{"id":"https://openalex.org/W4392018403","doi":"https://doi.org/10.1111/apm.13386","title":"Informed development of a multi\u2010species biofilm in chronic obstructive pulmonary disease","display_name":"Informed development of a multi\u2010species biofilm in chronic obstructive pulmonary disease","publication_year":2024,"publication_date":"2024-02-21","ids":{"openalex":"https://openalex.org/W4392018403","doi":"https://doi.org/10.1111/apm.13386","pmid":"https://pubmed.ncbi.nlm.nih.gov/38379455"},"language":"en","primary_location":{"id":"doi:10.1111/apm.13386","doi":"https://doi.org/10.1111/apm.13386","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apm.13386","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apm.13386","source":{"id":"https://openalex.org/S135377718","display_name":"Apmis","issn_l":"0903-4641","issn":["0903-4641","1600-0463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APMIS","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apm.13386","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035565987","display_name":"Bryn Short","orcid":"https://orcid.org/0000-0003-3478-2525","observed_orcids":["https://orcid.org/0000-0003-3478-2525"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bryn Short","raw_affiliation_strings":["School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences (MVLS) University of Glasgow Glasgow UK"],"raw_orcid":"https://orcid.org/0000-0003-3478-2525","affiliations":[{"raw_affiliation_string":"School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences (MVLS) University of Glasgow Glasgow UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033270933","display_name":"Christopher Delaney","orcid":"https://orcid.org/0000-0001-9467-4468","observed_orcids":["https://orcid.org/0000-0001-9467-4468"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher Delaney","raw_affiliation_strings":["School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences (MVLS) University of Glasgow Glasgow UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences (MVLS) University of Glasgow Glasgow UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069488615","display_name":"William Johnston","orcid":"https://orcid.org/0000-0001-8794-575X","observed_orcids":["https://orcid.org/0000-0001-8794-575X"]},"institutions":[{"id":"https://openalex.org/I195939026","display_name":"Glasgow Caledonian University","ror":"https://ror.org/03dvm1235","country_code":"GB","type":"education","lineage":["https://openalex.org/I195939026"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Johnston","raw_affiliation_strings":["Safeguarding Health through Infection Prevention (SHIP) Research Group, Research Centre for Health Glasgow Caledonian University  Glasgow UK","Safeguarding Health through Infection Prevention (SHIP) Research Group, Research Centre for Health, Glasgow Caledonian University, Glasgow;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safeguarding Health through Infection Prevention (SHIP) Research Group, Research Centre for Health Glasgow Caledonian University  Glasgow UK","institution_ids":["https://openalex.org/I195939026"]},{"raw_affiliation_string":"Safeguarding Health through Infection Prevention (SHIP) Research Group, Research Centre for Health, Glasgow Caledonian University, Glasgow;","institution_ids":["https://openalex.org/I195939026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009942080","display_name":"Gary J. Litherland","orcid":"https://orcid.org/0000-0001-5264-0219","observed_orcids":["https://orcid.org/0000-0001-5264-0219"]},"institutions":[{"id":"https://openalex.org/I868834043","display_name":"University of the West of Scotland","ror":"https://ror.org/04w3d2v20","country_code":"GB","type":"education","lineage":["https://openalex.org/I868834043"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gary J. Litherland","raw_affiliation_strings":["Hamilton International Technology Park  Glasgow UK","Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences University of the West of Scotland  Paisley UK","Hamilton International Technology Park, Glasgow; and","Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences, University of the West of Scotland, Paisley;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamilton International Technology Park  Glasgow UK","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences University of the West of Scotland  Paisley UK","institution_ids":["https://openalex.org/I868834043"]},{"raw_affiliation_string":"Hamilton International Technology Park, Glasgow; and","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences, University of the West of Scotland, Paisley;","institution_ids":["https://openalex.org/I868834043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028521025","display_name":"John C. Lockhart","orcid":"https://orcid.org/0000-0001-8115-9205","observed_orcids":["https://orcid.org/0000-0001-8115-9205"]},"institutions":[{"id":"https://openalex.org/I868834043","display_name":"University of the West of Scotland","ror":"https://ror.org/04w3d2v20","country_code":"GB","type":"education","lineage":["https://openalex.org/I868834043"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John C. Lockhart","raw_affiliation_strings":["Hamilton International Technology Park  Glasgow UK","Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences University of the West of Scotland  Paisley UK","Hamilton International Technology Park, Glasgow; and","Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences, University of the West of Scotland, Paisley;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamilton International Technology Park  Glasgow UK","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences University of the West of Scotland  Paisley UK","institution_ids":["https://openalex.org/I868834043"]},{"raw_affiliation_string":"Hamilton International Technology Park, Glasgow; and","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences, University of the West of Scotland, Paisley;","institution_ids":["https://openalex.org/I868834043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073005415","display_name":"Craig Williams","orcid":"https://orcid.org/0000-0001-5002-6215","observed_orcids":["https://orcid.org/0000-0001-5002-6215"]},"institutions":[{"id":"https://openalex.org/I2799673572","display_name":"Royal Lancaster Infirmary","ror":"https://ror.org/056nq0726","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I172622728","https://openalex.org/I2799673572"]},{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Craig Williams","raw_affiliation_strings":["Microbiology Department, Lancaster Royal Infirmary, University of Lancaster, Lancaster, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Lancaster Royal Infirmary, University of Lancaster, Lancaster, UK","institution_ids":["https://openalex.org/I2799673572","https://openalex.org/I67415387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024412354","display_name":"William Gordon Mackay","orcid":"https://orcid.org/0000-0003-0293-8054","observed_orcids":["https://orcid.org/0000-0003-0293-8054"]},"institutions":[{"id":"https://openalex.org/I868834043","display_name":"University of the West of Scotland","ror":"https://ror.org/04w3d2v20","country_code":"GB","type":"education","lineage":["https://openalex.org/I868834043"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William G. Mackay","raw_affiliation_strings":["Hamilton International Technology Park  Glasgow UK","Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences University of the West of Scotland  Paisley UK","Hamilton International Technology Park, Glasgow; and","Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences, University of the West of Scotland, Paisley;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamilton International Technology Park  Glasgow UK","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences University of the West of Scotland  Paisley UK","institution_ids":["https://openalex.org/I868834043"]},{"raw_affiliation_string":"Hamilton International Technology Park, Glasgow; and","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences, University of the West of Scotland, Paisley;","institution_ids":["https://openalex.org/I868834043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008206603","display_name":"Gordon Ramage","orcid":"https://orcid.org/0000-0002-0932-3514","observed_orcids":["https://orcid.org/0000-0002-0932-3514"]},"institutions":[{"id":"https://openalex.org/I195939026","display_name":"Glasgow Caledonian University","ror":"https://ror.org/03dvm1235","country_code":"GB","type":"education","lineage":["https://openalex.org/I195939026"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gordon Ramage","raw_affiliation_strings":["Safeguarding Health through Infection Prevention (SHIP) Research Group, Research Centre for Health Glasgow Caledonian University  Glasgow UK","School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences (MVLS) University of Glasgow Glasgow UK","Safeguarding Health through Infection Prevention (SHIP) Research Group, Research Centre for Health, Glasgow Caledonian University, Glasgow;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safeguarding Health through Infection Prevention (SHIP) Research Group, Research Centre for Health Glasgow Caledonian University  Glasgow UK","institution_ids":["https://openalex.org/I195939026"]},{"raw_affiliation_string":"School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences (MVLS) University of Glasgow Glasgow UK","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"Safeguarding Health through Infection Prevention (SHIP) Research Group, Research Centre for Health, Glasgow Caledonian University, Glasgow;","institution_ids":["https://openalex.org/I195939026"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008206603"],"corresponding_institution_ids":["https://openalex.org/I195939026","https://openalex.org/I7882870"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":{"value":4330,"currency":"USD","value_usd":4330},"fwci":0.3242,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.29103013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"132","issue":"5","first_page":"336","last_page":"347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/biofilm-model","display_name":"biofilm model","score":0.6909999847412109},{"id":"https://openalex.org/keywords/lung-microbiome","display_name":"lung microbiome","score":0.9449999928474426},{"id":"https://openalex.org/keywords/haemophilus","display_name":"Haemophilus","score":0.8489999771118164},{"id":"https://openalex.org/keywords/moraxella","display_name":"Moraxella","score":1.0},{"id":"https://openalex.org/keywords/streptococcus","display_name":"Streptococcus","score":1.0},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7120000123977661},{"id":"https://openalex.org/keywords/fungal-colonization","display_name":"fungal colonization","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.8226497173309326},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6589329242706299},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5391566753387451},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47683706879615784},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.44716182351112366},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4383082985877991},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2922379672527313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2671986222267151},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.17892101407051086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1111/apm.13386","doi":"https://doi.org/10.1111/apm.13386","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apm.13386","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apm.13386","source":{"id":"https://openalex.org/S135377718","display_name":"Apmis","issn_l":"0903-4641","issn":["0903-4641","1600-0463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APMIS","raw_type":"journal-article"},{"id":"pmid:38379455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38379455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica","raw_type":"Meta-Analysis"},{"id":"pmh:oai:researchonline.gcu.ac.uk:openaire_cris_publications/b9f0afc5-15a8-4cf5-bfc4-c2fa8af2ba05","doi":null,"is_oa":true,"landing_page_url":"https://researchonline.gcu.ac.uk/en/publications/b9f0afc5-15a8-4cf5-bfc4-c2fa8af2ba05","pdf_url":null,"source":{"id":"https://openalex.org/S7407055385","display_name":"ResearchOnline","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Short, B, Delaney, C, Johnston, W, Litherland, G J, Lockhart, J C, Williams, C, Mackay, W G & Ramage, G 2024, 'Informed development of a multi-species biofilm in chronic obstructive pulmonary disease', APMIS, vol. 132, no. 5, pp. 336-347. https://doi.org/10.1111/apm.13386","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.gla.ac.uk:318717","doi":null,"is_oa":true,"landing_page_url":"http://eprints.gla.ac.uk/view/author/64286.html>,","pdf_url":"https://eprints.gla.ac.uk/318717/1/318717.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Articles"},{"id":"pmh:oai:pure.atira.dk:openaire/ad5a235d-11ea-4db2-872a-3711e360597c","doi":null,"is_oa":true,"landing_page_url":"https://research-portal.uws.ac.uk/en/publications/ad5a235d-11ea-4db2-872a-3711e360597c","pdf_url":"https://myresearchspace.uws.ac.uk/ws/files/46136087/2024_02_02_Short_et_al_Informed_final.pdf","source":{"id":"https://openalex.org/S4306402572","display_name":"The UWS Academic Portal (University of the West of Scotland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I868834043","host_organization_name":"University of the West of Scotland","host_organization_lineage":["https://openalex.org/I868834043"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Short, B, Delaney, C, Johnston, W, Litherland, G J, Lockhart, J C, Williams, C, Mackay, W G & Ramage, G 2024, 'Informed development of a multi-species biofilm in chronic obstructive pulmonary disease', Journal of Pathology, Microbiology and Immunology - the APMIS Journal, vol. 132, no. 5, pp. 336-347. https://doi.org/10.1111/apm.13386","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:researchonline.gcu.ac.uk:openaire/b9f0afc5-15a8-4cf5-bfc4-c2fa8af2ba05","doi":null,"is_oa":true,"landing_page_url":"https://researchonline.gcu.ac.uk/en/publications/b9f0afc5-15a8-4cf5-bfc4-c2fa8af2ba05","pdf_url":null,"source":{"id":"https://openalex.org/S4306402566","display_name":"ResearchOnline (Glasgow Caledonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I195939026","host_organization_name":"Glasgow Caledonian University","host_organization_lineage":["https://openalex.org/I195939026"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Short, B, Delaney, C, Johnston, W, Litherland, G J, Lockhart, J C, Williams, C, Mackay, W G & Ramage, G 2024, 'Informed development of a multi-species biofilm in chronic obstructive pulmonary disease', APMIS, vol. 132, no. 5, pp. 336-347. https://doi.org/10.1111/apm.13386","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/apm.13386","doi":"https://doi.org/10.1111/apm.13386","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apm.13386","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apm.13386","source":{"id":"https://openalex.org/S135377718","display_name":"Apmis","issn_l":"0903-4641","issn":["0903-4641","1600-0463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APMIS","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G58353949","display_name":null,"funder_award_id":"INT-VA/045","funder_id":"https://openalex.org/F4320337753","funder_display_name":"Interreg"}],"funders":[{"id":"https://openalex.org/F4320337753","display_name":"Interreg","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392018403.pdf","grobid_xml":"https://content.openalex.org/works/W4392018403.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W19619120","https://openalex.org/W1643130021","https://openalex.org/W1859222707","https://openalex.org/W1895090196","https://openalex.org/W2000873665","https://openalex.org/W2006617902","https://openalex.org/W2032502193","https://openalex.org/W2034285706","https://openalex.org/W2035643252","https://openalex.org/W2042429567","https://openalex.org/W2056279562","https://openalex.org/W2068332307","https://openalex.org/W2077691383","https://openalex.org/W2087537704","https://openalex.org/W2090110893","https://openalex.org/W2108734609","https://openalex.org/W2113925621","https://openalex.org/W2123235711","https://openalex.org/W2123311799","https://openalex.org/W2163267243","https://openalex.org/W2163401084","https://openalex.org/W2166358290","https://openalex.org/W2260966294","https://openalex.org/W2333373066","https://openalex.org/W2418248809","https://openalex.org/W2530495088","https://openalex.org/W2559784131","https://openalex.org/W2591730815","https://openalex.org/W2607948310","https://openalex.org/W2613136430","https://openalex.org/W2735960034","https://openalex.org/W2737870032","https://openalex.org/W2771045365","https://openalex.org/W2783137360","https://openalex.org/W2790637257","https://openalex.org/W2883251903","https://openalex.org/W2884607621","https://openalex.org/W2911964244","https://openalex.org/W2948355575","https://openalex.org/W2959992540","https://openalex.org/W2963276645","https://openalex.org/W2999779420","https://openalex.org/W3004967314","https://openalex.org/W3044875548","https://openalex.org/W3087860294","https://openalex.org/W3111162011","https://openalex.org/W3117997704","https://openalex.org/W3209967777","https://openalex.org/W4223573680","https://openalex.org/W4224706215","https://openalex.org/W4285298210","https://openalex.org/W4294176499","https://openalex.org/W4362454649","https://openalex.org/W6638901165"],"related_works":["https://openalex.org/W3096105029","https://openalex.org/W7046568955","https://openalex.org/W6930102460","https://openalex.org/W2324100401","https://openalex.org/W4313380234","https://openalex.org/W2343196110","https://openalex.org/W2416157325","https://openalex.org/W4394978338","https://openalex.org/W4399423494","https://openalex.org/W3175122704"],"abstract_inverted_index":{"Recent":[0],"evidence":[1],"indicates":[2],"that":[3,65,93,182],"microbial":[4],"biofilm":[5,29,53,121,127,159,164],"aggregates":[6],"inhabit":[7],"the":[8,40,116,158,169],"lungs":[9],"of":[10,39,50,56,69,118,129,133,145,168],"COPD":[11,32,44,70,170],"patients":[12,97],"and":[13,19,77,101,147,173,186],"actively":[14],"contribute":[15],"towards":[16],"chronic":[17],"colonization":[18],"repeat":[20],"infections.":[21],"However,":[22,142],"there":[23],"are":[24],"no":[25,137],"contextually":[26],"relevant":[27],"complex":[28],"models":[30],"for":[31,108,195],"research.":[33],"In":[34],"this":[35],"study,":[36],"a":[37,126],"meta-analysis":[38],"lung":[41,171],"microbiome":[42,172],"in":[43,115,140,151,154,176,188],"was":[45,113],"used":[46],"to":[47,74,83,106],"inform":[48],"development":[49],"an":[51,119,148],"optimized":[52],"model":[54,165],"composed":[55],"genera":[57],"highly":[58],"associated":[59],"with":[60,136],"COPD.":[61],"Bioinformatic":[62],"analysis":[63],"showed":[64],"although":[66],"diversity":[67],"matrices":[68],"microbiomes":[71],"were":[72],"similar":[73],"healthy":[75],"controls,":[76],"internal":[78],"compositions":[79],"made":[80],"it":[81],"possible":[82],"accurately":[84],"differentiate":[85],"between":[86],"these":[87,96,189],"cohorts":[88],"(AUC":[89],"=":[90],"0.939).":[91],"Genera":[92],"best":[94],"defined":[95],"included":[98,114],"Haemophilus,":[99],"Moraxella":[100],"Streptococcus.":[102],"Many":[103],"studies":[104],"fail":[105],"account":[107],"fungi;":[109],"therefore,":[110],"Candida":[111],"albicans":[112],"creation":[117],"interkingdom":[120,190],"model.":[122],"These":[123],"organisms":[124],"formed":[125],"capable":[128],"tolerating":[130],"high":[131],"concentrations":[132],"antimicrobial":[134,178],"therapies":[135,144],"significant":[138,152],"reductions":[139,153],"viability.":[141],"combined":[143],"antibiotics":[146],"antifungal":[149],"resulted":[150],"viable":[155],"cells":[156],"throughout":[157],"(p":[160],"<":[161],"0.05).":[162],"This":[163],"is":[166],"representative":[167],"results":[174],"from":[175],"vitro":[177],"challenge":[179],"experiments":[180],"indicate":[181],"targeting":[183],"both":[184],"bacteria":[185],"fungi":[187],"communities":[191],"will":[192],"be":[193],"required":[194],"more":[196],"positive":[197],"clinical":[198],"outcomes.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-02-22T00:00:00"}
