{"id":"https://openalex.org/W4392234159","doi":"https://doi.org/10.1016/j.omtn.2024.102160","title":"Modifying miRs for effective reprogramming of fibroblasts to cardiomyocytes","display_name":"Modifying miRs for effective reprogramming of fibroblasts to cardiomyocytes","publication_year":2024,"publication_date":"2024-02-28","ids":{"openalex":"https://openalex.org/W4392234159","doi":"https://doi.org/10.1016/j.omtn.2024.102160","pmid":"https://pubmed.ncbi.nlm.nih.gov/38495845","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10943962"},"language":"en","primary_location":{"id":"doi:10.1016/j.omtn.2024.102160","doi":"https://doi.org/10.1016/j.omtn.2024.102160","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2024.102160","pdf_url":"http://www.cell.com/article/S2162253124000477/pdf","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2162253124000477/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100639246","display_name":"Xinghua Wang","orcid":"https://orcid.org/0000-0002-7115-0095","observed_orcids":["https://orcid.org/0000-0002-7115-0095"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinghua Wang","raw_affiliation_strings":["Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049210073","display_name":"Syeda Samara Baksh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syeda S. Baksh","raw_affiliation_strings":["Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055837585","display_name":"Richard E. Pratt","orcid":"https://orcid.org/0000-0002-8725-6249","observed_orcids":["https://orcid.org/0000-0002-8725-6249"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E. Pratt","raw_affiliation_strings":["Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090663343","display_name":"Victor J. Dzau","orcid":"https://orcid.org/0000-0002-8280-519X","observed_orcids":["https://orcid.org/0000-0002-8280-519X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor J. Dzau","raw_affiliation_strings":["Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054437328","display_name":"Conrad P. Hodgkinson","orcid":"https://orcid.org/0000-0002-6460-7333","observed_orcids":["https://orcid.org/0000-0002-6460-7333"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Conrad P. Hodgkinson","raw_affiliation_strings":["Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":"https://orcid.org/0000-0002-6460-7333","affiliations":[{"raw_affiliation_string":"Mandel Center for Hypertension and Atherosclerosis, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054437328"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.8057,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.65394475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"2","first_page":"102160","last_page":"102160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.1988999992609024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.05660000070929527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-reprogramming","display_name":"fibroblast reprogramming","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cardiomyocyte-differentiation","display_name":"cardiomyocyte differentiation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/scar-fibroblasts","display_name":"scar fibroblasts","score":0.8569999933242798},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9380000233650208},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.7699999809265137},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mir-1","display_name":"miR-1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mir-133a","display_name":"miR-133a","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mir-208a","display_name":"miR-208a","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mir-499","display_name":"miR-499","score":1.0}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.9130479097366333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5893413424491882},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5015215873718262},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36920425295829773},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3576560616493225},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17892101407051086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.163692444562912},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10928916931152344}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.omtn.2024.102160","doi":"https://doi.org/10.1016/j.omtn.2024.102160","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2024.102160","pdf_url":"http://www.cell.com/article/S2162253124000477/pdf","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10943962","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10943962","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10943962/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Nucleic Acids","raw_type":"Text"},{"id":"pmid:38495845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38495845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Nucleic acids","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9c4cf1afc2cb4325b8d0a12e4c079fb9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9c4cf1afc2cb4325b8d0a12e4c079fb9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102160- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.omtn.2024.102160","doi":"https://doi.org/10.1016/j.omtn.2024.102160","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2024.102160","pdf_url":"http://www.cell.com/article/S2162253124000477/pdf","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309138","display_name":"Edna and Fred L. Mandel, Jr. Foundation","ror":"https://ror.org/02vv1ca29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392234159.pdf","grobid_xml":"https://content.openalex.org/works/W4392234159.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W2005606491","https://openalex.org/W2009127910","https://openalex.org/W2013420333","https://openalex.org/W2030390194","https://openalex.org/W2032599303","https://openalex.org/W2033023829","https://openalex.org/W2033873241","https://openalex.org/W2044818544","https://openalex.org/W2058099844","https://openalex.org/W2076361525","https://openalex.org/W2106586369","https://openalex.org/W2112322704","https://openalex.org/W2131884100","https://openalex.org/W2156140279","https://openalex.org/W2167202160","https://openalex.org/W2173185327","https://openalex.org/W2260943715","https://openalex.org/W2290864968","https://openalex.org/W2299762322","https://openalex.org/W2313658741","https://openalex.org/W2397329584","https://openalex.org/W2408984719","https://openalex.org/W2522665294","https://openalex.org/W2554457530","https://openalex.org/W2610602137","https://openalex.org/W2626336399","https://openalex.org/W2663868744","https://openalex.org/W2780773606","https://openalex.org/W2802371347","https://openalex.org/W2889270927","https://openalex.org/W2951567297","https://openalex.org/W3043056027","https://openalex.org/W3096033627","https://openalex.org/W3113234688","https://openalex.org/W3185593797","https://openalex.org/W4210268958","https://openalex.org/W4214706758","https://openalex.org/W4224235635","https://openalex.org/W4285384559","https://openalex.org/W4285391574","https://openalex.org/W4288455241","https://openalex.org/W4295750961","https://openalex.org/W4317033661","https://openalex.org/W4322494954","https://openalex.org/W4367627995","https://openalex.org/W4388538794"],"related_works":["https://openalex.org/W4380794255","https://openalex.org/W3163775975","https://openalex.org/W3096033627","https://openalex.org/W4380794148","https://openalex.org/W4285384559","https://openalex.org/W3144836240","https://openalex.org/W2931209620","https://openalex.org/W2408984719","https://openalex.org/W2299762322","https://openalex.org/W4293247348"],"abstract_inverted_index":{"Reprogramming":[0],"scar":[1],"fibroblasts":[2],"into":[3],"cardiomyocytes":[4],"has":[5],"been":[6],"proposed":[7],"to":[8,72,137],"reverse":[9],"the":[10,17,66,76,81],"damage":[11],"associated":[12],"with":[13,56,75,91,109,115],"myocardial":[14],"infarction.":[15],"However,":[16],"limited":[18],"improvement":[19],"in":[20,102],"cardiac":[21],"function":[22],"calls":[23],"for":[24],"enhanced":[25,29],"strategies.":[26],"We":[27,47],"reported":[28],"efficacy":[30,101,107],"of":[31,83,120],"our":[32],"miR":[33,36,62,68,93,96],"reprogramming":[34,58,100,106,140],"cocktail":[35],"combo":[37,69,97,134],"(miR-1,":[38],"miR-133a,":[39],"miR-208a,":[40],"and":[41,117,127],"miR-499)":[42],"via":[43,80],"RNA-sensing":[44,53,77],"receptor":[45,54,78],"stimulation.":[46],"hypothesized":[48],"that":[49,132,153],"we":[50],"could":[51],"combine":[52],"activation":[55],"fibroblast":[57,139],"by":[59],"chemically":[60],"modifying":[61],"combo.":[63],"To":[64],"test":[65],"hypothesis,":[67],"was":[70],"modified":[71],"enhance":[73,138],"interaction":[74],"Rig1":[79],"addition":[82],"a":[84,110],"5\u2032-triphosphate":[85],"(5\u2032ppp)":[86],"group.":[87],"Importantly,":[88],"when":[89],"compared":[90],"unmodified":[92],"combo,":[94],"5\u2032ppp-modified":[95],"markedly":[98],"improved":[99],"vitro":[103],".":[104],"Enhanced":[105],"correlated":[108],"type-I":[111],"interferon":[112,121],"immune":[113],"response":[114],"strong":[116],"selective":[118],"secretion":[119],"\u03b2":[122],"(IFN\u03b2).":[123],"Antibody":[124],"blocking":[125],"studies":[126],"media":[128],"replacement":[129],"experiments":[130],"indicated":[131],"5\u2032ppp-miR":[133],"utilized":[135],"IFN\u03b2":[136],"efficacy.":[141],"In":[142],"conclusion,":[143],"miRs":[144],"can":[145],"acquire":[146],"powerful":[147],"additional":[148],"roles":[149],"through":[150],"chemical":[151],"modification":[152],"potentially":[154],"increases":[155],"their":[156],"clinical":[157],"applications.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-03-05T00:00:00"}