{"id":"https://openalex.org/W4392022425","doi":"https://doi.org/10.1016/s2665-9913(23)00341-7","title":"Clinical consequences of infliximab immunogenicity and the effect of proactive therapeutic drug monitoring: exploratory analyses of the randomised, controlled NOR-DRUM trials","display_name":"Clinical consequences of infliximab immunogenicity and the effect of proactive therapeutic drug monitoring: exploratory analyses of the randomised, controlled NOR-DRUM trials","publication_year":2024,"publication_date":"2024-02-22","ids":{"openalex":"https://openalex.org/W4392022425","doi":"https://doi.org/10.1016/s2665-9913(23)00341-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/38402891"},"language":"en","primary_location":{"id":"doi:10.1016/s2665-9913(23)00341-7","doi":"https://doi.org/10.1016/s2665-9913(23)00341-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2665-9913(23)00341-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210233594","display_name":"The Lancet Rheumatology","issn_l":"2665-9913","issn":["2665-9913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-3","medline","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Rheumatology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4392022425"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025212259","display_name":"Marthe Kirkes\u00e6ther Brun","orcid":"https://orcid.org/0000-0001-5148-9684","observed_orcids":["https://orcid.org/0000-0001-5148-9684"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Marthe Kirkes\u00e6ther Brun","raw_affiliation_strings":["Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: marthe.k.brun@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: marthe.k.brun@gmail.com","institution_ids":["https://openalex.org/I184942183","https://openalex.org/I4210117451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058070491","display_name":"Johanna Elin Gehin","orcid":"https://orcid.org/0000-0002-9896-0223","observed_orcids":["https://orcid.org/0000-0002-9896-0223"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Johanna E Gehin","raw_affiliation_strings":["Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037227826","display_name":"K. H. Bj\u00f8rlykke","orcid":"https://orcid.org/0000-0003-2369-6760","observed_orcids":["https://orcid.org/0000-0003-2369-6760"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I2800192669","display_name":"Akershus University Hospital","ror":"https://ror.org/0331wat71","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800192669"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kristin Hammersb\u00f8en Bj\u00f8rlykke","raw_affiliation_strings":["Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Akershus University Hospital, L\u00f8renskog, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Akershus University Hospital, L\u00f8renskog, Norway","institution_ids":["https://openalex.org/I184942183","https://openalex.org/I2800192669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102918631","display_name":"David John Warren","orcid":"https://orcid.org/0000-0001-6854-1282","observed_orcids":["https://orcid.org/0000-0001-6854-1282"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"David John Warren","raw_affiliation_strings":["Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000012610","display_name":"Rolf Anton Klaasen","orcid":"https://orcid.org/0000-0002-6078-5108","observed_orcids":["https://orcid.org/0000-0002-6078-5108"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Rolf A Klaasen","raw_affiliation_strings":["Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104196097","display_name":"Joseph Sexton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Joseph Sexton","raw_affiliation_strings":["Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I4210117451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086857031","display_name":"\u00d8ystein Sandanger","orcid":"https://orcid.org/0000-0001-7475-7362","observed_orcids":["https://orcid.org/0000-0001-7475-7362"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"\u00d8ystein Sandanger","raw_affiliation_strings":["Section of Dermatology, Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Dermatology, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035671675","display_name":"Tore Kristian Kvien","orcid":"https://orcid.org/0000-0002-8441-3093","observed_orcids":["https://orcid.org/0000-0002-8441-3093"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Tore K Kvien","raw_affiliation_strings":["Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183","https://openalex.org/I4210117451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006572893","display_name":"Cato M\u00f8rk","orcid":"https://orcid.org/0009-0004-2246-249X","observed_orcids":["https://orcid.org/0009-0004-2246-249X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cato M\u00f8rk","raw_affiliation_strings":["Akershus Dermatology Center, L\u00f8renskog, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Akershus Dermatology Center, L\u00f8renskog, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008586750","display_name":"J\u00f8rgen Jahnsen","orcid":"https://orcid.org/0000-0002-0419-2914","observed_orcids":["https://orcid.org/0000-0002-0419-2914"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I2800192669","display_name":"Akershus University Hospital","ror":"https://ror.org/0331wat71","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800192669"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"J\u00f8rgen Jahnsen","raw_affiliation_strings":["Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Akershus University Hospital, L\u00f8renskog, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Akershus University Hospital, L\u00f8renskog, Norway","institution_ids":["https://openalex.org/I184942183","https://openalex.org/I2800192669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077936932","display_name":"Nils Bolstad","orcid":"https://orcid.org/0000-0003-3633-8428","observed_orcids":["https://orcid.org/0000-0003-3633-8428"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Nils Bolstad","raw_affiliation_strings":["Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011957275","display_name":"Kristin Kaasen J\u00f8rgensen","orcid":"https://orcid.org/0000-0002-3693-7706","observed_orcids":["https://orcid.org/0000-0002-3693-7706"]},"institutions":[{"id":"https://openalex.org/I2800192669","display_name":"Akershus University Hospital","ror":"https://ror.org/0331wat71","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800192669"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kristin Kaasen J\u00f8rgensen","raw_affiliation_strings":["Department of Gastroenterology, Akershus University Hospital, L\u00f8renskog, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Akershus University Hospital, L\u00f8renskog, Norway","institution_ids":["https://openalex.org/I2800192669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000542169","display_name":"Espen Andre Haavardsholm","orcid":"https://orcid.org/0000-0002-1427-4745","observed_orcids":["https://orcid.org/0000-0002-1427-4745","https://orcid.org/0000-0002-5893-1698"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Espen A Haavardsholm","raw_affiliation_strings":["Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183","https://openalex.org/I4210117451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059000621","display_name":"Guro L\u00f8vik Goll","orcid":"https://orcid.org/0000-0002-8506-725X","observed_orcids":["https://orcid.org/0000-0002-8506-725X"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Guro L\u00f8vik Goll","raw_affiliation_strings":["Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Health and Society, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Health and Society, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183","https://openalex.org/I4210117451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025438429","display_name":"Silje Watterdal Syversen","orcid":"https://orcid.org/0000-0003-2159-3696","observed_orcids":["https://orcid.org/0000-0003-2159-3696"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Silje Watterdal Syversen","raw_affiliation_strings":["Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Health and Society, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway; Institute of Health and Society, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183","https://openalex.org/I4210117451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025212259"],"corresponding_institution_ids":["https://openalex.org/I184942183","https://openalex.org/I4210117451"],"apc_list":{"value":6300,"currency":"USD","value_usd":6300},"apc_paid":null,"fwci":3.7867,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.94382022,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"6","issue":"4","first_page":"e226","last_page":"e236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antidrug-antibodies","display_name":"antidrug antibodies","score":0.8240000009536743},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/immune-mediated-inflammatory-diseases","display_name":"immune-mediated inflammatory diseases","score":0.9380000233650208},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.8100000023841858},{"id":"https://openalex.org/keywords/disease-worsening","display_name":"disease worsening","score":0.9129999876022339},{"id":"https://openalex.org/keywords/infusion-related-reactions","display_name":"infusion reactions","score":0.9070000052452087},{"id":"https://openalex.org/keywords/rheumatology","display_name":"rheumatology","score":0.5350000262260437},{"id":"https://openalex.org/keywords/gastroenterology","display_name":"gastroenterology","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dermatology","display_name":"dermatology","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.905613899230957},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.8089591860771179},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6856288313865662},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.5623098015785217},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5020685195922852},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.48645588755607605},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.48448964953422546},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.47724223136901855},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4620394706726074},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42095381021499634},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2174369990825653},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1806621551513672},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.14672619104385376},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s2665-9913(23)00341-7","doi":"https://doi.org/10.1016/s2665-9913(23)00341-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2665-9913(23)00341-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210233594","display_name":"The Lancet Rheumatology","issn_l":"2665-9913","issn":["2665-9913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-3","medline","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Rheumatology","raw_type":"journal-article"},{"id":"pmid:38402891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38402891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet. Rheumatology","raw_type":"Randomized Controlled Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335102","display_name":"Helse S\u00f8r-\u00d8st RHF","ror":"https://ror.org/02qx2s478"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1176283365","https://openalex.org/W1918195983","https://openalex.org/W1996472975","https://openalex.org/W2022033278","https://openalex.org/W2064189084","https://openalex.org/W2122404129","https://openalex.org/W2125889316","https://openalex.org/W2139133180","https://openalex.org/W2149309054","https://openalex.org/W2159628003","https://openalex.org/W2163203964","https://openalex.org/W2410520654","https://openalex.org/W2744879509","https://openalex.org/W2778397807","https://openalex.org/W2809750595","https://openalex.org/W2916794721","https://openalex.org/W2926897045","https://openalex.org/W2999400123","https://openalex.org/W3029877526","https://openalex.org/W3042809965","https://openalex.org/W3110650867","https://openalex.org/W3157525851","https://openalex.org/W3212746417","https://openalex.org/W4200136929","https://openalex.org/W4210258765","https://openalex.org/W4211167126","https://openalex.org/W4223501902","https://openalex.org/W4280535403","https://openalex.org/W4307414454","https://openalex.org/W4307687730","https://openalex.org/W4322495487"],"related_works":["https://openalex.org/W4379520167","https://openalex.org/W2999400123","https://openalex.org/W3083885499","https://openalex.org/W3157525851","https://openalex.org/W4210459066","https://openalex.org/W4223501902","https://openalex.org/W3201229368","https://openalex.org/W4200136929","https://openalex.org/W2411209198","https://openalex.org/W4392029101"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-02-23T00:00:00"}