{"id":"https://openalex.org/W4392000008","doi":"https://doi.org/10.29322/ijsrp.14.01.2023.p14525","title":"Uric Acid Lowering Effect of Losartan in Patients with Stage 1 Hypertension and Asymptomatic Hyperuricemia","display_name":"Uric Acid Lowering Effect of Losartan in Patients with Stage 1 Hypertension and Asymptomatic Hyperuricemia","publication_year":2024,"publication_date":"2024-01-24","ids":{"openalex":"https://openalex.org/W4392000008","doi":"https://doi.org/10.29322/ijsrp.14.01.2023.p14525"},"language":"en","primary_location":{"id":"doi:10.29322/ijsrp.14.01.2023.p14525","doi":"https://doi.org/10.29322/ijsrp.14.01.2023.p14525","is_oa":true,"landing_page_url":"https://doi.org/10.29322/ijsrp.14.01.2023.p14525","pdf_url":"https://www.ijsrp.org/research-paper-0124/ijsrp-p14525.pdf","source":{"id":"https://openalex.org/S4210203267","display_name":"International Journal of Scientific and Research Publications","issn_l":"2250-3153","issn":["2250-3153"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":"https://openalex.org/P4323237798","host_organization_name":"International Journal of Scientific and Research Publications","host_organization_lineage":["https://openalex.org/P4323237798"],"host_organization_lineage_names":["International Journal of Scientific and Research Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Scientific and Research Publications","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4392000008"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.ijsrp.org/research-paper-0124/ijsrp-p14525.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108902668","display_name":"Pyae Sone Thet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267335","display_name":"Defence Services Medical Academy","ror":"https://ror.org/028v1cr38","country_code":"MM","type":"education","lineage":["https://openalex.org/I4405267335"]}],"countries":["MM"],"is_corresponding":false,"raw_author_name":"Pyae Sone Thet","raw_affiliation_strings":["Department of Pharmacology , Defence Services Medical Academy , Yangon , Myanmar","No"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , Defence Services Medical Academy , Yangon , Myanmar","institution_ids":["https://openalex.org/I4405267335"]},{"raw_affiliation_string":"No","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093970854","display_name":"Kyaw Zwar Htoon","orcid":"https://orcid.org/0009-0005-0665-3322","observed_orcids":["https://orcid.org/0009-0005-0665-3322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyaw Zwar Htoon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034401917","display_name":"Khin Ohnmar Kyaing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khin Ohnmar Kyaing","raw_affiliation_strings":["Medical Battalion , Sittwe , Rakhine State , Myanmar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Battalion , Sittwe , Rakhine State , Myanmar","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093970855","display_name":"Cho Mg Mg Myint","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cho Mg Mg Myint","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"1","first_page":"255","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.8730000257492065},{"id":"https://openalex.org/keywords/serum-uric-acid","display_name":"serum uric acid","score":0.9279999732971191},{"id":"https://openalex.org/keywords/stage-1-hypertension","display_name":"stage 1 hypertension","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.8240000009536743},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.8199999928474426},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.9764602184295654},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.8807291984558105},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.7433397769927979},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7337018251419067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6959211826324463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5581122636795044},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5068894028663635},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34430867433547974},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33085811138153076},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3305265009403229},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.32191094756126404},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.20727300643920898},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.07180503010749817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04875054955482483},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.29322/ijsrp.14.01.2023.p14525","doi":"https://doi.org/10.29322/ijsrp.14.01.2023.p14525","is_oa":true,"landing_page_url":"https://doi.org/10.29322/ijsrp.14.01.2023.p14525","pdf_url":"https://www.ijsrp.org/research-paper-0124/ijsrp-p14525.pdf","source":{"id":"https://openalex.org/S4210203267","display_name":"International Journal of Scientific and Research Publications","issn_l":"2250-3153","issn":["2250-3153"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":"https://openalex.org/P4323237798","host_organization_name":"International Journal of Scientific and Research Publications","host_organization_lineage":["https://openalex.org/P4323237798"],"host_organization_lineage_names":["International Journal of Scientific and Research Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Scientific and Research Publications","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.29322/ijsrp.14.01.2023.p14525","doi":"https://doi.org/10.29322/ijsrp.14.01.2023.p14525","is_oa":true,"landing_page_url":"https://doi.org/10.29322/ijsrp.14.01.2023.p14525","pdf_url":"https://www.ijsrp.org/research-paper-0124/ijsrp-p14525.pdf","source":{"id":"https://openalex.org/S4210203267","display_name":"International Journal of Scientific and Research Publications","issn_l":"2250-3153","issn":["2250-3153"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":"https://openalex.org/P4323237798","host_organization_name":"International Journal of Scientific and Research Publications","host_organization_lineage":["https://openalex.org/P4323237798"],"host_organization_lineage_names":["International Journal of Scientific and Research Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Scientific and Research Publications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392000008.pdf","grobid_xml":"https://content.openalex.org/works/W4392000008.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4249566621","https://openalex.org/W7202276241","https://openalex.org/W2320494054","https://openalex.org/W2388497174","https://openalex.org/W2322923062","https://openalex.org/W3140998688","https://openalex.org/W2549527193","https://openalex.org/W3217751078","https://openalex.org/W3130548382","https://openalex.org/W2365972798"],"abstract_inverted_index":{"Hyperuricemia":[0],"is":[1],"a":[2,50,70,134,152,166,178,193],"recognized":[3],"risk":[4],"factor":[5],"for":[6,81,93],"cardiovascular":[7],"diseases,":[8],"particularly":[9],"prevalent":[10],"in":[11,35,137,196],"individuals":[12],"with":[13,61,130,140,165],"hypertension.Addressing":[14],"hyperuricemia":[15],"holds":[16],"the":[17,21,29,94,155],"potential":[18],"to":[19,88],"mitigate":[20],"onset":[22],"of":[23,33,73,101,114,124,173,185],"hypertension.This":[24],"investigation":[25],"focused":[26],"on":[27,158],"exploring":[28],"uric":[30,104,146,160,198],"acid-reducing":[31],"capabilities":[32],"losartan":[34,127,142,176,191],"patients":[36],"exhibiting":[37],"stage":[38,62],"1":[39,63],"hypertension":[40,64],"(as":[41],"per":[42],"JNC":[43],"VIII)":[44],"accompanied":[45],"by":[46,85],"asymptomatic":[47,66],"hyperuricemia.Conducted":[48],"as":[49],"community-based":[51],"before-and-after":[52],"interventional":[53],"study,":[54],"this":[55],"research":[56],"involved":[57],"27":[58],"male":[59],"participants":[60],"and":[65,118,177,209],"hyperuricemia.The":[67],"intervention":[68],"comprised":[69],"treatment":[71],"regimen":[72],"losartan,":[74,117],"initially":[75],"at":[76,109],"25":[77,115,174],"mg":[78,90,116,126,175,187],"once":[79,91],"daily":[80,92],"4":[82,96,112,122,171,183],"weeks,":[83,97],"followed":[84],"an":[86,120],"escalation":[87],"50":[89,125,186],"subsequent":[95],"totaling":[98],"8":[99],"weeks":[100,113,123,172,184],"continuous":[102],"therapy.Serum":[103],"acid":[105,147,161,199],"levels":[106],"were":[107],"assessed":[108],"baseline,":[110],"after":[111,170,182],"following":[119],"additional":[121],"therapy.Comparative":[128],"analysis":[129],"baseline":[131],"data":[132],"revealed":[133],"significant":[135,153],"reduction":[136,169,181],"blood":[138],"pressure":[139],"both":[141],"doses,":[143],"although":[144],"serum":[145,159],"level":[148,162],"did":[149],"not":[150],"show":[151],"decrease.Notably,":[154],"dose-dependent":[156,194],"effect":[157,195],"was":[163],"evident,":[164],"1.80":[167],"%":[168,180],"6.52":[179],"losartan.In":[188],"summary,":[189],"while":[190],"demonstrated":[192],"lowering":[197],"levels,":[200],"achieving":[201],"normal":[202],"range":[203],"values":[204],"may":[205],"necessitate":[206],"larger":[207],"doses":[208],"extended":[210],"therapy":[211],"duration.":[212]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-02-22T00:00:00"}
