{"id":"https://openalex.org/W4392292474","doi":"https://doi.org/10.3389/fpsyt.2024.1358568","title":"Association between CNS-active drugs and risk of Alzheimer\u2019s and age-related neurodegenerative diseases","display_name":"Association between CNS-active drugs and risk of Alzheimer\u2019s and age-related neurodegenerative diseases","publication_year":2024,"publication_date":"2024-02-29","ids":{"openalex":"https://openalex.org/W4392292474","doi":"https://doi.org/10.3389/fpsyt.2024.1358568","pmid":"https://pubmed.ncbi.nlm.nih.gov/38487578","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10937406"},"language":"en","primary_location":{"id":"doi:10.3389/fpsyt.2024.1358568","doi":"https://doi.org/10.3389/fpsyt.2024.1358568","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2024.1358568","pdf_url":"https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1358568/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1358568/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058398787","display_name":"Helena Cortes\u2010Flores","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helena Cortes-Flores","raw_affiliation_strings":["Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States","Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034841588","display_name":"Georgina Torrandell\u2010Haro","orcid":"https://orcid.org/0000-0003-2872-8282","observed_orcids":["https://orcid.org/0000-0003-2872-8282"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgina Torrandell-Haro","raw_affiliation_strings":["Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States","Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005920250","display_name":"Roberta D\u00edaz Brinton","orcid":"https://orcid.org/0000-0001-8450-772X","observed_orcids":["https://orcid.org/0000-0001-8450-772X"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roberta Diaz Brinton","raw_affiliation_strings":["Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States","Department of Neurology, University of Arizona College of Medicine, Tucson, AZ, United States","Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Neurology, University of Arizona College of Medicine, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005920250"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":2.758,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.90830474,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":null,"first_page":"1358568","last_page":"1358568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.2533999979496002,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.953000009059906},{"id":"https://openalex.org/keywords/age-related-neurodegenerative-diseases","display_name":"age-related neurodegenerative diseases","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cns-active-drugs","display_name":"CNS-active drugs","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.7400000095367432},{"id":"https://openalex.org/keywords/sedatives","display_name":"sedatives","score":0.7020000219345093},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stimulants","display_name":"stimulants","score":0.9520000219345093},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.7760000228881836},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5619999766349792},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5879999995231628},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.824999988079071},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7020000219345093},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8128950595855713},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6201112866401672},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5311431288719177},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5251293182373047},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.4367635250091553},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.42380428314208984},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.42264240980148315},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.41286951303482056},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3967812657356262},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.38061392307281494}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fpsyt.2024.1358568","doi":"https://doi.org/10.3389/fpsyt.2024.1358568","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2024.1358568","pdf_url":"https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1358568/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10937406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10937406","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10937406/pdf/fpsyt-15-1358568.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Psychiatry","raw_type":"Text"},{"id":"pmid:38487578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38487578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bdd748d6dcf4460794c10a256e6ae1e3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bdd748d6dcf4460794c10a256e6ae1e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Psychiatry, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fpsyt.2024.1358568","doi":"https://doi.org/10.3389/fpsyt.2024.1358568","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2024.1358568","pdf_url":"https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1358568/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7823639649","display_name":"Sex Differences in the Molecular Determinants of Alzheimer's Disease Risk: Prodromal Endophenotype","funder_award_id":"R01AG057931","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000893714","display_name":"Arizona Alzheimer's Disease Research Center","funder_award_id":"P30AG072980","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000908146","display_name":"Perimenopause in Brain Aging and Alzheimer's Disease","funder_award_id":"P01AG026572","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392292474.pdf","grobid_xml":"https://content.openalex.org/works/W4392292474.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W646218571","https://openalex.org/W1618134065","https://openalex.org/W1977085392","https://openalex.org/W1987594301","https://openalex.org/W1987947540","https://openalex.org/W2007491312","https://openalex.org/W2011248746","https://openalex.org/W2016643416","https://openalex.org/W2029214063","https://openalex.org/W2029803700","https://openalex.org/W2039400277","https://openalex.org/W2039459228","https://openalex.org/W2044241508","https://openalex.org/W2044931971","https://openalex.org/W2049227843","https://openalex.org/W2053696585","https://openalex.org/W2056096387","https://openalex.org/W2060542243","https://openalex.org/W2062195428","https://openalex.org/W2063361808","https://openalex.org/W2067657652","https://openalex.org/W2085611222","https://openalex.org/W2091177718","https://openalex.org/W2101090291","https://openalex.org/W2106628227","https://openalex.org/W2107381357","https://openalex.org/W2108335346","https://openalex.org/W2110569861","https://openalex.org/W2111180320","https://openalex.org/W2115090099","https://openalex.org/W2115559222","https://openalex.org/W2118414216","https://openalex.org/W2133565799","https://openalex.org/W2134121431","https://openalex.org/W2148854950","https://openalex.org/W2154212660","https://openalex.org/W2163894029","https://openalex.org/W2168813272","https://openalex.org/W2237598232","https://openalex.org/W2340417956","https://openalex.org/W2375334377","https://openalex.org/W2461807154","https://openalex.org/W2472346278","https://openalex.org/W2473063342","https://openalex.org/W2474977510","https://openalex.org/W2514003618","https://openalex.org/W2523720507","https://openalex.org/W2574641496","https://openalex.org/W2583500102","https://openalex.org/W2601303472","https://openalex.org/W2605242528","https://openalex.org/W2725095925","https://openalex.org/W2753752849","https://openalex.org/W2786608785","https://openalex.org/W2802032956","https://openalex.org/W2807313810","https://openalex.org/W2883742078","https://openalex.org/W2886154055","https://openalex.org/W2887701645","https://openalex.org/W2894120541","https://openalex.org/W2912515969","https://openalex.org/W2934709382","https://openalex.org/W2939313337","https://openalex.org/W2945372214","https://openalex.org/W2953172090","https://openalex.org/W2955010960","https://openalex.org/W2963936193","https://openalex.org/W2976981404","https://openalex.org/W3003466078","https://openalex.org/W3004091996","https://openalex.org/W3007172709","https://openalex.org/W3007752565","https://openalex.org/W3012694947","https://openalex.org/W3022773530","https://openalex.org/W3028374504","https://openalex.org/W3043705966","https://openalex.org/W3080118913","https://openalex.org/W3087366406","https://openalex.org/W3110411991","https://openalex.org/W3111233115","https://openalex.org/W3128621421","https://openalex.org/W3156000332","https://openalex.org/W3162100029","https://openalex.org/W3167249883","https://openalex.org/W3174121292","https://openalex.org/W3193419110","https://openalex.org/W3197184955","https://openalex.org/W3202631805","https://openalex.org/W4200210270","https://openalex.org/W4220825176","https://openalex.org/W4225357290","https://openalex.org/W4225741213","https://openalex.org/W4229037660","https://openalex.org/W4281689406","https://openalex.org/W4281716570","https://openalex.org/W4283387616","https://openalex.org/W4285730545","https://openalex.org/W4295197991","https://openalex.org/W4309717790","https://openalex.org/W4310461604","https://openalex.org/W4310944664","https://openalex.org/W4311378007","https://openalex.org/W4317868507","https://openalex.org/W4378902844"],"related_works":["https://openalex.org/W4406051054","https://openalex.org/W7127213134","https://openalex.org/W3110411991","https://openalex.org/W7134116872","https://openalex.org/W4412080117","https://openalex.org/W4407179922","https://openalex.org/W4390201504","https://openalex.org/W3210811131","https://openalex.org/W7117311559","https://openalex.org/W7161554430"],"abstract_inverted_index":{"Objective:":[0],"As":[1],"neuropsychiatric":[2,346],"conditions":[3],"can":[4],"increase":[5],"the":[6,13,19,103,270,322,338],"risk":[7,20,80,134,167,183,197,265,282,296,323,339],"of":[8,15,21,49,135,161,163,168,184,236,249,253,272,297,314,340],"age-related":[9,91,302,341],"neurodegenerative":[10],"diseases":[11],"(NDDs),":[12],"impact":[14,162],"CNS-active":[16,106,127,256,290],"drugs":[17,107,128,238,291],"on":[18,166],"developing":[22,298],"Alzheimer's":[23],"Disease":[24,32],"(AD),":[25],"non-AD":[26],"dementia,":[27],"Multiple":[28],"Sclerosis":[29,37],"(MS),":[30],"Parkinson's":[31],"(PD)":[33],"and":[34,43,76,83,96,108,113,147,175,201,233,239,275,300],"Amyotrophic":[35],"Lateral":[36],"(ALS)":[38],"was":[39,59,129,258,306],"investigated.":[40],"Research":[41],"design":[42],"methods:":[44],"A":[45],"retrospective":[46],"cohort":[47],"analysis":[48],"a":[50,55,132,212,247,254,273],"medical":[51],"claims":[52],"dataset":[53],"over":[54],"10":[56],"year":[57],"span":[58],"conducted":[60],"in":[61,204,216,263,343],"patients":[62,120,205,217,245],"aged":[63,206],"60":[64],"years":[65,208],"or":[66,209],"older.":[67],"Participants":[68],"were":[69,88,99,178,189,228,292],"propensity":[70],"score":[71],"matched":[72],"for":[73,90,199],"comorbidity":[74],"severity":[75],"demographic":[77],"parameters.":[78],"Relative":[79],"(RR)":[81],"ratios":[82,95],"95%":[84,142,155],"confidence":[85],"intervals":[86],"(CI)":[87],"determined":[89,100],"NDDs.":[92,303],"Cumulative":[93],"hazard":[94],"treatment":[97,114],"duration":[98,115],"to":[101,126,225,244,267,336],"assess":[102],"association":[104],"between":[105],"NDDs":[109,149,202,342],"at":[110],"different":[111],"ages":[112],"intervals.":[116],"Results:":[117],"In":[118],"309,128":[119],"who":[121],"met":[122],"inclusion":[123],"criteria,":[124],"exposure":[125],"associated":[130,179,190,259,278,293],"with":[131,180,191,211,218,246,260,269,279,294,317,345],"decreased":[133],"AD":[136,169,185,193,200,250,264,281,299],"(0.86%":[137],"vs":[138,151],"1.73%,":[139],"RR:":[140,153],"0.50;":[141],"CI:":[143,156],"0.47-0.53;":[144],"p":[145,158],"<.0001)":[146],"all":[148],"(3.13%":[150],"5.76%,":[152],"0.54;":[154],"0.53-0.56;":[157],"<.0001).":[159],"Analysis":[160],"drug":[164,257],"class":[165],"indicated":[170],"that":[171,289],"antidepressant,":[172],"sedative,":[173],"anticonvulsant,":[174],"stimulant":[176],"medications":[177],"significantly":[181],"reduced":[182,295],"whereas":[186],"atypical":[187,307,318],"antipsychotics":[188,319],"increased":[192,310],"risk.":[194,311],"The":[195,304],"greatest":[196,280],"reduction":[198,262],"occurred":[203],"70":[207],"older":[210],"protective":[213],"effect":[214],"only":[215],"long-term":[219],"therapy":[220,316],"(>3":[221],"years).":[222],"Furthermore,":[223],"responders":[224],"these":[226,286,326,330],"therapeutics":[227],"characterized":[229],"by":[230,325],"diagnosed":[231],"obesity":[232],"higher":[234],"prescriptions":[235],"anti-inflammatory":[237],"menopausal":[240],"hormonal":[241],"therapy,":[242],"compared":[243,266],"diagnosis":[248],"(non-responders).":[251],"Addition":[252],"second":[255],"greater":[261],"monotherapy,":[268],"combination":[271,315],"Z-drug":[274],"an":[276],"SNRI":[277],"reduction.":[283],"Conclusion:":[284],"Collectively,":[285],"findings":[287],"indicate":[288],"other":[301],"exception":[305],"antipsychotics,":[308],"which":[309],"Potential":[312],"use":[313],"could":[320],"mitigate":[321],"conferred":[324],"drugs.":[327],"Evidence":[328],"from":[329],"analyses":[331],"advance":[332],"precision":[333],"prevention":[334],"strategies":[335],"reduce":[337],"persons":[344],"disorders.":[347]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-03-05T00:00:00"}
