{"id":"https://openalex.org/W4392296554","doi":"https://doi.org/10.3390/biom14030293","title":"Pregnancy-Specific Beta-1-Glycoprotein 1 Increases HTR-8/SVneo Cell Migration through the Orai1/Akt Signaling Pathway","display_name":"Pregnancy-Specific Beta-1-Glycoprotein 1 Increases HTR-8/SVneo Cell Migration through the Orai1/Akt Signaling Pathway","publication_year":2024,"publication_date":"2024-02-29","ids":{"openalex":"https://openalex.org/W4392296554","doi":"https://doi.org/10.3390/biom14030293","pmid":"https://pubmed.ncbi.nlm.nih.gov/38540713","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10968057"},"language":"en","primary_location":{"id":"doi:10.3390/biom14030293","doi":"https://doi.org/10.3390/biom14030293","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom14030293","pdf_url":"https://www.mdpi.com/2218-273X/14/3/293/pdf?version=1709205296","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-273X/14/3/293/pdf?version=1709205296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052052299","display_name":"Qunhua Wang","orcid":"https://orcid.org/0009-0006-2816-7090","observed_orcids":["https://orcid.org/0009-0006-2816-7090"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qunhua Wang","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","Department of Obstetrics and Gynaecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China","The Fifth Clinical College of Anhui Medical University, Hefei 230032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"The Fifth Clinical College of Anhui Medical University, Hefei 230032, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112652945","display_name":"Yan Fang","orcid":"https://orcid.org/0009-0002-4936-4406","observed_orcids":["https://orcid.org/0009-0002-4936-4406"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Fang","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","The Fifth Clinical College of Anhui Medical University, Hefei 230032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Fifth Clinical College of Anhui Medical University, Hefei 230032, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100665393","display_name":"Yuan Li","orcid":"https://orcid.org/0000-0003-0438-7794","observed_orcids":["https://orcid.org/0000-0003-0438-7794"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Li","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","The Fifth Clinical College of Anhui Medical University, Hefei 230032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Fifth Clinical College of Anhui Medical University, Hefei 230032, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052896194","display_name":"Huali Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huali Liu","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","The Fifth Clinical College of Anhui Medical University, Hefei 230032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Fifth Clinical College of Anhui Medical University, Hefei 230032, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109687161","display_name":"Maoni Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maoni Zhu","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","The Fifth Clinical College of Anhui Medical University, Hefei 230032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Fifth Clinical College of Anhui Medical University, Hefei 230032, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101294073","display_name":"Xue Hu","orcid":"https://orcid.org/0009-0009-8827-6901","observed_orcids":["https://orcid.org/0009-0009-8827-6901"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Hu","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","The Fifth Clinical College of Anhui Medical University, Hefei 230032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Fifth Clinical College of Anhui Medical University, Hefei 230032, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104250920","display_name":"Jinzhuo Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinzhuo Zhou","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","The Fifth Clinical College of Anhui Medical University, Hefei 230032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Fifth Clinical College of Anhui Medical University, Hefei 230032, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108309290","display_name":"Anqi Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anqi Deng","raw_affiliation_strings":["School of Basic Medical Science, Anhui Medical University, Hefei 230032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Science, Anhui Medical University, Hefei 230032, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015651736","display_name":"Bing Q. Shen","orcid":"https://orcid.org/0000-0001-7263-4748","observed_orcids":["https://orcid.org/0000-0001-7263-4748"]},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":true,"raw_author_name":"Bing Shen","raw_affiliation_strings":["Dr. Neher\u2019s Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China"],"raw_orcid":"https://orcid.org/0000-0001-7263-4748","affiliations":[{"raw_affiliation_string":"Dr. Neher\u2019s Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100452326","display_name":"Hongbo Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongbo Chen","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","The Fifth Clinical College of Anhui Medical University, Hefei 230032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Fifth Clinical College of Anhui Medical University, Hefei 230032, China","institution_ids":["https://openalex.org/I197869895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015651736","https://openalex.org/A5100452326"],"corresponding_institution_ids":["https://openalex.org/I111950717","https://openalex.org/I197869895"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3069},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3069},"fwci":3.9683,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.93329098,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"293","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-onset-preeclampsia","display_name":"early-onset preeclampsia","score":0.968999981880188},{"id":"https://openalex.org/keywords/trophoblast-migration","display_name":"trophoblast migration","score":0.8870000243186951},{"id":"https://openalex.org/keywords/orai1","display_name":"Orai1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9919999837875366},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/trophoblast-invasion","display_name":"trophoblast invasion","score":0.8600000143051147},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7070000171661377},{"id":"https://openalex.org/keywords/preeclampsia-pathophysiology","display_name":"preeclampsia pathophysiology","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.8232111930847168},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7680121660232544},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.5143600702285767},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5064154863357544},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49489301443099976},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4914051294326782},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42578569054603577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39137163758277893},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3683812916278839},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3668231964111328},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3555644452571869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33763039112091064},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33536893129348755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2494429647922516},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.2016327679157257},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1979704201221466},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.1077694296836853},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09904101490974426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.059650957584381104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04996463656425476}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010714","descriptor_name":"Phosphatidylethanolamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/biom14030293","doi":"https://doi.org/10.3390/biom14030293","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom14030293","pdf_url":"https://www.mdpi.com/2218-273X/14/3/293/pdf?version=1709205296","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10968057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10968057","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10968057/pdf/biomolecules-14-00293.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmid:38540713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38540713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b70d316cce9a4823b0752960cd88c691","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b70d316cce9a4823b0752960cd88c691","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 14, Iss 3, p 293 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom14030293","doi":"https://doi.org/10.3390/biom14030293","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom14030293","pdf_url":"https://www.mdpi.com/2218-273X/14/3/293/pdf?version=1709205296","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2691814498","display_name":null,"funder_award_id":"2023AH053400","funder_id":"https://openalex.org/F4320326664","funder_display_name":"Anhui Provincial Department of Education"},{"id":"https://openalex.org/G4606276794","display_name":null,"funder_award_id":"2108085MH260","funder_id":"https://openalex.org/F4320334897","funder_display_name":"Natural Science Foundation of Anhui Province"},{"id":"https://openalex.org/G4819898209","display_name":null,"funder_award_id":"202204295107020050","funder_id":"https://openalex.org/F4320326650","funder_display_name":"Anhui Provincial Department of Science and Technology"},{"id":"https://openalex.org/G672298373","display_name":null,"funder_award_id":"2022e07020001","funder_id":"https://openalex.org/F4320326650","funder_display_name":"Anhui Provincial Department of Science and Technology"},{"id":"https://openalex.org/G8197864644","display_name":null,"funder_award_id":"2108085MH260","funder_id":"https://openalex.org/F4320326650","funder_display_name":"Anhui Provincial Department of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320314997","display_name":"Strong","ror":"https://ror.org/041vyzr56"},{"id":"https://openalex.org/F4320321603","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968"},{"id":"https://openalex.org/F4320326650","display_name":"Anhui Provincial Department of Science and Technology","ror":"https://ror.org/01e70gy59"},{"id":"https://openalex.org/F4320326664","display_name":"Anhui Provincial Department of Education","ror":null},{"id":"https://openalex.org/F4320334897","display_name":"Natural Science Foundation of Anhui Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392296554.pdf","grobid_xml":"https://content.openalex.org/works/W4392296554.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1577394481","https://openalex.org/W1934528477","https://openalex.org/W1978940943","https://openalex.org/W1999631485","https://openalex.org/W2012402693","https://openalex.org/W2041827740","https://openalex.org/W2045890236","https://openalex.org/W2078420687","https://openalex.org/W2079065036","https://openalex.org/W2093672972","https://openalex.org/W2102354440","https://openalex.org/W2163479283","https://openalex.org/W2329348752","https://openalex.org/W2521278162","https://openalex.org/W2561631604","https://openalex.org/W2562874465","https://openalex.org/W2604154469","https://openalex.org/W2731263582","https://openalex.org/W2801232002","https://openalex.org/W2912263218","https://openalex.org/W2935104625","https://openalex.org/W2946525881","https://openalex.org/W2962388486","https://openalex.org/W2980478798","https://openalex.org/W2982612901","https://openalex.org/W2993787099","https://openalex.org/W3082375444","https://openalex.org/W3084349177","https://openalex.org/W3090502644","https://openalex.org/W3112738131","https://openalex.org/W3126180845","https://openalex.org/W3150570549","https://openalex.org/W3163083130","https://openalex.org/W3172895635","https://openalex.org/W3195482594","https://openalex.org/W3200723998","https://openalex.org/W3214704925","https://openalex.org/W4206731013","https://openalex.org/W4220988016","https://openalex.org/W4296744479","https://openalex.org/W4297261343","https://openalex.org/W4305071813","https://openalex.org/W4308735430","https://openalex.org/W4317495257","https://openalex.org/W4379471788","https://openalex.org/W4381953241"],"related_works":["https://openalex.org/W7202130024","https://openalex.org/W2982612901","https://openalex.org/W3153335067","https://openalex.org/W3048287508","https://openalex.org/W4386251318","https://openalex.org/W2944160674","https://openalex.org/W4415083291","https://openalex.org/W4213013512","https://openalex.org/W3088784931","https://openalex.org/W2781497353"],"abstract_inverted_index":{"The":[0,79,100,115,133,144],"impaired":[1],"invasion":[2],"ability":[3],"of":[4,12,29,40,69,74,81,103,140,147,167,202],"trophoblast":[5,55,84,188],"cells":[6],"is":[7],"related":[8],"to":[9,65],"the":[10,27,38,49,67,72,119,137,151,159,168,182,198],"occurrence":[11],"preeclampsia":[13,33],"(PE).":[14],"We":[15],"previously":[16],"found":[17],"that":[18,118,177],"pregnancy-specific":[19],"beta-1-glycoprotein":[20],"1":[21],"(PSG1)":[22],"levels":[23,102,122],"were":[24,88,110,123],"decreased":[25],"in":[26,53,71,125,129,172],"serum":[28,73,120],"individuals":[30],"with":[31,77],"early-onset":[32],"(EOPE).":[34],"This":[35],"study":[36],"investigated":[37],"effect":[39,153],"PSG1":[41,70,82,121,134,156,179,190],"on":[42,83],"Orai1-mediated":[43],"store-operated":[44],"calcium":[45],"entry":[46],"(SOCE)":[47],"and":[48,86,95,106,142,200],"Akt":[50,108,160],"signaling":[51,161,184],"pathway":[52],"human":[54],"cell":[56,91],"migration.":[57,189],"An":[58],"enzyme-linked":[59],"immunosorbent":[60],"assay":[61],"(ELISA)":[62],"was":[63,176],"used":[64],"determine":[66],"level":[68],"pregnant":[75,131],"women":[76,127],"EOPE.":[78,203],"effects":[80],"proliferation":[85],"migration":[87],"examined":[89],"using":[90],"counting":[92],"kit-8":[93],"(CCK8)":[94],"wound":[96],"healing":[97],"experiments,":[98],"respectively.":[99],"expression":[101,139],"Orai1,":[104],"Akt,":[105],"phosphorylated":[107],"(p-Akt)":[109],"determined":[111],"through":[112],"Western":[113],"blotting.":[114],"results":[116],"confirmed":[117],"lower":[124],"EOPE":[126,173],"than":[128],"healthy":[130],"women.":[132],"treatment":[135,199],"upregulated":[136],"protein":[138],"Orai1":[141,148],"p-Akt.":[143],"selective":[145],"inhibitor":[146],"(MRS1845)":[149],"weakened":[150],"migration-promoting":[152],"mediated":[154],"by":[155],"via":[157],"suppressing":[158],"pathway.":[162],"Our":[163],"findings":[164],"revealed":[165],"one":[166],"mechanisms":[169],"possibly":[170],"involved":[171],"pathophysiology,":[174],"which":[175],"downregulated":[178],"may":[180,191],"reduce":[181],"Orai1/Akt":[183],"pathway,":[185],"thereby":[186],"inhibiting":[187],"serve":[192],"as":[193],"a":[194],"potential":[195],"target":[196],"for":[197],"diagnosis":[201]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-05T00:00:00"}