{"id":"https://openalex.org/W4392285035","doi":"https://doi.org/10.7759/cureus.55230","title":"The Role of Human Epidermal Growth Factor Receptor 2 (HER2)-Targeted Therapies in Early-Stage Breast Cancer: Current Practices, Treatment De-escalation, and Future Prospects","display_name":"The Role of Human Epidermal Growth Factor Receptor 2 (HER2)-Targeted Therapies in Early-Stage Breast Cancer: Current Practices, Treatment De-escalation, and Future Prospects","publication_year":2024,"publication_date":"2024-02-29","ids":{"openalex":"https://openalex.org/W4392285035","doi":"https://doi.org/10.7759/cureus.55230","pmid":"https://pubmed.ncbi.nlm.nih.gov/38558735","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10981386"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.55230","doi":"https://doi.org/10.7759/cureus.55230","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7759/cureus.55230","pdf_url":"https://www.cureus.com/articles/225994-the-role-of-human-epidermal-growth-factor-receptor-2-her2-targeted-therapies-in-early-stage-breast-cancer-current-practices-treatment-de-escalation-and-future-prospects.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/225994-the-role-of-human-epidermal-growth-factor-receptor-2-her2-targeted-therapies-in-early-stage-breast-cancer-current-practices-treatment-de-escalation-and-future-prospects.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071781749","display_name":"Mohamed Hashem","orcid":"https://orcid.org/0000-0003-2593-3387","observed_orcids":["https://orcid.org/0000-0003-2593-3387"]},"institutions":[{"id":"https://openalex.org/I293158433","display_name":"Airedale NHS Foundation Trust","ror":"https://ror.org/0057f6x09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I293158433"]},{"id":"https://openalex.org/I4210160067","display_name":"Mid Yorkshire Hospitals NHS Trust","ror":"https://ror.org/05g23q746","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067"]},{"id":"https://openalex.org/I4210166758","display_name":"Bradford Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/05gekvn04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210166758"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mohamed Hashem","raw_affiliation_strings":["Breast Surgery, Mid Yorkshire NHS Teaching Trust, Wakefield, GBR",". Breast Surgery, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, GBR",". Oncology, Airedale NHS Foundation Trust, Airedale, GBR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Surgery, Mid Yorkshire NHS Teaching Trust, Wakefield, GBR","institution_ids":["https://openalex.org/I4210160067"]},{"raw_affiliation_string":". Breast Surgery, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, GBR","institution_ids":["https://openalex.org/I4210166758"]},{"raw_affiliation_string":". Oncology, Airedale NHS Foundation Trust, Airedale, GBR","institution_ids":["https://openalex.org/I293158433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017394660","display_name":"Shazza Rehman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I293158433","display_name":"Airedale NHS Foundation Trust","ror":"https://ror.org/0057f6x09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I293158433"]},{"id":"https://openalex.org/I4210160067","display_name":"Mid Yorkshire Hospitals NHS Trust","ror":"https://ror.org/05g23q746","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067"]},{"id":"https://openalex.org/I4210166758","display_name":"Bradford Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/05gekvn04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210166758"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shazza Rehman","raw_affiliation_strings":["Oncology, Airedale NHS Foundation Trust, Airedale, GBR",". Breast Surgery, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, GBR",". Breast Surgery, Mid Yorkshire NHS Teaching Trust, Wakefield, GBR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Airedale NHS Foundation Trust, Airedale, GBR","institution_ids":["https://openalex.org/I293158433"]},{"raw_affiliation_string":". Breast Surgery, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, GBR","institution_ids":["https://openalex.org/I4210166758"]},{"raw_affiliation_string":". Breast Surgery, Mid Yorkshire NHS Teaching Trust, Wakefield, GBR","institution_ids":["https://openalex.org/I4210160067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111647292","display_name":"Mohamed Salhab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I293158433","display_name":"Airedale NHS Foundation Trust","ror":"https://ror.org/0057f6x09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I293158433"]},{"id":"https://openalex.org/I4210160067","display_name":"Mid Yorkshire Hospitals NHS Trust","ror":"https://ror.org/05g23q746","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067"]},{"id":"https://openalex.org/I4210166758","display_name":"Bradford Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/05gekvn04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210166758"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohamed Salhab","raw_affiliation_strings":["Breast Surgery, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, GBR",". Breast Surgery, Mid Yorkshire NHS Teaching Trust, Wakefield, GBR",". Oncology, Airedale NHS Foundation Trust, Airedale, GBR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Surgery, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, GBR","institution_ids":["https://openalex.org/I4210166758"]},{"raw_affiliation_string":". Breast Surgery, Mid Yorkshire NHS Teaching Trust, Wakefield, GBR","institution_ids":["https://openalex.org/I4210160067"]},{"raw_affiliation_string":". Oncology, Airedale NHS Foundation Trust, Airedale, GBR","institution_ids":["https://openalex.org/I293158433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071781749"],"corresponding_institution_ids":["https://openalex.org/I293158433","https://openalex.org/I4210160067","https://openalex.org/I4210166758"],"apc_list":null,"apc_paid":null,"fwci":0.2131,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.24137931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"16","issue":"2","first_page":"e55230","last_page":"e55230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/treatment-de-escalation","display_name":"treatment de-escalation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.8999999761581421},{"id":"https://openalex.org/keywords/oncoplastic-surgery","display_name":"oncoplastic surgery","score":0.9629999995231628},{"id":"https://openalex.org/keywords/targeted-axillary-dissection","display_name":"targeted axillary dissection","score":0.9769999980926514},{"id":"https://openalex.org/keywords/her2-low-breast-cancer","display_name":"HER2-low breast cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/brca-mutations","display_name":"BRCA mutations","score":0.9509999752044678},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7835595011711121},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7420998811721802},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.6347401142120361},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5856180191040039},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5672681331634521},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4411274790763855},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.43542274832725525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4305873513221741},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4268978238105774},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13574647903442383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.55230","doi":"https://doi.org/10.7759/cureus.55230","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7759/cureus.55230","pdf_url":"https://www.cureus.com/articles/225994-the-role-of-human-epidermal-growth-factor-receptor-2-her2-targeted-therapies-in-early-stage-breast-cancer-current-practices-treatment-de-escalation-and-future-prospects.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10981386","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10981386","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10981386/pdf/cureus-0016-00000055230.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:38558735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38558735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7759/cureus.55230","doi":"https://doi.org/10.7759/cureus.55230","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7759/cureus.55230","pdf_url":"https://www.cureus.com/articles/225994-the-role-of-human-epidermal-growth-factor-receptor-2-her2-targeted-therapies-in-early-stage-breast-cancer-current-practices-treatment-de-escalation-and-future-prospects.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392285035.pdf","grobid_xml":"https://content.openalex.org/works/W4392285035.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1966064734","https://openalex.org/W1984007340","https://openalex.org/W2040935952","https://openalex.org/W2095861620","https://openalex.org/W2103218083","https://openalex.org/W2123591186","https://openalex.org/W2128458647","https://openalex.org/W2146384083","https://openalex.org/W2149908785","https://openalex.org/W2162982444","https://openalex.org/W2169344919","https://openalex.org/W2172114428","https://openalex.org/W2264000214","https://openalex.org/W2268087059","https://openalex.org/W2379981061","https://openalex.org/W2531786368","https://openalex.org/W2588881638","https://openalex.org/W2896573371","https://openalex.org/W2897669536","https://openalex.org/W2902218997","https://openalex.org/W2904048809","https://openalex.org/W2915321625","https://openalex.org/W2948726637","https://openalex.org/W2991742203","https://openalex.org/W3012380787","https://openalex.org/W3012670330","https://openalex.org/W3098948927","https://openalex.org/W3126817559","https://openalex.org/W3135558121","https://openalex.org/W3141316397","https://openalex.org/W3150705348","https://openalex.org/W3152168685","https://openalex.org/W3153619412","https://openalex.org/W3178119289","https://openalex.org/W3185687075","https://openalex.org/W3204381429","https://openalex.org/W4211123279","https://openalex.org/W4214740004","https://openalex.org/W4220900509","https://openalex.org/W4225401319","https://openalex.org/W4281640394","https://openalex.org/W4282592293","https://openalex.org/W4283713242","https://openalex.org/W4284894881","https://openalex.org/W4288969863","https://openalex.org/W4304084160","https://openalex.org/W4322490942","https://openalex.org/W4384564576","https://openalex.org/W4385972605","https://openalex.org/W4390706870"],"related_works":["https://openalex.org/W138847825","https://openalex.org/W6910198541","https://openalex.org/W4318473611","https://openalex.org/W7155159617","https://openalex.org/W7167809983","https://openalex.org/W2560781428","https://openalex.org/W4415538838","https://openalex.org/W4388269231","https://openalex.org/W4285065508","https://openalex.org/W4230413973"],"abstract_inverted_index":{"Human":[0],"epidermal":[1],"growth":[2],"factor":[3],"receptor":[4,154],"2":[5],"(HER2)-targeted":[6],"therapy":[7,114],"has":[8],"transformed":[9],"the":[10,28,109,161,172,189],"treatment":[11,121,168,202],"paradigm":[12],"for":[13,68,102,191],"early-stage":[14,177],"HER2-positive":[15,135,176],"breast":[16,128,136,178],"cancer,":[17],"providing":[18],"personalized":[19],"and":[20,78,87,115,151,185,194,204,211],"effective":[21],"interventions.":[22],"This":[23],"comprehensive":[24],"review":[25,106],"delves":[26],"into":[27,167],"current":[29],"state":[30],"of":[31,126,163,175],"HER2-targeted":[32,51],"therapies,":[33],"emphasizing":[34],"pivotal":[35],"clinical":[36],"trials":[37],"that":[38,49],"have":[39],"demonstrated":[40],"their":[41,164],"substantial":[42],"impact":[43],"on":[44],"long-term":[45],"outcomes.":[46,89],"Combination":[47],"therapies":[48,184],"integrate":[50],"agents":[52],"with":[53,138],"chemotherapy":[54,64],"exhibit":[55],"enhanced":[56],"tumor":[57,72],"responses,":[58],"particularly":[59],"in":[60,71,120,134,160,208],"neoadjuvant":[61],"settings.":[62],"Neoadjuvant":[63],"(NACT)":[65],"is":[66,100,130,199],"explored":[67],"its":[69],"role":[70],"downsizing,":[73],"facilitating":[74],"breast-conserving":[75],"surgery":[76],"(BCS),":[77],"incorporating":[79],"oncoplastic":[80],"solutions":[81],"to":[82,200],"address":[83],"both":[84],"oncologic":[85],"efficacy":[86],"aesthetic":[88],"Innovative":[90],"axillary":[91,97],"management":[92],"post-NACT,":[93],"such":[94],"as":[95],"targeted":[96,183],"dissection":[98],"(TAD),":[99],"discussed":[101,159],"minimizing":[103],"morbidity.":[104],"The":[105,123,197],"further":[107],"explores":[108],"delicate":[110],"balance":[111],"between":[112],"maximal":[113],"de-escalation,":[116],"reflecting":[117],"recent":[118],"trends":[119],"approaches.":[122],"therapeutic":[124],"landscape":[125,174],"HER2-low":[127],"cancer":[129,137,179],"examined,":[131],"highlighting":[132],"considerations":[133],"BReast":[139],"CAncer":[140],"gene":[141],"(BRCA)":[142],"mutations.":[143],"Emerging":[144],"immunotherapeutic":[145],"strategies,":[146],"encompassing":[147],"immune":[148],"checkpoint":[149],"inhibitors":[150],"chimeric":[152],"antigen":[153],"(CAR)":[155],"T-cell":[156],"therapy,":[157],"are":[158],"context":[162],"potential":[165],"integration":[166],"paradigms.":[169],"In":[170],"conclusion,":[171],"evolving":[173,213],"treatment,":[180],"characterized":[181],"by":[182],"multidisciplinary":[186],"approaches,":[187],"underscores":[188],"need":[190],"ongoing":[192],"research":[193],"collaborative":[195],"efforts.":[196],"aim":[198],"refine":[201],"strategies":[203],"enhance":[205],"patient":[206],"outcomes":[207],"this":[209],"dynamic":[210],"rapidly":[212],"field.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-03-05T00:00:00"}
