{"id":"https://openalex.org/W4392200795","doi":"https://doi.org/10.3390/ijms25052754","title":"Radiotherapy Metastatic Prostate Cancer Cell Lines Treated with Gold Nanorods Modulate miRNA Signatures","display_name":"Radiotherapy Metastatic Prostate Cancer Cell Lines Treated with Gold Nanorods Modulate miRNA Signatures","publication_year":2024,"publication_date":"2024-02-27","ids":{"openalex":"https://openalex.org/W4392200795","doi":"https://doi.org/10.3390/ijms25052754","pmid":"https://pubmed.ncbi.nlm.nih.gov/38474003","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10931958"},"language":"en","primary_location":{"id":"doi:10.3390/ijms25052754","doi":"https://doi.org/10.3390/ijms25052754","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25052754","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms25052754","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015558354","display_name":"S\u00edlvia Soares","orcid":"https://orcid.org/0000-0002-4344-7860","observed_orcids":["https://orcid.org/0000-0002-4344-7860"]},"institutions":[{"id":"https://openalex.org/I157071867","display_name":"Fernando Pessoa University","ror":"https://ror.org/04h8e7606","country_code":"PT","type":"education","lineage":["https://openalex.org/I157071867"]},{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4405252589","display_name":"Hospital-Escola da Universidade Fernando Pessoa","ror":"https://ror.org/02ajw2j97","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4405252589"]},{"id":"https://openalex.org/I4405256175","display_name":"Instituto de Investiga\u00e7\u00e3o Inova\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/03vsddp82","country_code":"PT","type":"facility","lineage":["https://openalex.org/I157071867","https://openalex.org/I4405256175"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["ES","PT"],"is_corresponding":false,"raw_author_name":"S\u00edlvia Soares","raw_affiliation_strings":["(i3S), Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, 4200-135 Porto, Portugal","Biomark@UC/CEB\u2013Centre of Biological Engineering of Minho University, Department of Chemical Engineering, Faculty of Sciences and Technology, Coimbra University, 3030-790 Coimbra, Portugal","CEB, Centre of Biological Engineering, Minho University, 4710-057 Braga, Portugal","CECLIN, Centro de Estudos Cl\u00ednicos, Hospital Escola Fernando Pessoa, 4420-096 Gondomar, Portugal","FP-I3ID, Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento, FP-BHS, Biomedical and Health Sciences, Universidade Fernando Pessoa (UFP), 4249-004 Porto, Portugal","Faculty of Chemistry, University of Vigo, 36310 Vigo, Spain","Radiotherapy Service, S\u00e3o Jo\u00e3o Hospital Center, 4200-319 Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-4344-7860","affiliations":[{"raw_affiliation_string":"(i3S), Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, 4200-135 Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]},{"raw_affiliation_string":"Biomark@UC/CEB\u2013Centre of Biological Engineering of Minho University, Department of Chemical Engineering, Faculty of Sciences and Technology, Coimbra University, 3030-790 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CEB, Centre of Biological Engineering, Minho University, 4710-057 Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"CECLIN, Centro de Estudos Cl\u00ednicos, Hospital Escola Fernando Pessoa, 4420-096 Gondomar, Portugal","institution_ids":["https://openalex.org/I4405252589"]},{"raw_affiliation_string":"FP-I3ID, Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento, FP-BHS, Biomedical and Health Sciences, Universidade Fernando Pessoa (UFP), 4249-004 Porto, Portugal","institution_ids":["https://openalex.org/I157071867","https://openalex.org/I4405256175"]},{"raw_affiliation_string":"Faculty of Chemistry, University of Vigo, 36310 Vigo, Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"Radiotherapy Service, S\u00e3o Jo\u00e3o Hospital Center, 4200-319 Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029921554","display_name":"F\u00e1tima Aires","orcid":"https://orcid.org/0000-0001-8111-9123","observed_orcids":["https://orcid.org/0000-0001-8111-9123"]},"institutions":[{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"F\u00e1tima Aires","raw_affiliation_strings":["Radiotherapy Service, S\u00e3o Jo\u00e3o Hospital Center, 4200-319 Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-8111-9123","affiliations":[{"raw_affiliation_string":"Radiotherapy Service, S\u00e3o Jo\u00e3o Hospital Center, 4200-319 Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100979297","display_name":"Armanda Monteiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Armanda Monteiro","raw_affiliation_strings":["Radiotherapy Service, S\u00e3o Jo\u00e3o Hospital Center, 4200-319 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiotherapy Service, S\u00e3o Jo\u00e3o Hospital Center, 4200-319 Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079884393","display_name":"Gabriela Pinto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Gabriela Pinto","raw_affiliation_strings":["Radiotherapy Service, S\u00e3o Jo\u00e3o Hospital Center, 4200-319 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiotherapy Service, S\u00e3o Jo\u00e3o Hospital Center, 4200-319 Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008801454","display_name":"Isabel Cristina Jacinto de Faria","orcid":"https://orcid.org/0000-0002-1467-7800","observed_orcids":["https://orcid.org/0000-0002-1467-7800"]},"institutions":[{"id":"https://openalex.org/I157071867","display_name":"Fernando Pessoa University","ror":"https://ror.org/04h8e7606","country_code":"PT","type":"education","lineage":["https://openalex.org/I157071867"]},{"id":"https://openalex.org/I4405252589","display_name":"Hospital-Escola da Universidade Fernando Pessoa","ror":"https://ror.org/02ajw2j97","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4405252589"]},{"id":"https://openalex.org/I4405256175","display_name":"Instituto de Investiga\u00e7\u00e3o Inova\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/03vsddp82","country_code":"PT","type":"facility","lineage":["https://openalex.org/I157071867","https://openalex.org/I4405256175"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Isabel Faria","raw_affiliation_strings":["CECLIN, Centro de Estudos Cl\u00ednicos, Hospital Escola Fernando Pessoa, 4420-096 Gondomar, Portugal","FP-I3ID, Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento, FP-BHS, Biomedical and Health Sciences, Universidade Fernando Pessoa (UFP), 4249-004 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CECLIN, Centro de Estudos Cl\u00ednicos, Hospital Escola Fernando Pessoa, 4420-096 Gondomar, Portugal","institution_ids":["https://openalex.org/I4405252589"]},{"raw_affiliation_string":"FP-I3ID, Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento, FP-BHS, Biomedical and Health Sciences, Universidade Fernando Pessoa (UFP), 4249-004 Porto, Portugal","institution_ids":["https://openalex.org/I157071867","https://openalex.org/I4405256175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077381786","display_name":"M. Goreti F. Sales","orcid":"https://orcid.org/0000-0001-9936-7336","observed_orcids":["https://orcid.org/0000-0001-9936-7336"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Goreti Sales","raw_affiliation_strings":["Biomark@UC/CEB\u2013Centre of Biological Engineering of Minho University, Department of Chemical Engineering, Faculty of Sciences and Technology, Coimbra University, 3030-790 Coimbra, Portugal","CEB, Centre of Biological Engineering, Minho University, 4710-057 Braga, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-9936-7336","affiliations":[{"raw_affiliation_string":"Biomark@UC/CEB\u2013Centre of Biological Engineering of Minho University, Department of Chemical Engineering, Faculty of Sciences and Technology, Coimbra University, 3030-790 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CEB, Centre of Biological Engineering, Minho University, 4710-057 Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068916349","display_name":"Miguel A. Correa\u2010Duarte","orcid":"https://orcid.org/0000-0003-1950-1414","observed_orcids":["https://orcid.org/0000-0003-1950-1414"]},"institutions":[{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel A. Correa-Duarte","raw_affiliation_strings":["CINBIO, University of Vigo, 36310 Vigo, Spain","Southern Galicia Institute of Health Research (IISGS), Biomedical Research Networking Center for Mental Health (CIBERSAM), 36310 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1950-1414","affiliations":[{"raw_affiliation_string":"CINBIO, University of Vigo, 36310 Vigo, Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"Southern Galicia Institute of Health Research (IISGS), Biomedical Research Networking Center for Mental Health (CIBERSAM), 36310 Madrid, Spain","institution_ids":["https://openalex.org/I4210090703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027522073","display_name":"Susana G. Guerreiro","orcid":"https://orcid.org/0000-0002-2432-2755","observed_orcids":["https://orcid.org/0000-0002-2432-2755"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana Guerreiro","raw_affiliation_strings":["(i3S), Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, 4200-135 Porto, Portugal","Department of Biomedicine, Biochemistry Unit, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal","Faculty of Nutrition and Food Sciences, University of Porto, 4150-180 Porto, Portugal","Institute of Molecular Pathology and Immunology of the University of Porto-IPATIMUP, 4200-465 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(i3S), Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, 4200-135 Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]},{"raw_affiliation_string":"Department of Biomedicine, Biochemistry Unit, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Faculty of Nutrition and Food Sciences, University of Porto, 4150-180 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Institute of Molecular Pathology and Immunology of the University of Porto-IPATIMUP, 4200-465 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018170292","display_name":"R\u00faben Fernandes","orcid":"https://orcid.org/0000-0001-8933-3984","observed_orcids":["https://orcid.org/0000-0001-8933-3984"]},"institutions":[{"id":"https://openalex.org/I157071867","display_name":"Fernando Pessoa University","ror":"https://ror.org/04h8e7606","country_code":"PT","type":"education","lineage":["https://openalex.org/I157071867"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4405252589","display_name":"Hospital-Escola da Universidade Fernando Pessoa","ror":"https://ror.org/02ajw2j97","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4405252589"]},{"id":"https://openalex.org/I4405256175","display_name":"Instituto de Investiga\u00e7\u00e3o Inova\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/03vsddp82","country_code":"PT","type":"facility","lineage":["https://openalex.org/I157071867","https://openalex.org/I4405256175"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"R\u00faben Fernandes","raw_affiliation_strings":["(i3S), Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, 4200-135 Porto, Portugal","CECLIN, Centro de Estudos Cl\u00ednicos, Hospital Escola Fernando Pessoa, 4420-096 Gondomar, Portugal","FP-I3ID, Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento, FP-BHS, Biomedical and Health Sciences, Universidade Fernando Pessoa (UFP), 4249-004 Porto, Portugal","UFP@RISE, Rede de Investiga\u00e7\u00e3o em Sa\u00fade, Universidade Fernando Pessoa, 4249-004 Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-8933-3984","affiliations":[{"raw_affiliation_string":"(i3S), Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, 4200-135 Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]},{"raw_affiliation_string":"CECLIN, Centro de Estudos Cl\u00ednicos, Hospital Escola Fernando Pessoa, 4420-096 Gondomar, Portugal","institution_ids":["https://openalex.org/I4405252589"]},{"raw_affiliation_string":"FP-I3ID, Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento, FP-BHS, Biomedical and Health Sciences, Universidade Fernando Pessoa (UFP), 4249-004 Porto, Portugal","institution_ids":["https://openalex.org/I157071867","https://openalex.org/I4405256175"]},{"raw_affiliation_string":"UFP@RISE, Rede de Investiga\u00e7\u00e3o em Sa\u00fade, Universidade Fernando Pessoa, 4249-004 Porto, Portugal","institution_ids":["https://openalex.org/I157071867"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5018170292"],"corresponding_institution_ids":["https://openalex.org/I157071867","https://openalex.org/I4210158732","https://openalex.org/I4405252589","https://openalex.org/I4405256175"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":0.9895,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.71423349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"25","issue":"5","first_page":"2754","last_page":"2754"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/gold-nanorods","display_name":"gold nanorods","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pegylated-gold-nanoparticles","display_name":"PEGylated gold nanoparticles","score":0.968999981880188},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.6269999742507935},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.7390000224113464},{"id":"https://openalex.org/keywords/du145-cells","display_name":"DU145 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.926873505115509},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8102255463600159},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7736682295799255},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.7553059458732605},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6305831670761108},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5269212126731873},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4777906835079193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46645182371139526},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4371403157711029},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4156021475791931},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37922707200050354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2620423436164856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21655291318893433},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09215506911277771},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms25052754","doi":"https://doi.org/10.3390/ijms25052754","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25052754","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10931958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10931958","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10931958/pdf/ijms-25-02754.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:38474003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38474003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:repositorium.uminho.pt:1822/91947","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/91947","pdf_url":"https://repositorium.uminho.pt/bitstreams/fbadf0b1-2be1-49b6-ae9a-292429776e40/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:www.investigo.biblioteca.uvigo.es:11093/6526","doi":null,"is_oa":true,"landing_page_url":"https://www.mdpi.com/1422-0067/25/5/2754","pdf_url":"https://www.investigo.biblioteca.uvigo.es/xmlui/bitstream/11093/6526/1/2024_soares_prostate_nanorods.pdf","source":{"id":"https://openalex.org/S4377196408","display_name":"Investigo Institutional repository of UVigo (Universidade de Vigo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I6289922","host_organization_name":"Universidade de Vigo","host_organization_lineage":["https://openalex.org/I6289922"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/91947","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/91947","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3390/ijms25052754","doi":"https://doi.org/10.3390/ijms25052754","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25052754","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1644446168","display_name":null,"funder_award_id":"NORTE-01-0145-FEDER-024325","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5708027778","display_name":"Utiliza\u00e7\u00e3o de Aptameros para o Teran\u00f3stico e para a Medicina de Precis\u00e3o no Carcinoma da Pr\u00f3stata","funder_award_id":"2022.09032.PTDC","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7455025106","display_name":"NanoTeragn\u00f3stico com microRNAs: Aplica\u00e7\u00e3o na Radioterapia","funder_award_id":"SFRH/BD/138271/2018","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392200795.pdf","grobid_xml":"https://content.openalex.org/works/W4392200795.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1186528251","https://openalex.org/W1962426289","https://openalex.org/W1966851131","https://openalex.org/W1972864222","https://openalex.org/W2013860287","https://openalex.org/W2022687771","https://openalex.org/W2040207029","https://openalex.org/W2047188879","https://openalex.org/W2070297079","https://openalex.org/W2070412447","https://openalex.org/W2074908827","https://openalex.org/W2093557716","https://openalex.org/W2096107614","https://openalex.org/W2100975741","https://openalex.org/W2118980569","https://openalex.org/W2121629705","https://openalex.org/W2135139795","https://openalex.org/W2141549067","https://openalex.org/W2144149602","https://openalex.org/W2148987788","https://openalex.org/W2154493509","https://openalex.org/W2169444299","https://openalex.org/W2194514952","https://openalex.org/W2274282837","https://openalex.org/W2433153259","https://openalex.org/W2507290758","https://openalex.org/W2602117126","https://openalex.org/W2736520162","https://openalex.org/W2741888702","https://openalex.org/W2791726012","https://openalex.org/W2793989844","https://openalex.org/W2886718156","https://openalex.org/W2906480369","https://openalex.org/W2919948854","https://openalex.org/W3033301166","https://openalex.org/W3041438991","https://openalex.org/W3108978735","https://openalex.org/W3121139016","https://openalex.org/W3130164520","https://openalex.org/W3187989686","https://openalex.org/W3191534679","https://openalex.org/W3201647914","https://openalex.org/W3205473828","https://openalex.org/W3206708808","https://openalex.org/W3208606855","https://openalex.org/W4210781932","https://openalex.org/W4213089453","https://openalex.org/W4214906265","https://openalex.org/W4229015141","https://openalex.org/W4291214691","https://openalex.org/W4292400766","https://openalex.org/W4309732834","https://openalex.org/W4313491557","https://openalex.org/W4321374088"],"related_works":["https://openalex.org/W7039584301","https://openalex.org/W2096107614","https://openalex.org/W3092921601","https://openalex.org/W3187989686","https://openalex.org/W2741888702","https://openalex.org/W2889032949","https://openalex.org/W2082573420","https://openalex.org/W2070632875","https://openalex.org/W3029912375","https://openalex.org/W4321374088"],"abstract_inverted_index":{"MicroRNA":[0],"(miRNA)":[1],"modulation":[2],"has":[3],"been":[4,46],"identified":[5],"as":[6,48],"a":[7,49,117],"promising":[8],"strategy":[9],"for":[10,58,158],"improving":[11],"the":[12,33,62,69,81,137,162],"response":[13],"of":[14,29,35,64,71,165],"human":[15,100,111],"prostate":[16,102,112],"cancer":[17],"(PCa)":[18],"to":[19,38,52,61,79,91,153,176,195],"radiotherapy":[20],"(RT).":[21],"Studies":[22],"have":[23,45],"shown":[24],"that":[25,128],"mimics":[26],"or":[27],"inhibitors":[28],"miRNAs":[30,60],"could":[31,179,192],"modulate":[32,80],"sensitivity":[34],"PCa":[36,54,85,173],"cells":[37,55,147],"RT.":[39],"In":[40,145,171],"addition,":[41,146],"pegylated":[42,75],"gold":[43,76],"nanoparticles":[44],"studied":[47],"therapeutic":[50],"approach":[51],"treat":[53],"and/or":[56],"vehicles":[57],"carrying":[59],"inside":[63],"cells.":[65,86],"Therefore,":[66],"we":[67],"evaluated":[68],"capacity":[70],"hypofractionated":[72,177],"RT":[73,142,178],"and":[74,96,107,109,122,136,143,151,169,190],"nanorods":[77],"(AuNPr-PEG)":[78],"miRNA":[82,129,188],"signature":[83],"on":[84,98,133,184],"Thus,":[87],"RT-qPCR":[88],"was":[89],"used":[90,194],"analyze":[92],"miRNA-95,":[93,166],"miRNA-106-5p,":[94],"miRNA-145-5p,":[95],"miRNA-541-3p":[97],"three":[99],"metastatic":[101,186,197],"cell":[103,114,119,134,198],"lines":[104],"(PC3,":[105],"DU145,":[106],"LNCaP)":[108],"one":[110],"epithelial":[113],"line":[115],"(HprEpiC,":[116],"non-tumor":[118],"line)":[120],"with":[121,149],"without":[123],"treatment.":[124],"Our":[125],"results":[126],"showed":[127],"expression":[130,163],"levels":[131,164],"depend":[132],"type":[135],"treatment":[138,182],"combination":[139],"applied":[140],"using":[141],"AuNPr-PEG.":[144],"pre-treated":[148],"AuNPr-PEG":[150,191],"submitted":[152,175],"2.5":[154],"Gy":[155],"per":[156],"day":[157],"3":[159],"days":[160],"decreased":[161],"miRNA-106,":[167],"miRNA-145,":[168],"miRNA-541-3p.":[170],"conclusion,":[172],"patients":[174],"receive":[180],"personalized":[181],"based":[183],"their":[185],"cellular":[187],"signature,":[189],"be":[193],"increase":[196],"radiosensitivity.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-02-28T00:00:00"}