{"id":"https://openalex.org/W4392237249","doi":"https://doi.org/10.1111/jcpe.13966","title":"Gingipains may be one of the key virulence factors of Porphyromonas gingivalis to impair cognition and enhance blood\u2013brain barrier permeability: An animal study","display_name":"Gingipains may be one of the key virulence factors of Porphyromonas gingivalis to impair cognition and enhance blood\u2013brain barrier permeability: An animal study","publication_year":2024,"publication_date":"2024-02-27","ids":{"openalex":"https://openalex.org/W4392237249","doi":"https://doi.org/10.1111/jcpe.13966","pmid":"https://pubmed.ncbi.nlm.nih.gov/38414291"},"language":"en","primary_location":{"id":"doi:10.1111/jcpe.13966","doi":"https://doi.org/10.1111/jcpe.13966","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jcpe.13966","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Fulong Li","orcid":"https://orcid.org/0000-0002-4819-3935","observed_orcids":["https://orcid.org/0000-0002-4819-3935"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fulong Li","raw_affiliation_strings":["Center of Implantology, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China"],"raw_orcid":"https://orcid.org/0000-0002-4819-3935","affiliations":[{"raw_affiliation_string":"Center of Implantology, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027175928","display_name":"Chunliang Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunliang Ma","raw_affiliation_strings":["Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084567007","display_name":"Shuang Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Lei","raw_affiliation_strings":["Department of Pediatric Dentistry, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051944121","display_name":"Yaping Pan","orcid":"https://orcid.org/0000-0001-6711-8992","observed_orcids":["https://orcid.org/0000-0001-6711-8992"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaping Pan","raw_affiliation_strings":["Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100763505","display_name":"Li Lin","orcid":"https://orcid.org/0000-0003-3619-8007","observed_orcids":["https://orcid.org/0000-0003-3619-8007"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Lin","raw_affiliation_strings":["Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101837575","display_name":"Chunling Pan","orcid":"https://orcid.org/0000-0002-3835-9719","observed_orcids":["https://orcid.org/0000-0002-3835-9719"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunling Pan","raw_affiliation_strings":["Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340586","display_name":"Qian Li","orcid":"https://orcid.org/0000-0002-3814-8292","observed_orcids":["https://orcid.org/0000-0002-3814-8292"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Li","raw_affiliation_strings":["Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102343911","display_name":"Fengxue Geng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengxue Geng","raw_affiliation_strings":["Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041606192","display_name":"Dongyu Min","orcid":"https://orcid.org/0000-0001-6646-9555","observed_orcids":["https://orcid.org/0000-0001-6646-9555"]},"institutions":[{"id":"https://openalex.org/I2800959905","display_name":"Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/030e3n504","country_code":"CN","type":"education","lineage":["https://openalex.org/I2800959905"]},{"id":"https://openalex.org/I4210136919","display_name":"Affiliated Hospital of Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/03vt3fq09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongyu Min","raw_affiliation_strings":["Key Laboratory of Ministry of Education for TCM Viscera State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, China","Traditional Chinese Medicine Experimental Center, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Ministry of Education for TCM Viscera State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, China","institution_ids":["https://openalex.org/I2800959905"]},{"raw_affiliation_string":"Traditional Chinese Medicine Experimental Center, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China","institution_ids":["https://openalex.org/I4210136919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082150792","display_name":"Xiaolin Tang","orcid":"https://orcid.org/0000-0002-6906-2619","observed_orcids":["https://orcid.org/0000-0002-6906-2619"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaolin Tang","raw_affiliation_strings":["Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Disease, China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082150792"],"corresponding_institution_ids":["https://openalex.org/I91656880"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":5.0894,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.96736212,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"51","issue":"7","first_page":"818","last_page":"839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.15449999272823334,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gingipains","display_name":"gingipains","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rgpa","display_name":"RgpA","score":0.8270000219345093},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mfsd2a","display_name":"MFSD2A","score":0.8740000128746033},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ddx3x","display_name":"DDX3X","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9620000123977661},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8650000095367432},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.593999981880188},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.621999979019165},{"id":"https://openalex.org/keywords/brain-endothelial-cells","display_name":"brain endothelial cells","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.9685354232788086},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.6357161998748779},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6341471076011658},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5554144978523254},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5420992374420166},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.4854796230792999},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.47967958450317383},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.43437883257865906},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.41330093145370483},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37106209993362427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3643569350242615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3501091003417969},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.343849778175354},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3394958972930908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3093932569026947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2819414734840393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1753758192062378},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.16625311970710754},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14920952916145325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09718123078346252},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06385591626167297}],"mesh":[{"descriptor_ui":"D000080867","descriptor_name":"Gingipain Cysteine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016866","descriptor_name":"Bacteroidaceae Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016866","descriptor_name":"Bacteroidaceae Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016966","descriptor_name":"Porphyromonas gingivalis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jcpe.13966","doi":"https://doi.org/10.1111/jcpe.13966","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jcpe.13966","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},{"id":"pmid:38414291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38414291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical periodontology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7758706537","display_name":null,"funder_award_id":"81670999","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8795162643","display_name":null,"funder_award_id":"LJKZ0782","funder_id":"https://openalex.org/F4320324560","funder_display_name":"Department of Education of Liaoning Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324560","display_name":"Department of Education of Liaoning Province","ror":"https://ror.org/0022v2454"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1508289240","https://openalex.org/W1529133069","https://openalex.org/W1652980569","https://openalex.org/W1933811916","https://openalex.org/W1968060691","https://openalex.org/W1968931400","https://openalex.org/W1990521726","https://openalex.org/W1993215965","https://openalex.org/W1994902496","https://openalex.org/W2005364235","https://openalex.org/W2034275438","https://openalex.org/W2041042259","https://openalex.org/W2041546150","https://openalex.org/W2049057420","https://openalex.org/W2052568053","https://openalex.org/W2075427475","https://openalex.org/W2092474731","https://openalex.org/W2101476558","https://openalex.org/W2109884554","https://openalex.org/W2114789645","https://openalex.org/W2129976921","https://openalex.org/W2131745475","https://openalex.org/W2141220224","https://openalex.org/W2145663913","https://openalex.org/W2155908452","https://openalex.org/W2159303287","https://openalex.org/W2606840533","https://openalex.org/W2621695716","https://openalex.org/W2734955423","https://openalex.org/W2765303421","https://openalex.org/W2786608785","https://openalex.org/W2794111391","https://openalex.org/W2799487719","https://openalex.org/W2802436906","https://openalex.org/W2805321653","https://openalex.org/W2883139656","https://openalex.org/W2884580428","https://openalex.org/W2895374072","https://openalex.org/W2895430781","https://openalex.org/W2909774810","https://openalex.org/W2912555658","https://openalex.org/W2951748044","https://openalex.org/W2973586775","https://openalex.org/W2999063584","https://openalex.org/W3004780997","https://openalex.org/W3022548569","https://openalex.org/W3026134920","https://openalex.org/W3083406432","https://openalex.org/W3100416080","https://openalex.org/W3112745729","https://openalex.org/W3123296814","https://openalex.org/W3202774225","https://openalex.org/W3215589713","https://openalex.org/W4205861010","https://openalex.org/W4226064241","https://openalex.org/W4293105598","https://openalex.org/W4294991989","https://openalex.org/W4315628832","https://openalex.org/W4316464480","https://openalex.org/W6669400088"],"related_works":["https://openalex.org/W4315628832","https://openalex.org/W4205248667","https://openalex.org/W4411131393","https://openalex.org/W4388363989","https://openalex.org/W4415831724","https://openalex.org/W4416772116","https://openalex.org/W3216938867","https://openalex.org/W4205861010","https://openalex.org/W4409073198","https://openalex.org/W4320921961"],"abstract_inverted_index":{"AIM:":[0],"Blood-brain":[1],"barrier":[2],"(BBB)":[3],"disorder":[4],"is":[5],"one":[6,173],"of":[7,41,93,108,155,174,179],"the":[8,36,46,82,86,91,97,135,153,156,163,175,190],"early":[9],"findings":[10],"in":[11,80,85,99,118,134,159],"cognitive":[12,24,77,130],"impairments.":[13],"We":[14],"have":[15],"recently":[16],"found":[17],"that":[18],"Porphyromonas":[19],"gingivalis":[20,43,58,63,66,124,181],"bacteraemia":[21],"can":[22],"cause":[23],"impairment":[25],"and":[26,88,96,101,125,137,146,162,185],"increased":[27,140],"BBB":[28,94,141,157,187],"permeability.":[29],"This":[30],"study":[31],"aimed":[32],"to":[33,45,182],"find":[34],"out":[35],"possible":[37],"key":[38,176],"virulence":[39,177],"factors":[40,178],"P.":[42,57,62,123,180],"contributing":[44],"pathological":[47,132],"process.":[48],"MATERIALS":[49],"AND":[50],"METHODS:":[51],"C57/BL6":[52],"mice":[53,129],"were":[54,104,120],"infected":[55],"with":[56],"or":[59,61],"gingipains":[60,126],"lipopolysaccharide":[64],"(P.":[65],"LPS":[67],"group)":[68],"by":[69,113,189],"tail":[70],"vein":[71],"injection":[72],"for":[73],"8":[74],"weeks.":[75],"The":[76,106],"behaviour":[78],"changes":[79,84,98,133],"mice,":[81],"histopathological":[83],"hippocampus":[87,136],"cerebral":[89,138],"cortex,":[90,139],"alternations":[92],"permeability,":[95,142],"Mfsd2a":[100,112,144],"Cav-1":[102,148],"levels":[103],"measured.":[105],"mechanisms":[107],"Ddx3x-induced":[109],"regulation":[110],"on":[111],"arginine-specific":[114],"gingipain":[115],"A":[116],"(RgpA)":[117],"BMECs":[119],"explored.":[121],"RESULTS:":[122],"significantly":[127],"promoted":[128],"impairment,":[131],"inhibited":[143],"expression":[145],"up-regulated":[147],"expression.":[149],"After":[150],"RgpA":[151],"stimulation,":[152],"permeability":[154,188],"model":[158],"vitro":[160],"increased,":[161],"Ddx3x/Mfsd2a/Cav-1":[164,191],"regulatory":[165],"axis":[166],"was":[167],"activated.":[168],"CONCLUSIONS:":[169],"Gingipains":[170],"may":[171],"be":[172],"impair":[183],"cognition":[184],"enhance":[186],"axis.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-05T00:00:00"}