{"id":"https://openalex.org/W4392183116","doi":"https://doi.org/10.7554/elife.89465.3.sa4","title":"Author Response: Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling","display_name":"Author Response: Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling","publication_year":2024,"publication_date":"2024-02-26","ids":{"openalex":"https://openalex.org/W4392183116","doi":"https://doi.org/10.7554/elife.89465.3.sa4"},"language":"en","primary_location":{"id":"doi:10.7554/elife.89465.3.sa4","doi":"https://doi.org/10.7554/elife.89465.3.sa4","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7554/elife.89465.3.sa4","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.7554/elife.89465.3.sa4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"E Nicholas Petersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Nicholas Petersen","raw_affiliation_strings":["Scripps Research Institute, Jupiter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute, Jupiter","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025659709","display_name":"Mahmud Arif Pavel","orcid":"https://orcid.org/0009-0005-2813-315X","observed_orcids":["https://orcid.org/0009-0005-2813-315X","https://orcid.org/0000-0002-2709-8744"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmud Arif Pavel","raw_affiliation_strings":["University of Illinois at Chicago, Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104249369","display_name":"Samuel S. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel S Hansen","raw_affiliation_strings":["Scripps Research Institute, Jupiter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute, Jupiter","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079553489","display_name":"Manasa V. Gudheti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manasa Gudheti","raw_affiliation_strings":["University of Utah, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446197","display_name":"Hao Wang","orcid":"https://orcid.org/0000-0003-1966-7940","observed_orcids":["https://orcid.org/0000-0003-1966-7940"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Wang","raw_affiliation_strings":["Massachusetts Institute of Technology, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Boston","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004297048","display_name":"Zixuan Yuan","orcid":"https://orcid.org/0000-0003-0665-5086","observed_orcids":["https://orcid.org/0000-0003-0665-5086"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zixuan Yuan","raw_affiliation_strings":["Scripps Research Institute, Jupiter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute, Jupiter","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103875971","display_name":"Keith R. Murphy","orcid":"https://orcid.org/0000-0001-6085-7477","observed_orcids":["https://orcid.org/0000-0001-6085-7477"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith R Murphy","raw_affiliation_strings":["Scripps Research Institute, Jupiter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute, Jupiter","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014717275","display_name":"William W. Ja","orcid":"https://orcid.org/0000-0002-4003-7356","observed_orcids":["https://orcid.org/0000-0002-4003-7356"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Ja","raw_affiliation_strings":["Scripps Research Institute, Jupiter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute, Jupiter","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075413007","display_name":"Heather Anne Ferris","orcid":"https://orcid.org/0000-0002-6321-3447","observed_orcids":["https://orcid.org/0000-0002-6321-3447"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather A Ferris","raw_affiliation_strings":["University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026863162","display_name":"Erik M. J\u00f8rgensen","orcid":"https://orcid.org/0000-0002-2978-8028","observed_orcids":["https://orcid.org/0000-0002-2978-8028"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik Jorgensen","raw_affiliation_strings":["University of Utah, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019457716","display_name":"Scott B. Hansen","orcid":"https://orcid.org/0000-0003-0086-9753","observed_orcids":["https://orcid.org/0000-0003-0086-9753"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott B Hansen","raw_affiliation_strings":["Scripps Research Institute, Jupiter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute, Jupiter","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.2791000008583069,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trek-1","display_name":"TREK-1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pld2","display_name":"phospholipase D2","score":0.824999988079071},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.8650000095367432},{"id":"https://openalex.org/keywords/membrane-mechanics","display_name":"membrane mechanics","score":0.6100000143051147},{"id":"https://openalex.org/keywords/fluid-shear","display_name":"fluid shear","score":0.6439999938011169},{"id":"https://openalex.org/keywords/super-resolution-imaging","display_name":"super-resolution imaging","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pain-modulation","display_name":"pain modulation","score":0.593999981880188},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.6169999837875366},{"id":"https://openalex.org/keywords/second-messenger-signaling","display_name":"second messenger signaling","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.651211678981781},{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.6161911487579346},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.4826810657978058},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32096347212791443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3208138346672058},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3148472011089325},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3052261471748352},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2429456114768982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22743064165115356},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2254127562046051},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.10477235913276672}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.89465.3.sa4","doi":"https://doi.org/10.7554/elife.89465.3.sa4","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7554/elife.89465.3.sa4","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.89465.3.sa4","doi":"https://doi.org/10.7554/elife.89465.3.sa4","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7554/elife.89465.3.sa4","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385363351","https://openalex.org/W3174614074","https://openalex.org/W1980802466","https://openalex.org/W2982294226","https://openalex.org/W6925389291","https://openalex.org/W3176490875","https://openalex.org/W98403486","https://openalex.org/W3217390172","https://openalex.org/W2394067252","https://openalex.org/W2585677607"],"abstract_inverted_index":{"\u201cOuch!\u201d:":[0],"you":[1],"have":[2],"just":[3],"stabbed":[4],"your":[5],"little":[6],"toe":[7],"on":[8,253],"the":[9,31,50,80,108,129,149,167,179,184,225,243,259,270,285,292,300],"sharp":[10],"corner":[11],"of":[12,52,60,65,96,135,183,228,261,302,350],"a":[13,153,195,201,249],"coffee":[14],"table.":[15],"That":[16],"painful":[17],"sensation":[18],"stems":[19],"from":[20,162],"nerve":[21,160,303],"cells":[22,103,161,266,304],"converting":[23],"information":[24,106],"about":[25],"external":[26,86,314],"forces":[27,87,223,315],"into":[28],"electric":[29],"signals":[30],"brain":[32],"can":[33,239,305],"interpret.":[34],"Increasingly,":[35],"new":[36,202],"evidence":[37],"is":[38,58,117,173],"suggesting":[39],"that":[40,99,131,156,204,221,251,258,299,310],"this":[41,189],"process":[42],"may":[43,326],"be":[44,236,327],"starting":[45],"at":[46],"fat-based":[47],"structures":[48,70],"within":[49],"membrane":[51,57,81,130,210,245,301],"these":[53,171,323],"cells.":[54],"The":[55,218],"cell":[56],"formed":[59,134],"two":[61],"interconnected,":[62],"flexible":[63],"sheets":[64],"lipids":[66,211],"in":[67,89,93,128,279,318,352],"which":[68,340],"embedded":[69],"or":[71],"molecules":[72,185],"are":[73,132,341],"free":[74],"to":[75,82,85,91,107,119,142,158,175,178,207,213,235,264,276,312,329],"move.":[76],"This":[77],"organisation":[78],"allows":[79],"physically":[83,143],"respond":[84,212],"and,":[88],"turn,":[90,280],"set":[92],"motion":[94],"chains":[95],"molecular":[97],"events":[98],"help":[100,311],"fine-tune":[101],"how":[102,209,269],"relay":[104],"such":[105,335],"brain.":[109],"For":[110],"instance,":[111],"an":[112],"enzyme":[113],"known":[114],"as":[115,336],"PLD2":[116,137,232],"bound":[118],"lipid":[120,229],"rafts":[121],"\u2013":[122],"precisely":[123],"arranged,":[124],"rigid":[125],"fatty":[126],"\u2018clumps\u2019":[127],"partly":[133],"cholesterol.":[136],"has":[138],"also":[139],"been":[140],"shown":[141],"interact":[144],"with":[145,200,343],"and":[146,181,215,233,274,278,283,316,332,338,347],"then":[147,240],"activate":[148],"ion":[150],"channel":[151],"TREK-1,":[152],"membrane-based":[154],"protein":[155],"helps":[157],"prevent":[159],"relaying":[163],"pain":[164,319,345],"signals.":[165],"However,":[166],"exact":[168],"mechanism":[169],"underpinning":[170],"interactions":[172],"difficult":[174],"study":[176,293],"due":[177],"nature":[180],"size":[182],"involved.":[186],"To":[187],"address":[188],"question,":[190],"Petersen":[191,295],"et":[192,296],"al.":[193,297],"combined":[194],"technology":[196],"called":[197],"super-resolution":[198],"imaging":[199],"approach":[203],"allowed":[205],"them":[206],"observe":[208],"pressure":[214],"fluid":[216],"shear.":[217],"experiments":[219],"showed":[220],"mechanical":[222],"disrupt":[224],"careful":[226],"arrangement":[227],"rafts,":[230],"causing":[231],"TREK-1":[234],"released.":[237],"They":[238],"move":[241],"through":[242],"surrounding":[244],"where":[246],"they":[247],"reach":[248],"switch":[250],"turns":[252],"TREK-1.":[254,290],"Further":[255],"work":[256],"revealed":[257],"levels":[260,349],"cholesterol":[262,351],"available":[263],"mouse":[265],"directly":[267],"influenced":[268],"clumps":[271],"could":[272],"form":[273],"bind":[275],"PLD2,":[277],"dialled":[281],"up":[282],"down":[284],"protective":[286],"signal":[287],"mediated":[288],"by":[289,294],"Overall,":[291],"shows":[298],"contain":[306],"cholesterol-based":[307],"\u2018fat":[308],"sensors\u2019":[309],"detect":[313],"participate":[317],"regulation.":[320],"By":[321],"dissecting":[322],"processes,":[324],"it":[325],"possible":[328],"better":[330],"understand":[331],"treat":[333],"conditions":[334],"diabetes":[337],"lupus,":[339],"associated":[342],"both":[344],"sensitivity":[346],"elevated":[348],"tissues.":[353]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-02-27T00:00:00"}