor_name":"Radiation Dose Hypofractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069473","descriptor_name":"Radiation Dose Hypofractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069473","descriptor_name":"Radiation Dose Hypofractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069473","descriptor_name":"Radiation Dose Hypofractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069473","descriptor_name":"Radiation Dose Hypofractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069473","descriptor_name":"Radiation Dose Hypofractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069473","descriptor_name":"Radiation Dose Hypofractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069473","descriptor_name":"Radiation Dose Hypofractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069475","descriptor_name":"Re-Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069475","descriptor_name":"Re-Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069475","descriptor_name":"Re-Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069475","descriptor_name":"Re-Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069475","descriptor_name":"Re-Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069475","descriptor_name":"Re-Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069475","descriptor_name":"Re-Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069475","descriptor_name":"Re-Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000080443","descriptor_name":"Diffuse Intrinsic Pontine Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000080443","descriptor_name":"Diffuse Intrinsic Pontine Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000080443","descriptor_name":"Diffuse Intrinsic Pontine Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000080443","descriptor_name":"Diffuse Intrinsic Pontine Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000080443","descriptor_name":"Diffuse Intrinsic Pontine Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000080443","descriptor_name":"Diffuse Intrinsic Pontine Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000080443","descriptor_name":"Diffuse Intrinsic Pontine Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000080443","descriptor_name":"Diffuse Intrinsic Pontine Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020295","descriptor_name":"Brain Stem Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D020295","descriptor_name":"Brain Stem Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D020295","descriptor_name":"Brain Stem Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D020295","descriptor_name":"Brain Stem Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D020295","descriptor_name":"Brain Stem Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D020295","descriptor_name":"Brain Stem Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D020295","descriptor_name":"Brain Stem Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D020295","descriptor_name":"Brain Stem Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/pbc.30929","doi":"https://doi.org/10.1002/pbc.30929","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.30929","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood & Cancer","raw_type":"journal-article"},{"id":"pmid:38430472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38430472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11791744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11791744","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11791744/pdf/nihms-2047587.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatr Blood Cancer","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11791744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11791744","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11791744/pdf/nihms-2047587.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatr Blood Cancer","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320308932","display_name":"Radiological Society of North America","ror":"https://ror.org/00rj4x019"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392349230.pdf","grobid_xml":"https://content.openalex.org/works/W4392349230.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1981043389","https://openalex.org/W2020272224","https://openalex.org/W2030393556","https://openalex.org/W2044972361","https://openalex.org/W2066192985","https://openalex.org/W2072000519","https://openalex.org/W2081356727","https://openalex.org/W2100565163","https://openalex.org/W2106343920","https://openalex.org/W2141279304","https://openalex.org/W2149791601","https://openalex.org/W2155451340","https://openalex.org/W2172328801","https://openalex.org/W2553613919","https://openalex.org/W2583297407","https://openalex.org/W2591171877","https://openalex.org/W2791645547","https://openalex.org/W2808090012","https://openalex.org/W2889803667","https://openalex.org/W2896178016","https://openalex.org/W2933306564","https://openalex.org/W3015685048","https://openalex.org/W3092075346","https://openalex.org/W3095952707","https://openalex.org/W3128665870","https://openalex.org/W4206071669","https://openalex.org/W4211143014","https://openalex.org/W4283390688"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"BACKGROUND:":[0],"Re-irradiation":[1],"(reRT)":[2],"increases":[3],"survival":[4,73,234],"in":[5,114,123,183,190,215,249],"locally":[6],"recurrent":[7],"diffuse":[8],"intrinsic":[9],"pontine":[10],"glioma":[11],"(DIPG).":[12],"There":[13,210],"is":[14,26,259],"no":[15,212],"standard":[16],"dose":[17,110,197],"and":[18,71,80,120,146,174,187,220,240,256],"fractionation":[19,24],"for":[20,36,51,91,168],"reRT,":[21,108],"but":[22],"conventional":[23],"(CF)":[25],"typically":[27],"used.":[28],"We":[29,43],"report":[30],"our":[31,54],"institutional":[32],"experience":[33],"of":[34,82,166,246,252],"reRT":[35,50,90,167,205,230],"DIPG,":[37,92],"which":[38],"includes":[39],"hypofractionation":[40],"(HF).":[41],"METHODS:":[42],"reviewed":[44],"pediatric":[45],"patients":[46,87,226],"treated":[47],"with":[48,231],"brainstem":[49],"DIPG":[52],"at":[53],"institution":[55],"from":[56,77,153,164],"2012":[57],"to":[58,100,207,237],"2022.":[59],"Patients":[60],"were":[61],"grouped":[62],"by":[63],"HF":[64,169,185,219,232,258],"or":[65,199],"CF.":[66],"Outcomes":[67],"included":[68],"steroid":[69,196,216],"use,":[70],"overall":[72],"(OS)":[74],"was":[75,111,131,141,155,172,211],"measured":[76],"both":[78],"diagnosis":[79,154],"start":[81,165],"reRT.":[83],"RESULTS:":[84],"Of":[85,103],"22":[86],"who":[88,106],"received":[89,148],"two":[93],"did":[94],"not":[95],"complete":[96],"their":[97],"course":[98],"due":[99,206],"clinical":[101,208],"decline.":[102],"the":[104,109,184,191,250],"20":[105],"completed":[107],"20-30":[112],"Gy":[113,122],"2-Gy":[115],"fractions":[116,125],"(n":[117,126],"=":[118,127,179,223],"6)":[119],"30-36":[121],"3-Gy":[124],"14).":[128],"Median":[129,151,162],"age":[130],"5":[132],"years":[133],"(range:":[134,144],"3-14),":[135],"median":[136],"interval":[137],"since":[138],"initial":[139],"RT":[140],"8":[142],"months":[143,157,203],"3-20),":[145],"12":[147],"concurrent":[149],"bevacizumab.":[150],"OS":[152,163],"18":[156],"[95%":[158],"confidence":[159],"interval:":[160],"17-24].":[161],"versus":[170],"CF":[171,192,221],"8.2":[173],"7.5":[175],"months,":[176],"respectively":[177],"(p":[178,222],".20).":[180],"Thirteen":[181],"(93%)":[182],"group":[186,193],"three":[188],"(75%)":[189],"tapered":[194],"pre-treatment":[195],"down":[198],"off":[200],"within":[201],"2":[202],"after":[204],"improvement.":[209],"significant":[213],"difference":[214],"taper":[217],"between":[218],".4).":[224],"No":[225],"developed":[227],"radionecrosis.":[228],"CONCLUSION:":[229],"achieved":[233],"duration":[235],"comparable":[236],"published":[238],"outcomes":[239],"effectively":[241],"palliated":[242],"symptoms.":[243],"Future":[244],"investigation":[245],"this":[247],"regimen":[248],"context":[251],"new":[253],"systemic":[254],"therapies":[255],"upfront":[257],"warranted.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}