{"id":"https://openalex.org/W4392045396","doi":"https://doi.org/10.3390/ijms25052563","title":"Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion","display_name":"Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion","publication_year":2024,"publication_date":"2024-02-22","ids":{"openalex":"https://openalex.org/W4392045396","doi":"https://doi.org/10.3390/ijms25052563","pmid":"https://pubmed.ncbi.nlm.nih.gov/38473812","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10932253"},"language":"en","primary_location":{"id":"doi:10.3390/ijms25052563","doi":"https://doi.org/10.3390/ijms25052563","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25052563","pdf_url":"https://www.mdpi.com/1422-0067/25/5/2563/pdf?version=1708607393","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/25/5/2563/pdf?version=1708607393","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111133795","display_name":"Emerson De Fazio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emerson De Fazio","raw_affiliation_strings":["Department of Medicine, Vita-Salute San Raffaele University School of Medicine, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vita-Salute San Raffaele University School of Medicine, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093978977","display_name":"Matilde Pittarello","orcid":"https://orcid.org/0009-0001-7927-0825","observed_orcids":["https://orcid.org/0009-0001-7927-0825"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matilde Pittarello","raw_affiliation_strings":["Department of Medicine, Humanitas University School of Medicine, 20089 Rozzano, Italy"],"raw_orcid":"https://orcid.org/0009-0001-7927-0825","affiliations":[{"raw_affiliation_string":"Department of Medicine, Humanitas University School of Medicine, 20089 Rozzano, Italy","institution_ids":["https://openalex.org/I1339471597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032400212","display_name":"Alessandro Gans","orcid":"https://orcid.org/0000-0002-6222-8479","observed_orcids":["https://orcid.org/0000-0002-6222-8479"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Gans","raw_affiliation_strings":["Department of Neurology, University of Milan, 20122 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6222-8479","affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Milan, 20122 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077729994","display_name":"Bikona Ghosh","orcid":"https://orcid.org/0000-0003-0703-9656","observed_orcids":["https://orcid.org/0000-0003-0703-9656"]},"institutions":[{"id":"https://openalex.org/I96369009","display_name":"Dhaka Medical College and Hospital","ror":"https://ror.org/0150ewf57","country_code":"BD","type":"education","lineage":["https://openalex.org/I96369009"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Bikona Ghosh","raw_affiliation_strings":["School of Medicine and Surgery, Dhaka Medical College, Dhaka 1000, Bangladesh"],"raw_orcid":"https://orcid.org/0000-0003-0703-9656","affiliations":[{"raw_affiliation_string":"School of Medicine and Surgery, Dhaka Medical College, Dhaka 1000, Bangladesh","institution_ids":["https://openalex.org/I96369009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074473602","display_name":"Hasan Slika","orcid":"https://orcid.org/0000-0003-4597-3642","observed_orcids":["https://orcid.org/0000-0003-4597-3642"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hasan Slika","raw_affiliation_strings":["Hunterian Neurosurgical Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"],"raw_orcid":"https://orcid.org/0000-0003-4597-3642","affiliations":[{"raw_affiliation_string":"Hunterian Neurosurgical Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056044376","display_name":"Paolo Alimonti","orcid":"https://orcid.org/0009-0009-8359-9314","observed_orcids":["https://orcid.org/0009-0009-8359-9314"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Paolo Alimonti","raw_affiliation_strings":["Department of Medicine, Vita-Salute San Raffaele University School of Medicine, 20132 Milan, Italy","Department of Neurosurgery, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vita-Salute San Raffaele University School of Medicine, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261"]},{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010219978","display_name":"Betty Tyler","orcid":"https://orcid.org/0000-0001-9800-6969","observed_orcids":["https://orcid.org/0000-0001-9800-6969"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Betty Tyler","raw_affiliation_strings":["Hunterian Neurosurgical Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"],"raw_orcid":"https://orcid.org/0000-0001-9800-6969","affiliations":[{"raw_affiliation_string":"Hunterian Neurosurgical Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5010219978"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":1.7133,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.86681975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"25","issue":"5","first_page":"2563","last_page":"2563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9779999852180481},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-immune-cells","display_name":"tumor immune cells","score":0.640999972820282},{"id":"https://openalex.org/keywords/invasion-mechanisms","display_name":"invasion mechanisms","score":0.5189999938011169},{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7488067746162415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6191182732582092},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.5807991027832031},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5730919241905212},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5611339807510376},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.481720507144928},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.4557506740093231},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43744516372680664},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3778228759765625},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33391010761260986},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2949504256248474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2366495430469513},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18145322799682617},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms25052563","doi":"https://doi.org/10.3390/ijms25052563","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25052563","pdf_url":"https://www.mdpi.com/1422-0067/25/5/2563/pdf?version=1708607393","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10932253","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10932253","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:38473812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38473812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms25052563","doi":"https://doi.org/10.3390/ijms25052563","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25052563","pdf_url":"https://www.mdpi.com/1422-0067/25/5/2563/pdf?version=1708607393","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392045396.pdf","grobid_xml":"https://content.openalex.org/works/W4392045396.grobid-xml"},"referenced_works_count":217,"referenced_works":["https://openalex.org/W1496797348","https://openalex.org/W1506672302","https://openalex.org/W1515660230","https://openalex.org/W1516589908","https://openalex.org/W1530763983","https://openalex.org/W1536836107","https://openalex.org/W1545715882","https://openalex.org/W1587587103","https://openalex.org/W1603809034","https://openalex.org/W1606181359","https://openalex.org/W1792532087","https://openalex.org/W1848088766","https://openalex.org/W1861502977","https://openalex.org/W1882450096","https://openalex.org/W1887747927","https://openalex.org/W1970849733","https://openalex.org/W1971601756","https://openalex.org/W1976096075","https://openalex.org/W1977820874","https://openalex.org/W1984989438","https://openalex.org/W1985323012","https://openalex.org/W1985485745","https://openalex.org/W1987606222","https://openalex.org/W1989687440","https://openalex.org/W2003046273","https://openalex.org/W2011788217","https://openalex.org/W2012957035","https://openalex.org/W2013328926","https://openalex.org/W2013749488","https://openalex.org/W2014522837","https://openalex.org/W2016064098","https://openalex.org/W2018016372","https://openalex.org/W2019318549","https://openalex.org/W2019787798","https://openalex.org/W2020026579","https://openalex.org/W2020048627","https://openalex.org/W2024514018","https://openalex.org/W2027474877","https://openalex.org/W2034437737","https://openalex.org/W2035912195","https://openalex.org/W2041617965","https://openalex.org/W2043741162","https://openalex.org/W2049212652","https://openalex.org/W2057217877","https://openalex.org/W2060431203","https://openalex.org/W2060950703","https://openalex.org/W2062158931","https://openalex.org/W2064214863","https://openalex.org/W2066301450","https://openalex.org/W2069897030","https://openalex.org/W2071242951","https://openalex.org/W2073259535","https://openalex.org/W2077776183","https://openalex.org/W2080648518","https://openalex.org/W2087770076","https://openalex.org/W2089694031","https://openalex.org/W2091233038","https://openalex.org/W2094592775","https://openalex.org/W2095554947","https://openalex.org/W2097333265","https://openalex.org/W2098538891","https://openalex.org/W2101125333","https://openalex.org/W2106862355","https://openalex.org/W2109816625","https://openalex.org/W2111940175","https://openalex.org/W2113282518","https://openalex.org/W2116039248","https://openalex.org/W2118687720","https://openalex.org/W2120100866","https://openalex.org/W2123040085","https://openalex.org/W2124736921","https://openalex.org/W2125867824","https://openalex.org/W2128130529","https://openalex.org/W2132230893","https://openalex.org/W2133117291","https://openalex.org/W2137103099","https://openalex.org/W2137339420","https://openalex.org/W2137439281","https://openalex.org/W2140088548","https://openalex.org/W2146933354","https://openalex.org/W2148192822","https://openalex.org/W2150322923","https://openalex.org/W2157500906","https://openalex.org/W2162518430","https://openalex.org/W2167548068","https://openalex.org/W2169872783","https://openalex.org/W2170989073","https://openalex.org/W2208036228","https://openalex.org/W2210882761","https://openalex.org/W2262878506","https://openalex.org/W2270769175","https://openalex.org/W2279320212","https://openalex.org/W2291868789","https://openalex.org/W2292706194","https://openalex.org/W2314427842","https://openalex.org/W2320523858","https://openalex.org/W2327577561","https://openalex.org/W2342038746","https://openalex.org/W2395943362","https://openalex.org/W2411869533","https://openalex.org/W2462516843","https://openalex.org/W2472469504","https://openalex.org/W2516228874","https://openalex.org/W2519034789","https://openalex.org/W2569806458","https://openalex.org/W2591701973","https://openalex.org/W2598268037","https://openalex.org/W2605795763","https://openalex.org/W2626629374","https://openalex.org/W2749511637","https://openalex.org/W2758553652","https://openalex.org/W2761941966","https://openalex.org/W2782274120","https://openalex.org/W2791552546","https://openalex.org/W2791673616","https://openalex.org/W2801609626","https://openalex.org/W2802666736","https://openalex.org/W2803329568","https://openalex.org/W2884522219","https://openalex.org/W2884741638","https://openalex.org/W2885475988","https://openalex.org/W2885875354","https://openalex.org/W2886743609","https://openalex.org/W2889646458","https://openalex.org/W2892868260","https://openalex.org/W2894591213","https://openalex.org/W2895926103","https://openalex.org/W2896205604","https://openalex.org/W2897787848","https://openalex.org/W2898207129","https://openalex.org/W2901970540","https://openalex.org/W2903011464","https://openalex.org/W2903416202","https://openalex.org/W2906806915","https://openalex.org/W2913667667","https://openalex.org/W2914612812","https://openalex.org/W2915980124","https://openalex.org/W2916454046","https://openalex.org/W2949944282","https://openalex.org/W2950581103","https://openalex.org/W2953102624","https://openalex.org/W2954405832","https://openalex.org/W2961217357","https://openalex.org/W2972692767","https://openalex.org/W2973455289","https://openalex.org/W2973686658","https://openalex.org/W2974724557","https://openalex.org/W2983802573","https://openalex.org/W2991252402","https://openalex.org/W2997878069","https://openalex.org/W2999084078","https://openalex.org/W3003319709","https://openalex.org/W3003704799","https://openalex.org/W3012251148","https://openalex.org/W3014821907","https://openalex.org/W3016059578","https://openalex.org/W3018624366","https://openalex.org/W3032258743","https://openalex.org/W3080716835","https://openalex.org/W3087365268","https://openalex.org/W3089667275","https://openalex.org/W3090106138","https://openalex.org/W3092450336","https://openalex.org/W3105238692","https://openalex.org/W3107142932","https://openalex.org/W3107450189","https://openalex.org/W3109776255","https://openalex.org/W3111104197","https://openalex.org/W3112558105","https://openalex.org/W3135886923","https://openalex.org/W3144429865","https://openalex.org/W3154190927","https://openalex.org/W3158736312","https://openalex.org/W3160336536","https://openalex.org/W3190491649","https://openalex.org/W3192530615","https://openalex.org/W3194142449","https://openalex.org/W3199766766","https://openalex.org/W3207653555","https://openalex.org/W3208599903","https://openalex.org/W3215445294","https://openalex.org/W4205110933","https://openalex.org/W4205570394","https://openalex.org/W4224869288","https://openalex.org/W4225110328","https://openalex.org/W4239737508","https://openalex.org/W4285820274","https://openalex.org/W4288950914","https://openalex.org/W4289745126","https://openalex.org/W4293527493","https://openalex.org/W4295519626","https://openalex.org/W4297977472","https://openalex.org/W4303418779","https://openalex.org/W4306146737","https://openalex.org/W4308773363","https://openalex.org/W4310641975","https://openalex.org/W4311472839","https://openalex.org/W4318476437","https://openalex.org/W4327736431","https://openalex.org/W4364375137","https://openalex.org/W4365516056","https://openalex.org/W4366090161","https://openalex.org/W4367857311","https://openalex.org/W4376134750","https://openalex.org/W4381468472","https://openalex.org/W4382362021","https://openalex.org/W4385417543","https://openalex.org/W4387141242","https://openalex.org/W4388142090","https://openalex.org/W4388946750","https://openalex.org/W4390879112","https://openalex.org/W4394998531","https://openalex.org/W4397009438","https://openalex.org/W4410595403","https://openalex.org/W4414090196","https://openalex.org/W6756807416","https://openalex.org/W7099405366"],"related_works":["https://openalex.org/W3011370684","https://openalex.org/W3081056070","https://openalex.org/W4206378965","https://openalex.org/W3157369487","https://openalex.org/W3207148533","https://openalex.org/W201861943","https://openalex.org/W4288950914","https://openalex.org/W4213267121","https://openalex.org/W2916308420","https://openalex.org/W2911155554"],"abstract_inverted_index":{"Gliomas":[0],"are":[1,30],"diffusely":[2],"infiltrating":[3],"brain":[4,19,35,67,94,117],"tumors":[5,32],"whose":[6],"prognosis":[7],"is":[8,41,56],"strongly":[9],"influenced":[10],"by":[11,65,90,111,129,176],"their":[12],"extent":[13],"of":[14,61,87,104,125,173,191,195],"invasion":[15,174],"into":[16,76],"the":[17,59,80,85,101,121,140,147,153,171,184,188,192],"surrounding":[18],"tissue.":[20,118],"While":[21],"lower-grade":[22],"gliomas":[23,29],"present":[24],"more":[25],"circumscribed":[26],"borders,":[27],"high-grade":[28],"aggressive":[31],"with":[33,49,135,139],"widespread":[34],"infiltration":[36,68],"and":[37,47,108,138,166,178],"dissemination.":[38],"Glioblastoma":[39],"(GBM)":[40],"known":[42],"for":[43,93],"its":[44,62],"high":[45],"invasiveness":[46],"association":[48],"poor":[50],"prognosis.":[51],"Its":[52],"low":[53],"survival":[54],"rate":[55],"due":[57],"to":[58,114,163],"certainty":[60],"recurrence,":[63],"caused":[64],"microscopic":[66],"which":[69],"makes":[70],"surgical":[71],"eradication":[72],"unattainable.":[73],"New":[74],"insights":[75],"GBM":[77],"biology":[78],"at":[79],"single-cell":[81],"level":[82],"have":[83],"enabled":[84],"identification":[86],"mechanisms":[88,109,172,194],"exploited":[89],"glioma":[91,164],"cells":[92,113,133],"invasion.":[95,167,196],"In":[96],"this":[97],"review,":[98],"we":[99,182],"explore":[100],"current":[102,185],"understanding":[103],"several":[105],"molecular":[106,193],"pathways":[107],"used":[110],"tumor":[112,126,132,141],"invade":[115],"normal":[116],"We":[119,144,168],"address":[120,170],"intrinsic":[122],"biological":[123],"drivers":[124],"cell":[127],"invasion,":[128],"tackling":[130],"how":[131],"interact":[134],"each":[136],"other":[137],"microenvironment":[142],"(TME).":[143],"focus":[145],"on":[146,187],"recently":[148],"discovered":[149],"neuronal":[150],"niche":[151],"in":[152],"TME,":[154],"including":[155],"local":[156],"as":[157,159],"well":[158],"distant":[160],"neurons,":[161],"contributing":[162],"growth":[165],"then":[169],"promoted":[175],"astrocytes":[177],"immune":[179],"cells.":[180],"Finally,":[181],"review":[183],"literature":[186],"therapeutic":[189],"targeting":[190]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-23T00:00:00"}
