{"id":"https://openalex.org/W4392232018","doi":"https://doi.org/10.1021/acs.molpharmaceut.3c01164","title":"Optimizing Nonsink Dissolution Testing for Amorphous Solid Dispersions: Exploring Sample Handling Variables","display_name":"Optimizing Nonsink Dissolution Testing for Amorphous Solid Dispersions: Exploring Sample Handling Variables","publication_year":2024,"publication_date":"2024-02-28","ids":{"openalex":"https://openalex.org/W4392232018","doi":"https://doi.org/10.1021/acs.molpharmaceut.3c01164","pmid":"https://pubmed.ncbi.nlm.nih.gov/38416030"},"language":"en","primary_location":{"id":"doi:10.1021/acs.molpharmaceut.3c01164","doi":"https://doi.org/10.1021/acs.molpharmaceut.3c01164","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.3c01164","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047766848","display_name":"Lucas Jos\u00e9 de Alencar Danda","orcid":"https://orcid.org/0000-0003-1526-1572","observed_orcids":["https://orcid.org/0000-0003-1526-1572"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Lucas Jos\u00e9 de Alencar Danda","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1526-1572","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100585381","display_name":"Alane Rafaela de Carvalho Amaral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alane Rafaela de Carvalho Amaral","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040209491","display_name":"Jos\u00e9 Lamartine Soares\u2010Sobrinho","orcid":"https://orcid.org/0000-0002-3280-0294","observed_orcids":["https://orcid.org/0000-0002-3280-0294"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Lamartine Soares-Sobrinho","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081070477","display_name":"M\u00f4nica Felts de La Roca Soares","orcid":"https://orcid.org/0000-0002-4873-915X","observed_orcids":["https://orcid.org/0000-0002-4873-915X"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Monica Felts de La Roca Soares","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047766848"],"corresponding_institution_ids":["https://openalex.org/I25112270"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.4914,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52322738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"21","issue":"4","first_page":"1861","last_page":"1871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amorphous-solid-dispersions","display_name":"amorphous solid dispersions","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sample-handling","display_name":"sample handling","score":0.722000002861023},{"id":"https://openalex.org/keywords/centrifugation","display_name":"centrifugation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sample-preparation","display_name":"sample preparation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/low-substituted-hydroxypropyl-cellulose","display_name":"low-substituted hydroxypropyl cellulose","score":0.925000011920929},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/posaconazole","display_name":"posaconazole","score":1.0}],"concepts":[{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.8290054798126221},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.6868717670440674},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5927368402481079},{"id":"https://openalex.org/C2781218482","wikidata":"https://www.wikidata.org/wiki/Q724426","display_name":"Hydroxypropyl cellulose","level":3,"score":0.5825687646865845},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5201749801635742},{"id":"https://openalex.org/C200447597","wikidata":"https://www.wikidata.org/wiki/Q334104","display_name":"Supersaturation","level":2,"score":0.5107686519622803},{"id":"https://openalex.org/C56052488","wikidata":"https://www.wikidata.org/wiki/Q103382","display_name":"Amorphous solid","level":2,"score":0.5043476819992065},{"id":"https://openalex.org/C14029885","wikidata":"https://www.wikidata.org/wiki/Q5282807","display_name":"Dissolution testing","level":4,"score":0.501469612121582},{"id":"https://openalex.org/C2778571141","wikidata":"https://www.wikidata.org/wiki/Q273318","display_name":"Syringe","level":2,"score":0.464967280626297},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.4569667875766754},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.21502956748008728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15062972903251648},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1337306797504425},{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.09031534194946289},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.molpharmaceut.3c01164","doi":"https://doi.org/10.1021/acs.molpharmaceut.3c01164","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.3c01164","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:38416030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38416030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W657638685","https://openalex.org/W1590254871","https://openalex.org/W1965096889","https://openalex.org/W2030670872","https://openalex.org/W2032268755","https://openalex.org/W2040527214","https://openalex.org/W2082023338","https://openalex.org/W2085535677","https://openalex.org/W2133061394","https://openalex.org/W2243158166","https://openalex.org/W2253675932","https://openalex.org/W2320607110","https://openalex.org/W2335434301","https://openalex.org/W2346957939","https://openalex.org/W2556496813","https://openalex.org/W3102566053","https://openalex.org/W3169596185","https://openalex.org/W3176438268","https://openalex.org/W4380204602"],"related_works":["https://openalex.org/W2246665909","https://openalex.org/W1976021540","https://openalex.org/W4307582062","https://openalex.org/W657638685","https://openalex.org/W4311273187","https://openalex.org/W2346957939","https://openalex.org/W7159938441","https://openalex.org/W51494704","https://openalex.org/W2904810865","https://openalex.org/W2547416249"],"abstract_inverted_index":{"This":[0,127,168],"study":[1],"aims":[2],"to":[3,102,123],"investigate":[4],"key":[5],"variables":[6,184],"affecting":[7],"the":[8,83,93,139,150,163,174],"dissolution":[9,52,187],"of":[10,86,109,152,166,176,181],"amorphous":[11,63],"pharmaceuticals.":[12],"We":[13],"examined":[14],"sample":[15,25,36,115],"treatment":[16],"methods":[17],"(centrifugation":[18],"vs":[19],"syringe":[20,87],"filtration),":[21],"time":[22],"delays":[23,155],"between":[24,114],"collection":[26,116],"and":[27,34,50,72,117,137],"processing":[28],"(immediate,":[29],"2,":[30],"or":[31,41,75,111],"24":[32,112],"h),":[33],"different":[35],"preparations":[37],"(bare":[38],"powder,":[39],"capsules,":[40],"tablets).":[42],"These":[43],"factors":[44],"were":[45],"evaluated":[46],"through":[47],"both":[48],"sink":[49],"nonsink":[51,90,120],"experiments,":[53],"using":[54],"controlled":[55],"supersaturation":[56],"conditions":[57,121],"(sink":[58],"index":[59],"\u2248":[60],"0.1)":[61],"with":[62],"solid":[64],"dispersions":[65],"(ASDs)":[66],"containing":[67],"low-substituted":[68],"hydroxypropyl":[69],"cellulose":[70],"(L-HPC)":[71],"either":[73],"indomethacin":[74],"posaconazole":[76],"as":[77,131],"model":[78],"drugs.":[79],"Our":[80],"results":[81],"highlighted":[82],"significant":[84],"impact":[85],"filtration":[88],"on":[89],"dissolutions,":[91],"particularly":[92,160],"notable":[94],"reduction":[95],"in":[96,161],"dissolved":[97],"drug":[98],"concentration,":[99],"possibly":[100],"due":[101],"filtration-induced":[103],"precipitation.":[104],"Moreover,":[105],"introducing":[106],"a":[107],"delay":[108],"2":[110,144],"h":[113],"quantitation":[118],"under":[119],"led":[122],"substantial":[124],"concentration":[125],"changes.":[126],"effect":[128],"was":[129,141],"not":[130],"pronounced":[132],"when":[133],"samples":[134],"underwent":[135],"centrifugation,":[136],"only":[138],"analysis":[140],"delayed":[142],"for":[143,154],"h.":[145],"The":[146],"findings":[147],"also":[148],"emphasize":[149],"importance":[151],"accounting":[153],"introduced":[156],"by":[157],"pharmaceutical":[158],"formulations,":[159],"assessing":[162],"kinetic-solubility":[164],"profiles":[165],"ASDs.":[167],"research":[169],"offers":[170],"valuable":[171],"insights":[172],"into":[173],"field":[175],"ASDs,":[177],"enhancing":[178],"our":[179],"understanding":[180],"how":[182],"these":[183],"can":[185],"influence":[186],"results.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-03-05T00:00:00"}
